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模拟成岩或低级变质作用对铁氧化菌席的影响

中国科学：地球科学 2014年第5期44卷 1263-1272页

作者：李俊李一良香港大学厉树雄科学馆地球科学系薄扶林道999077

生存于微氧、近中性pH环境的铁氧化细菌所形成大量的螺旋柄状或长杆鞘状胞外聚合物有利于沉淀其环境中的铁氧化物,而这些胞外聚合物可被视为其地球微生物学标志.太古代晚期至早元古代的海洋是微氧富铁的环境,因此铁氧化代谢成为当时生... 详细信息

生存于微氧、近中性pH环境的铁氧化细菌所形成大量的螺旋柄状或长杆鞘状胞外聚合物有利于沉淀其环境中的铁氧化物,而这些胞外聚合物可被视为其地球微生物学标志.太古代晚期至早元古代的海洋是微氧富铁的环境,因此铁氧化代谢成为当时生物圈的重要组成部分,但与之相关的生物物质及铁矿化记录在经历漫长的地质演化后不可避免的发生变化而难以识别.本研究实验模拟了嗜中性微好氧铁氧化菌席可能经历的成岩作用,通过对比现代铁氧化细菌产生的胞外聚合物及铁氧化物在经历高温-高压前后的变化,揭示了生物物质-矿物体系在成岩作用中可能经历的变化过程.实验结果显示螺旋柄状物和长杆鞘状物以及铁氧化物球状聚合物在100MPa和300℃作用之后,其生物结构特征仍可以识别,表明微生物有机质-铁氧化物混合体系可能在地质记录中被一定程度的保存,为前寒武沉积记录中铁代谢的起源和演化的识别提供了参考.

关键词：早期生物圈铁氧化菌胞外聚合物成岩-低级变质模拟实验铁氧化物

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特应性皮炎寒湿证病证结合小鼠模型的构建研究

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中国中医基础医学杂志 2024年第9期30卷 1500-1507页

作者：吴汶丰余彦栩吴清叶思褀张瑜刘俊峰莫秀梅陈达灿晏烽根广州中医药大学第二临床医学院广州510405 广州中医药大学第二附属医院广州510120 粤港澳中医药与免疫疾病研究联合实验室广州510120 省部共建中医湿证国家重点实验室广州510120

目的构建特应性皮炎(atopic dermatitis,AD)寒湿证病证结合小鼠模型,并对模型进行宏观表征及微观指标评价。方法将Balb/c小鼠随机分为正常对照组、疾病模型组、寒湿证组、病证结合组,每组6只。其中正常对照组小鼠外涂基质液;疾病模型组... 详细信息

目的构建特应性皮炎(atopic dermatitis,AD)寒湿证病证结合小鼠模型,并对模型进行宏观表征及微观指标评价。方法将Balb/c小鼠随机分为正常对照组、疾病模型组、寒湿证组、病证结合组,每组6只。其中正常对照组小鼠外涂基质液;疾病模型组小鼠外涂二硝基氯苯(dinitrochlorobenzene,DNCB),模拟特应性皮炎疾病模型;寒湿证组小鼠在外涂基质液基础上,采用人工气候箱模拟寒湿环境[温度(4±2)℃、相对湿度(90±5)%],并结合高脂饲料喂养模拟寒湿证;病证结合组小鼠在DNCB造模基础上,结合寒湿证证候模拟方法进行复合造模。采用经皮水分流失测量仪对动物经皮水分流失(transepidermal water loss,TEWL)进行测量和评估;对小鼠皮炎和寒湿证证候情况进行观察评价;对搔抓行为进行记录分析;HE染色观察小鼠背部皮肤组织病理改变,并对其表皮厚度和炎症细胞浸润情况进行分析;Western blot法检测皮肤中紧密连接蛋白1(Claudin-1)、瞬时受体电位香草酸3(transient receptor potential vanilloid 3,TRPV3)和TRPV4蛋白的表达水平;利用流式细胞术分析淋巴结辅助性T细胞17(helper T cells 17,Th17)/调节性T细胞(regulatory T cells,Treg)比值。结果与疾病模型组比较,病证结合组小鼠的证候评分明显升高(P<0.001),TEWL值明显升高、背部皮肤表皮厚度明显增加(P<0.05),背部皮肤的Claudin-1、TRPV3蛋白表达量显著降低(P<0.01),而TRPV4蛋白表达显著升高(P<0.05)。结论采用DNCB进行特应性皮炎疾病造模,并结合寒湿环境及高脂饮食的寒湿证造模方式,能够成功构建特应性皮炎寒湿证病证结合小鼠模型。该研究为后续深入探索特应性皮炎寒湿证病证结合动物模型构建及中药复方对AD的药效学研究提供了较理想的动物模型。

关键词：特应性皮炎寒湿证病证结合 Claudin-1 TRPV3 TRPV4 Th17/Treg细胞比值

Effects of Delayed Second Cochlear Implant

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journal of Otology 2006年第2期1卷 119-123页

作者： XIA Rui-ming1, WU Xi-hong2, jANG Zi-gang1, jING yuan-yuan1, LIN yun-juan1, yu Li-sheng1 1. Department of Otolaryngology, People’s Hospital, Peking University, P. R. China 11, Xizhimen South St, 100044 Beijing, P.R. China 2. Speech and Hearing Research Center, Peking University, China R.M. Xia, X.H. Wu, Z.G. jang, y.y. jing, y.j. Lin, L.S.yu Department of Otolaryngology People’s Hospital Peking University P. R. China 11 Xizhimen South St 100044 Beijing P.R. China Speech and Hearing Research Center Peking University China R.M. Xia X.H. Wu Z.G. Jang Y.Y. Jing Y.J. Lin L.S.Yu

Objective Since Helms’ successful bilateral cochlear implantation with good results in 1996, there have been increasing number of reports on bilateral cochlear implantation. Most second device have been implantated within one year after the first. Considering effects of long time auditory deprivation, it is not clear whether a delayed second cochlear implant serves to add additional benefits and how it may interact with central nervous system plasticity. Methods Three cases who received delayed second cochlear implants at People’s Hospital of Peking University from 2002 to 2005 were reviewed. The interval between the first and second implants was longer than 2 years in all three patients. Sound perception, and unilateral/bilateral speech discrimination in quiet and noise were evaluated. In addition, GAP detection test was conducted in one patient. Results In one case, having both implants on provided improved performance compared to using only one implant both in quiet and noise. Presumably due to visual interference from lip-reading or short interval between second implant and testing, one patient showed no improvement from using the second implant either in quiet or noise, while the last case demonstrated additional benefits from the second implant only in quiet. In all three patients, performance in recognizing the four tones in Mandarin was superior over word recognition. Conclusions Considerable plasticity in the cerebral auditory center is preserved, despite long acoustic deprivation in some children who have received unilateral cochlear implant. Delayed second implants can result in significant improvements in some of these children. Visual interference from lip-reading may be an obstacle during retraining. The better recognition of tones in the Mandarin language may represent a different sound discrimination mechanism in the auditory system, although it may also be related to the signal processing mechanisms of the implant used (MED-EL COMBI 40+).

关键词： bilateral cochlear implant auditory deprivation

DFT Study of VOC Pollutants Catalyzed by Optimal MoxOy:Exploration of Reaction Mechanism of CH3COOH + MoO2

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Chinese journal of Structural Chemistry 2020年第5期39卷 861-872页

作者： GAO Xiao-Zhen PANG yu yANG jing yANG Xiao-Chun SHEN yu-Long jIA jing-Xian MENG Xiang-jun yangquan Municipal Key Laboratory of Quantum Manipulation Shanxi Institute of TechnologyYangquan 045000China Department of Chemistry Tangshan Normal CollegeTangshan 063000China Department of Atmospheric Sciences Texas A&M universityTX 77843USA

We propose the complicated catalytic mechanisms for the acetic acid molecule catalyzed by transition metal oxide MoO2 based on density functional theory *** geometries and energetic values of all stationaries and transition states involved in the three different reaction pathways(ChannelsⅠ,ⅡandⅢ)are reported and *** reaction mechanisms are fully different from that of MoxOy catalyzing volatile organic compounds(VOCs)in previous *** completely new mechanisms catalyzed by MoO2 for acetic acid have been discovered for the first ***Ⅰ(ⅠA andⅠB)andⅡare both addition reactions and channelⅢis hydrogen abstraction reaction by producing a leaving *** barrier energies of reaction are also compared with other catalytic reactions,showing that MoO2 catalyst expresses a lower barrier energy(8.22 kcal/mol)by addition reaction,which represents MoO2 tends to absorb acetic acid pollution gas via addition reaction rather than release toxic *** also means that MoO2 is a more effective and representative catalyst and is suitable for further study of catalytic carboxylic acids,so the reaction mechanisms may provide a useful theoretical guidance and solution for the catalysis of carboxylic acids.

关键词： reaction mechanism acetic acid elimination molybdenum dioxide addition reaction hydrogen abstraction reaction

SyNTHESIZED AND MECHANICAL PROPERTy STUDy OF DOPED TITANIUM DIOXIDE FILM

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Acta Metallurgica Sinica(English Letters) 1999年第4期12卷 673-677页

作者： j.y. Chen , y.XLeng, P.yang, H. Sun and N. Huang The Departmentof Materials Engineering,Southwestjiaotong University ,Chengdu 610031 ,China

In thispaper,the magnetronsputtering wasadoptedtosynthesize Ta5 + doped Titanium dioxidefilms. Micro hardness and wear resistance of doped Titani um dioxide films was studied. The results showed that the doping element haveimproved the micro hardness and the wearability of TiO2 film ,and that the micro hardness wasalwaysimproved with theincreasingofthe dopingele mentdensity buttheimproved degreeofthe wearresistance wasdecreasingaf terincreasing and possessed an optimum valuein a certain densityfilm .

关键词： doping film micro hardness wearability

Visible-light-irradiated tandem sulfonylation/cyclization of indole tethered alkenes for the synthesis of tetrahydrocarbazoles

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Chinese Chemical Letters 2022年第11期33卷 4886-4890页

作者： yingjie yu Aiyao Liu jingrui He Chengting Wang Haibo Mei jianlin Han jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China

A visible-light-mediated reaction of indole derivatives employing arylsulfonyl chlorides as sulfonyl surrogates has been developed,which proceeds via the sequence of reduction of sulfonyl chloride,sulfonylation,and intramolecular *** mild protocol transforms a diverse array of indole tethered alkenes and simple sulfonyl chlorides into highly valuable functionalized tetrahydrocarbazoles in good *** reaction is also suitable for gram-scale synthesis,which provides an efficient and green access to multi-substituted tetrahydrocarbazoles.

关键词： Visible-light-irradiation Sulfonylation Tetrahydrocarbazoles Indoles Tandem radical reaction Sulfonyl chlorides

Tidal　bedforms　in　eastern　part　of　the　Bohai　Sea

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Acta Oceanologica Sinica 1998年第2期17卷 209-231页

作者： Liu Z. Berne S. Wang K. Marsset T. Xia D. Tang y. Bourillet j.F. First Institute of Oceanography State Oceanic Administration Qingdao 266003 China IFREMER Centre de Brest BP 70 29280 Plouzane France

ＴｉｄａｌｂｅｄｆｏｒｍｓｉｎｅａｓｔｅｒｎｐａｒｔｏｆｔｈｅＢｏｈａｉＳｅａＬｉｕＺｈｅｎｘｉａ，Ｓ．Ｂｅｒｎｅ，ＷａｎｇＫｕｉｙａｎｇ，Ｔ．Ｍａｒｓｓｅｔ，ＸｉａＤｏｎｇｘｉｎｇ，ＴａｎｇＹｕｘｉａｎｇ，Ｊ．Ｆ．... 详细信息

ＴｉｄａｌｂｅｄｆｏｒｍｓｉｎｅａｓｔｅｒｎｐａｒｔｏｆｔｈｅＢｏｈａｉＳｅａＬｉｕＺｈｅｎｘｉａ，Ｓ．Ｂｅｒｎｅ，ＷａｎｇＫｕｉｙａｎｇ，Ｔ．Ｍａｒｓｓｅｔ，ＸｉａＤｏｎｇｘｉｎｇ，ＴａｎｇＹｕｘｉａｎｇ，Ｊ．Ｆ．Ｂｏｕｒｉｌｌｅｔ（Ｒｅｃｅｉｖｅ...

关键词： part the Bohai

Observation of submicron aerosols at Mount Tai in east China from 2010 to 2012:Impact of different air masses on chemical components and size distribution

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Observation of submicron aerosols at Mount Tai in east China...

Temperature Characteristics of Spontaneous Coal Combustion Waste Piles in Relation to Vegetation Pattern

十一届全国气溶胶会议暨第十届海峡两岸气溶胶技术研讨会

作者： y.M.Zhang X.y.Zhang j.y.Sun G.y.Hu X.j.Shen T.T.Wang D.Z.Wang y.Zhao Key Laboratory for Atmospheric Chemistry Chinese Academy of Meteorological Sciences Wu Han University Heilongjiang Province Meteorological Bureau Tai An meteorological bureau

Real-time measurements of non-refractory submicron aerosols(NR-PM1) were conducted using an aerodyne mass spectrometry(Q-AMS) at the summit of Mount Tai(1534m above sea level)in Shandong province, locates in the center of the Central East China(CEC) region, from june 2010 to january 2012, as a part of National basic research project monitoring campaign. The mass concentrations and size distributions of non-refractory submicron particle(NR-PM1) species(i.e., sulfate, nitrate, ammonium, chloride, and organics) were measured in situ at 5-min time resolution. Overall, 146 days valid data was obtained during the whole campaign, which covers four different seasons. The average total mass concentration of NR-PM1 was 42.9 g m-3, with 31%sulfate, 32% organics, 19% nitrate and 18% ammonium. The average mass concentration of NR-PM1 is highest(59.9 g m-3) in summer and lowest(31.9 g m-3) in spring. Species occupied different percentages in different seasons, sulfate in summer, Organics in fall and winter, while nitrate dominants the NR-PM1 in spring respectively. To investigate the size-resolved mass concentrations of aerosol chemical components from different sources, seven air masses were clustered based on the 72 hours back trajectory with HySPLIT model. Cluster I, IV and V with short pathway represent the local and regional sources, and the concentrations from these clusters were higher than that from cluster III and VI which originated from remote and clean North-West sources. According to the results of diurnal cycles for chemical species in NR-PM1 higher at noon and lower at midnight from seven clusters, it was concluded that the site was controlled under the transitions between PBL and FT at daytime and nighttime. The size distributions of chemical species were different from different air masses, cluster I, II, IV, V and VII showed same shape with accumulation mode(500-600nm), the concentration at nighttime is lower than at daytime. For cluster VI and III, it demonstra

关键词： NR-PM1 Chemical species mass concentration Size distribution Mt.Tai

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Temperature Characteristics of Spontaneous Coal Combustion W...