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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang chen Yi-Wei Yang Rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-bo Bai Jie Bao Ping Cao Qi-Ping chen Zhen chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-Bin Liu Guang-yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang peng-cheng Wang Zhao-Hui Wang zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang Mao-yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron techniques.Neutron resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an object.The back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test experiments.The results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at Back-n.This study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

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改进YOLOv5的智慧课堂人脸检测算法

计算机工程与应用 2024年第11期60卷 251-257页

作者：钟源袁家政李鸿天刘宏哲徐成北京联合大学北京市信息服务工程重点实验室北京100101 北京联合大学脑与认知智能北京实验室北京100101 北京开放大学科学技术学院北京100081

智慧课堂是人工智能领域热门的应用场景。针对课堂场景下摄像头位置较远且偏,图像中目标存在人脸过小和遮挡导致漏检或错检等问题,提出了一种改进YOLOv5的智慧课堂人脸检测算法YOLOv5-SASA。该算法主要包括三个部分,在backbone层沿用了C... 详细信息

智慧课堂是人工智能领域热门的应用场景。针对课堂场景下摄像头位置较远且偏,图像中目标存在人脸过小和遮挡导致漏检或错检等问题,提出了一种改进YOLOv5的智慧课堂人脸检测算法YOLOv5-SASA。该算法主要包括三个部分,在backbone层沿用了CSPDarknet53网络,通过在最后的空间池化层中使用BasicRFB模块来有效增强网络的特征提取能力;采用NWD损失函数来提高模型对小目标检测的鲁棒性,同时在head层中引入了独立自注意力机制模块SASA,以解决人脸遮挡的问题,并降低模型的参数量;通过降低中间层通道神经元的数量、调节学习率等方式,对改进的YOLOv5网络进行了优化,以避免模型过拟合。实验结果表明,所提出的方法在WiderFace验证集的easy、medium和hard难度下的效果均优于原网络,分别达到了97.5%、96.3%和86.5%的准确率,能够有效提升课堂场景下人脸检测的精度。

关键词：智慧课堂人脸检测 YOLOv5 独立自注意力机制

宽温区Yb∶YAG板条激光模块热畸变仿真研究

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激光与红外 2024年第4期54卷 503-507页

作者：朱铎宋艳洁陈中正许元斋薄勇彭钦军中国科学院物理与化学技术研究所固体激光重点实验室北京100190 中国科学院理化技术研究所功能晶体与激光技术重点实验室北京100190 中国科学院大学北京100190 齐鲁中科光学物理与工程技术研究所山东济南250000

本文对不同冷却温度下的Yb:YAG晶体板条激光模块高功率运转时的温度场、应力场及对应的热畸变进行了仿真分析研究。结果显示,随着冷却温度从300 K降低至77K,板条的温度梯度热应力与应变都明显降低。当冷却温度为77 K时,最大主应力为4.14... 详细信息

本文对不同冷却温度下的Yb:YAG晶体板条激光模块高功率运转时的温度场、应力场及对应的热畸变进行了仿真分析研究。结果显示,随着冷却温度从300 K降低至77K,板条的温度梯度热应力与应变都明显降低。当冷却温度为77 K时,最大主应力为4.14 MPa,仅为常温时的15.6%,最大主应变为3.82×10^(-5),仅为常温时的6%。为了分析Yb:YAG晶体板条激光模块不同冷却温度下输出激光的光束质量,以确定其最佳运转温度,我们采用光线追迹的方法,对单程通过板条的1030 nm探测光进行仿真。可以看到,当冷却温度为77 K时,远场光斑能量更为集中,且探测光光程差的PV值为0.7941μm,仅为300 K时的59.6%。模拟结果表明低温运转有利于Yb:YAG晶体板条激光模块产生高功率高光束质量激光输出,这为高功率高光束质量Yb:YAG晶体板条激光的设计工作奠定了基础。

关键词：板条激光器 Yb∶YAG 热效应仿真模拟

Identifying Qingkailing(清开灵)ingredients-dependent mesenchymal-epithelial transition factor-axiation“π”structuring module with angiogenesis and neurogenesis effects

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Journal of Traditional Chinese Medicine 2024年第1期44卷 35-43页

作者： chenG Kunming yuan Jianan LIU Jun ZHANG Shengpeng XU Qixiang XIE Yong ZHAO Jingfeng ZHANG Xiaoxu TANG Xudong ZHENG Yongqiu WANG zhong Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui Teaching and Research Section of Traditional Chinese MedicineSchool of PharmacyWannan Medical CollegeWuhu 241000China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of EducationDepartment of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Department of Gastroenterology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China

OBJECTIVE:To explore the functional role of the drugdependent mesenchymal-epithelial transition(Met)-axiation"π"structural module of neurogenesis after processing by three components of Qingkailing injection in neurogenesis and angiogenesis in cerebral ischemia.METHODS:We used a Glutathione S-transferase(GST)-pull down assay,isothermal titration calorimetry assay,and other related methods to identify the relationships among Met,inositol polyphosphate phosphatase like 1(Inppl1),and death associated protein kinase 3(Dapk3)in this allosteric module.The biological effects of the modules of neurons generation composed of Met,Inppl1,and Dapk3 were measured through Western blot,apoptosis analysis,and double immunofluorescence labeling.RESULTS:The GST-pull down assay revealed that proline-serine-threonine rich domain of Met binds to the Src homology domain of Inppl1 to form a protein-protein complex;Dapk3 with a C-terminal domain interacts weakly with the protein kinase C domain of Met in the intracellular region.Thus,we obtained a“π”structuring module considered a neural regeneration module.The biological effects of angiogenesis and neurogenesis modules composed of Met,Inppl1,and Dapk3 were also verified.CONCLUSION:The study suggested that understanding the functional modules that contribute to pharmaceutics might provide novel signatures that can be used as endpoints to define disease processes under stroke or cerebral ischemia conditions.

关键词： brain ischemia stroke neurogenesis angiogenesis modular pharmacology Met-axiation allosteric module

接种丛枝菌根真菌配合氮肥减施对辣椒–大豆间作体系氮素吸收的影响

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植物营养与肥料学报 2024年第1期30卷 137-146页

作者：余众刘圆圆夏懿张仕颖王豹岳献荣夏运生云南农业大学云南昆明650201 云南省土壤培肥与污染修复工程研究中心云南昆明650201 四川农业大学四川成都610000

【目的】叶菜及经济效益较高的茄果类如辣椒、番茄等占云南省设施蔬菜栽培面积的62.19%,蔬菜连作以及氮肥的大量施用制约了设施蔬菜高产优质,降低了土壤质量。研究接种丛枝菌根真菌(AMF)和氮水平对作物生长、土壤氮残留及生物相关特性... 详细信息

【目的】叶菜及经济效益较高的茄果类如辣椒、番茄等占云南省设施蔬菜栽培面积的62.19%,蔬菜连作以及氮肥的大量施用制约了设施蔬菜高产优质,降低了土壤质量。研究接种丛枝菌根真菌(AMF)和氮水平对作物生长、土壤氮残留及生物相关特性的影响,为提高设施蔬菜产量,减少氮肥施用量,降低土壤氮残留提供理论依据。【方法】以大豆和辣椒间作为种植模式进行盆栽试验。设计了接种AMF、氮肥用量、种植模式三因素试验。在大豆、辣椒单作、大豆辣椒间作3个种植模式下,分别设3个施氮(N)水平:0、100、200 mg/kg土(N0、N1、N2);每个氮水平下,再设土壤不接种、接种AMF菌剂处理(NM、AMF),共组成18个处理。在蔬菜收获期,取样测定蔬菜生物量、根系长度、AMF侵染率,测定根际土壤硝态氮、铵态氮含量、氮代谢酶活性以及菌丝密度。【结果】接种AMF、施氮量、种植模式及三者的交互作用对辣椒和大豆根系AMF侵染率、植株生物量和根长的影响都达到显著水平(P<0.01)。N1处理显著增加了辣椒、大豆根系的菌根侵染率,且在间作条件下的增幅最高;N1处理下,接种AMF和间作均显著增加了辣椒、大豆植株生物量和氮吸收量,抑制了根系的伸长。N2处理显著增加了土壤铵态氮和硝态氮含量,接种AMF显著降低了辣椒、大豆植株根际土壤铵态氮和硝态氮含量,间作则显著降低了辣椒根际土壤硝态氮含量和大豆根际土壤铵态氮含量。接种AMF、间作均明显增加了植物根际土壤中蛋白酶、脲酶及硝酸还原酶活性。N1处理显著增加了土壤菌丝密度,间作条件下接种AMF显著增加了辣椒根际土壤菌丝密度。【结论】配合间作和接种AMF措施,氮肥减施可提高蔬菜根际菌根侵染率,增加土壤中菌丝密度,提高氮代谢酶活性,从而促进蔬菜生长和氮素吸收,减少土壤氮残留,因此,蔬菜间作种植下,接种AMF配合氮肥减施有望成为改善设施土壤肥力,提高氮肥利用效率,促进蔬菜健康生长,减少土壤氮素残留的配套技术。

关键词：连作设施土壤丛枝菌根真菌辣椒大豆间作氮肥减施土壤氮循环相关酶活性菌丝密度土壤氮残留

Geroprotection from ergothioneine treatment in Drosophila melanogaster by improving intestinal barrier and activation of intestinal autophagy

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Food Science and Human Wellness 2024年

作者： Hong-Yu Pan Na Wang Qian-Wang Zheng yuan Zou Jing-Ru zhong Guo-Zhao Luo Ming-Zhen Tu Li-Qiong Guo Jun-Fang Lin College of Food Science South China Agricultural University.Guangzhou Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province Faculty of Food Science and Engineering Kunming University of Science and Technology Guangzhou Alchemy Biotechnology Co. Ltd

Ergothioneine is a natural amino acid with powerful antioxidant activity. Previous studies have demonstrated that ergothioneine can increase the lifespan of Drosophila melanogaster and Caenorhabditis elegans， and enhance telomerase activity. In present study， the metagenomics sequencing and qRT-PCR analysis were employed to characterize the composition and diversity of gut microbiome in aging flies. And the alterations in the gut barrier， gut morphology， and other gut physiological indicators of aging flies were evaluated. Here， the results showed that EGT induced little variations in gut microbiota composition in flies at mid-life， and significant alterations in the gut microbiota populations were only observed in flies at late-life. And ergothioneine attenuated age-related gut injuries， including decreasing reactive oxygen species levels in intestinal enterocytes， reduction of intestinal cells death， and preservation of gut integrity in aging flies. Ergothioneine also improved the gut morphology by preserving the structure and shape of cell organelles and inducing the intestinal autophagy. And activation of intestinal autophagy also contributed to the longevity effect mediated by ergothioneine in an unidentified mechanism.

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基于CiteSpace对(制)何首乌的研究热点及发展趋势的可视化分析

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中国临床药理学杂志 2024年第9期40卷 1363-1367页

作者：唐芳曲丽媛岑柏宏王萍孙冬梅许重远南方医科大学南方医院临床药学中心广东广州510515 南方医科大学国家药品监督管理局药物代谢研究与评价重点实验室及广东省新药筛选重点实验室广东广州510515 广东一方制药有限公司广东佛山528244 广东省中药配方颗粒企业重点实验室广东佛山528244

目的对有关(制)何首乌中英文文献进行文献计量分析,探讨(制)何首乌的研究重点和趋势,为今后的科学研究提供依据。方法利用中国知网、Web of Science数据库检索(制)何首乌的有关文献,并基于CiteSpace 6.1.R6软件利用文献计量学方法,对文... 详细信息

目的对有关(制)何首乌中英文文献进行文献计量分析,探讨(制)何首乌的研究重点和趋势,为今后的科学研究提供依据。方法利用中国知网、Web of Science数据库检索(制)何首乌的有关文献,并基于CiteSpace 6.1.R6软件利用文献计量学方法,对文章的发表年份、作者、作者国家、关键词等内容进行可视化分析。结果本研究总共纳入中文文献1131篇、英文文献386篇,共计1517篇。近30年以来,在该领域的中文文献发文总量先上升后下滑,英文文献的发文总量则呈现波动性增长态势。发文量较高的作者为肖小河和王伽伯及其团队,该团队主要从事何首乌肝损伤机制与炮制减毒研究以及临床中药学与安全用药研究。关键词分析表明,本研究领域的研究热点和发展方向为(制)何首乌的效毒同源成分以及肝毒性机制及早期预警监测的研究。结论(制)何首乌效毒同源化学成分的研究一直很活跃,对于效毒同源成分转换关系与机制研究以及肝毒性机制的研究将是该领域的研究重点与发展趋势。

关键词： (制)何首乌 CiteSpace 研究热点发展趋势可视化分析效毒关系

Hemolysis attributed to high dose vitamin C:Two case reports

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World Journal of Clinical Cases 2024年第17期12卷 3168-3176页

作者： Shi-Wan Wang Xiao-Wei Zhang Jin-Xiu Qu Yi-zhong Rao Shuai Lu Bing Wang Jia He yuan Zhao Ben-Qiang Rao Center for Oncology Nutrition and Metabolism Beijing Shijitan HospitalCapital Medical University/Key Laboratory of Cancer FSMP for State Market RegulationBeijing 100038China

BACKGROUND High-dose vitamin C treatment(HVCT)can reduce the adverse effect of chemotherapy and enhance the effect of antitumor therapy,which has been considered one of the safest alternative treatments.However,the severity of its adverse effects may have been underestimated.The most serious adverse effect is hemolysis,which may result in acute kidney injury or death.Although glucose-6-phosphate dehydrogenase(G6PD)deficiency is considered to be the main cause,the probability and pathological mechanism are not completely understood,leading to a lack of effective and standardized treatment methods.CASE SUMMARY Two patients with colorectal cancer developed hemolytic anemia after using 1 g/kg HVCT.In contrast to previous cases,the lowest hemoglobin level in the two cases wasbone marrow suppression.both patients improved and were discharged after blood replacement therapy.Our cases had the most severe degree of hemolysis but the best prognosis,suggesting that our treatment may be helpful for rescue of drug-induced hemolysis.This is the first review of the literature on hemolysis caused by HVCT,and we found that all patients with G6PD deficiency developed hemolysis after HVCT.CONCLUSION G6PD deficiency should be considered as a contraindication to HVCT,and it is not recommended for patients with bone marrow suppression,moderate-tosevere anemia,hematopoietic abnormalities,or abnormal liver and kidney function.Early blood purification and steroid therapy may avoid acute kidney injury or death caused by HVCT-related hemolytic anemia.

关键词： Hemolysis Vitamin C Adverse effects Acute kidney injury Cancer Case report

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循环流化床锅炉压火启动调峰技术综述

热能动力工程 2024年第3期39卷 1-8页

作者：刘众元武晓俊国网山西省电力公司电力科学研究院山西太原030001

为了促进新能源电量消纳,循环流化床锅炉压火启动调峰研究得到广泛关注。本文针对锅炉压火启动技术,从压火启动原理、发展历程、需要关注的核心问题及应对措施进行了概述,总结分析了压火时长、机组安全性、污染物生成和控制及无循环泵直... 详细信息

为了促进新能源电量消纳,循环流化床锅炉压火启动调峰研究得到广泛关注。本文针对锅炉压火启动技术,从压火启动原理、发展历程、需要关注的核心问题及应对措施进行了概述,总结分析了压火时长、机组安全性、污染物生成和控制及无循环泵直流CFB锅炉压火调峰等问题,提出了压火时长计算、NOx控制及压火启动调峰对机组寿命的影响等未来重点研究方向。

关键词：循环流化床压火调峰