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Variable phenotypes and outcomes associated with the MMACHC c.482G>A mutation:follow-up in a large CblC disease cohort

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World Journal of Pediatrics 2024年第8期20卷 848-858页

作者： Sheng-Nan Wu Hui-Shu E yue yu Shi-Ying ling li-li liang Wen-Juan Qiu Hui-Wen Zhang Rui-Xue Shuai Hai-Yan Wei Chi-Ju Yang Peng Xu Xi-Gui Chen Hui Zou Ji-Zhen Feng Ting-Ting Niu Hai-li Hu Kai-Chuang Zhang De-yun Lu Zhu-Wen Gong Xia Zhan Wen-Jun Ji Xue-Fan Gu Yong-Xing Chen lian-Shu Han Department of Endocrinology and Metabolism Henan Key Laboratory of Children’s Genetics and Metabolic DiseasesChildren’s Hospital Affiliated to Zhengzhou UniversityHenan Children’s HospitalZhengzhou Children’s HospitalNo.255 Gangdu StreetZhengzhouChina Department of Pediatric Endocrinology and Genetics Fujian Children’s HospitalFuzhouChina The Center for Pediatric liver Diseases Children’s HospitalFudan UniversityShanghaiChina Department of Pediatric Endocrinology/Genetics Shanghai Institute for Pediatric ResearchXinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityNo.1665 Kongjiang RoadShanghaiChina Department of Pediatrics Second Affiliated Hospital of Naval Medical UniversityShanghaiChina Center of Neonatal Disease Screening Jining Maternal and Child Health Care HospitalJiningChina Center of Neonatal Disease Screening Jinan Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Shijiazhuang Maternal and Child Health Care HospitalShijiazhuangChina Center of Neonatal Disease Screening Shandong Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Hefei Maternal and Child Health Care HospitalHefeiChina

Background The aim of this study was to characterize the variable phenotypes and outcomes associated with the methylmalonic aciduria and homocystinuria type C protein gene(MMACHC)c.482G>A mutation in 1.5 Chinese cases with CblC *** We carried out a national,retrospective multicenter study of 1.5 Chinese patients with CblC disease attributable to the MMACHC c.482G>A variant either in a homozygous or compound heterozygous *** control group consisted of 200 patients diagnosed with CblC disease who did not possess the c.482G>A *** features,including disease onset,symptoms,biochemical metabolites,gene mutation,and follow-up outcomes were reviewed and analyzed in *** median follow-up period spanned 3 years and 8 months,with a range of 1.year and 2 months to 1. years and 1. *** Among 1.5 patients carrying the c.482G>A variant,1.5(64.1.)cases were diagnosed by newborn screening(NBS),60(30.8%)cases were detected due to disease onset,and 1.(5.1.)cases were identified from sibling *** hundred and seventeen(93.6%)individuals who were diagnosed by NBS,and nine patients who came from sibling diagnoses remained asymptomatic in this *** 69 symptomatic patients of the c.482G>A group,more patients presented with later onset,and the top six common clinical symptoms at disease onset were developmental delay(59.4%),lower limb weakness and poor exercise tolerance(50.7%),cognitive decline(37.7%),gait instability and abnormal posture(36.2%),seizures(26.1.),and psychiatric and behavioral disturbances(24.6%).In the 1.9 symptomatic patients lacking c.482G>A variants,the most frequently observed clinical manifestations at disease onset included developmental delay(81.8%),lethargy and feeding difficulty(62.9%),lower limb weakness and poor exercise tolerance(54.7%),prolonged neonatal jaundice(51.6%),vomiting(47.2%),and seizures(32.7%).Before treatment,the levels of blood propionylcarnitine,propionylcarnitine/acetylcarnitine ratio

关键词： c.482G>A CblC disease MMACHC gene Newborn screening Outcome Use our pre-submission checklist Avoid common mistakes on your manuscript.

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Measurement of the neutron total cross section of^(9)Be at the Back-n white neutron source of CSNS

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Chinese Physics C 2024年第8期48卷 140-152页

作者： Jiangbo Bai Jingyu Tang liqun Shi Yonghao Chen Han Yi Jie Bao yu Bao Ping Cao Haolei Chen Zhen Chen Zengqi Cui Ruirui Fan Changqing Feng Keqing Gao Xiaolong Gao MinHao Gu Changcai Han Guozhu He Yongcheng He Yang Hong Yiwei Hu Hanxiong Huang Xiru Huang Haoyu Jiang Wei Jiang Zhijie Jiang Hantao Jing ling Kang Bo li Chao li Jiawen li Qiang li Xiao li Yang li Jie liu Shubin liu Ze Long Guangyuan Luan Changjun Ning Mengchen Niu Binbin Qi Jie Ren Xichao Ruan Zhaohui Song Kang Sun Zhijia Sun Zhixin Tan Xinyi Tang Binbin Tian lijiao Wang Pengcheng Wang Zhaohui Wang Xiaoguang Wu Xuan Wu likun Xie Xiaoyun Yang li yu Tao yu Yongji yu Guohui Zhang linhao Zhang Qiwei Zhang Xianpeng Zhang yuliang Zhang Zhiyong Zhang Luping Zhou Zhihao Zhou Kejun Zhu institute of Modern Physics Fudan UniversityShanghai 200433China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Sate Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Northwest institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

The neutron total cross section data of^(9)Be are essential in the nuclear structure model research of light nuclei and nuclear power *** neutron total cross section of^(9)Be in the 0.3 eV−1.0 MeV energy region has been measured using time-of-flight and transmission methods with the Neutron Total Cross Sectional Spectrometer(NTOX)based on the multi-cell fast fission chamber at the china Spallation Neutron Source(CSNS)-Back-n white neutron source(Back-n).The fission count-neutron energy distributions of ^(235)U and ^(238)U without samples and with Be samples with three thicknesses were measured in the double-bunch operation mode for a beam power of 1.0 *** Bayesian method was used to eliminate the influence of the double-bunch problem on neutron measurement in the energy region above 1. *** neutron total cross section of^(9)Be results was consistent with ENDF/B-VIII.0 evaluation library data in the 0.3 eV−20 MeV energy *** the energy ranges of 0.3 eV to 1. keV and 0.01.to 20 MeV,the deviations between our results and the evaluation results of ENDF/B-VIII.0 were within 2.5%and 1.%,*** the resonance energy region,the measured resonance energies in our experiment were 0.63,0.8{1. 2.8 MeV,*** results showed that the total cross section uncertainties of three Be samples were within 2.2%in the energy region below 1.*** total cross section uncertainty of 30 mm Be from ^(235)U was the smallest and less than 5%in the energy region of 0.3 eV−1.0 *** results of this experiment can provide technical support for further data analysis and related nuclear data evaluation.

关键词： ^(9)Be neutron total cross section CSNS Back-n time-of-flight method transmission method multi-cell fast fission chamber

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Tildrakizumab for moderate-to-severe plaque psoriasis in Chinese patients:A 1.-week randomized placebo-controlled phase III trial with long-term extension

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Chinese Medical Journal 2024年第10期137卷 1190-1198页

作者： Chen yu Songmei Geng Bin Yang yunhua Deng Fuqiu li Xiaojing Kang Mingye Bi Furen Zhang Yi Zhao Weili Pan Zhongwei Tian Jinhua Xu Zhenghua Zhang Nan yu Xinsuo Duan Shuping Guo Qing Sun Weiquan li Juan Tao Zhijun liu yuanyuan Yin Gang Wang Department of Dermatology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Dermatology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China Department of Dermatology Dermatology Hospital of Southern Medical UniversityGuangzhouGuangdong 510091China Department of Dermatology Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Dermatology The Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China Department of Dermatology Wuxi People’s Hospital of Wuxi CityWuxiJiangsu 214023China Department of Dermatology Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and VenereologyShandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250022China Department of Dermatology Beijing Tsinghua Changgung HospitalBeijing 102218China Department of Dermatology Zhejiang Provincial People’s HospitalHangzhouZhejiang 310014China Department of Dermatology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiangHenan 453100China Department of Dermatology Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Dermatology General Hospital of Ningxia Medical UniversityYinchuanNingxia 750000China Department of Dermatology Affiliated Hospital of Chengde Medical UniversityChengdeHebei 067000China Department of Dermatology The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Dermatology Qilu Hospital of Shandong UniversityJinanShandong 250012China Department of Dermatology Yuebei People’s HospitalShaoguanGuangdong 512026China Department of Dermatology Union Hospital Tongji Medical Collage Huazhong University of Science and TechnologyWuhanHubei 430022China Department of Dermatology and Venereal Diseases The First Affiliated Hospit

Background:There is a need for effective and safe therapies for psoriasis that provide sustained *** aim of this study was to assess the efficacy and safety of tildrakizumab,an anti-interleukin-23p1. monoclonal antibody,for treating moderate-to-severe plaque psoriasis in Chinese ***:In this multi-center,double-blind,phase III trial,patients with moderate-to-severe plaque psoriasis were enrolled and randomly assigned(1.1.to receive subcutaneous tildrakizumab 1.0 mg or placebo at weeks 0 and *** initially assigned to placebo were switched to receive tildrakizumab at weeks 1.,1.,and every 1. weeks *** in the tildrakizumab group continued with tildrakizumab at week 1.,and every 1. weeks until week *** primary endpoint was the Psoriasis Area and Severity Index(PASI 75)response rate at week ***:At week 1.,tildrakizumab demonstrated significantly higher PASI 75 response rates(66.4%[73/1.0]vs.1..7%[1./1.0];difference,51.4%[95%confidence interval(CI),40.72,62.1.];P1.and Physician’s Global Assessment(60.9%[67/1.0]vs.1..0%[1./1.0];difference,49.1.[95%CI,38.64,59.62];P1.compared to *** 75 response continued to improve over time in both tildrakizumab and placebo-switching to tildrakizumab groups,reaching maximal efficacy after 28 weeks(86.8%[92/1.6]vs.82.4%[89/1.8])and maintained up to 52 weeks(91.3%[95/1.4]vs.87.4%[90/1.3]).Most treatment-emergent adverse events were mild and not related to ***:Tildrakizumab demonstrated durable efficacy through week 52.and was well tolerated in Chinese patients with moderate-to-severe plaque *** registration:***,NCT051.8766.

关键词： Tildrakizumab Interleukin 23 Plaque psoriasis Chinese Randomized controlled trial

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Mifepristone in Combination with Misoprostol for the Termination of Pregnancy at 8-1. Weeks' Gestational Age: A Multicentre Randomized Controlled Trial

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Journal of Reproduction and Contraception 2013年第2期24卷 101-113页

作者： Qiu-ju CHEN Ju ZHANG Zi-rong HUANG Xiao-fang FAN Hai-yun WANG Hong ZHU Shu-ping HOU yu-huan liU Qin-qin QIAO Ping ZHANG Yan liU Chun-mei QIAN yue-di TAN Ai-hong li Catherine Meads Wei-hong ZHANG li-nan CHENG shanghai {1. of Planned Parenthood Research shanghai Pharmaceutical (group) Company New Hualian Pharmaceutical Factory Obstertrics & Gynecology Hospital of fudan University The Maternity and Child Hospital of Putuo District The First Maternity and Child Hospital of Tongji University Gongli Hospital of Pudong District Department of Gynecology & Obstetric the Sixth Hospital Affiliated Shanghai Jiaotong University shanghai Changhai Hospital The first Hospital of shanghai Xinhua Hospital of shanghai Jiaotong University Ruijin Hospital of shanghai Jiaotong University The Tenth Hospital of shanghai The Centre Hospital of Putuo District The Maternity & Child Hospital of Minhang District Barts and the London School of Medicine and Dentistry Queen Mary University of London (for the EBM Connect Collaboration) International Centre for Reproductive Health Ghent University Belgium University libre de Bruxelles Perinatal Epidemiology and Reproductive Health Unit School of Public Health

Objective To compare the efficacy and safety of medical abortion of different regimens for termination of pregnancy at 8-1. weeks of gestation. Methods Healthy pregnant women requesting medical abortion at 8-1. weeks＇ gestation within 1. hospitals in shanghai were randomly allocated to four treatment groups. Three intervention groups were given mifepristone 200 mg as a single dose then 24 h later misoprostol 600 #g at 3 h intervals vaginally, orally or vaginally followed by orally, respectively. Control group was given mifepristone 1.0 mg for 2 d, followed at 48 h by initiation of misoprostol 600 μg vaginally every 1. h. The primary outcome measures were the successful abortion rate, the induction-to-abortion interval, vaginal bleeding and side effects. Results Efficacy outcomes were analyzed for 1.1.2 women （92.67%）, excluding 88 protocol violations. Termination successful rates were similar among the four groups from 97.1. to 97.8%. The average dose of misoprostol and the incidence of side effects in control group were lower than those in three intervention groups. Stratified analysis showed that the interval of induction-to-abortion at gestation of 1.1. weeks was decreased in control group. Conclusion The four regimens have the similar termination successful rates in spite of different administration intervals or routes. Control group was recommended for the advantages of reduced dose of misoprostol and fewer side effects.

关键词： medical abortion 8 1. weeks' gestation randomized controlled trial (RCT)

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Current Mycoplasma pneumoniae epidemic among children in shanghai:unusual pneumonia caused by usual pathogen

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World Journal of Pediatrics 2024年第1期20卷 5-10页

作者： Xiao-Bo Zhang Wen He Yong-Hao Gui Quan Lu Yong Yin Jian-Hua Zhang Xiao-Yan Dong Ying-Wen Wang Ying-Zi Ye Hong Xu Jia-yu Wang Bing Shen Dan-Ping Gu li-Bo Wang Yi Wang Department of Respiratory Medicine Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China State Key Laboratory of Genetic Engineering at School of life Sciences Institute of Reproduction&DevelopmentChildren's Hospital of Fudan UniversityShanghaiChina Department of Respiratory Medicine Children's Hospital of Shanghai Jiao Tong UniversityShanghaiChina Department of Respiratory Medicine Shanghai Children's Medical CenterAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Pediatric Respiratory Xinhua HospitalAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Nursing Children's Hospital of Fudan UniversityShanghaiChina Department of Infectious Diseases Children's Hospital of Fudan UniversityShanghaiChina Department of Nephrology Children's Hospital of Fudan UniversityShanghaiChina NHC Key Laboratory of Neonatal Diseases Children's Hospital of Fudan UniversityShanghaiChina shanghai Shenkang Hospital Development Center ShanghaiChina Center for Medical Quality Control Management of shanghai ShanghaiChina Department of Neurology Children's Hospital of Fudan University399Wanyuan RoadShanghai 201102China

Mycoplasma pneumoniae(***),primarily transmitted through respiratory droplets when infected individuals cough or sneeze,is a common cause of communityacquired pneumonia,especially among school-age children and *** infection occurs endemically with an epidemic peak every few *** worldwide incidence confirmed by direct test methods was reported to be 8.61.between 201. and 2020 across all age groups[1..

关键词： pneumonia epidemic respiratory

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含不同链长的三个卟啉LB膜修饰电极的光电响应研究

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化学学报 2006年第4期64卷 301-305页

作者：李富友余军华张宝文黄春辉复旦大学先进材料实验室上海200433 中国科学院理化技术研究所北京100101

利用LB(Langmuir-Blodgett)技术将含不同链长的卟啉化合物(C4Py,C6Py和C8Py)单层膜转移到ITO(indium-tinoxide)导电玻璃上,发现其具有良好的光电转换性质.卟啉化合物修饰后的紫外吸收光谱与光电流工作谱重叠,表明卟啉化合物起到了敏化... 详细信息

利用LB(Langmuir-Blodgett)技术将含不同链长的卟啉化合物(C4Py,C6Py和C8Py)单层膜转移到ITO(indium-tinoxide)导电玻璃上,发现其具有良好的光电转换性质.卟啉化合物修饰后的紫外吸收光谱与光电流工作谱重叠,表明卟啉化合物起到了敏化光电流产生的效果;而且电子给体、电子受体和偏压对其敏化效果的实验结果表明:光诱导电子转移是产生光电响应的主要原因.而且,这三个卟啉化合物的光电响应性质与碳链长度相关,其中含有六个碳链的C6Py表现出最佳的光电转化效果.

关键词：卟啉化合物 LB膜光电响应

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ACTION OF BSNXD AND DHEA IN PREVENTING AND CURING POSTMENOPAUSAL OSTEOPOROSIS

ACTION OF BSNXD AND DHEA IN PREVENTING AND CURING POSTMENOPA...

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The 5th International Conference on Reproductive Endocrinology

作者： Wang yu-dong li Da-jin Zhu Ying Laboratory for Reproductive Immunology Hospital and {1. of Obstetrics & Gynecology shanghai Medical College fudan University shanghai china.

＜正＞Objectives:To investigate the effect of Bu-shen-ning-xin （补肾宁心） decoction （BSNXD） and dehydroepiandrosterone （DHEA） on postmenopausal osteoporosis （PMOP）. Methods:Female BALB/c mice （8～9 months age） were divided randomly into six groups containing ten mice per *** of group 1.were left intact and served as a normal control group （NC group）, mice of group 2 were operated without lesion of ovarian （Sham operation group）.Mice of groups 3～6 were ovariectomized and,after a 7-day delay to allow for producing osteoporosis,were afforded with

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石墨烯的等离子体增强化学气相沉积法合成

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印染 2018年第5期44卷 12-17页

作者：姚涵何叶丽陈育明上海交通大学附属中学嘉定分校上海201800 上海市纺织科学研究院有限公司上海200082 复旦大学信息科学与工程学院上海200433

石墨烯具有优异的光电性能,是极具潜力的新一代导电材料。采用传统的热化学气相沉积法制备单层石墨烯需要高温反应条件,试验尝试采用等离子体增强化学气相沉积法(Plasma Enhanced Chemical Vapor Deposition,PECVD),在550℃的反应温度下... 详细信息

石墨烯具有优异的光电性能,是极具潜力的新一代导电材料。采用传统的热化学气相沉积法制备单层石墨烯需要高温反应条件,试验尝试采用等离子体增强化学气相沉积法(Plasma Enhanced Chemical Vapor Deposition,PECVD),在550℃的反应温度下,较短的反应时间内,在铜箔衬底上制备出石墨烯薄膜。考察了甲烷和氢气流量比、氩气的作用以及衬底通电与否等因素对石墨烯生长的影响。研究发现,在甲烷与氢气流量比为1.1.通入氩气,不给铜箔衬底通电的试验条件下,制备出的石墨烯薄膜电阻值为4.1. kΩ,显示出较好的光电特性。

关键词：石墨烯等离子体化学气相沉积低温光电特性

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Consensus on the clinical diagnosis and treatment of grade 3 pancreatic neuroendocrine tumors

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胰腺病学杂志(英文) 2024年第2期07卷 97-105页

作者： Chen Jie Wu Wenming Bai Chunmei Chi Yihebali Huo li Jiang liming Ji yuan Luo Jie li Jie li Jingnan Lou Wenhui Shao Chenghao Shen lin Wang Feng Wang yu Xue ling Xu Jin yuan Chunhui yu Xianjun Yin Xiaoyu Zhao Hong Zhu Xiongzeng Zhao yupei Centre for Neuroendocrine Tumors Fudan University Shanghai Cancer Center Shanghai China Department of General Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China Department of Medical Oncology Peking Union Medical College Hospital Chinese Academy of Medical Science &amp Peking Union Medical College Beijing China Department of Medical Oncology National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Nuclear Medicine State Key Laboratory of Complex Severe and Rare Diseases Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/ Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Pathology Zhongshan Hospital Fudan University Shanghai China Department of Pathology China-Japan Friendship Hospital Beijing China Department of Gastroenterological Oncology Beijing Cancer Hospital Peking University Cancer Hospital &amp institute Beijing China Department of Gastroenterology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Department of Pancreatic Surgery Zhongshan Hospital Fudan University Shanghai China Department of Pancreatic-Biliary Surgery Second Affiliated Hospital of Naval Medical University Shanghai China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital &amp Department of Nuclear Medicine Nanjing First Hospital Nanjing Medical University Nanjing China Depar

The World Health Organization (WHO) 201. classifications for neuroendocrine neoplasms (NENs) subdivided grade 3 pancreatic neuroendocrine neoplasms (pNENs) into G3 well-differentiated pancreatic neuroendocrine tumors (G3 pNETs) and poorly differentiated pancreatic neuroendocrine carcinomas (pNECs), according to the mitotic count, Ki-67 index, and cell differentiation. As a new category, G3 pNETs remain a challenging group of tumors to manage by lacking large randomized trials and consensus to support its clinical practice. Therefore, the Chinese Pancreatic Surgery Association, Chinese Society of Surgery, Chinese Medical Association gathered experts in this field to formulate this consensus for the diagnosis and treatment of G3 pNETs.

关键词： Clinical diagnosis Grade 3 Pancreatic neuroendocrine tumors Treatment

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Effect of OVX on nociceptive responses and possible mechanisms in adult female rats

Effect of OVX on nociceptive responses and possible mechanis...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： li-Hong li,Zhi-Qi ZHAO,yu-Qiu ZHANG~* {1. of Neurobiology,{1.s of Brain Science and State Key Laboratory of Medical Neurobiology,fudan University,shanghai 200032,china

＜正＞Objective Estrogen plays a key role in pain *** the effect is inconsistent and the mechanism is still *** study used OVX rat model to measure the pain behavior in basal,inflammatory and neuropathic pain（CCI model）and to study the possible *** We used the behavioral test:von Frey test （hindlimbs）,Hargreaves’test（hindlimbs）,tail flick test（proximal and distal tail）and formalin test in different groups to measure the nociceptive *** location of estrogen receptors（ERs）were identified by immunofluorescence *** Western blot was used to measure the protein level of ER and ***（1.Significant allodynia and hyperalgesia appeared 5 weeks post-OVX surgery and could be attenuated by long term 1.β-estradiol（E2） replacement（s.c,1.week）.But CCI did not produce further decrease of mechanical pain threshold in OVX rats. This indicated the relatively lower level of estrogen might inhibit the allodynia accompanied by neuropathic pain. （2）Double immunofluorescence showed co-localization of ERa and ERβwith NeuN（neuronal marker）but not with GFAP（astrocyte marker）and OX42（microglia marker）in spinal.（3）ERαand Akt were up-regulated in 5 weeks after OVX surgery and could be restored after E2 administration.（4）The formalin nociceptor responses were decreased after intrathecal injection of PI3K inhibitor（wortmannin）.Conclusion ERain spinal neuron may play an important role in the induction of hyperalgesia and allodynia in OVX rats through PI3K/Akt.

关键词： pain OVX estrogen allodynia hyperalgesia ERα ERβ CCI spinal neuron PI3K/Akt wortmannin

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