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Review on micro-mechanism of forming emulsification during rare earth extraction by acidic extractants

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Journal of Rare Earths 2025年第1期43卷 9-20,I0001页

作者： jie Liu Yuxiu Zhao Zhirong Wang Minghui Jia Wenxiang Xia Guizhi wu Wenda Guo Ru'an Chi Kun Huang School of Environmental and Municipal Engineering Qingdao University of TechnologyQingdao266100China Open Project of Key Laboratory of Green Chemical Engineering Process of Ministry of Education Wuhan Institute of Technologywuhan430205China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

Solvent extraction is the main method used to separate and purify rare earth *** the process of rare earths extraction,emulsification often generated due to the instability of the aqueous and organic phases or improper operating *** emulsification occurs,it would not only lead to low rare earths recovery efficiency,small product quantities,high production costs and the losing of extractant and rare earth resources,but also result in serious environmental ***,it is very important to study the micro-mechanisms of emulsification and establish new methods to prevent emulsification at the *** this paper,possible factors resulting in emulsification,such as the compositions and properties of the organic and aqueous phases,the operating conditions of the rare earths extraction are *** micro-mechanisms of emulsification are summarized basing on the microscopic structures in the bulk phase,aggregations of the extractants at the organic-aqueous interface,spectral characterizations and computational *** this basis,new formation mechanisms are proposed for *** explorations are employed to verify the correctness of these new ***,future directions for studies of the emulsification micro-mechanism are *** study provides a theoretical basis for further understanding the micro-mechanisms of interfacial instability resulting in emulsification in the process of rare earths extraction.

关键词： Extraction Rare earths Emulsification Mechanism Interface

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太赫兹频段下基于EMD的人体生命特征检测

信号处理 2013年第12期29卷 1650-1659页

作者：刘通徐政五吴元杰皮亦鸣电子科技大学电子工程学院四川成都611731

非接触式的心跳呼吸信号检测对重症患者心跳呼吸的远程监控、自然灾害中受害者的搜寻等都有重要的应用。本文针对人体心跳呼吸信号相对于复杂环境属于微弱信号的情况,提出了一种太赫兹频段下基于经验模态分解(EMD)的人体生命特征检测方... 详细信息

非接触式的心跳呼吸信号检测对重症患者心跳呼吸的远程监控、自然灾害中受害者的搜寻等都有重要的应用。本文针对人体心跳呼吸信号相对于复杂环境属于微弱信号的情况,提出了一种太赫兹频段下基于经验模态分解(EMD)的人体生命特征检测方法。首先建立太赫兹雷达人体目标回波模型,对回波信号进行经验模态分解。然后进行时频分析,得到心跳呼吸微多普勒信息,提取其频谱质心曲线。再做第二次时频分析,实现心跳呼吸频率的提取与分离。在高斯杂波环境中进行了仿真实验,检测结果表明,基于EMD的检测方法与直接检测方法相比,取得了更好的检测效果,具有较强抗噪能力,适合于微弱信号处理。

关键词：太赫兹经验模态分解时频分析频谱质心呼吸心跳检测

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小世界神经网络的二次超谐波随机共振

物理学报 2007年第10期56卷 5679-5683页

作者：周小荣罗晓曙蒋品群袁五届广西师范大学物理与电子工程学院桂林541004

随机共振现象是非线性系统中普遍存在的自然现象.主要通过研究小世界生物神经网络中的输出信噪比与反映小世界效应的重连概率p、耦合强度c以及输入信号振幅A之间的关系,来揭示小世界生物神经网络的二次超谐波随机共振的一些规律.发现对... 详细信息

随机共振现象是非线性系统中普遍存在的自然现象.主要通过研究小世界生物神经网络中的输出信噪比与反映小世界效应的重连概率p、耦合强度c以及输入信号振幅A之间的关系,来揭示小世界生物神经网络的二次超谐波随机共振的一些规律.发现对于Hodgkin-Huxley小世界神经网络,并不是信号越强,信噪比越大,而是输入信号的振幅A存在一个最优值AO,此时网络信噪比最大.

关键词：随机共振二次超谐波小世界网络信噪比

Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding yuan-yuan Fang Wen-jie Fan Chen-Yu Zhang Shao-Fei Wang Jing Hu Wei Han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan Li Xi Liu Wenping Liang Yu Li Liyong wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

丹蛭降糖胶囊联合运动对糖尿病大鼠胰腺NADPH氧化酶亚单位p22phox表达水平的影响

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中国中西医结合杂志 2013年第5期33卷 641-645页

作者：吴元洁方朝晖郑书国吴元波王正吕明安安徽中医学院中医基础学教研室合肥230038 安徽中医学院第一附属医院内分泌科合肥230031 皖南医学院药理教研室芜湖241002 安徽医科大学附属省立医院神经内科合肥230001 安徽中医学院第一附属医院骨科合肥230031 安徽中医学院方剂学教研室合肥230038

目的探讨益气养阴活血方丹蛭降糖胶囊联合运动对糖尿病大鼠胰腺烟酰胺腺嘌呤二核苷酸磷酸(nicotinamide adenine dinucleotide phosphate,NADPH)氧化酶亚单位22kD多肽(p22phox)蛋白表达水平的影响。方法雄性Wistar大鼠60只,分为正常组... 详细信息

目的探讨益气养阴活血方丹蛭降糖胶囊联合运动对糖尿病大鼠胰腺烟酰胺腺嘌呤二核苷酸磷酸(nicotinamide adenine dinucleotide phosphate,NADPH)氧化酶亚单位22kD多肽(p22phox)蛋白表达水平的影响。方法雄性Wistar大鼠60只,分为正常组、模型组、运动组、丹蛭降糖胶囊组(简称中药组)及丹蛭降糖胶囊加运动组(简称中药加运动组),用小剂量链脲佐菌素(STZ)联合高脂饲料的方法建立糖尿病大鼠模型,用免疫组化法检测大鼠胰腺组织中p22phox、8-羟基脱氧鸟苷(8-hydroxy-2-de-axyguanine,8-OHdG)的表达,用Western blot检测各组p22phox表达水平。结果模型组p22phox、8-OHdG的表达水平明显高于正常组,差异有统计学意义(P<0.01),免疫组化观察到p22phox、8-OHdG主要在胰岛细胞胞浆中表达,中药、运动能明显降低p22phox、8-OHdG水平(P<0.01),运动与中药联用对降低p22phox、8-OHdG水平有协同作用(P<0.05)。结论运动、丹蛭降糖胶囊及两者联用能降低NADPH氧化酶的表达,减少氧化应激的来源,从而保护胰岛β细胞。

关键词：运动丹蛭降糖胶囊糖尿病大鼠氧化应激 NADPH氧化酶

Huanglian-Renshen-Decoction Maintains Isletβ-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine

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Chinese Journal of Integrative Medicine 2025年第1期31卷 39-48页

作者： wu Wen-bin GAO Fan TANG Yue-heng WANG Hong-zhan DONG Hui LU Fu-er yuan Fen Institution of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective: To elucidate the effect of Huanglian-Renshen-Decoction(HRD) on ameliorating type 2 diabetes mellitus by maintaining islet β-cell identity through regulating paracrine and endocrine glucagon-like peptide-1(GLP-1)/GLP-1 receptor(GLP-1R) in both islet and intestine. Methods: The db/db mice were divided into the model(distilled water), low-dose HRD(LHRD, 3 g/kg), high-dose HRD(HHRD, 6 g/kg), and liraglutide(400 μg/kg) groups using a random number table, 8 mice in each group. The db/m mice were used as the control group(n=8, distilled water). The entire treatment of mice lasted for 6 weeks. Blood insulin, glucose, and GLP-1levels were quantified using enzyme-linked immunosorbent assay kits. The proliferation and apoptosis factors of islet cells were determined by immunohistochemistry(IHC) and immunofluorescence(IF) staining. Then,GLP-1, GLP-1R, prohormone convertase 1/3(PC1/3), PC2, v-maf musculoaponeurotic fibrosarcoma oncogene homologue A(MafA), and pancreatic and duodenal homeobox 1(PDX1) were detected by Western blot, IHC,IF, and real-time quantitative polymerase chain reaction, respectively. Results: HRD reduced the weight and blood glucose of the db/db mice, and improved insulin sensitivity at the same time(P<0.05 or P<0.01). HRD also promoted mice to secrete more insulin and less glucagon(P<0.05 or P<0.01). Moreover, it also increased the number of islet β cell and decreased islet α cell mass(P<0.01). After HRD treatment, the levels of GLP-1,GLP-1R, PC1/3, PC2, MafA, and PDX1 in the pancreas and intestine significantly increased(P<0.05 or P<0.01).Conclusion: HRD can maintain the normal function and identity of islet β cell, and the underlying mechanism is related to promoting the paracrine and endocrine activation of GLP-1 in pancreas and intestine.

关键词： type 2 diabetes mellitus Huanglian-Renshen-Decoction isletβcell glucagon-like peptide-1 glucagon-like peptide-1 receptor Chinese medicine

A resurfaced sensor NLR confers new recognition specificity to non-MAX effectors

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Journal of Integrative Plant Biology 2025年第1期67卷 11-14页

作者： Tongtong Zhu Xuefeng wu Guixin yuan Dongli Wang Vijai Bhadauria You-Liang Peng Junfeng Liu Xin Zhang The State Key Laboratory of Maize Bio-breeding Joint International Research Laboratory of Crop Molecular BreedingMinistry of Agriculture Key Laboratory for Crop Pest Monitoring and Green ControlCollege of Plant ProtectionChina Agricultural UniversityBeijing 100193China Joint International Research Laboratory of Crop Molecular BreedingChina Agricultural UniversityBeijing 100193China Frontiers Science Center for Molecular Design Breeding China Agricultural UniversityBeijing 100193China Sanya Institute of China Agricultural University Sanya 572025China

To defend against pathogens,plants have evolved an innate immune system,encompassing pattern-triggered immunity(PTI)and effector-triggered immunity(ETI).Nucleotide-binding leucine-rich repeat receptors(NLRs)detect pat... 详细信息

关键词： immunity specificity pattern

Homologous CoS2 interface with directed electron transfer and strong chloridion repulsion for efficient seawater oxidation

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Science China Chemistry 2025年

作者： yuan Tian Jiang-Bo Chen jie Ying Ge Tian Yu-Xuan Xiao Yi Lu Si-Ming wu Wei Geng Ling Shen Xiao-Yu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu Laboratory

Seawater electrolysis is a highly promising method to produce high energy density hydrogen,especially in dry areas that have scarce freshwater ***,application of seawater electrolysis is confronted by two major problems associated with catalysts employed for the anodic oxygen evolution reaction （OER） including the competitive hypochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to synthesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density,this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability of CoS2is reflected in a negligible decline in activity during promotion of the OER for 100 *** of density functional theory calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy for strongly repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

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