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Chinese Chemical Letters 2024年第10期35卷 92-101页

作者： Zhe-Han Yang Jie Yin Lei Xin yuanfang Li Yijie Huang ruo yuan Ying Zhuo Chongqing Key Laboratory of Catalysis and Functional Organic Molecules College of Environment and ResourcesChongqing Technology and Business UniversityChongqing 400067China Key Laboratory of Luminescence and Real-Time Analytic Chemistry(Southwest University) Ministry of EducationCollege of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China

DNA-based hydrogels are exceptional materials for biological applications because of their numerous advantages such as biodegradability,biocompatibility,hydrophilicity,super absorbency,porosity,and *** these advantages,the ability of DNA-based hydrogels to respond to specific physical and chemical triggers and undergo reversible phase transitions has garnered significant attention in the fields of disease diagnosis(biosensors)and treatment(drug delivery).This article focuses on the recent advancements in the research of DNA-based hydrogels and discusses the different types of these hydrogels,the synthetic methods,their unique properties,and their applications in biosensors and drug *** types of DNA hydrogels are categorized based on their building blocks,and the process of synthesis as well as the unique characteristics of DNA-based hydrogels are ***,DNA-based responsive hydrogels utilized as intelligent materials for the development of biosensors are ***,this article also presents the current status of DNA-based responsive hydrogels in drug delivery for cancer treatment,wound healing,and other therapeutic ***,this paper discusses the current challenges in expanding the practical application of DNA-based hydrogels.

关键词： DNA-based hydrogel Intelligent hydrogel Manufacture Characteristics Diseasediagnosis and treatment

北京地铁资产运维标准体系研究及其数字化应用

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标准科学 2024年第4期 61-67页

作者：傅兵袁若岑黄颖俊北京市地铁运营有限公司北京市地铁运营有限公司技术创新研究院分公司北明软件有限公司

本文基于北京地铁资产全寿命周期管理、维修业务精细化管控与信息化管理三重需求,提出北京地铁资产运维标准体系架构设计思路。结合北京地铁智能运维平台的建设与运行,按照统一规划、统一设计、统一建设与统一运维的原则,构建标准数字... 详细信息

本文基于北京地铁资产全寿命周期管理、维修业务精细化管控与信息化管理三重需求,提出北京地铁资产运维标准体系架构设计思路。结合北京地铁智能运维平台的建设与运行,按照统一规划、统一设计、统一建设与统一运维的原则,构建标准数字化转型的应用场景,围绕标准形式数字化与标准过程数字化两个转型方向,提出标准体系贯通应用于智能运维平台建设及应用场景的工作思路,推动标准化工作向数字化、网络化与智能化转型,并以北京地铁6号线智能运维平台试点应用为案例,验证了标准体系指导并规范信息化系统的建设及运行工作的作用及意义。

关键词：标准体系资产运维数字化智能化应用场景

A Novel Tetraiodocadmate（Ⅱ） - PVC Membrane Electrode for the Potentiometric Determination of Cadmium（Ⅱ）

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Chinese Chemical Letters 2006年第7期17卷 941-944页

作者： Fu Chang WANG Ya Qin CHAI ruo yuan Chongqing Key Laboratory of Analytical Chemistry College of Chemistry and Chemical Engineering Southwest University Chongqing 400715

A novel tetraiodocadmate（Ⅱ）-selective membrane electrode consisting of tetraiodo-cadmate（Ⅱ）-rhodamin B ion pair （TICRhB） dispersed in a PVC matrix plasticized with 2-nitrophenyl octyl ether （o-NPOE） was prepared. The sensor demonstrated a near-Nernstian response for 1×10^-2 to 2×10^-6 mol/L cadmium （Ⅱ） at 25℃ with an anionic slope of 29.0. It revealed very good selectivity for Cd^2＋ with negligible interference from many cations and anions, and could be used in a pH range of 3 to 6.

关键词： Tetraiodocadmate(Ⅱ) ion pair membrane electrode.

A capacitive sensor based on molecularly imprinted polymers and poly(p-aminobenzene sulfonic acid) film for detection of pazufloxacin mesilate

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Science China Chemistry 2007年第4期50卷 547-553页

作者： ZHOU Lu YE GuangRong yuan ruo CHAI YaQin CHEN SuMing College of Chemistry and Chemical Engineering Southwest UniversityChongqing 400715China

A novel capacitive sensor for pazufloxacin mesilate (pazufloxacin) determination was developed by electropolymerizing p-aminobenzene sulfonic (p-ABSA) and molecularly imprinted polymers (MPs), which was synthesized through thermal radical copolymerization of metharylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) in the presence of pazufloxacin template molecules, on the gold electrode surface. Furthermore, 1-dedecanethiol was used to insulate the modified electrode. Alternating current (ac) impedance experiments were carried out with a Model IM6e to obtain the capacitance responses. Under the optimum conditions, the sensor showed linear capacitance response to pazufloxacin in the range of 5 ng·mL?1 to 5 μg·mL?1 with a relative standard deviation (RSD) 5.3% (n=7) and a detection limit of 1.8 ng·mL?1. The recoveries for different concentration levels of pazufloxacin samples varied from 94.0% to 102.0%. Electrochemical experiments indicated the capacitive sensor exhibited good sensitivity and selectivity and showed excellent parameters of regeneration and stability.

关键词： capacitive sensor molecularly imprinted polymers p-aminobenzene sulfonic acid pazufloxacin mesilate

Determination of carcinoembryonic antigen using a novel amperometric enzyme-electrode based on layer-by-layer assembly of gold nanoparticles and thionine

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Science China Chemistry 2007年第1期50卷 97-104页

作者： yuan ruo ZHUO Ying CHAI YaQin ZHANG Ying SUN AiLi Chongqing Key Laboratory of Analytical Chemistry College of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China

Electrochemical sensing of carcinoembryonic antigen(CEA)on a gold electrode modified by the se- quential incorporation of the mediator,thionine(Thi),and gold nanoparticles(nano-Au),through co- valent linkage and electrostatic interactions onto a self-assembled monolayer configuration is de- scribed in this *** enzyme,horseradish peroxidase(HRP),was employed to block the possible remaining active sites of the nano-Au monolayer,avoid the non-specific adsorption,instead of bovine serum albumin(BSA),and amplify the response of the antigen-antibody *** ex- periments indicated highly efficient electron transfer by the imbedded Thi mediator and adsorbed *** HRP kept its activity after immobilization,and the studied electrode showed sensitive response to CEA and high stability during a long period of *** working range for the system was 2.5 to 80.0 ng/mL with a detection limit of 0.90 ng/*** model membrane system in this work is a potential biosensor for mimicking the other immunosensor and enzyme sensor.

关键词： immunosensor gold nanoparticles(nano-Au) thionine(Thi) carcinoembryonic antigen(CEA) horseradish peroxidase(HRP) layer-by-layer(LBL)

Glucose oxidase as a blocking agent-based signal amplification strategy for the fabrication of label-free amperometric immunosensors

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Science China Chemistry 2011年第3期54卷 536-544页

作者： SONG ZhongJu yuan ruo CHAI YaQin CHE Xin LV Ping Key Laboratory on Luminescence and Real-Time Analysis Ministry of EducationCollege of Chemistry and Chemical EngineeringKey Laboratory of Eco-environments in Three Gorges Reservoir RegionSouthwest UniversityChongqing 400715China

An effective electrochemical signal amplification strategy based on enzyme membrane modification and redox probe immobilization was proposed to construct an amperometric immunosensor.L-cysteine@ferrocene functionalized chitosan,which possessed not only efficient redox-activity but also excellent film-forming ability,was coated on the bare glass carbon electrode. Moreover,the thiol groups(SH)in the ferrocenyl compound were used for gold nanoparticles immobilization via the strong bonding interaction,which could further be utilized for the immobilization of antibody biomolecules with well-retained ***,glucose oxidase(GOD)as the enzyme membrane was employed to block the possible remaining active sites and avoid the nonspecific *** the excellent electrocatalytic properties of GOD towards glucose,the amplification of antigen-antibody interaction and the enhanced sensitivity could be *** the optimal conditions,the linear range of the proposed immunosensor for the determination of carcinoembryonic antigen(CEA)was from 0.05 to 100 ng/mL with a detection limit of 0.02 ng/mL(S/N=3).Moreover,the immunosensor exhibited good selectivity,stability and reproducibility, which provided a promising potential for clinical immunoassay.

关键词： amperometric immunosensor chitosan gold colloidal nanoparticles(GNPs) Ferrocene-monocarboxylic(Fc-COOH) carcinoembryonic antigen(CEA)

圆弧锯形仿生PDC齿的破岩机理及钻头钻进分析

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科学技术与工程 2024年第24期24卷 10280-10286页

作者：吴泽兵袁若飞张文溪刘家乐胡诗尧姜雯西安石油大学机械工程学院西安710065

为进一步提升聚晶金刚石复合片(polycrystalline diamond composite, PDC)钻头在深部硬地层的钻井性能,抑制黏滞滑动现象的发生,以鼹鼠爪趾为原型,在仿生相似原理和锯形齿结构基础上提出一种圆弧锯形仿生齿。基于弹塑性力学和有限元非... 详细信息

为进一步提升聚晶金刚石复合片(polycrystalline diamond composite, PDC)钻头在深部硬地层的钻井性能,抑制黏滞滑动现象的发生,以鼹鼠爪趾为原型,在仿生相似原理和锯形齿结构基础上提出一种圆弧锯形仿生齿。基于弹塑性力学和有限元非线性动力学理论建立了切削齿、钻头破岩的仿真模型,对比锯形齿与圆弧锯形齿的破岩过程,并对比了布置两种齿形钻头的整体钻进过程。结果表明:圆弧锯形齿破碎岩石主要以犁削和铲削为主,能够将载荷集中一点,更容易达到岩石的屈服极限,同时使岩石受拉应力更容易破碎,相比锯形齿所受切削力减小15.8%,效率更高。使用圆弧锯形仿生PDC齿的钻头破岩量更大,进尺提升明显,所受扭矩更小,能有效解决钻头的黏滞滑动。研究结果对国内高性能钻头的设计具有重要参考价值。

关键词：聚晶金刚石复合片(PDC)钻头仿生仿真有限元破岩

Unmodified and positively charged gold nanoparticles for sensitive colorimetric detection of folate receptor via terminal protection of small molecule-linked ss DNA

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Science China Chemistry 2016年第6期59卷 770-775页

作者： Min Wang Fangzhen Li Bingying Jiang Junqiang Xu Shuo Li Yun Xiang ruo yuan School of Chemistry and Chemical Engineering Chongqing University of Technology School of Chemistry and Chemical Engineering Southwest University

The detection of protein/small molecule interactions plays important roles in drug discovery and protein/metabolite interactions in biology. In this work, by coupling the terminal protection of small molecule-linked ss DNA strategy with the unmodified and positively charged gold nanoparticle((+)Au NP) nanoprobes, we have developed a sensitive and simple colorimetric sensor for the detection of folate receptor, a highly expressed protein in many kinds of malignant tumors. The target folate receptor binds the folate moieties of the folate-linked ss DNA through high affinity interactions and protects the protein-bound ss DNA from digestion by exonuclease I. The protected ss DNA thus adsorbs the((+)Au NP) through electrostatic interactions, leading to a red-to-blue color change of the sensing solution for sensitive colorimetric detection of folate receptor at the sub-nanomolar level. Besides, this colorimetric sensor shows high selectivity toward folate receptor against other control proteins. The developed sensor avoids the modification/conjugation of the Au NP nanoprobes and the involvement of any expensive instruments for signal transduction in protein detection. Featured with these obvious advantages, the colorimetric sensor strategy demonstrated herein can be easily expanded for sensitive and convenient detection of various protein/small molecule interactions.

关键词： colorimetry positively charged gold nanoparticles sensor terminal protection folate receptor

Advanced Pt hollow nanospheres/rubrene nanoleaves coupled with M-shaped DNA walker for ultrasensitive electrochemiluminescence bioassay

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Chinese Chemical Letters 2023年第6期34卷 247-251页

作者： Yumeng Song Xiuli Tao Wenbin Liang Xia Zhong ruo yuan Ying Zhuo Key Laboratory of Luminescence Analysis and Molecular Sensing Ministry of EducationCollege of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China

Herein,an intense electrochemiluminescence(ECL)was achieved based on Pt hollow nanospheres/rubrene nanoleaves(Pt HNSs/Rub NLs)without the addition of any coreactant,which was employed for ultrasensitive detection of carcinoembryonic antigen(CEA)coupled with an M-shaped DNA walker(M-DNA walker)as signal ***,in comparison with platinum nanoparticles(Pt NPs),Pt HNSs revealed excellent catalytic performance and pore confinement-enhanced ECL,which could significantly amplify ECL intensity of Rub NLs/dissolved O_(2)(DO)binary ***,the tracks and M-DNA walker were confined on the Pt HNSs simultaneously to promote the reaction efficiency,whose M-structure boosted the interaction sites between walking strands and tracks and reduced the rigidity of their *** the CEA approached the sensing interface,the M-DNA walker was activated based on highly specific aptamer recognition to recover ECL intensity with the assistance of exonucleaseⅢ(ExoⅢ).As proof of concept,the“on-off-on”switch aptasensor was constructed for CEA detection with a low detection limit of 0.20 fg/m *** principle of the constructed ECL aptasensor also enables a universal platform for sensitive detection of other tumor markers.

关键词： Platinum hollow nanospheres Electrochemiluminescence aptasensor M-shaped DNA walker On-off-on switch Carcinoembryonic antigen

CDs assembled metal-organic framework:Exogenous coreactant-free biosensing platform with pore confinement-enhanced electrochemiluminescence

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Chinese Chemical Letters 2022年第11期33卷 4803-4807页

作者： Xiu-Li Tao Mei-Chen Pan Xia Yang ruo yuan Ying Zhuo Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationCollege of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China

Despite the various synthesis approachs to obtain luminous carbon dots(CDs),it is still quite challenging to construct the efficient electrochemiluminescence(ECL)owing to their low ECL reactivity and easy ***,an efficient and concise ECL system was skillfully constructed by taking advantage of the nitrogen and sulfur co-doped CDs(N,S-CDs)with surfaces rich in hydrazide groups as luminophors to emit intense ECL,and metal-organic framework(MOF)as the matrix to confine CDs in its ***,the proposed CDs assembled MOF(CDs/ZIF-8)enhanced anodic ECL signal up to 250%of pure CDs under the exogenous coreactant-free *** a proof of concept,the highly sensitive detection of uric acid(UA)was realized by the constructed ECL platform with a low detection limit of 3.52 nmol/L ranging from 10 nmol/L to 50μmol/*** work expanded ideas for the application of pore confinement effect,and provided references for the detection of disease biomarkers of gout and hyperuricemia.

关键词： Carbon dots Zeolitic imidazolate framework-8 Pore confinement-enhanced ECL Exogenous coreactant-free Uric acid