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Comparison of uniform resampling and nonuniform sampling direct-reconstruction methods in k-space for FD-OCT

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Journal of Innovative Optical Health Sciences 2023年第5期16卷 93-106页

作者： Yanrong Yang Yun Dai yuehua Zhou Yaliang Yang College of Ophthalmology Chengdu University of Traditional Chinese Medicine Chengdu 610075 P.R.China Institute of Optics and Electronics Chinese Academy of Sciences Chengdu 610209P.R.China Key Laboratory of Adaptive Optics Chinese Academy of Sciences Chengdu 610209P.R.China Key Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection with TCM Chengdu 610075 P.R.China Ineye Hospital of Chengdu University of TCM Chengdu 610075 P.R.China

The nonuniform distribution of interference spectrum in wavenumber k-space is a key issue to limit the imaging quality of Fourier-domain optical coherence tomography(FD-OCT).At present,the reconstruction quality at different depths among a variety of processing methods in k-space is still *** simulated and experimental interference spectra at different depths,the effects of common six processing methods including uniform resampling(linear interpolation(LI),cubic spline interpolation(CSI),time-domain interpolation(TDI),and K-B window convolution)and nonuniform sampling direct-reconstruction(Lomb periodogram(LP)and nonuniform discrete Fourier transform(NDFT))on the reconstruction quality of FD-OCT were quantitatively analyzed and compared in this *** results obtained by using simulated and experimental data were *** the experimental results,the averaged peak intensity,axial resolution,and signal-to-noise ratio(SNR)of NDFT at depth from 0.5 to 3.0mm were improved by about 1.9 dB,1.4 times,and 11.8 dB,respectively,compared to the averaged indices of all the uniform resampling methods at all ***,the improvements of the above three indices of LP were 2.0 dB,1.4 times,and 11.7 dB,*** analysis method and the results obtained in this work are helpful to select an appropriate processing method in k-space,so as to improve the imaging quality of FD-OCT.

关键词： Optical coherence tomography signal processing uniform resampling nonuniform sampling direct-reconstruction reconstruction quality.

上海市某三级甲等医院肿瘤科护士医学叙事能力现状调查

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上海护理 2024年第8期24卷 39-42页

作者：胡守紫毛月华海军军医大学第三附属医院上海200438

目的了解某三级甲等医院肿瘤科护士医学叙事能力现状并探讨其影响因素,为促进肿瘤科护士人文护理能力提升提供参考。方法 2022年12月,以便利抽样法选取上海市某三级甲等综合医院的191名肿瘤科护士为研究对象,采用医学叙事能力量表对其... 详细信息

目的了解某三级甲等医院肿瘤科护士医学叙事能力现状并探讨其影响因素,为促进肿瘤科护士人文护理能力提升提供参考。方法 2022年12月,以便利抽样法选取上海市某三级甲等综合医院的191名肿瘤科护士为研究对象,采用医学叙事能力量表对其进行调查,通过单因素分析和多元线性回归分析,探析肿瘤科护士医学叙事能力的影响因素。结果被调查191名肿瘤科护士的医学叙事能力总均分为(139.50±19.10)分,处于较低水平。多元线性回归分析结果显示,护士的工作年限及对叙事医学的熟悉程度对其医学叙事能力存在一定影响(P<0.05)。结论护理管理者可通过开展相关培训等措施,加强对护士医学叙事能力培养,提高护士对患者故事的敏感度和理解力,从而能够为患者提供更有温度的人文关怀护理,促进患者健康结局改善和护理满意度提升。

关键词：肿瘤科医院护士医学叙事能力调查

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Heat shock protein 72 confers protection in retinal ganglion cells and lateral geniculate nucleus neurons via blockade of the SAPK/JNK pathway in a chronic ocular-hypertensive rat model

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Neural Regeneration Research 2014年第14期9卷 1395-1401页

作者： Ning Li yuehua Li Xuanchu Duan Department of Ophthalmology The First Affiliated Hospital of Anhui Medical University Department of Ophthalmology Second Xiangya HospitalCentral South University

Optic nerve transection increased the expression of heat shock protein 72 （HSP72） in the lateral geniculate body, indicating that this protein is involved in the prevention of neuronal injury. Zinc sulfate and quercetin induced and inhibited the expression of HSP72, respectively. Intraperitoneal injections of zinc sulfate, SP600125 （c-Jun N-terminal kinase inhibitor）, or quercetin were performed on retinal ganglion cells in a Wistar rat model of chronic ocular hypertension. Our results showed that compared with the control group, the expression of HSP72 in retinal ganglion cells and the lateral geniculate body was increased after the injection of zinc sulfate, but was decreased after the injection of quercetin. The expression of phosphorylated c-Jun N-terminal kinases and phosphorylated c-Jun were visible 3 days after injection in the control group, and reached apeak at 7 days. Zinc sulfate and SP600125 significantly decreased the expression of p-c-Jun, whereas quercetin significantly enhanced the expression of this protein. These results suggest that HSP72 protects retinal ganglion cells and lateral geniculate body in a rat model of chronic ocular hypertension from injury by blocking the activation of the stress-activated kinase/c-Jun N-terminal kinase apoptotic pathway.

关键词： nerve regeneration peripheral nerve injury glaucoma heat shock protein 72 retinalganglion cells lateral geniculate body zinc sulfate quercetin SAPK/JNK pathway neuroprotection p-INK p-c-Jun NSFC grant neural regeneration

补阳还五汤合参芪地黄汤化裁调控VEGF-C/VEGFR3通路抑制淋巴管新生对糖尿病肾病小鼠的保护作用

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中药新药与临床药理 2024年第6期35卷 778-788页

作者：黄家安张孟娟杨帆刘妍王月华河北中医药大学河北石家庄050200 河北省中西医结合肝肾病证研究重点实验室河北石家庄050091 河北中医药大学中西医结合研究所河北石家庄050091

目的基于调控VEGF-C/VEGFR3通路抑制淋巴管新生探讨补阳还五汤合参芪地黄汤化裁对糖尿病肾病(DKD)小鼠的保护作用及机制。方法将24只雄性db/db小鼠随机分为模型组、中药组(补阳还五汤合参芪地黄汤化裁,生药量24.44 g·kg-1)和西药组(厄... 详细信息

目的基于调控VEGF-C/VEGFR3通路抑制淋巴管新生探讨补阳还五汤合参芪地黄汤化裁对糖尿病肾病(DKD)小鼠的保护作用及机制。方法将24只雄性db/db小鼠随机分为模型组、中药组(补阳还五汤合参芪地黄汤化裁,生药量24.44 g·kg-1)和西药组(厄贝沙坦,13.5 mg·kg-1),每组8只,另外取8只db/m小鼠作为对照组。灌胃给药,每日1次,连续12周。检测小鼠血糖(FBG)、总胆固醇(TC)、甘油三脂(TG)、尿白蛋白/肌酐比值(ACR)及肾脏指数;采用HE、Masson染色法观察肾脏组织病理变化;免疫组化法检测肾脏组织纤连蛋白(FN)、Ⅰ型胶原蛋白(ColⅠ)、波形蛋白(Vimentin)、α平滑肌肌动蛋白(α-SMA)、转化生长因子β1(TGF-β1)、血管内皮生长因子受体3(VEGFR3)、血管内皮生长因子C(VEGF-C)、淋巴管内皮透明质酸受体1(LYVE-1)、平足蛋白(PDPN)、肿瘤坏死因子α(TNF-α)和白细胞介素1β(IL-1β)的表达;Western Blot法检测肾脏组织ColⅠ、Vimentin、α-SMA、TGF-β1、VEGFR3、VEGF-C、LYVE-1、TNF-α、IL-1β蛋白表达;Real-time PCR法检测肾脏组织FN、ColⅠ、TGF-β1、VEGF-C、VEGFR3、TNF-α、IL-1βmRNA表达。结果与对照组比较,模型组小鼠的血清FBG、TG、TC、ACR水平及肾脏指数均明显升高(P<0.05);肾小球肥大,系膜外基质增加,基底膜增厚,囊腔变窄,肾小管上皮细胞变性、坏死,间质有大量炎性细胞浸润,肾小管萎缩,纤维化水平明显升高(P<0.05);肾间质中FN、ColⅠ、Vimentin、α-SMA、TGF-β1、VEGFR3、LYVE-1、TNF-α、IL-1β蛋白表达,胞质中VEGF-C蛋白表达及肾小管毛细血管周围VEGFR3、PDPN蛋白表达均明显上调(P<0.05);肾脏组织中ColⅠ、Vimentin、α-SMA、TGF-β1、VEGFR3、VEGF-C、LYVE-1、TNF-α、IL-1β蛋白表达均明显上调(P<0.05);肾脏组织中FN、ColⅠ、TGF-β1、VEGF-C、VEGFR3、TNF-α、IL-1βmRNA表达水平均明显升高(P<0.05)。与模型组比较,中药组小鼠的血清TG、TC、ACR水平均明显降低(P<0.05);肾脏组织损伤有不同程度好转,炎性细胞浸润有一定程度减轻,纤维化水平明显降低(P<0.05);肾间质中FN、ColⅠ、Vimentin、α-SMA、TGF-β1、VEGFR3、LYVE-1、TNF-α、IL-1β蛋白表达,胞质中VEGF-C蛋白表达及肾小管毛细血管周围VEGFR3、PDPN蛋白表达均明显下调(P<0.05);肾脏组织中ColⅠ、Vimentin、α-SMA、TGF-β1、VEGFR3、VEGF-C、LYVE-1、TNF-α、IL-1β蛋白表达均明显下调(P<0.05);肾脏组织中FN、ColⅠ、TGF-β1、VEGF-C、VEGFR3、TNF-α、IL-1βmRNA表达水平均明显降低(P<0.05)。结论补阳还五汤合参芪地黄汤化裁可降低DKD小鼠肾脏组织炎症及纤维化水平,其机制可能与调控VEGF-C/VEGFR3通路抑制淋巴管新生有关。

关键词：补阳还五汤合参芪地黄汤化裁糖尿病肾病 VEGF-C/VEGFR3通路淋巴管新生炎症纤维化小鼠

Vibration Characteristics and Power Transmission of Coupled Rectangular Plates with Elastic Coupling Edge and Boundary Restraints

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Chinese Journal of Mechanical Engineering 2012年第2期25卷 262-276页

作者： CHEN yuehua JIN Guoyong DU Jingtao LIU Zhigang College of Power and Energy Engineering Harbin Engineering UniversityHarbin 150001China

Coupled-plate structures are widely used in the practical engineering such as aeronautical,civil and naval engineering *** works can be found on the vibration of the coupled-plate structure due to the increased mathematical complexity compared with the single plate *** order to study analytically the vibration characteristics and power transmission of the coupled-plate structure,an analytical model consisting of three coupled plates elastically restrained along boundary edges and elastically coupled with arbitrary angle is considered,in which four groups of springs are distributed consistently along each edge of the model to simulate the transverse shearing forces,bending moments,in-plane longitudinal forces and in-plane shearing forces *** elastic coupling condition and general boundary condition of both flexural and in-plane vibrations taken into account by setting the stiffness of corresponding springs,the double Fourier series solution to the dynamic response of the structure was obtained by employing the Rayleigh-Ritz *** order to validate the model,the natural frequency and velocity response of the model are firstly checked against results published in literatures and the ANSYS data,and good agreement was ***,numerical simulation of the effects of several relevant parameters on the vibration characteristics and power transmission of the coupled structure were performed,including boundary conditions,coupling conditions,coupling angle,and location of the external *** and energy transmission behaviors were analyzed *** results show that the power transmission can be significantly influenced by the boundary restraints and the location of *** the excitation is located at the central symmetry point of the model,the energy flow shows a symmetrical *** the location deviates from the central symmetry point,the power circumfluence occurs and the vortex energy field is formed

关键词： vibration power transmission coupled-plate structure elastic restraints

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公立医院一院多区财务管理策略探析

中国医院 2024年第5期28卷 13-16页

作者：李雪辉崔梦迪潘悦华陈仪瑢上海交通大学医学院附属瑞金医院上海市200025

随着公立医院迈入高质量发展阶段,一院多区的发展模式日益成为公立医院医疗资源扩容、满足社会医疗服务需求的重要模式。本文分析了公立医院一院多区背景下财务管理现状,通过阐述上海交通大学医学院附属瑞金医院在一院多区财务管理中的... 详细信息

随着公立医院迈入高质量发展阶段,一院多区的发展模式日益成为公立医院医疗资源扩容、满足社会医疗服务需求的重要模式。本文分析了公立医院一院多区背景下财务管理现状,通过阐述上海交通大学医学院附属瑞金医院在一院多区财务管理中的建设路径、具体做法以及成效,为公立医院一院多区财务管理提供更多科学建议和借鉴,以推动公立医院实现高质量发展。

关键词：公立医院一院多区财务管理高质量发展

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Feasibility analysis of gob-side entry retaining on a working face in a steep coal seam

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International Journal of Mining Science and Technology 2014年第4期24卷 499-503页

作者： Deng yuehua Wang Shouquan Sichuan Coal Industry Group Limited Liability Company

Based on the decline in exploitation of coal resources, steep coal seam mining and mining face tensions continue to explore the feasibility analysis of steeply inclined faces in the gob. One of the key factors in utilizing the technology of gob-side entry retaining in steep coal seams is to safely and effectively prevent caving rock blocks from rushing into the gob-side entry by sliding downwards along levels. Using theoretical analysis and field methods, we numerically simulated the mining process on a fully-mechanized face in a steep coal seam. The stress and deformation process of roof strata has been analyzed, and the difficulty of utilizing the technology is considered and combined with practice in a steep working face in Lvshuidong mine. The feasibility of utilizing the technology of gob-side entry retaining in a steep coal seam has been recognised. We propose that roadways along the left lane offshoot body use a speciallymade reinforced steel dense net to build a dense rock face at the lower head. The results show that the lane offshoot branch creates effective roof control, safe conditions for roadway construction workers, and practical application of steeply inclined gob.

关键词： Gob-side entry retaining Steep coal seam Fully-mechanized mining Feasibility analysis Numerical simulation

机器人辅助、荧光腹腔镜导航保留十二指肠全胰切除术1例临床报告

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中国普通外科杂志 2024年第3期33卷 456-461页

作者：姜改明郑凯李宇铠康强柯阳李越华昆明医科大学第二附属医院肝胆胰外科二病区云南昆明650101

背景与目的:机器人技术与导航技术相结合为外科手术的精准性以及减少术后并发症提供了有力的保障和支持,但目前仍未见机器人辅助、荧光腹腔镜导航保留十二指肠全胰切除的报道。本文总结1例终末期慢性胰腺炎伴胰管结石行达芬奇机器人辅... 详细信息

背景与目的:机器人技术与导航技术相结合为外科手术的精准性以及减少术后并发症提供了有力的保障和支持,但目前仍未见机器人辅助、荧光腹腔镜导航保留十二指肠全胰切除的报道。本文总结1例终末期慢性胰腺炎伴胰管结石行达芬奇机器人辅助、荧光腹腔镜导航保留十二指肠全胰切除术治疗的临床经验。方法:回顾性分析昆明医科大学第二附属医院肝胆胰外科二病区2022年11月1例终末期慢性胰腺炎伴胰管结石患者行达芬奇机器人辅助、荧光腹腔镜导航保留十二指肠全胰切除术的临床资料。结果:患者,男性,61岁。术前诊断:慢性胰腺炎,胰管结石,胰腺钙化,胰腺萎缩,2型糖尿病。手术顺利,手术时间300 min,出血量200 mL。术后病理提示慢性胰腺炎、胰管结石。术后未出现出血、胰瘘、胆汁漏、十二指肠缺血坏死等并发症,仅出现血糖升高,给予胰岛素皮下注射血糖控制良好,于术后10 d康复出院。结论:在熟练掌握机器人辅助腹腔镜下胰体尾切除术和保留十二指肠的胰头切除术的前提下,严格把握适应证,开展达芬奇机器人辅助、荧光腹腔镜导航保留十二指肠全胰切除术是安全可行的,但该术式的远期疗效有待进一步的观察。

关键词：胰腺切除术胰腺炎,慢性机器人手术荧光染料

基于多光谱屈光地形图的儿童青少年视网膜周边离焦研究

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眼科新进展 2024年第5期44卷 396-400页

作者：汪思瑶梁双凤郭玉娟李羽周跃华成都中医药大学眼科学院四川省成都市610075 北京茗视光眼科北京市100062 成都中医大银海眼科医院四川省成都市610084

目的探究视网膜周边离焦与儿童青少年近视的关系。方法纳入2022年10月至2023年4月在成都中医大银海眼科医院就诊的8~15岁儿童青少年192例(192眼,均取右眼),根据等效球镜度(SE)分为正视组、低度近视组和中度近视组,每组各64例(64眼)。散... 详细信息

目的探究视网膜周边离焦与儿童青少年近视的关系。方法纳入2022年10月至2023年4月在成都中医大银海眼科医院就诊的8~15岁儿童青少年192例(192眼,均取右眼),根据等效球镜度(SE)分为正视组、低度近视组和中度近视组,每组各64例(64眼)。散瞳验光,并以SE记录;IOL Master 900检测生物学参数,包括眼轴长度(AL)、中央角膜厚度(CCT)、晶状体厚度(LT)、角膜曲率值[水平角膜曲率值(K 1)和垂直角膜曲率值(K 2)];采用多光谱屈光地形图测量视网膜离焦量,正值为远视性离焦,负值为近视性离焦。以黄斑中心凹为圆心,视网膜总离焦记录为TRDV;环形区域分为0°~10°、>10°~20°、>20°~30°、>30°~40°、>40°~53°,分别记录为RDV-0°~10°、RDV-10°~20°、RDV-20°~30°、RDV-30°~40°、RDV-40°~53°;象限区域分为上侧、下侧、颞侧、鼻侧,分别记录为RDV-S、RDV-I、RDV-T、RDV-N。通过单因素方差分析和非参数检验分析不同范围离焦量的差异;Spearman和Pearson相关性分析SE、AL与离焦量的关系。结果正视组、低度近视组和中度近视组受检者的RDV-20°~30°、RDV-30°~40°、RDV-40°~53°均为远视性离焦。三组受检者TRDV、RDV-10°~20°、RDV-20°~30°、RDV-30°~40°、RDV-40°~53°、RDV-S、RDV-T、RDV-N相比,差异均有统计学意义(均为P0.05);RDV-10°~20°与AL呈正相关(P=0.012),与SE不相关(P=0.233)。结论视网膜周边远视性离焦随着偏心度和近视程度增大而增大。视网膜离焦具有不对称性。周边(10°~53°)、上侧、鼻侧、颞侧视网膜离焦可能与近视进展密切相关。

关键词：多光谱屈光地形图视网膜离焦近视儿童青少年