检索结果-南通市图书馆

Combination of p-Coumaric acid and lactoferrin ameliorates cognitive deficits through suppressing C/EBPβ/AEP pathway and modulating intestinal flora in APP/PS1 mice

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Yan Zhou Yi-Tian Sun Hui Guo Yan-Zi Liang Si-yuan Zhu Yu Sha zhong-Xiao Wan Jia-Ying Xu Jian-Rong Jiang Li-Qiang Qin yun-Hong Li Department of Nutrition and Food Hygiene School of Public Health Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases MOE Key Laboratory of Geriatric Diseases and Immunology Suzhou Medical college of Soochow University Department of Medical Technology Suzhou Vocational Health College State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection Suzhou Medical college of Soochow University Suzhou Municipal Center for Disease Control and Prevention

Alzheimer's disease （AD） has become an important public health issue worldwide. P-Coumaric acid （CA） and lactoferrin （Lf） possessed antioxidant， anti-inflammatory， and anti-AD activities. Herein， we hypothesized that a combination treatment of CA and Lf would synergistically improve AD symptoms and studied its mechanisms. Twelve-week-old APP/PS1 mice were treated with CA， Lf， or both CA and Lf for 8 weeks. Results showed that individual and combined treatments could ameliorate cognitive deficits to varying degrees， with stronger effects for combined intervention than for CA or Lf alone. Specifically， combined treatment was most effective in improving nesting ability and reducing Aβ1-42deposition in mice. Moreover， combined treatment was more effective in suppressing APP， BACE1， and inflammation; it inhibited the CCAAT-enhancer-binding protein （C/EBPβ）/asparagine endopeptidase （AEP） signaling pathway in the hippocampus and colon and upregulated the expression of tight junction protein ZO-1 in the colon; it also decreased the F/B ratio at the phylum level and increased the relative abundance of Prevotellaceae， Lachnospira， and Eubacterium at the genus level. Overall， the combination of CA and Lf may ameliorate cognitive deficits in APP/PS1 mice by improving inflammation and inhibiting the C/EBPβ/AEP signaling pathway via modulating gut microbiome.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于ERT技术反演红壤剖面水分入渗过程

土壤学报 2024年第3期61卷 714-726页

作者：田园钟雪梅彭新华汪亚及高磊桂林理工大学地球科学学院桂林541004 土壤与农业可持续发展国家重点实验室(中国科学院南京土壤研究所) 南京210008 中国科学院大学北京100049

水分运动是土壤中物质和能量传输的主要驱动力,但是水分在土壤中的运动轨迹复杂多变,难以直接捕捉。本研究以第四纪红黏土发育的红壤为研究对象,借助电阻率成像技术(ERT),反演水分在林地和农地土壤中的入渗过程。研究发现,ERT技术能够... 详细信息

水分运动是土壤中物质和能量传输的主要驱动力,但是水分在土壤中的运动轨迹复杂多变,难以直接捕捉。本研究以第四纪红黏土发育的红壤为研究对象,借助电阻率成像技术(ERT),反演水分在林地和农地土壤中的入渗过程。研究发现,ERT技术能够实现水分在红壤包气带入渗过程的可视化,ERT测定的表观电阻率的变化量与烘干法测定的土壤水分之间呈极显著正相关关系(P<0.01),林地的决定系数为0.72,农地为0.53。土地利用类型影响水分入渗的范围和方式,在2 cm水头高度注水100 L的情况下,林地的入渗深度大于80 cm,而农地约为50 cm,在此基础上,继续注水200 min,林地和农地均出现明显的优先流现象。但是,林地的优先流较农地更为发育,林地是通过根系等大孔隙快速向下传输,而农地则以“指流”的方式,间断性向深层运动。在土壤层次复杂、背景含水量高、土壤黏重等不利因素的影响下,ERT技术依然能捕捉优先流在红壤中发生和发育的过程。

关键词：电阻率层析成像技术土地利用类型红黏土土壤水分优先流

在线全文

学校读者我要写书评

暂无评论

考虑水盐运移的分散性盐渍土冻融破坏机制

长安大学学报（自然科学版） 2024年第2期44卷 1-11页

作者：孔元元梁晨涛王智慧谢柏涵成忠焱长安大学公路学院陕西西安710064

为探究冻融循环过程中土体冻-盐胀破坏机理,结合冻结温度试验和扫描电子显微镜进行研究,分析了不同循环次数、不同盐的种类和不同含水率条件下的冻融循环对土体结构和性质的影响,得到了不同循环次数下的冻结温度变化曲线和不同含水率条... 详细信息

为探究冻融循环过程中土体冻-盐胀破坏机理,结合冻结温度试验和扫描电子显微镜进行研究,分析了不同循环次数、不同盐的种类和不同含水率条件下的冻融循环对土体结构和性质的影响,得到了不同循环次数下的冻结温度变化曲线和不同含水率条件下冻土的SEM电镜扫描图片,并基于经典传热理论和水盐运移方程,建立数值模型,再现了冻融过程中的水盐运移过程,在此基础上结合试验对水盐运移过程中土体的破坏机制进行分析研究。研究结果表明:由于研究区土体的分散性,其冻结过程只存在恒定阶段和递降阶段,且随着冻融循环次数的增大,土体的冻结温度会先升高然后在某一温度保持稳定,这与冻融循环过程中土体粒度大小和颗粒排布的方式改变相关,内部的微裂隙逐渐贯通;土体在冻融循环过程所发生的水盐迁移是土体强度和结构发生变化的重要原因,且随着冻融循环过程的进行,土中的水盐成分会在温度梯度和溶质梯度的影响下产生迁移和积累;相较于碳酸氢钠,硫酸钠在冻融过程中对于土体结构的改变更为显著,具体表现在冻结过程中硫酸钠结晶析出体积变为原来的3.18倍,导致冻融循环后土体膨胀。本研究有助于揭示季节性冻土区含盐冻土工程的冻融破坏机制。

关键词：道路工程水盐运移数值模拟盐渍土冻融循环

Quality Standard of Tibetan Medicine Nardostachys jatamansi Herba Based on"An Integrated Plant but Multi-purpose"

在线全文

学校读者我要写书评

暂无评论

Medicinal Plant 2024年第3期15卷 16-22页

作者： Hairong zhong Yuebu HAILAI Shaoshan ZHANG Wenbing LI yuan LIU College of Pharmacy Sichuan College of Traditional Chinese MedicineMianyang 621000China Sichuan Provincial Qiang-Yi Medicinal Resources Protection and Utilization Technology and Engineering Laboratory Chengdu 610225China Key Laboratory of Protection and Utilization of Ethnic Medicinal Resources on Qinghai-Tibet Plateau State Ethnic Affairs CommissionChengdu 610225China Southwest Minzu University Chengdu 610225China

[Objectives]To establish the quality standard of Nardostachys jatamansi Herba.[Methods]The characters and microscopical identification of N.jatamansi Herba were carried out.The contents of moisture,total ash,acid-insoluble ash and extract were determined according to the relevant methods of the Chinese Pharmacopoeia(2020 edition).Using chlorogenic acid and 3,5-O-dicaffeoylquinic acid as quality control indexes,TLC and HPLC methods were established for qualitative and quantitative determination,and HPLC fingerprints were established.[Results]The characteristics of character identification,microscopic identification and thin layer identification were obvious.The moisture content ranged from 2.7%to 7.8%,with an average value of 5.4%.The total ash content ranged from 6.7%to 16.2%,with an average of 11.0%.The acid-insoluble ash content ranged from 0.7%to 8.5%,with an average of 3.6%.Extractives content ranged from 20.9%to 34.4%,with an average of 29.7%.Chlorogenic acid content was between 0.45%and 1.30%,with an average value of 0.77%.The content of 3,5-O-dicaffeoylquinic acid ranged from 0.18%to 0.58%,with an average of 0.31%.The similarity of each batch was between 0.930 and 0.994,indicating that the quality of medicinal materials from different producing areas was stable.[Conclusions]The quality standard of N.jatamansi Herba was established,which could provide quality control basis for rational,comprehensive and efficient utilization of N.jatamansi DC.resources and clinical use.

关键词： Nardostachys jatamansi Herba Chlorogenic acid 3 5-O-dicaffeoylquinic acid Fingerprint Quality standard Resource utilization

TCP1表达对HL60和HL60/A 细胞增殖及细胞内药物蓄积的调控作用及其机制

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国实验血液学杂志 2024年第1期32卷 71-77页

作者：陈小芳陈显凌陈元仲福建医科大学附属协和医院感染科福建医科大学附属协和医院血液科福建省血液病学重点实验室福建省血液病研究所福建福州350001

目的:研究TCP1表达对HL60及HL60/A细胞增殖及细胞内药物蓄积的影响及其机制。方法:利用慢病毒转染技术构建敲低、过表达TCP1的HL60/A细胞和HL60细胞及其对照组细胞,Western blot评估敲低、过表达效率。采用CCK-8法检测细胞增殖能力;激... 详细信息

目的:研究TCP1表达对HL60及HL60/A细胞增殖及细胞内药物蓄积的影响及其机制。方法:利用慢病毒转染技术构建敲低、过表达TCP1的HL60/A细胞和HL60细胞及其对照组细胞,Western blot评估敲低、过表达效率。采用CCK-8法检测细胞增殖能力;激光共聚焦显微镜及流式细胞术检测细胞内的药物蓄积;流式细胞术及Western blot检测膜转运蛋白(MRP1、P-gP)及p-AKT的表达水平。结果:在HL60/A细胞中敲低TCP1的表达能够抑制细胞增殖,增加细胞内药物蓄积,降低转运蛋白MRP1及P-gP的表达,在HL60细胞中过表达TCP1能够促进细胞的增殖,减少细胞内药物蓄积,提高转运蛋白MRPI及P-gP的表达。同时利用PI3K抑制剂LY294002抑制PI3K/AKT信号能够拮抗TCP1过表达所致的细胞增殖活性增强、细胞内药物蓄积减少及MRP1、P-gP表达的升高。结论:TCP1能够促进细胞增殖,并通过激活PI3K/AKT信号促进转运蛋白MRP1、P-gP的表达,降低细胞内的药物蓄积。

关键词： TCP1 急性髓系白血病药物蓄积 MRP1 P-gP PI3K/AKT信号通路

Circular RNA circ_0003609 ameliorates hypertrophied ligamentum flavum by regulating the miR-155/SIRT1 axis

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2024年第6期48卷 1001-1008页

作者： GUIBIN zhong SHURONG WANG YUJIN HE DAMING FENG KE WEI YANQIU YANG JIANWEI chen JUNLING chen Department of Orthopaedics Baoshan BranchRen Ji HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghai200444China Department of Orthopaedics Ren Ji HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghai200127China Department of Operation and Anaesthesia Ren Ji HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghai200127China Department of Orthopaedics Huai Yuan Chang Jiu HospitalHuaiyuan233499China

Background:Hypertrophy of the ligamentumﬂavum(HLF)is a common contributor to spinal stenosis which results in signiﬁcant neurological impairments.Circular RNA(circRNA)circ_0003609 has been linked to HLF;however,the exact mechanism by which it causes this disease is unclear.Methods:Circ_0003609 expressions were regulated in HLF cells by overexpression vectors and RNA interference.Cell proliferation andﬁbrosis-related gene expression were checked by the Cell Counting Kit-8(CCK-8)assay and western blotting.CircBank’s prediction of the association between miR-155 and circ_0003609 was supported by a dual-luciferase reporter experiment.The function of the miR-155/sirtuin 1(SIRT1)axis in controlling HLFﬁbrosis was further examined.Results:Overexpression of circ_0003609 suppressed HLF cell propagation andﬁbrosis compared to its silencing.It was found that circ_0003609 served as the sponge for miR-155 and that the circ_0003609/miR-155 axis controlled theﬁbrosis of HLF cells.It was found that circ_0003609 acted as a sponge for miR-155,regulating theﬁbrosis of HLF cells.Further,miR-155 targets SIRT1,and the miR-155/SIRT1 axis promotes HLF cellﬁbrosis.Conclusion:Circ_0003609 ameliorates hypertrophied ligamentumﬂavum(LF)by modulating the miR-155/SIRT1 axis,indicating a potential treatment approach for HLF.

关键词： Circular RNA Circ_0003609 Hypertrophy of ligamentum flavum MiR-155 Sirtuin 1 Fibrosis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于注意力机制LSTM的电离层TEC预测

地球物理学报 2024年第2期67卷 439-451页

作者：刘海军雷东兴袁静乐会军单维锋李良超王浩然李忠袁国铭防灾科技学院河北廊坊065201 中国科学院地质与地球物理研究所中国科学院地球与行星物理重点实验室北京100029

电离层总电子含量(Total Electron Content,TEC)的监测与预报是空间环境研究的重要内容,对卫星通讯和导航定位等有重要意义.TEC值影响因素较多,很难确定精确物理模型来对其进行预测.本文设计了基于注意力机制的LSTM模型(Att-LSTM),采用... 详细信息

电离层总电子含量(Total Electron Content,TEC)的监测与预报是空间环境研究的重要内容,对卫星通讯和导航定位等有重要意义.TEC值影响因素较多,很难确定精确物理模型来对其进行预测.本文设计了基于注意力机制的LSTM模型(Att-LSTM),采用过去24小时TEC观测数据对未来TEC进行预测.选择北半球东经100°上,每2.5°纬度选择一个位置,共计36个位置来验证本文提出模型的性能,并与主流的深度学习模型如DNN、RNN、LSTM进行对比实验.取得了如下成果:(1)在选定的36个地区未来2小时单点预测上,基于本文的Att-LSTM模型的TEC预测性能明显优于其他对比模型;(2)讨论了纬度对Att-LSTM预测未来2小时TEC值时性能的影响,发现在北纬0°到60°之间,Att-LSTM预测性能随着纬度的升高而略有降低,在北纬62.5°~87.5°之间,模型预测性能出现扰动,预测效果略差;(3)讨论了磁暴期和磁静期模型的预测性能,发现无论是磁暴期还是磁静期,本文模型预测性能均较好;(4)还讨论了对未来多时点预测效果,实验结果表明,本文所提出的模型对未来2、4个小时的预测拟合度R-Square均超过0.95,预测结果比较可靠,对未来6、8、10个小时预测拟合度最高为0.7934,预测拟合度R-Square下降迅速,预测结果不可靠.

关键词：注意力机制长短期记忆神经网络电离层总电子含量

Study on the occurrence and influencing factors of gastrointestinal symptoms in hemodialysis patients with uremia

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第7期16卷 2157-2166页

作者： Dan yuan Xiao-Qi Wang Feng Shao Jing-Jing Zhou zhong-Xin Li Department of Nephrology Beijing Luhe Hospital Affiliated to Capital Medical UniversityBeijing 101100China

BACKGROUND Gastrointestinal symptoms are common in patients with uremia undergoing hemodialysis,and these symptoms seriously affect patients'prognosis.AIM To assess the occurrence and factors influencing gastrointestinal symptoms in patients with uremia undergoing hemodialysis.METHODS We retrospectively selected 98 patients with uremia who underwent regular hemo-dialysis treatment in the blood purification center of our hospital from December 2022 to December 2023.The gastrointestinal symptoms and scores of each dimension were evaluated using the Gastrointestinal Symptom Grading Scale(GSRS).Patients were divided into gastrointestinal symptoms and no gastrointestinal symptom groups according to whether they had gastrointestinal symptoms.The factors that may affect gastrointestinal symptoms were identified by single-factor analysis.Multiple logistic regression analysis was performed to identify independent risk factors for gastrointestinal symptoms.RESULTS Gastrointestinal symptoms included indigestion,constipation,reflux,diarrhea,abdominal pain,and eating disorders,and the total average GSRS score was 1.35±0.47.This study showed that age,number of tablets,dialysis time,glucocorticoid,parathyroid hormone(PTH),combined diabetes mellitus and C-reactive protein(CRP)were independent risk factors for gastrointestinal symptoms in patients with uremia undergoing hemodialysis,whereas body mass index(BMI),hemoglobin(Hb),and urea clearance index were independent protective factors(P<0.05).CONCLUSION Gastrointestinal symptoms are mostly mild in patients with uremia undergoing hemodialysis,most commonly including dyspepsia,eating disorders,and gastroesophageal reflux.The independent influencing factors mainly include the BMI,age,number of pills taken,dialysis time,urea clearance index,Hb,use of glucocorticoids,and thyroid hormone level.PTH,CRP,and diabetes are clinically related factors influencing the occurrence of gastrointestinal symptoms,and targeted prevention can be performed.

关键词： Uremic hemodialysis Gastrointestinal symptoms Influencing factors Blood pressure dialysis Chronic renal failure

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

水毛花种子萌发特性的差异及休眠解除方法

植物生态学报 2024年第5期48卷 638-650页

作者：袁涵钟爱文刘送平彭焱松徐磊中国科学院庐山植物园江西九江330000 南昌大学生命科学学院南昌330031

水毛花(Schoenoplectiella triangulata)是一种广泛应用于湿地植被恢复中的挺水植物,探究不同地区水毛花种群种子的萌发特性与休眠特性对其种质收集和科学利用至关重要。该研究测定了水毛花种子形态特性、萌发特性的种群间差异,并对其... 详细信息

水毛花(Schoenoplectiella triangulata)是一种广泛应用于湿地植被恢复中的挺水植物,探究不同地区水毛花种群种子的萌发特性与休眠特性对其种质收集和科学利用至关重要。该研究测定了水毛花种子形态特性、萌发特性的种群间差异,并对其休眠机制进行探索,结果显示:(1)水毛花的种子存在生理休眠,其形态、千粒质量和吸水特性在种群间存在显著差异。(2)光照和变温条件有助于水毛花种子的萌发。(3)低温沙藏、低温水藏和常温沙藏有助于水毛花种子休眠的解除;氟啶酮和赤霉素处理均有助于打破水毛花种子的休眠,但在不同地区水毛花种群间存在差异。(4)不同地区水毛花种群间种子形态特性、萌发特性以及休眠特性的差异与采集地的环境因子相关。该研究结果表明水毛花种子应用于湿地生态修复时应考虑种源的问题,在播种前对其进行适当处理可以提高发芽率和生态修复成效。

关键词：莎草科水毛花种子萌发种子休眠层积