Cholesterol-induced deformation of the gramicidin A channel inhibiting potassium ion binding and transport

作     者：肖盼 曹宇 朱瑾 梁清 Pan Xiao;Yu Cao;Jin Zhu;Qing Liang

作者机构：Center for Statistical and Theoretical Condensed Matter Physics & Department of PhysicsZhejiang Normal UniversityJinhua 321004China Zhejiang Institute of Photoelectronics & Zhejiang Institute for Advanced Light SourceZhejiang Normal UniversityJinhua 321004China 

出 版 物：《Chinese Physics B》 (中国物理B（英文版）)

年 卷 期：2024年第33卷第5期

页      面：696-702页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 070205[理学-凝聚态物理] 08[工学] 0836[工学-生物工程] 0702[理学-物理学] 

基　　金：Project supported by the National Natural Science Foundation of China(Grant No.11674287) the Zhejiang Provincial Natural Science Foundation of China(Grant No.LY19A040009) 

主　　题：gramicidin A lipid bilayer molecular dynamics interaction 

摘      要：Gramicidin A(gA)is a kind of antibiotic peptide produced by bacillus brevis and it can dimerize across lipid bilayers to form a monovalent cation *** this work,we investigate the impact of cholesterol in the lipid bilayer on the binding of potassium ions with the gA channel and the transport of the ions across the *** results indicate that cholesterol can significantly influence the conformational stability of the gA channel and cause the channel deformation which inhibits the potassium ion binding with the channel and transport across the *** work provides some molecular insights into understanding of influence of lipids on the activity of gA channel in both model membranes and plasma membranes of intact cells.