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Cholic acid mitigates osteoarthritis by inhibiting the NF-κB/PERK/ SIRT1 signaling pathway

BIOCELL 2024年第7期48卷 1095-1104页

作者： JIAOE SHENG ZUMIN YI SANSHAN HE QINGCHAO WU XIA HUANG GUOQING YAN yufang dai LINCHONG SU The Minda Hospital of Hubei Minzu University Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic DiseaseEnshi445000China The Obstetrics and Gynecology of Jianshi County Hospital of Traditional Chinese Medicine Enshi445300China

Introduction:Cholic acid(CA)is a natural steroid useful in treating chronic bronchitis and *** the other hand,its potential impact on osteoarthritis(OA)is ***:Using an in vitro and in vivo osteoarthritis model,we sought to assess the chondroprotective properties of ***:We employed the Cell Counting Kit-8 to measure the impact of CA on chondrocyte activity to assess the toxicity of the *** molecular biology experimental techniques were used to investigate potential signaling pathways that CA may use to prevent inﬂammation and give chondrocytes ***,how CA affects the OA model in Sprague-Dawley(SD)rats was ***:CA signiﬁcantly suppressed the up-regulation of the interleukin-1β(IL-1β),cyclooxygenase-2(COX-2),and matrix metalloproteinase 13(MMP-13)and the downregulation of aggrecan and type II collagen A1(COL2A)in chondrocytes treated tumor necrosis factor-alpha(TNF-α).Differentially expressed genes(DEG)enrichment revealed IL-17,TNF,chemokine,cytokine-cytokine receptor,toll-like receptor,and nucleotide oligomerization domain-like receptor were the primary signaling *** enriched DEGs included CXCL6,CCL20,MMP3,CXCL3,CXCL11,CCL5,CXCL10,MMP9,MMP13,and CXCL2;these DEGs are involved in inﬂammatory responses and their expression induced by TNF-αwas reversed by CA *** inhibits p65 nuclear translocation and inhibitory subunit kappa B alpha(IκBα)phosphorylation induced by TNF-α.Furthermore,CA attenuated protein expression of protein kinase RNA-like endoplasmic reticulum kinase(PERK),inositol-requiring transmembrane kinase/endoribonuclease 1α(IRE1α),glucose regulatory protein 78(GRP78),and sirtuin 1(SIRT1),and down-regulation of phosphorylation of AMP-activated protein kinase-α(p-AMPKα)in TNF-α-treated ***:CA signiﬁcantly ameliorated cartilage degradation in the OA rat *** alleviated the inﬂammatory response through the nuclear factor kappa B/PERK/SIRT1 axis and

关键词： Cholic acid Cartilage Inﬂammation RNA sequencing Differentially expressed genes

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农民专业化发展视角下中国乡村建设的演进脉络及逻辑关联

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重庆社会科学 2024年第5期 39-60页

作者：梁成艾代玉芳铜仁学院梵净教育研究院贵州铜仁554300 铜仁学院马克思主义学院贵州铜仁554330

在当前这一全面推进第二个百年奋斗目标的关键时刻,探究中国乡村建设的演进脉络及逻辑关联,需以“运动、活动和行动”之“三动”型乡村建设演进活动为研究切入点,明晰中国乡村建设演进的导向性逻辑基点是农民地位的变更迭代,其规范性逻... 详细信息

在当前这一全面推进第二个百年奋斗目标的关键时刻,探究中国乡村建设的演进脉络及逻辑关联,需以“运动、活动和行动”之“三动”型乡村建设演进活动为研究切入点,明晰中国乡村建设演进的导向性逻辑基点是农民地位的变更迭代,其规范性逻辑节点是制度供给的位序变化,而幸福美好生活实现则是其整合性逻辑旨归。但这一整合性逻辑旨归的有效彰显,需要“凸显政府在乡村建设变革中的主导地位、强化农民在乡村建设变革中的主体作用、聚焦农民在乡村建设变革中的全面发展、浓厚社会在乡村建设变革中的参与效应”等创新举措的助力。

关键词：农民专业化乡村建设演进脉络逻辑关联

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Optimized nitrogen application for maximizing yield and minimizing nitrogen loss in film mulching spring maize production on the Loess Plateau,China

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Journal of Integrative Agriculture 2024年第5期23卷 1671-1684页

作者： Qilong Song Jie Zhang Fangfang Zhang yufang Shen Shanchao Yue Shiqing Li State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau College of Natural Resources and EnvironmentNorthwestA&FUniversityYangling712100China Life Science Department Luoyang Normal UniversityLuoyang 471934China

Excessive use of N fertilizers(driven by high-yield goals)and its consequent environmental problems are becoming increasingly acute in agricultural systems.A 2-year field experiment was conducted to investigate the effects of three N application methods(application of solid granular urea once(OF)or twice(TF),application of solid granular urea mixed with controlled-release urea once(MF),and six N rates(0,60,120,180,240,and 300 kg N ha^(-1))on maize yield,economic benefits,N use efficiency,and soil N balance in the maize(Zea mays L.)film mulching system on the Loess Plateau,*** grain yield and economic return of maize were significantly affected by the N rate and application *** with the OF treatment,the MF treatment not only increased the maize yield(increased by 9.0-16.7%)but also improved the economic return(increased by 10.9-25.8%).The agronomic N use efficiency(NAE),N partial factor productivity(NPFP)and recovery N efficiency(NRE)were significantly improved by 19.3-66.7,9.0-16.7 and 40.2-71.5%,respectively,compared with the OF *** economic optimal N rate(EONR)of the OF,TF,and MF was 145.6,147.2,and 144.9 kg ha^(-1) in 2019,and 206.4,186.4,and 146.0 kg ha^(-1) in 2020,*** apparent soil N loss at EONR of the OF,TF,and MF were 97.1-100.5,78.5-79.3,and 50.5-68.1 kg ha^(-1),*** results support MF as a one-time N application method for delivering high yields and economic benefits,with low N input requirements within film mulching spring maize system on the Loess Plateau.

关键词： maize yield N management economic optimal N rate Loess Plateau

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Analyze the Performance of Electroactive Anticorrosion Coating of Medical Magnesium Alloy Using Deep Learning

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Computers, Materials & Continua 2024年第4期79卷 263-278页

作者： Yashan Feng Yafang Tian Yongxin Yang yufang Zhang Haiwei Guo Jing’an Li Advanced Functional Materials Laboratory Zhengzhou Railway Vocational and Technical CollegeZhengzhou450000China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450000China

Electroactive anticorrosion coatings are specialized surface treatments that prevent or minimize corrosion. Thestudy employs strategic thermodynamic equilibriumcalculations to pioneer a novel factor in corrosion protection.A first-time proposal, the total acidity (TA) potential of the hydrogen (pH) concept significantly shapes medicalmagnesium alloys. These coatings are meticulously designed for robust corrosion resistance, blending theoreticalinsights and practical applications to enhance our grasp of corrosion prevention mechanisms and establisha systematic approach to coating design. The groundbreaking significance of this study lies in its innovativeintegration of the TA/pH concept,which encompasses the TA/pH ratio of the chemical environment. This approachsurpasses convention by acknowledging the intricate interplay between the acidity and pH levels within thecoating formulation, thereby optimizing metal-phosphate-based conversion coatings and transforming corrosionmitigation strategies. To authenticate the TA/pH concept, the study comprehensively compares its findings withexisting research, rigorously validating the theoretical framework and reinforcing the correlates among TA/pHvalues and observed corrosion resistance in the coatings. The influence of mutations that occur naturally inthe detergent solution on persistent phosphorus changes is shown by empirical confirmation, which improvescorrosion resistance. This realization advances the field ofmaterials and the field’s knowledge of coated generation,particularly anticorrosion converter layers.

关键词： Medical magnesium alloys hydrogen gas anticorrosion total acidity potential of the hydrogen(pH)

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Potential Secretory Transporters and Biosynthetic Precursors of Biological Nitrification Inhibitor 1,9-Decanediol in Rice as Revealed by Transcriptome and Metabolome Analyses

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Rice science 2024年第1期31卷 87-102页

作者： DI Dongwei MA Mingkun ZHANG Xiaoyang LU yufang Herbert J.KRONZUCKER SHI Weiming State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China School of Food Science and Engineering Foshan UniversityFoshan 528000China School of BioSciences The University of MelbourneParkvilleVIC 3010Australia University of Chinese Academy of Sciences Beijing 100049China

Biological nitrification inhibitors(BNIs)are released from plant roots and inhibit the nitrification activity of microorganisms in soils,reducing NO_(3)^(‒)leaching and N2O emissions,and increasing nitrogenuse efficiency(NUE).Several recent studies have focused on the identification of new BNIs,yet little is known about the genetic loci that govern their biosynthesis and *** applied a combined transcriptomic and metabolomic analysis to investigate possible biosynthetic pathways and transporters involved in the biosynthesis and release of BNI 1,9-decanediol(1,9-D),which was previously identified in rice root *** results linked four fatty acids,icosapentaenoic acid,linoleate,norlinolenic acid,and polyhydroxy-α,ω-divarboxylic acid,with 1,9-D biosynthesis and three transporter families,namely the ATP-binding cassette protein family,the multidrug and toxic compound extrusion family,and the major facilitator superfamily,with 1,9-D release from roots into the soil *** finding provided candidates for further work on the genes implicated in the biosynthesis and secretion of 1,9-D and pinpoint genetic loci for crop breeding to improve NUE by enhancing 1,9-D secretion,with the potential to reduce NO_(3)^(‒)leaching and N2O emissions from agricultural soils.

关键词： 1,9-decanediol biological nitrification inhibitor metabolomic analysis nitrogen-use efficiency transcriptomic analysis

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Comparison of the water consumption levels of four shelterbelt tree species in a typical arid oasis in Northwest China

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 169-176页

作者： Shuai Fu Bingxian Xu yufang Leng Yuxin Peng Guogen Tao Lanhai Li School of Taxation and Public Administration Jiangxi University of Finance and EconomicsNanchang 330013China Research team of International price analysis and prediction of bulk commodities Jiangxi University of Finance and EconomicsNanchang 330013China School of Foreign Languages Jiangxi University of Finance and EconomicsNanchang 330013China Laboratory of Water Cycle and Water Use in Arid Region Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China Tianshan Snow Cover and Avalanche Observation and Research Station of Xinjiang Xinyuan 835800XinjiangChina

The shelterbelt is an indispensable barrier to the ecological and economic development of an *** moisture,groundwater and irrigation greatly affect the shelterbelt water consumption and *** this study,the transpiration rate of shelterbelt trees,soil moisture and meteorological data were collected to determine the effects of soil moisture and meteorological factors on the water consumption of different shelterbelt tree species via multivariate statistical *** results showed that the water consumption rate was positively correlated with solar radiation,air temperature and ***,the leaf transpiration rate exhibited the trend of *** Jabl.˃***˃*** Carr.>***,while the average daily water consumption decreased in the order of ***>*** Jabl.>*** Carr.>*** average daily water consumption levels of ***,*** Jabl.,*** *** *** were(9.15±0.92)kg/(tree∙d),(6.95±1.41)kg/(tree∙d),(4.43±1.32)kg/(tree∙d),and(1.58±0.18)kg/(tree∙d),*** the growing season,the soil water consumption levels of ***,*** Jabl.,*** Carr.,and *** in each shelterbelt tree stand reached 674.8,336.9,358.1 and 161.7 kg,*** than 96%of the soil moisture lost was provided by the upper 120-cm soil *** the influence and contribution of soil water and meteorological factors to shelterbelt water consumption is beneficial for shelterbelt management and protection.

关键词： water consumption irrigation management shelterbelts soil moisture climatic factors

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The function of doping nitrogen on removing fluoride with decomposing La-MOF-NH_2:Density functional theory calculation and experiments

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Journal of Environmental Sciences 2024年第1期135卷 118-129页

作者： Hongguo Zhang KuilinWan Jia Yan Qian Li yufang Guo Lei Huang Samuel Raj Babu Arulmani Jian Luo School of Environmental Science and Engineering Guangzhou UniversityGuangzhou 510006China Guangzhou University-Linkoping University Research Center on Urban Sustainable Development Guangzhou UniversityGuangzhou 510006China School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

Fluoride is an important pollutant in wastewater,and adsorption is an effective way to remove *** nitrogen plays an important role in adsorbent materials,computational models were developed to understand the changes in work function resulting from nitrogen ***-N-C-800℃,was prepared by pyrolyzing La-MOF-NH_(2)to verify the influence on the performance of removing fluoride by *** and electrochemical performance tests were performed to characterize La-N-C-800℃.Adsorption kinetics,adsorption thermodynamics,initial concentrations,pH,and ions competition were investigated using La-N-C-800℃for fluoride *** addition,density functional theory was applied to evaluate the function of *** nitrogen atoms were added,the density of states,partial density of states,populations,and different orbits of charge were calculated to discover deep *** strengthened the carbon structure and La_(2)O_(3)structure to remove *** addition,nitrogen can also act as an adsorption site in the carbon *** results provide design ideas for improving the performance of adsorbent materials by doping elements.

关键词： Capacitive deionization Fluoride La-MOFs Doping nitrogen

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面向2035年我国青年科技人才薪酬激励研究

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科技管理研究 2021年第9期41卷 131-137页

作者：代毓芳张向前华侨大学工商管理学院华侨大学人力资源管理研究中心福建泉州362021

聚焦于青年科技人才的薪酬体系,探讨如何利用薪酬体系的信息性和控制性暗示,激励青年科技人才不断创新的机理。基于自我决定理论,深入剖析薪酬体系与创新之间的关系,构建创新驱动的青年科技人才薪酬机制。结果表明,目前的青年科技人才... 详细信息

聚焦于青年科技人才的薪酬体系,探讨如何利用薪酬体系的信息性和控制性暗示,激励青年科技人才不断创新的机理。基于自我决定理论,深入剖析薪酬体系与创新之间的关系,构建创新驱动的青年科技人才薪酬机制。结果表明,目前的青年科技人才薪酬构成名目复杂混乱,创新核心价值不突出;资源分配不均,青年科技人才整体薪酬水平有待提升;青年科技人才突破式创新较缺乏,关键核心技术瓶颈难以突破,并提出对策建议。

关键词：青年科技人才薪酬激励创新

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Multistep continuous flow synthesis of Erlotinib

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Chinese Chemical Letters 2024年第4期35卷 371-375页

作者： Hui Jin Qin Cai Peiwen Liu Yan Chen Derong Wang Weiping Zhu yufang Xu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

Erlotinib is an orally administered, highly effective, specific epidermal growth factor receptor tyrosine kinase inhibitor, used to treat non-small cell lung cancer and pancreatic cancer. The traditional synthetic methods for Erlotinib exhibit long reaction time and safety concern. Herein, we describe a novel five-step route for the synthesis of Erlotinib in flow. These five steps comprise etherification, nitration, reduction,addition and cyclization reactions. All steps were optimized and converted to continuous flow process,which drastically reduces the reaction time and considerably improves the process safety as well as the total yield. Enabled by five continuous flow units, Erlotinib is efficiently afforded with an E-factor of 38,an overall yield of 83%, and a total residence time of 25.1 min. Majority steps in this process have been optimized for quantitative conversion, which offers the possibility of telescoping the entire process.

关键词： Erlotinib Continuous flow synthesis Microchannel flow reactor Process optimization Continuous nitration Continuous hydrogenation

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Early-life famine exposure,adulthood obesity patterns,and risk of low-energy fracture

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Frontiers of Medicine 2024年第1期18卷 192-203页

作者： Hongyan Qi Chunyan Hu Jie Zhang Lin Lin Shuangyuan Wang Hong Lin Xiaojing Jia Yuanyue Zhu Yi Zhang Xueyan Wu Mian Li Min Xu Yu Xu Tiange Wang Zhiyun Zhao Weiqing Wang yufang Bi Meng dai Yuhong Chen Jieli Lu Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People’s Republic of ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China

Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains *** study included 5323 community-dwelling subjects aged⩾40 years from ***-life famine exposure was identified based on the participants’birth *** obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of⩾40 typically caused by falls from standing height or *** to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95%confidence intervals(CIs)of 3.55(1.57–8.05),3.90(1.57–9.71),and 3.53(1.05–11.88),respectively,but not in *** interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95%CI:3.32,1.17–9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.

关键词： famine obesity body mass index waist-to-hip ratio low-energy fracture

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