检索结果-南通市图书馆

1.55μm Fabry-Perot Thermo-Optical Tunable Filter with Amorphous-Si as Cavity

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2003年第9期24卷 911-915页

作者：左玉华蔡晓毛容伟黄昌俊成步文李传波罗丽萍高俊华白云霞姜磊马朝华王良臣余金中王启明中国科学院半导体研究所集成光电子国家重点实验室北京100083 中国科学院半导体研究所光电子工艺中心北京100083

A 1.55μm Fabry-Perot (F-P) thermo-optical t unable filter is *** cavity is made of amorphous silicon (a-Si) layer grown by electron-beam evaporation *** to the excellent thermo-optical property of a-Si,the refractive index of the F-P cavity will be changed by heating;the transmittance resonant peak will therefore shift *** measured tuning rang is 12nm, FWHM (full-width-at-half-maximum) of the transmissi on peak is 9nm,and heating efficiency is 0.1K/*** large FWHM is mainly due to th e non-ideal coating deposition and mirror *** improvements to increase the efficiency of heating are suggested.

关键词： thermo-optical effect Fabry-Perot tunable filter a-Si

Current trends in drug metabolism and pharmacokinetics

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2019年第6期9卷 1113-1144页

作者： yuhua Li Qiang Meng Mengbi Yang Dongyang Liu Xiangyu Hou Lan Tang Xin Wang Yuanfeng Lyu Xiaoyan Chen Kexin Liu Ai-Ming Yu Zhong zuo Huichang Bi School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510275China The First Affiliated Hospital of Nanchang University Nanchang 330006China College of Pharmacy Dalian Medical UniversityDalian 116044China School of Pharmacy the Chinese University of Hong KongHong KongChina Drug Clinical Trial Center Peking University Third HospitalBeijing 100191China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China School of Life Sciences East China Normal UniversityShanghai 200241China UC Davis School of Medicine SacramentoCA 95817USA

Pharmacokinetics(PK)is the study of the absorption,distribution,metabolism,and excretion(ADME)processes of a *** PK properties is essential for drug development and precision *** this review we provided an overview of recent research on PK with focus on the following aspects:(1)an update on drug-metabolizing enzymes and transporters in the determination of PK,as well as advances in xenobiotic receptors and noncoding RNAs(ncRNAs)in the modulation of PK,providing new understanding of the transcriptional and posttranscriptional regulatory mechanisms that result in inter-individual variations in pharmacotherapy;(2)current status and trends in assessing drug-drug interactions,especially interactions between drugs and herbs,between drugs and therapeutic biologies,and microbiota-mediated interactions:(3)advances in understanding the effects of diseases on PK,particularly changes in metabolizing enzymes and transporters with disease progression;(4)trends in mathematical modeling including physiologically-based PK modeling and novel animal models such as CRISPR/Cas9-based animal models for DMPK studies:(5)emerging non-classical xenobiotic metabolic pathways and the involvement of novel metabolic enzymes,especially *** challenges and perspectives on future directions are discussed,and may stimulate the development of new research models,technologies,and strategies towards the development of better drugs and improved clinical practice.

关键词： Pharmacokinetics Drug metabolism Drug-drug interactions Modeling Metabolizing enzymes Transporters Nuclear receptors Noncoding RNAs

1.3μm Si-Based MOEMS Optical Tunable Filter with a Tuning Range of 90nm

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2003年第11期24卷 1140-1144页

作者：左玉华黄昌俊成步文蔡晓毛容伟李传波罗丽萍高俊华白云霞姜磊马朝华朱家廉王良臣余金中王启明中国科学院半导体研究所集成光电子学国家重点实验室北京100083

Optical filters capable of single control parameter based wide tuning are implemented and studied.A prototype surface micromachined 1 3μm Si based MOEMS (micro opto electro mechanical systems) tunable filter exhibits a continuous and large tuning range of 90nm at 50V tuning *** filter can be integrated with Si based photodetector in a low cost component for coarse wavelength division multiplexing systems operating in the 1 3μm band.

关键词： MOEMS Fabry Perot tunable filter surface micromaching

A Facile Synthesis of 9,10-Dimethoxybenzo[6,7]- ox-epino[3,4-<i>b</i>]quinolin-13(6<i>H</i>)-one and Its Derivatives

在线全文

学校读者我要写书评

暂无评论

International Journal of Organic Chemistry 2013年第2期3卷 119-124页

作者： Dingqiao Yang Xiuli Liang Xiongjun zuo yuhua Long Key Laboratory of Theoretical Chemistry of Environment Ministry of Education School of Chemistry and Environment South China Normal University Guangzhou China

A concise and efficient method for the synthesis of novel 9,10-imethoxybenzo[6,7]oxepino[3,4-b]quinolin13(6H)-one and its derivatives 7a-p has been developed via the intramolecular Friedel-Crafts acylation reactions of 6,7-dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylic acids 6a-p with polyphosphoric acid (PPA) as catalyst and solvent under mild conditions. The key intermediates 6a-p were prepared through the in situ formation of ethyl 6,7-dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylates 5a-p followed by hydrolysis with aqueous ethanolic sodium hydroxide solution. The novel synthetic method has the advantages of good yields, easy work-up, and environmentally friendly character, which may provide a novel highly efficient process for making quinoline and related azaheterocycle libraries.

关键词： The Intramolecular Friedel-Crafts Acylation Reaction: 9 10-Dimethoxybenzo [6 7]oxepino[3 4-b]quinolin-13(6H)-one and Its Derivatives 6 7-Dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylic Acid: Ethyl 7-dimethoxy-2-(phenoxymethyl)quinoline-3-carboxylate: PPA

基于ComBat方法调谐^(18)F-FDG PET脑显像的初步研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华核医学与分子影像杂志 2024年第7期44卷 412-416页

作者：焦方阳王丹朱毓华鲁佳荧琚紫昭徐蒨葛璟洁华涛吴平施匡宇管一晖左传涛复旦大学附属华山医院核医学/PET中心上海200235 陆军军医大学大坪医院核医学科重庆400042 瑞士伯尔尼大学核医学科伯尔尼3010

目的基于ComBat方法对同一厂家不同型号PET采集的脑显像数据进行影像调谐,探讨该同质化方法对数据中心效应的影响。方法用2台不同型号PET/CT仪(德国Siemens Biograph64 TruePoint与Biograph128 mCT)对三维(3D)Hoffman脑模型进行^(18)F-F... 详细信息

目的基于ComBat方法对同一厂家不同型号PET采集的脑显像数据进行影像调谐,探讨该同质化方法对数据中心效应的影响。方法用2台不同型号PET/CT仪(德国Siemens Biograph64 TruePoint与Biograph128 mCT)对三维(3D)Hoffman脑模型进行^(18)F-FDG PET显像;对14名健康受试者[男8名、女6名;年龄(57.7±9.5)岁]用Biograph64 TruePoint、12名健康受试者[男9名、女3名;年龄(55.8±10.5)岁]用Biograph128 mCT PET/CT仪行^(18)F-FDG PET脑显像(受试者来源:复旦大学附属华山医院;时间:2020年11月至2023年3月)。依据自动解剖标记(AAL)脑模板将全脑划分为116个脑区,应用ComBat同质化方法对采集的脑模型及健康受试者ROI内PET数据进行影像调谐。对2台PET/CT所得数据影像调谐前后的放射性计数、SUV比值(SUVR)进行Mann-Whitney U检验;对健康受试者的数据进行基于体素的统计参数图(SPM)两独立样本t检验。结果对于3D Hoffman脑模型,Biograph64 TruePoint和Biograph128 mCT PET/CT的调谐前放射性计数[5590.33(4961.67,6102.95)与6116.03(5420.97,6660.66);z=-9.35,P0.05;SUVR:1.04(1.01,1.09)~2.32(2.24,2.40);z值:-0.82~0,均P>0.05]。SPM分析显示调谐前2台PET/CT仪采集的健康受试者脑内葡萄糖代谢在大脑皮质、基底节、中脑及小脑存在差异,调谐后有差异的脑区明显减少。结论ComBat同质化方法可有效地消除同一厂家不同型号PET/CT间系统性技术差异,为多中心脑显像研究提供1种简单、易实现的调谐方法。

关键词：脑图像处理,计算机辅助正电子发射断层显像术氟脱氧葡萄糖F18

(Y,Bi,Sc)VO_4:Eu^(3+)的制备及其发光特性

在线全文

学校读者我要写书评

暂无评论

稀有金属材料与工程 2007年第3期36卷 386-389页

作者：左银艳王育华高辉兰州大学物理科学与技术学院功能与环境材料研究所甘肃兰州730000

用高温固相法在900℃,保温6h的条件下制备了YVO4单相粉末样品。在紫外光254nm激发下,YVO4:Eu3+的激发光谱由VO43-的吸收带和Eu3+的电荷迁移带组成。发射光谱为Eu3+的5D0→7FJ(J=1,2,4)跃迁。在Eu3+含量一定的情况下掺杂Bi3+和Sc3+,随着B... 详细信息

用高温固相法在900℃,保温6h的条件下制备了YVO4单相粉末样品。在紫外光254nm激发下,YVO4:Eu3+的激发光谱由VO43-的吸收带和Eu3+的电荷迁移带组成。发射光谱为Eu3+的5D0→7FJ(J=1,2,4)跃迁。在Eu3+含量一定的情况下掺杂Bi3+和Sc3+,随着Bi3+浓度的增加,激发光谱宽化,但发射强度变弱;Sc3+浓度的增加则使YVO4:Eu3+的发射强度先增加后降低。在147nm激发下,(Y,Bi,Sc)VO4:Eu3+的发射光谱相对于YVO4:Eu3+有降低趋势。

关键词： (Y,Bi,Sc)Vo4:Eu^3+ 荧光粉 UV/VUV

PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第4期10卷 1564-1581页

作者： Jingyi Luo Qing Lian Deliang Zhu Minglei Zhao Tingfang Mei Bizhi Shang Zeqiu Yang Chujun Liu Wenchang Xu Lan Zhou Keling Wu Xinqi Liu yuhua Lai Fuxiang Mao Weihua Li Chengguo zuo Kang Zhang Mingkai Lin Yehong Zhuo Yizhi Liu Lin Lu Ling Zhao State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhouGuangdong 510060China Dongguan Guangming Ophthalmic Hospital Dongguan523000China Guangdong Provincial People’s Hospital Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Ophthalmology Huizhou Municipal Central HospitalHuizhouGuangdong 516000China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510000China Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacao 999078China Guangzhou Regenerative Medicine and Health Guangdong Laboratory GuangzhouGuangdong 510530China Research Unit of Ocular Development and Regeneration Chinese Academy of Medical SciencesGuangzhouGuangdong 510060China

Glaucoma is the leading cause of irreversible blindness *** the pathogen-esis of glaucoma,activated microglia can lead to retinal ganglion cells(RGCs)apoptosis and death,however,the molecular mechanisms remain largely *** demonstrate that phospholipid scramblase 1(PLSCR1)is a key regulator promoting RGCs apoptosis and their clearance by *** evidenced in retinal progenitor cells and RGCs of the acute ocular hypertension(AOH)mouse model,overexpressed PLSCR1 induced its translocation from the nucleus to the cytoplasm and cytomembrane,as well as elevated phosphatidylserine exposure and reactive oxygen species generation with subsequent RGCs apoptosis and *** damages were effectively attenuated by PLSCR1 *** the AOH model,PLSCR1 led to an increase in M1 type microglia activation and retinal *** of PLSCR1 resulted in strongly elevated phagocytosis of apoptotic RGCs by activated *** together,our study provides important insights linking activated microglia to RGCs death in the glaucoma pathogenesis and other RGC-related neurodegenerative diseases.

关键词： Apoptosis Glaucoma Phagocytosis PLSCR1 Retinal ganglion cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

花生半喂入联合收获二次清选机构研究

中国农机化学报 2024年第3期45卷 117-125页

作者：李冬杰王东伟何晓宁左百强张春晓李绪青岛农业大学机电工程学院山东青岛266109

针对目前半喂入花生联合收获机其清选环节存在清选损失率高、荚果含杂率高等问题,基于花生一次清选后花生荚果破损机理,设计一种二次清选装置,主要包括输送链、栅条筛、筛架、液压缸、滑土板,并确定该装置的基本参数。通过ADAMS软件分析... 详细信息

针对目前半喂入花生联合收获机其清选环节存在清选损失率高、荚果含杂率高等问题,基于花生一次清选后花生荚果破损机理,设计一种二次清选装置,主要包括输送链、栅条筛、筛架、液压缸、滑土板,并确定该装置的基本参数。通过ADAMS软件分析,建立清选过程中花生与装置碰撞模型,确定以筛子转速、筛子安装高度、筛子倾角为主要影响因素,并针对“宇花14号”花生品种进行试验研究。结果表明:筛子安装高度为29 cm、筛子转速为147 r/min、筛子安装角度为19°,对应的荚果含杂率为1.65%、清选损失率为1.37%。试验结果表明,应用该装置的两垄四行花生联合机作业效果明显提高。

关键词：花生联合收获半喂入二次清选 ADAMS

热机械处理中退火时间对Fe-Mn-Si基合金形状记忆效应的影响

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

材料工程 2023年第11期51卷 87-93页

作者：左阳孙礼鑫宋帆彭华备陈聪文玉华四川大学机械工程学院成都610065 中国核动力研究设计院核反应堆系统设计技术重点实验室成都610213

热机械处理能显著改善Fe-Mn-Si基合金的形状记忆效应。本工作中,对铸态Fe-Mn-Si基合金进行热锻、20%冷轧变形及固溶处理,随后在1073 K对部分经10%室温拉伸变形的试样进行不同时间退火处理。借助背散射电子显微分析(EBSD)、RGM-4300型万... 详细信息

热机械处理能显著改善Fe-Mn-Si基合金的形状记忆效应。本工作中,对铸态Fe-Mn-Si基合金进行热锻、20%冷轧变形及固溶处理,随后在1073 K对部分经10%室温拉伸变形的试样进行不同时间退火处理。借助背散射电子显微分析(EBSD)、RGM-4300型万能试验机、示差四端电阻法及弯曲法研究热机械处理中退火时间对Fe-Mn-Si基合金微观组织和形状记忆效应的影响规律。结果表明:固溶态Fe-Mn-Si基合金的可恢复应变为4.1%;当经过退火时间为10 min的热机械处理后,合金的可恢复应变显著提高至5.3%;当进一步延长热机械处理的退火时间,合金的可恢复应变随之下降;当热机械处理的退火时间为180 min时,合金的可恢复应变下降至4.9%。随着热机械处理的退火时间延长,退火孪晶分数增加,堆垛层错密度下降,从而导致Fe-Mn-Si基合金促进应力诱发ε马氏体相变和抑制塑性滑移的能力变弱。这是Fe-Mn-Si基合金的可恢复应变随着热机械处理的退火时间延长而降低的主要原因。

关键词：形状记忆合金热机械处理退火孪晶堆垛层错