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Cellular zinc metabolism and zinc signaling:from biological functions to diseases and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan Chen Peiyao yu Wai Nok Chan Fuda Xie Yigan Zhang Li liang Kam Tong Leung Kwok Wai Lo Jun yu Gary M.K.Tse Wei Kang Ka Fai To Department of Anatomical and Cellular Pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CUHK-Shenzhen Research Institute The Chinese University of Hong KongShenzhenChina Department of Pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of Biomedical Research Taihe HospitalHubei University of MedicineShiyanChina Department of Pediatrics The Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc metabolism at the cellular level is critical for many biological processes in the body.A key observation is the disruption of cellular homeostasis,often coinciding with disease progression.As an essential factor in maintaining cellular equilibrium,cellular zinc has been increasingly spotlighted in the context of disease development.Extensive research suggests zinc’s involvement in promoting malignancy and invasion in cancer cells,despite its low tissue concentration.This has led to a growing body of literature investigating zinc’s cellular metabolism,particularly the functions of zinc transporters and storage mechanisms during cancer progression.Zinc transportation is under the control of two major transporter families:SLC30(ZnT)for the excretion of zinc and SLC39(ZIP)for the zinc intake.Additionally,the storage of this essential element is predominantly mediated by metallothioneins(MTs).This review consolidates knowledge on the critical functions of cellular zinc signaling and underscores potential molecular pathways linking zinc metabolism to disease progression,with a special focus on cancer.We also compile a summary of clinical trials involving zinc ions.Given the main localization of zinc transporters at the cell membrane,the potential for targeted therapies,including small molecules and monoclonal antibodies,offers promising avenues for future exploration.

关键词： metabolism invasion involvement

Spatiotemporal variations in glacier area and surface velocity of the northern Antarctic Peninsula during 2018-2022

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Advances in Climate Change Research 2024年第2期15卷 297-311页

作者： yu-Long KANG Shi-Chang KANG Wan-Qin GUO Tao CHE zong-Li JIANG Zhen-Feng WANG Qiang-Qiang XU Cheng-De YANG State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100083China Key Laboratory of Remote Sensing of Gansu Province Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China School of Earth Sciences and Spatial Information Engineering Hunan University of Science and TechnologyXiangtan 411201China

Ice sheet serves as a crucial indicator for assessing climate change.Mass loss in recent remote sensing-based studies indicated that the Antarctic Peninsula has rapid rates of glacier retreat and speed up of surface velocity.However,observations of seasonal variability of ice speed are limited,and glacier-area changes require multi-temporal monitoring.This study investigated the changes in area and surface velocities of∼375 glaciers on the northern Antarctic Peninsula(NAP)utilizing satellite images acquired by the Sentinel 1&2 satellites during 2018-2022.The results indicate that the glacier area reduced by approximately 166.1±44.2 km^(2)(-0.2%±0.1%per year)during the study period,with an acceleration after 2020(-0.4%±0.3%per year),and the most dramatic reduction happened on the eastern NAP.The maximum annual ice speeds on the NAP generally exceeded 3500 m per year,while the ice speeds in 2021 were the highest(exceeded 4210 m per year).The ice speed variability in austral autumn was higher than in other seasons,meanwhile the summer ice speeds showed an increasing trend.The glacier G012158E47018N,McNeile Glacier,glacier G299637E64094S and Drygalski Glacier showed the most remarkable ice speed variations represented by high daily velocities and strong fluctuations on their termini.Our results demonstrated that the variations in glacier area and seasonal ice speed on the NAP were responsive to the ice-ocean-atmosphere processes.Therefore,seasonal velocity and area variations should be considered when conducting accurate mass balance calculations,model validations and change mechanism analyses under climate warming scenarios.

关键词： Glacier area Seasonal ice speed Sentinel 1&2 Northern Antarctic Peninsula Ice-ocean-atmosphere processes

Elaborating strengthen mechanism of Pt-Ir solid solution superalloy at finite temperature

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Rare Metals 2024年第3期43卷 1243-1256页

作者： Wei yu Xiao-yu Chong yun-Xuan Zhou Meng-Di Gan Ying-Xue liang Yan Wei Ai-Min Zhang Chang-Yi Hu Xing-yu Gao Li Chen Hai-Feng Song Jing Feng Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China yunnan Precious Metals Laboratory Co.LTD Kunming650106China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing100088China

Pt-Ir alloy is potential superalloys used above 1300℃because of their high strength and creep resistance.However,the ductility of Pt-Ir alloy has rapidly deteriorated with the increase of Ir,resulting in poor machinability.This work quantitatively evaluated the solid solution strengthening(SSS)and grain refinement strengthening(GRS)of Pt-Ir alloy using first-principles calculations combined with experimental characterization.Here,the stretching force constants in the second nearest neighbor region(SFC^(2nd))of pure Ir(193.7 eV·nm^(-2))are 3.40 times that of pure Pt(57.0 eV·nm^(-2)),i.e.,the interatomic interaction is greatly enhanced with the increase of Ir content,which leads to the decrease of ductility,and modulus misfit plays a dominant role in SSS.Then,the physical mechanisms responsible for the hardness(H_(V))of Pt-Ir alloy,using the power-law-scaled function of electron work function coupled SSS and GRS,are attributed to the electron redistribution caused by different Ir content.Furthermore,a thorough assessment of the thermodynamic characteristics of Pt-Ir binary alloy was conducted,culminating in development of a mapping model that effectively relates enmposition,temperature and strength.The results revealed that the compressive strength incrcases with the Ir content,and the highest strength was observed in Pt_(0.25)Ir_(0.75).This study provides valuable insights into the Pt-Ir alloy system.

关键词： Elastic properties Phonon Solid solution strengthen Force constants CALPHAD

Identification of overlay differentially expressed genes in both rats and goats with blast lung injury through comparative transcriptomics

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Chinese Journal of Traumatology 2024年第1期27卷 34-41页

作者： Hong Wang Jun-Hong Gao Xiao-Lin Fan Qing Lu liang Li Ning Ma Qi Wang yu-Hao Zhang Xi'an Key Laboratory of Toxicology and Biological Effects Research Center for Toxicological and Biological EffectsInstitute for Hygiene of Ordnance IndustryXi'an710065China

Purpose:To identify the potential target genes of blast lung injury(BLI)for the diagnosis and treatment.Methods:This is an experimental study.The BLI models in rats and goats were established by conducting a fuel-air explosive power test in an unobstructed environment,which was subsequently validated through hematoxylin-eosin staining.Transcriptome sequencing was performed on lung tissues from both goats and rats.Differentially expressed genes were identified using the criteria ofq≤0.05 and|log2 fold change|≥1.Following that,enrichment analyses were conducted for gene ontology and the Kyoto Encyclopedia of Genes and Genomes pathways.The potential target genes were further confirmed through quantitative real-time polymerase chain reaction and enzyme linked immunosorbent assay.Results:Observations through microscopy unveiled the presence of reddish edema fluid,erythrocytes,and instances of focal or patchy bleeding within the alveolar cavity.Transcriptome sequencing analysis identified a total of 83 differentially expressed genes in both rats and goats.Notably,49 genes exhibited a consistent expression pattern,with 38 genes displaying up-regulation and 11 genes demonstrating down-regulation.Enrichment analysis highlighted the potential involvement of the interleukin-17 signaling pathway and vascular smooth muscle contraction pathway in the underlying mechanism of BLI.Furthermore,the experimental findings in both goats and rats demonstrated a strong association between BLI and several key genes,including anterior gradient 2,ankyrin repeat domain 65,bactericidal/permeability-increasing fold containing family A member 1,bactericidal/permeability-increasing fold containing family B member 1,and keratin 4,which exhibited up-regulation.Conclusions:Anterior gradient 2,ankyrin repeat domain 65,bactericidal/permeability-increasing fold containing family A member 1,bactericidal/permeability-increasing fold containing family B member 1,and keratin 4 hold potential as target genes for the prognosis,diagnosis,and treatment of BL

关键词： Blast lung injury Transcriptomic Target genes Differentially expressed genes

Achieving laparoscopic anatomic resection for hepatocellular carcinoma by fluorescence guided positive staining of hepatic cone unit

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 406-411页

作者： Jun-Fang Deng Chuan-Hui Peng yu Zhang Xiao-Feng Xu Rong-liang Tong Zheng-Long Zhai Di-yu Chen Cheng Zhang Li-Ming Wu Jian Wu Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Laparoscopic anatomical liver resection has been increasingly reported worldwide,but how to demarcate the resection planes is technically challenging[1].Positive staining technique with intraoperative indocyanine green(ICG)-fluorescence imaging has been introduced as an effective tool for real-time intraoperative guidance[2].Liver anatomy is complex.Generally,liver is composed of 9 segments,each is composed of two to three subsegments,and each subsegment contains several hepatic cone units.A hepatic cone unit is dominated by a tertiary or quaternary hepatic pedicles[3].

关键词： hepatic resection anatomy

Spray pyrolysis-derived W-doped MoSe2/rGO paper-like microspheres:optimization of microstructure and mesostructure for enhanced lithium storage

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Rare Metals 2024年第7期43卷 3019-3031页

作者： Wei Wang Jun-yu Chen Jie Ouyang Hong Yin Ao-Jie Li liang Chen Jun-Lin Huang yu-Can Zhu Gang-Yong Li Zhao-Hui Hou Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Chemistry and Chemical Engineering Hunan Institute of Science and Technology Hunan Province Key Laboratory of Materials Surface & Interface Science and Technology Material Science and Engineering SchoolCentral South University of Forestry and Technology International Iberian Nanotechnology Laboratory (INL)

Two-dimensional MoSe2is a promising candidate for lithium-ion battery anodes.However,its conductivity and lithium storage volumetric effect still need to be optimized.In this work,W-doped MoSe2/rGO paper-like microspheres are successfully prepared through ultrasonic spray pyrolysis,achieving optimization at both the microstructure and mesostructure to enhance the lithium storage performance of the material.Firstly,by utilizing the similar two-dimensional structure between MoSe2and rGO,self-assembly is achieved through spray pyrolysis,resulting in a well-defined van der Waals heterostructure at the interface on the microscale,enhancing the electron and ion transfer capability of the composite.Secondly,the mesoscale paper-like microsphere morphology provides additional volume expansion buffering space.Moreover,W-doping not only increases the interlayer spacing of MoSe2（0.73 nm）,thereby reducing the diffusion resistance of Li+,but also allow for the modulation of the energy band structure of the material.Density functional theory（DFT） calculations confirm that W-doped MoSe2/rGO exhibits the narrowest bandgap（0.892 eV）.Therefore,the composite demonstrates excellent lithium storage performance,maintaining a specific capacity of 732.9 mAh·g-1after 300 cycles at a current density of 1 A·g-1.

关键词： Molybdenum selenide Heterostructure Microspheres Li-ion batteries Kinetics

Electronic-scale assessment of high-temperature oxidation mechanisms in a novel Fe-based alloy

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Journal of Iron and Steel Research(International) 2024年第4期31卷 982-997页

作者： Wei-di Luo Ting-ping Hou Xuan liang Dong Zhang Heng-fu Lin yu Li Tian-liang Zhao Cheng-yang Hu Serhii Yershov Kai-ming Wu The State Key Laboratory of Refractories and Metallurgy.Wuhan University of Science and Technology.Wuhan 430081 HubeiChina Hubei Province Key Laboratory of Systems Science in Meallurgial Process Wuhan University of Science and Technology.Wuhan 430081.Hubei.China International Research Institute for Steel Technology Wuhan University of Science and Technology.Wuhan 430081.HubeiChina Collaborative Innovation Center for Advanced Steels w uhan University of Science and Technology.Wuhan 430081.HuleiChina

The development of alloys with high antioxidation performance is limited by the ambiguous details of the oxidation mechanism.Here,based on the structures of internal oxides detected by high-resolution transmission electron microscopy,a hybrid method combining first-principles calculation,climb image nudged elastic band method and quasi-harmonic Debye model has been implemented to explain the oxidation mechanism with an emphasis on the origin of delamination and cracking.The results showed that the delamination of oxides corresponds to the acceleration of diffusion of Cr element caused by lamellar structures.The reduction in the cracking occurrence at high temperature mainly results from the smaller bulk modulus of oxides.Furthermore,the stronger chemical bonds promoted by lamellar structures also correspond to the higher crackingresistance.

关键词： Oxidation Crystal structure Diffusion Cracking-First-principles calculation

Fractal model of spontaneous imbibition in low-permeability reservoirs coupled with heterogeneity of pore seepage channels and threshold pressure

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Petroleum Science 2024年第2期21卷 1002-1017页

作者： Ming-Sheng Zuo Hao Chen Xi-liang Liu Hai-Peng Liu Yi Wu Xin-yu Qi National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China College of Safety and Ocean Engineering China University of Petroleum(Beijing)Beijing102249China

Spontaneous imbibition(SI)is an important mechanism for enhancing oil recovery in low-permeability reservoirs.Due to the strong heterogeneity,and the non-Darcy flow,the construction of SI model for lowpermeability reservoirs is extremely challenging.Commonly,traditional SI models based on single or averaged capillary tortuosity ignore the influence of heterogeneity of pore seepage channels and the threshold pressure(TP)on imbibition.Therefore,in this work,based on capillary model and fractal theory,a mathematical model of characterizing SI considering heterogeneity of pore seepage channels is established.On this basis,the threshold pressure was introduced to determine the pore radius at which the wetted phase can displace oil.The proposed new SI model was verified by imbibition experimental data.The study shows that for weakly heterogeneous cores with permeability of 0-1 m D,the traditional SI model can characterize the imbibition process relatively accurately,and the new imbibition model can increase the coefficient of determination by 1.05 times.However,traditional model has serious deviations in predicting the imbibition recovery for cores with permeability of 10-50 m D.The new SI model coupling with heterogeneity of pore seepage channels and threshold pressure effectively solves this problem,and the determination coefficient is increased from 0.344 to 0.922,which is increased by2.68 times.For low-permeability reservoirs,the production of the oil in transitional pores(0.01-0.1μm)and mesopores(0.1-1μm)significantly affects the imbibition recovery,as the research shows that when the heterogeneity of pore seepage channels is ignored,the oil recovery in transitional pores and mesopores decreases by 7.54%and 4.26%,respectively.Sensitivity analysis shows that increasing interfacial tension,decreasing contact angle,oil-water viscosity ratio and threshold pressure will increase imbibition recovery.In addition,there are critical values for the influence of these factors on the imbibition recovery,which provides theoret

关键词： Spontaneous imbibition Low-permeability reservoir Fractal model Threshold pressure Capillary tube

Cholesterol-induced deformation of the gramicidin A channel inhibiting potassium ion binding and transport

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Chinese Physics B 2024年第5期33卷 696-702页

作者：肖盼曹宇朱瑾梁清 Center for Statistical and Theoretical Condensed Matter Physics & Department of Physics Zhejiang Normal UniversityJinhua 321004China Zhejiang Institute of Photoelectronics & Zhejiang Institute for Advanced Light Source Zhejiang Normal UniversityJinhua 321004China

Gramicidin A(gA)is a kind of antibiotic peptide produced by bacillus brevis and it can dimerize across lipid bilayers to form a monovalent cation channel.In this work,we investigate the impact of cholesterol in the lipid bilayer on the binding of potassium ions with the gA channel and the transport of the ions across the channel.The results indicate that cholesterol can significantly influence the conformational stability of the gA channel and cause the channel deformation which inhibits the potassium ion binding with the channel and transport across the channel.The work provides some molecular insights into understanding of influence of lipids on the activity of gA channel in both model membranes and plasma membranes of intact cells.

关键词： gramicidin A lipid bilayer molecular dynamics interaction