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Differential mRNA expression in peripheral blood is associated with oral squamous cell carcinoma:Recent advances and future challenges

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BIOCELL 2023年第7期47卷 1449-1458页

作者： XIA MU yubing hu DANDAN WU HONGYU YANG Department of Stomatology Zunyi Medical UniversityZunyi563000China Department of Oral and Maxillofacial Surgery Peking University Shenzhen Hospital Stomatology CenterShenzhen518000China Department of Nursing Henan UniversityKaifeng475000China

Oral squamous cell carcinoma(OSCC)is a malignant tumor triggered by the accumulation of multiple gene mutations in oral epithelial *** OSCC-related biomarkers have been reported in circulation in the peripheral blood that support the occurrence and development of *** advances in high-throughput and highly sensitive detection methods have overcome the limitation of the low concentration of most peripheral blood ***,blood biomarker detection has become an efficient screening tool for the early diagnosis of *** growing data available in public cancer and gene databases have provided new foundations for OSCC *** particular,the identification of OSCC biomarkers using bioinformatic tools has shed new light on the underlying mechanisms as well as on the genetic landscape of *** recently,mRNA targeting therapies have emerged as valuable anticancer treatment strategies,as they allow for the regulation of the expression of certain functional proteins to reverse genetic abnormalities or induce tissue ***,mRNA-targeting therapies can be used to regulate the expression of antigens,antibodies,or cellular receptors by immune ***,anti-cancer cellular immunotherapy carrying specific mRNAs has attracted significant attention in OSCC ***,we review the present knowledge on the role of peripheral blood mRNAs in the diagnosis,treatment,development,and prognosis of ***,we address future research prospects of mRNAs in the peripheral blood in OSCC and the opportunities and challenges that may arise in future clinical therapeutic applications.

关键词： Diagnosis mRNA therapy Peripheral blood biomarker

Utilizing interpretable stacking ensemble learning and NSGA-Ⅲ for the prediction and optimisation of building photo-thermal environment and energy consumption

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Building Simulation 2024年第5期17卷 819-838页

作者： Yeqin Shen yubing hu Kai Cheng Hainan Yan Kaixiang Cai Jianye hua Xuemin Fei Qinyu Wang School of Arts Jiangsu UniversityZhenjiang212013China School of Architecture and Urban Planning Nanjing UniversityNanjing210093China School of Computer Science and Communication Engineering Jiangsu UniversityZhenjiang212013China

This study develops an approach consisting of a stacking model integrated with a multi-objective optimisation algorithm aimed at predicting and optimising the ecological performance of *** integrated model consists of five base models and a meta-model,which significantly improves the prediction ***,the R2 value was improved by 9.19% and the error metrics MAE,MSE,MAPE,and CVRMSE were reduced by 69.47%,79.88%,67.32%,and 57.02%,respectively,compared to the single prediction *** to the research on interpretable machine learning,adding the SHAP value gives us a deeper understanding of the impact of each architectural design parameter on the *** the multi-objective optimisation part,we used the NSGA-Ⅲ algorithm to successfully improve the energy efficiency,daylight utilisation and thermal comfort of the ***,the optimal design solution reduces the energy use intensity by 31.6 kWh/m^(2),improves the useful daylight index by 39%,and modulated the thermal comfort index,resulting in a decrement of 0.69℃ for the summer season and an enhancement of 0.64℃ for the winter season,***,this study provides building designers and decision makers with a tool to make better design decisions at an early stage to achieve a better combination of energy efficiency,daylight utilisation and thermal comfort optimisation in an integrated manner,providing an important support for achieving sustainable building design.

关键词： building ecological performance ensemble learning multi-objective optimisation sustainable design explainable machine learning

New insights in nano-copper chromite catalyzing ultrafine AP:Evaluation of dispersity and mixing uniformity

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Defence Technology（防务技术） 2024年第2期32卷 120-133页

作者： Yong Kou Peng Luo Lei Xiao Yanping Xin Guangpu Zhang yubing hu Junqing Yang Hongxu Gao Fengqi Zhao Wei Jiang Gazi Hao National Special Superfine Powder Engineering Research Center of China School of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing210094China Xi'an North huian Chemical Industry Co.Ltd Xi'an710302China Xi'an Modern Chemistry Research Institute Xi'an710065China

Improving the application of nanomaterials has always been a research hotspot in the field of energetic materials(EMs)due to their obvious catalytic effect on the EMs,especially the uniformly dispersed ***,few studies have reported the dispersion of *** this study,the dispersity and mixing uniformity of nano-CuCr_(2)O_(4)was evaluated based on the difference of solid UV light absorption between the nano-catalytic materials and *** nano-CuCr_(2)O_(4)/ultrafine AP composites with different dispersity of nano-CuCr_(2)O_(4)were prepared by manual grinding and mechanical grinding with different grinding strength and griding *** then,the absorbance of different samples at 212 nm was obtained by solid UV testing due to the high repeatability of the absorbance at 210-214 nm for three parallel experiments,and the dispersity of different samples was calculated through the established difference ***,the samples were characterized by XRD,IR,SEM,EDS,DSC and TG-MS,which confirmed that different mixing methods did not change the structure of the samples(XRD and IR),and the mixing uniformity improved with the increase of grinding strength and grinding time(SEM and EDS).The scientificity and feasibility of the difference equation were further verified by *** dispersity of nano-CuCr_(2)O_(4)exhibits a positive intrinsic relationship with its catalytic performance,and the uniformly dispersed nano-CuCr_(2)O_(4)significantly reduces the thermal decomposition temperature of ultrafine AP from 367.7 to 338.8℃.The TG-MS patterns show that the dispersed nano-CuCr_(2)O_(4)advanced the thermal decomposition process of ultrafine AP by about 700 s,especially in the high temperature decomposition stage,and the more concentrated energy release characteristic is beneficial to further enhance the energy performance of AP-based *** above conclusions show that the evaluation method of dispersity based on solid UV curves could pro

关键词： Nano-CuCr_(2)O_(4) Ultrafine AP Dispersity UVeVis diffuse reflectance spectroscopy Thermal decomposition

In Situ Generation of N-Heteroaromatic Polymers:Metal-Free Multicomponent Polymerization for Photopatterning,Morphological Imaging,and Cr(Ⅵ)Sensing

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CCS Chemistry 2022年第7期4卷 2308-2320页

作者： yubing hu Neng Yan Xiaolin Liu Lingyu Pei Canbin Ye Wen-Xiong Wang Jacky W.Y.Lam Ben Zhong Tang Department of Chemistry The Hong Kong Branch of ChineseNational Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyThe Hong Kong University of Science and TechnologyGuangdong-Hong Kong-Macro Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsClear Water BayKowloonHong Kong 999077 HKUST-Shenzhen Research Institute NanshanShenzhen 518057 School of Energy and Environment State Key Laboratory of Marine PollutionCity University of Hong KongKowloonHong Kong 999077 Center for Aggregation-Induced Emission From Molecular AggregatesSCUT-HKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640 Shenzhen Institute of Molecular Aggregate Science and Engineering School of Science and EngineeringThe Chinese University of Hong KongShenzhenGuangdong 518172 AIE Institute Guangzhou Development DistinctHuangpuGuangzhou 510530

Electron-deficient N-heteroaromatic polymers are crucial for the high-tech applications of organicmaterials,especially in the electronic and optoelectronic ***,the development of new polymerizations to afford adaptable electron-donating-accepting scaffolds in N-heteroaromatic polymers is in high ***,we have developed metal-free multicomponent polymerizations of diynes,diamines,and glyoxylates successfully for in situ generation of poly(quinoline)s with high molecular weights(Mw up to 16,900)in nearly quantitative *** tuning the electron distributions of the polymer backbones,the resulting poly(quinoline)s showed various aggregation-induced behaviors and photoresponsive abilities:The thin films of the poly(quinoline)s could be fabricated readily intowell-resolved photopatterns by photolithography *** could be utilized as fluorescent probes to visualize themorphologies of polymer materials directly;these include spherulites and microphase separation of polymer *** nanoparticles demonstrated sensitive and highly selective fluorescence quenching to hexavalent chromium ion Cr(Ⅵ),thereby providing access for biological imaging of Cr(Ⅵ)in unicellular algae.

关键词： heteroaromatic polymers multicomponent polymerization morphology photopatterns chromium sensor

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《宋西事案》考略

民族研究 2005年第2期 52-61,109页

作者：胡玉冰宁夏大学人文学院中文系

祁承编修的《宋西事案》是惟一一部明朝人编修的传世汉文西夏史籍,该书的编修有很强的现实针对性,由于书序中有“违碍”之语,在清朝被禁毁。该书目前至少有两种版本传世,由于各本中存在着诸多文字上的错误,在利用时要加以校勘。

关键词：考略汉文西夏史籍宋现实针对性编修书序版本书目校勘

Bioinspired Hydrogels with Muscle-Like Structure for AIEgen-Guided Selective Self-Healing

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CCS Chemistry 2021年第4期3卷 1146-1156页

作者： Xiaofan Ji Zhao Li yubing hu huilin Xie Wenjie Wu Fengyan Song Haixiang Liu Jianguo Wang Meijuan Jiang Jacky WYLam Ben Zhong Tang Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Studyand Department of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyHong Kong Institute of Engineering Medicine Beijing Institute of TechnologyBeijing 100081 School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074 HKUST Shenzhen Research Institute Shenzhen 518057 Center for Aggregation-Induced Emission SCUT-HKUST Joint Research InstitutesState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640

Living systems,including human beings,animals,and plants,display the power to self-heal spontaneously after being *** self-healing is usually selective,which means that the healing efficiency is related to the spatial distribution of dynamic interfacial interactions of the two rupturing *** artificial systems use noncovalent interactions or dynamic covalent bonds to prepare self-healing ***,they can only show nonselective self-healing due to their homogeneous internal ***,we report the construction of a composite hydrogel Gel-C consisting of three different self-healing hydrogels(Gel-Y,Gel-G,and Gel-O)through the use of classic bilayer hydrogel *** the composite hydrogel was cut into two pieces,the relative orientation of the parts was rotated through different angles to study the differences in *** to the heterogeneous internal structure of the composite hydrogel and the recognition specificity of each included hydrogel,the interfacial dynamic interactions distribution of the two rupturing surfaces is *** results of tensile tests demonstrated that these rotated samples exhibited different self-healing *** system realized the transformation of artificial materials from nonselective self-healing to selective selfhealing,providing inspiration for the development of novel biological materials and engineering materials.

关键词： aggregation-induced emission fluorescence hydrogel noncovalent interactions dynamic covalent interactions self-healing

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负温环境下混凝土力学性能及水化特征研究

建筑材料学报 2017年第6期20卷 975-980页

作者：胡玉兵苗广营熊羽苏交科集团股份有限公司江苏南京211112 青海省公路建设管理局青海西宁810008 东南大学材料科学与工程学院江苏南京211189

研究了负温养护、交变温度养护下混凝土力学性能的发展情况,揭示了负温混凝土抗压强度、动弹性模量随龄期的变化规律,并利用微观测试方法分析了水泥水化特征和水化产物微观结构形貌.结果表明:在-10℃时,不掺防冻剂的混凝土早期强度极低... 详细信息

研究了负温养护、交变温度养护下混凝土力学性能的发展情况,揭示了负温混凝土抗压强度、动弹性模量随龄期的变化规律,并利用微观测试方法分析了水泥水化特征和水化产物微观结构形貌.结果表明:在-10℃时,不掺防冻剂的混凝土早期强度极低,甚至由于试件不能成型而无强度;防冻剂可有效减少混凝土早期负温养护引起的微裂缝.

关键词：负温混凝土力学性能水化

《花马池城图》:晚清西北地方士人的心态和选择

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宁夏社会科学 2018年第3期 174-181页

作者：胡玉冰韩中慧宁夏大学人文学院宁夏银川750021

《花马池城图》的思想史料价值在于它的绘制内容得以体现一直被学界较为忽视的晚清地方士人群体的心态研究。清末西北一隅,在特殊的历史境遇和自然恶劣的生存条件下,此图体现出地方士人是如何借用自己的身份和能力自觉地去关怀普通民众... 详细信息

《花马池城图》的思想史料价值在于它的绘制内容得以体现一直被学界较为忽视的晚清地方士人群体的心态研究。清末西北一隅,在特殊的历史境遇和自然恶劣的生存条件下,此图体现出地方士人是如何借用自己的身份和能力自觉地去关怀普通民众的生活诉求,如何在官方与民间话语的互动中起到缓和与沟通的作用。地方士人将花马池城民众这样一段不为人知、容易湮灭在官方记载中的生活图景,以文字注释的方式描述出来,并安排在整幅城图中最显眼的位置,使这样一段反映地方士人和普通民众的生存困境永远地保留在了地方志书中。《花马池城图》最终实现了"目中有人"的思想价值,其绘制中所面临的困境和选择,既是一段历史中的偶然,亦是亘古历史中的必然。

关键词：《花马池城图》危机心理晚清西北社会地方士人

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不动产单元实景三维构建研究与应用

自然资源信息化 2023年第5期 59-64页

作者：胡玉兵黄山市不动产登记中心安徽黄山245000

实景三维是集摄影测量、大数据、云计算等新兴技术于一体的融合产物,是地理空间要素的真实感知和数字重建,是数字化、智能化新型空间基础设施建设的重要内容。本文通过低空无人机倾斜摄影获取三维模型数据,对多源房产分层分户平面图进... 详细信息

实景三维是集摄影测量、大数据、云计算等新兴技术于一体的融合产物,是地理空间要素的真实感知和数字重建,是数字化、智能化新型空间基础设施建设的重要内容。本文通过低空无人机倾斜摄影获取三维模型数据,对多源房产分层分户平面图进行规范化处理,获得建模房产分户平面图数据,采用单体化精细建模等关键技术制作不动产单元实景三维模型并关联二维地籍及登记数据库数据,构建不动产单元实景三维。分析了不动产单元实景三维在不动产登记、测绘地理信息等领域的应用前景和效益情况。

关键词：实景三维不动产单元倾斜摄影房产分层分户平面图应用

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