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SH2.1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice

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Research 2024年第3期2023卷 369-389页

作者： Xiujuan Du Yuhua yan Juehua Yu Tailin Zhu {2.-{2.ng Huang lingli zhang Xingyue Shan Ren li yuan Dai hui LV Xiao-Yong zhang Jianfeng Feng Wei-Guang li Qiang Luo Fei li Developmental and Behavioral Pediatric Department Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and Ministry of Education-Shanghai Key Laboratory for Children's Environmental HealthXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Developmental and Behavioral Pediatric Department Shanghai Xinhua Children's HospitalShanghai 200092China National Clinical Research Center for Aging and Medicine at Huashan Hospital Institute of Science and Technology for Brain-lnspired IntelligenceMinistry of Education-Key Laboratory of Computational Neuroscience and Brain-lnspired IntelligenceFudan UniversityShanghai 200433China state key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science Institutes of Brain Science and Human Phenom InstituteFudan UniversityShanghai 200032China shanghai key Laboratory of Brain Functional Genomics(Ministry of Education) School of Life SciencesEast China Normal UniversityShanghai 200062China Department of Rehabilitation Medicine Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Center for Experimental Studies and Research The First Affliated Hospital of Kunming Medical UniversityKunming 650032China shanghai Research Center for Brain Science and Brain-lnspired Intelligence Shanghai201210China institute of Cognitive Neuroscience School of Psychology and Cognitive ScienceEast China Normal UniversityShanghai 200062China.

Fluid intelligence is a cognitive domain that encompasses general reasoning, pattern recognition, and problem-solving abilities independent of task-specific experience. Understanding its genetic and neural underpinnings is critical yet challenging for predicting human development, lifelong health, and well-being. One approach to address this challenge is to map the network of correlations between intelligence and other constructs. In the current study, we performed a genome-wide association study using fluid intelligence quotient scores from the UK Biobank to explore the genetic architecture of the associations between obesity risk and fluid intelligence. Our results revealed novel common genetic loci (SH2.1, TUFM, ATP2.1, and FOXO3) underlying the association between fluid intelligence and body metabolism. Surprisingly, we demonstrated that SH2.1 variation influenced fluid intelligence independently of its effects on metabolism but partially mediated its association with bilateral hippocampal volume. Consistently, selective genetic ablation of Sh2.1 in the mouse hippocampus, particularly in inhibitory neurons, but not in excitatory neurons, significantly impaired working memory, short-term novel object recognition memory, and behavioral flexibility, but not spatial learning and memory, mirroring the human intellectual performance. Single-cell genetic profiling of Sh2.1-regulated molecular pathways revealed that Sh2.1 deletion resulted in aberrantly enhanced extracellular signal-regulated kinase (ERK) signaling, whereas pharmacological inhibition of ERK signaling reversed the associated behavioral impairment. Our cross-species study thus provides unprecedented insight into the role of SH2.1 in fluid intelligence and has implications for understanding the genetic and neural underpinnings of lifelong mental health and well-being.

关键词： metabolism impaired reversed

Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation

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Protein & Cell 2024年第7期15卷 512-529页

作者： Kai-hui zhang Fei-Fei zhang Zhi-ling zhang Ke-Fei Fang Wen-Xing Sun Na Kong Min Wu Hai-Ou liu yan liu Zhi li Qing-Qing Cai yang Wang Quan-Wei Wei Peng-Cheng lin yan lin Wei Xu Cong-Jian Xu Yi-yuan yuan Shi-Min zhao The Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200090China shanghai key Laboratory of Metabo{2.c Remode{2.ng and Children’s Hospital of Fudan UniversityShanghai 200032China School of life sciences and {2.s of Biomedical sciences Fudan UniversityShanghai 200438China Department of Nutrition and Food Hygiene School of Public HealthNantong UniversityNantong 226019China Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China shanghai Fifth People’s Hospital of Fudan University Fudan UniversityShanghai 200240China Department of Animal Science and technology Nanjing Agricultural UniversityNanjing 210014China key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province College of PharmacyQinghai University for NationalitiesXining 810007China Pediatric Research institute Children’s Hospital Affiliated to Shandong University(Jinan Children’s Hospital)Jinan 250022China

Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory *** understanding of the ovulation drivers hinders PCOS ***,we report that follicle stimulating hormone(FSH)controls follicular fluid(FF)glutamine levels to determine *** ovulation starts from FF-exposing granulosa cell(GC)*** glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients ***-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS ***,follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic *** and glutamine inhibit the rapture of cultured murine *** removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or *** suggest that glutamine,FSH,and ASK1-JNK pathway are targetable to alleviate PCOS.

关键词： ovulation glutamine granulosa cells PCOS FSH

DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation

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Cancer Biology & Medicine 2024年第3期21卷 252-266页

作者： Junya yan Shibo Wang Jing zhang Qiangqiang {2. Xianchun Gao Nannan zhang yan Pan Haohao zhang Kun liu Jun Yu linbin Lu hui liu Xiaoliang Gao Sheng {12. Wenyao zhang Abudurousuli Reyila Yu Qi Qiujin zhang Shundong Cang {2.{2. Lu yanglin Pan yan Kong Yongzhan Nie state key Laboratory of Ho{2.stic Integrative Management of Gastrointestinal Cancers and National C{2.nical Research Center for Digestive Diseases Xijing Hospital of Air Force Military Medical UniversityXi'an 710032China Department of Oncology Henan Provincial People's HospitalZhengzhou University People's HospitalZhengzhou 450o03China Faculty of life Science Northwest UniversityXi'an 710069China Unit 732.1 of the People's liberation Army Nanjing 211800China key Laboratory of Resource Biology and Biotechnology in Western {2.(Ministry of Education) School of MedicineNorthwest UniversityXi'an 710069China Shaanxi University of chinese Medicine Second Clinical Medicine FacultyXi'an 712046China key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Renal Cancer and MelanomaPeking University Cancer Hospital and InstituteBeijing 100142China

Objective: DNA damage response(DDR) deficiency has emerged as a prominent determinant of tumor immunogenicity. This study aimed to construct a DDR-related immune activation(DRIA) signature and evaluate the predictive accuracy of the DRIA signature for response to immune checkpoint inhibitor(ICI) therapy in gastrointestinal(GI) ***: A DRIA signature was established based on two previously reported DNA damage immune response assays. Clinical and gene expression data from two published GI cancer cohorts were used to assess and validate the association between the DRIA score and response to ICI therapy. The predictive accuracy of the DRIA score was validated based on one ICI-treated melanoma and three pan-cancer published ***: The DRIA signature includes three genes(CXCL10, IDO1, and IFI44L). In the discovery cancer cohort, DRIA-high patients with gastric cancer achieved a higher response rate to ICI therapy than DRIA-low patients(81.8% vs. 8.8%;P 1), and the predictive accuracy of the DRIA score [area under the receiver operating characteristic curve(AUC) = 0.845] was superior to the predictive accuracy of PD-L1 expression, tumor mutational burden, microsatellite instability, and Epstein–Barr virus status. The validation cohort demonstrated that the DRIA score identified responders with microsatellite-stable colorectal and pancreatic adenocarcinoma who received dual PD-1 and CTLA-4 blockade with radiation therapy. Furthermore, the predictive performance of the DRIA score was shown to be robust through an extended validation in melanoma, urothelial cancer, and ***: The DRIA signature has superior and robust predictive accuracy for the efficacy of ICI therapy in GI cancer and pancancer, indicating that the DRIA signature may serve as a powerful biomarker for guiding ICI therapy decisions.

关键词： DNA damage response-related immune activation immune checkpoint inhibitors biomarker gastrointestinal cancer pan-cancer

Status of aquatic organisms resources and their environments in yangtze River system(2.17-2.2.)⋆

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Aquaculture and Fisheries 2024年第5期9卷 833-850页

作者： Haile yang li Shen Yongfeng He huiwu Tian Lei Gao Jinming Wu Zhigang Mei Nian Wei lin Wang Tingbing Zhu Feifei Hu Jinling Gong Hongchun Du Xinbin Duan Huatang Deng Daoqun Wang Fengyue Zhu Yunfeng li Fan Wu huijun Ru yan zhang Junyi li Junlin yang Yuntao Zhou Dongdong Fang Yinping Wang Danqing lin yanping yang Peijie li Silei liu Jian yang Ping Zhuang Sikai Wang Tao zhang Gang yang Wenbo yang lilai yuan Kun Cao Shuo Xu huiyuan liu Zhiqiang liang Chongrui Wang Hong li Xiping yuan Xin yang Yilong Fu yanping zhang Haixin zhang Zhiying Tao Sheng Wang Xiaoping Gao Binsong Jin Kemao li Guojie Wang Shenglong Jian Yingqin li Chenjiang Xue chunyun Lei Shaowei Xue Yi Sun Bin Zhu Ke Shao Xingkun Hu Meihua Xiong Jun Du Bin He Tao yan Yingying Huang yuanchao Zou Biwen Xie Yongming Wang Bin li Fei liu Yaoyao zhang Fei Fan Zhijian Wang Jing Huang Haoran Gu Hailong Ge yan Dan yan li Shuqiao Wang chuang zhang Lu Zhou Xue Wang Sheng Zeng yan Xiang Xugang He Jianhui Qin Chengxing Xia Jie Hou Yifu Shi lifang Gao Zhiqiang Zhu Hongbao Shen Yun Du Xuejun Duan Jiawu Xiong Deguo yang Shaoping liu zhaohui Ni hui zhang Kai liu Feng zhao Yingren li Jianwei Wang Qiwei Wei yangtze River Fisheries Research institute Chinese Academy of Fishery SciencesWuhan430223China institute of Hydrobiology Chinese Academy of SciencesWuhan430072China Fishery Resource and Environment Research Center Chinese Academy of Fishery SciencesBeijing100141China key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization Ministry of Agriculture and Rural AffairsFreshwater Fisheries Research CenterChinese Academy of Fishery SciencesWuxi214081China East china Sea Fisheries Research institute Chinese Academy of Fishery SciencesShanghai200090China institute of Fisheries Engineering Chinese Academy of Fishery SciencesBeijing100141China Hunan Fisheries Science institute Changsha410153China Jiangxi Fisheries Research institute Nanchang330039China Jiujiang academy of Fishery sciences Jiujiang332000China School of life sciences Nanchang UniversityNanchang330031China Qinghai Provincial Fishery technology Extension Center Xining810012China Yunnan academy of Fishery sciences Kunming650111China institute of Hydroecology Ministry of Water Resources and Chinese Academy of SciencesWuhan430079China Fisheries institute Sichuan Academy of Agricultural SciencesChengdu611731China School of life sciences Neijiang Normal UniversityNeijiang641100China School of life sciences Southwest UniversityChongqing400715China Chongqing Fishery sciences Research institute Chongqing401120China Guizhou Fisheries Research institute Guiyang550025China College of Fisheries Huazhong Agricultural UniversityWuhan430072China Hubei Fisheries Science Research institute Wuhan430070China Shaanxi Fisheries Research institute Xi’an710086China Innovation academy for Precision Measurement Science and technology Chinese Academy of SciencesWuhan430077China Nanjing institute of Geography and limnology Chinese Academy of SciencesNanjing210008China Central South Inventory and Planning institute of state Forestry and Grassland Administration Changsha410014China

The yangtze River is the mother river of *** promote the aquatic ecosystem protection of the great river,the Project of yangtze Fisheries Resources and Environment Investigation({2.7-2.2.)supported by the Ministry of Agriculture and Rural Affairs,*** carried out by 2. institutes and universities that located in the yangtze River basin surveys the status of(1)fish species composition and spatial distribution,(2.current fish abundance,(3)endangered fishes,(4)yangtze finless porpoise,(5)aquatic eco-environments,(6)water-level fluctuation areas,(7)capture fisheries and recreational fisheries of the yangtze River mainstream and 10 of its main tributaries,including Yalong River,Heng River,Min River(including Dadu River),Chishui River,Tuo River,Jialing River,Wu River,Han River,Dongting Lake and Poyang *** results showed that there were 443 fish species(belonging to 163 genus,37 families,and 18 orders)before {2.7,but only 32. fish species(including 15 new recorded exotic species)were recorded in the project of *** them,Cyprinus carpio,Carassius auratus,Hypophthalmichthys molitrix,Pelteobagrus fulvidraco,Coilia brachygnathus,Silurus asotus,Saurogobio dabryi,Ctenopharyngodon idellus,Pelteobagrus nitidus,Hemiculter leucisculus,Siniperca chuatsi,Coreius heterodon,Culter alburnus,Parabramis pekinensis,and Aristichthys nobilis were the dominant species across the whole yangtze River *** is estimated that there were 886 million individuals weighing 12..8 million kg,merely equivalent to 2..3%of the resources in 1950s,30.9%of the resources in 1960s,or 58.7%of the resources in *** the new list of protected fishes that recorded in the yangtze River system,only 15 of 2. were collected in this project of *** gladius has been affirmed to be Extinct by International Union for Conservation of Nature(IUCN).The wild individuals of Tenualosa reevesii and Luciobrama macrocephalus have disappeared for many years and maybe have been extinct

关键词： Fishes yangtze finless porpoise Resources Aquatic ecosystem Fisheries Background investigation yangtze river system

Risk factors and predictive model of cerebral edema after road traffic accidents-related traumatic brain injury

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chinese Journal of Traumatology 2024年第3期27卷 153-162页

作者： Di-You Chen Peng-Fei Wu Xi-yan Zhu Wen-Bing zhao Shi-Feng Shao Jing-Ru Xie Dan-Feng {2. liang zhang Kui li Shu-Nan Wang hui zhao institute for Traffic Medicine Daping HospitalArmy Medical UniversityChongqing400042China Department of Radiology Daping HospitalArmy Medical UniversityChongqing400042China Chongqing key Laboratory of Traffic Injury and Vehicle Ergonomics Chongqing400042China Wound Trauma Medical Center State Key Laboratory of TraumaBurns and Combined InjuryInstitute of Surgery ResearchDaping HospitalArmy Medical UniversityChongqing.400042China

Purpose:Cerebral edema(CE)is the main secondary injury following traumatic brain injury(TBI)caused by road traffic accidents(RTAs).It is challenging to be predicted *** this study,we aimed to develop a prediction model for CE by identifying its risk factors and comparing the timing of edema occurrence in TBI patients with varying levels of ***:This case-control study included 2.8 patients with TBI caused by *** cohort was divided into CE and non-CE groups,according to CT results within 7 *** data,imaging data,and clinical data were collected and *** variables that follow normal distribution were presented as mean±standard deviation,those that do not follow normal distribution were presented as median(Q1,Q3).Categorical variables were expressed as *** Chi-square test and logistic regression analysis were used to identify risk factors for *** curve fitting was performed to predict the time to secondary CE in TBI patients with different levels of *** efficacy of the model was evaluated using the receiver operator characteristic ***:According to the study,almost half(47.3%)of the patients were found to have *** risk factors associated with CE were bilateral frontal lobe contusion,unilateral frontal lobe contusion,cerebral contusion,subarachnoid hemorrhage,and abbreviated injury scale(AIS).The odds ratio values for these factors were 7.2.(95%confidence interval(CI):2.08-2..42.p=0.002.,2.85(95%CI:1.11-7.31,p=0.030),2.62.95%CI:1.12.6.13,p=0.02.),2.44(95%CI:1.2.-4.76,p=0.009),and 1.5(95%CI:1.10-2.04,p=0.009),*** also observed that patients with mild/moderate TBI(AIS≤3)had a 50%probability of developing CE 19.7 h after injury(χ^(2.=13.82.adjusted R2.0.51),while patients with severe TBI(AIS>3)developed CE after 12.5 h(χ^(2.=18.48,adjusted R2.0.54).Finally,we conducted a receiver operator characteristic curve analysis of CE time,which showed an area under the curve of 0

关键词： Road traffic accident Traumatic brain injury Cerebral edema Risk factors Time window

Einstein Probe discovery of EP2.0408a:A peculiar X-ray transient with an intermediate timescale

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Science china(physics,Mechanics & Astronomy) 2024年

作者： Wenda zhang Weimin yuan Zhixing ling Yong Chen Nanda Rea Arne Rau Zhiming Cai Huaqing Cheng Francesco Coti Zelati lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei yang Bing zhang Chen zhang Shuang-Nan zhang Yonghe zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier liming Dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P. U. Fynbo Lluis Galbany Saurabh W. Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong li Bifang liu Mingjun liu Xing liu yuan liu Zhu liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu yanjun Xu Suijian Xue Yongquan Xue Zijian zhang Zipei Zhu Hu Zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen Chenzhou Cui Weiwei Cui yanfeng Dai Dongwei Fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin Chengkui li Junfei li Longhui li Maoshun li Wei li Zhengda li Tianying lian Congzhan liu Heyang liu Huaqiu liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan liming Song hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu zhao Xu Changbin Xue Yulong Xue Ailiang yan Haonan yang Xiongtao yang yanji yang Juan zhang Mo zhang Wenjie zhang Zhen zhang Zhen zhang Ziliang zhang Donghua zhao Haisheng zhao Xiaofan zhao Zijian zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck institute for Extraterrestrial physics Innovation academy for Microsatellites chinese academy of {2. Department of physics University of Hong Kong School of physics and Astronomy University of Leicester School of physics and Astronomy Sun Yat-sen University National Astronomical Observatories Department of physics Anhui Normal University shanghai institute of {2. physics chinese academy of {2. physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of physics and Astronomy University of Nevada Las Vegas chinese academy of {2. South African Astronomical Observatory Department of Astronomy University of Cape Town Department of physics University of the Free state Universite' Paris Cite' CNRS Astroparticule et Cosmologie Universite' Paris Cite' CEA Paris-Saclay School of Astronomy and Space sciences IRFU/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr institute University of Copenhagen Department of physics and Astronomy Rutgers the state University of New Jersey institute for Cosmic Ray Research University of chinese academy of sciences The University of Tokyo ESA/ESTEC Noordwijk 2.0} AZ The Netherlands Department of Astronomy School of physics Huazhong University of Science and technology INAF-Osservatorio Astrofisico di Torino Sydney institute for Astronomy School of physics key Laboratory of Particle Astrophysics The University of Sydney Department of Astronomy Xiamen University institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and technology Hefei School of Astronomy and Space sciences University of Science and technology of china institute of High Energy physics institute of Deep Space sciences Deep Space Exploration Laboratory Department of Astronomy School of physics and Astronomy Yunnan University shanghai Astronomical Observatory chinese academy of Science

We report the discovery of a peculiar X-ray transient,EP2.0408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2.2.,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2.-1in 0.5-4 keV,300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 keV,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for4d,followed by a steep decay till becoming undetectable10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-2. d is found for EP2.0408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP2.0408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP2.0408a thus remains an *** suggest that EP2.0408a may represent a new type of transients with intermediate timescales of the order of10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

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Visualization of adaptive polymer flow and displacement in medium-permeable 3D core-on-a-chip

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Petroleum Science 2023年第2期20卷 1018-1029页

作者： yan zhang Xue-Zhi {2. Pei-hui Han li-yuan zhang David A.Weitz Yu-Jun Feng Polymer Research institute State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065SichuanPR China EOR Laboratory Exploration&Development Research InstituteDaqing Oilfield Limited CompanyPetroChinaDaqing163712HeilongjiangPR China School of Engineering and Applied sciences Harvard UniversityCambridge02138United States School of Petroleum Engineering China University of PetroleumQingdao266580ShandongPR China

Polymer flooding has been witnessed an effective technology for enhancing oil recovery from medium-to low-permeability reservoirs;however, direct visualization of polymer solution flow in such reservoir condition is still lacking. In this work, a three-dimensional (3D) core-on-a-chip device with a permeability of around 2.0 mD was prepared and employed to visualize the pore-scale flow and displacement of a self-adaptive polymer (SAP, 8.7 × 106 g·mol−1)−whose microscopic association structure and macroscopic viscosity can reversibly change in response to shear action−versus partially hydrolyzed polyacrylamide (HPAM), by recording their flow curves, monitoring dynamic transportation process via particle imaging velocimetry, and building 3D structure of remaining oil. The results show that, in single-phase flow, all polymer solutions exhibit flow thinning and then thickening regions as flow rate increases, but the transition between two regimes occurs at a small Weissenberg number (10−3−10−1) in this medium-permeable condition. In contrast to HPAM-1 with close weight-average molecular weight (Mw), the adaptive character not only extends SAP's shear-govern region, allowing SAP to propagate piece by piece and achieve higher accessible pore volume, but it also enhances the elastic resistibility of polymer in the extension-dominated regime, increasing the microscopic displacement efficiency. These two effects result in 1.5–3 times more oil recovery factor for SAP than for HPAM-1. Regarding ultra-high-Mw HPAM-2.(2. × 106 g·mol−1), plugging and chain degradation do occur, thus producing lower oil recovery than SAP. This work provides a direct approach for in-situ assessment of polymer-based displacing system under a more authentic condition of practical reservoirs.

关键词： Polymer flooding Medium-permeable transparent media Adaptive polymer In-situ rheology Particle imaging velocimetry

CEPC technical Design Report

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Radiation Detection technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen huirun Chen Jinhui Chen Ji-yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen chunhui Chen Hok chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-chung chu Xiaotong chu Ziliang chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research institute Co. LtdBeijing Beijing institute of technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker institute of Nuclear physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering {2. MianyangSichuan china building materials academy Beijing china Center of Advanced Science and technology Beijing china institute of Atomic Energy Beijing china Jiliang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of Mining and technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint institute for Nuclear Research(DLNP JINR) Dubna East china University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.15)and the Conceptual Design Report(CDR,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

Thermostable α-Diimine Nickel Complexes with Substituents on Acenaphthequinone-backbone for Ethylene Polymerization

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chinese Journal of Polymer Science 2020年第11期38卷 1214-1220,I0007页

作者： Rui-Fang zhang yan-{2. Hou Xu-ling Wei Ding-Ding zhao Mi-Mi Cui Fei-Fan Zhai Xiang-liu li Bin-yuan liu Min yang Hebei key Laboratory of Functional Polymers Tianjin Key Laboratory of Chemical Process SafetyInstitute of Polymer Science and EngineeringHebei University of TechnologyTianjin 300130China state key Laboratory of Separation Membranes and Membrane Processes School of Material Science and EngineeringTiangong UniversityTianjin 300160China Lanzhou Petrochemical Research Center Petrochemical Research Institute of CNPCLanzhou 730060China

In order to promote the thermostability of a-diimine nickel complex by ligand backbone structure,a series of α-diimine nickel complexes with substituents on acenaphthequinone backbone were synthesized and used as catalysts for ethylene *** the hydroxyethyl phenoxyl group was introduced to the acenaphthequinone-backbone,the thermal stability and activity of the catalyst could be significantly *** catalytic activity of complex C2.5-(4-(2.hydroxyethyl)phenoxyl)-N,N-bis(2.6-diisopropyl)acenaphthylene-1,2.diimine]nickel(Ⅱ)dibromide with isopropyl substituents on N-aryl reached 8.2.10^6g/(molNi·h)at 70℃and 2.*** activity of[5-(4-(2.hydroxyethyl)phenoxyl)-N,N-bis(2.6-dibenzhydryl-4-menthylphenyl)acenaphthylene-1,2.diimine]nickel(Ⅱ)dibromide(C3)still maintained at 6.7×10^5 g/(molNi·h)at 12.℃.Compared with C3 containing bulky dibenzhydryl substituents,the activity of C2.was sensitive to the change of the polymerization ***,the polyethylenes obtained from complex C3 had lower branching ***,the molecular weight could reach 971 kg/mol,which is almost 5 times as much as that of the polyethylene obtained from complex C2.

关键词： α-Diimine nickel Ethylene polymerization Thermostability ligand backbone structure