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Laparoscopic pancreaticoduodenectomy with portal or superior mesenteric vein resection and reconstruction for pancreatic cancer:A single-center experience

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 147-153页

作者： Ming-Jian Ma He cheng yu-sheng chen Xian-Jun yu chen Liu Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai Pancreatic Cancer Institute Shanghai 200032China Pancreatic Cancer Institute Fudan UniversityShanghai 200032China

Background: Open pancreaticoduodenectomy(OPD) with portal or superior mesenteric vein resection and reconstruction has been applied in pancreatic cancer patients with tumor infiltration or adherence. However, it is controversial whether laparoscopic pancreaticoduodenectomy(LPD) with major vascular resection and reconstruction is feasible. This study aimed to evaluate the safety and feasibility of LPD with major vascular resection compared with OPD with major vascular resection. Methods: We reviewed data for all pancreatic cancer patients undergoing LPD or OPD with vascular resection at Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, between February 2018 and May 2022. We compared the preoperative, intraoperative, and postoperative clinicopathological data of the two groups to conduct a comprehensive evaluation of LPD with major vascular resection. Results: A total of 63 patients underwent pancreaticoduodenectomy(PD) with portal or superior mesenteric vein resection and reconstruction, including 25 LPDs and 38 OPDs. The LPD group had less intraoperative blood loss(200 vs. 400 m L, P < 0.001), lower proportion of intraoperative blood transfusion(16.0% vs. 39.5%, P = 0.047), longer operation time(390 vs. 334 min, P = 0.004) and shorter postoperative hospital stay(11 vs. 14 days, P = 0.005). There was no perioperative death in all patients. There was no significant difference in the incidence of total postoperative complications, grade B/C postoperative pancreatic fistula, delayed gastric emptying and abdominal infection between the two groups. No postpancreatectomy hemorrhage nor bile leakage occurred during perioperative period. There was no significant difference in R0 resection rate and number of lymph nodes harvested between the two groups. Patency of reconstructed vessels in the two groups were 96.0% and 92.1%, respectively( P = 0.927). Conclusions: LPD with portal or superior mesenteric vein resection and reconstruction was safe, feasib

关键词： Laparoscopy Pancreaticoduodenectomy Whipple procedure Mesenteric veins Portal vein Pancreatic neoplasms

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云南省农作物秸秆综合利用对碳减排的贡献及影响研究

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价值工程 2024年第27期43卷 1-5页

作者：盛毓琛梁玉何俊杰云南农业大学建筑工程学院昆明650500 云南农业大学水利学院昆明650500

为提升云南省农作物秸秆综合利用水平及其对减排固碳的贡献,针对云南省农业碳排放量过高等问题,本研究基于相关数据,利用碳排放系数及温室气体排放因子等相关指标,以此测算并分析云南省2020年农业碳排放量、碳排放强度以及秸秆“五化”... 详细信息

为提升云南省农作物秸秆综合利用水平及其对减排固碳的贡献,针对云南省农业碳排放量过高等问题,本研究基于相关数据,利用碳排放系数及温室气体排放因子等相关指标,以此测算并分析云南省2020年农业碳排放量、碳排放强度以及秸秆“五化”利用减排固碳贡献。结果表明,2020年云南省各州市由于交通、经济、气候及地形条件存在差距,秸秆综合利用率在90%以上的有7个州市,80%以下的州市有9个;云南省农业碳排放量为286.37×10^(4)t,农业碳排放强度为0.41t/hm^(2),其中化肥导致的农业碳排放量最多,高达176.12×10^(4)t(占比61.5%);云南省农作物秸秆的“五化”利用为温室气体净减排做出重要贡献,其总量达到2.08×10^(5)tCO_(2)e(CO_(2)当量,下同)。其中,秸秆综合利用所带来的温室气体减排量为2.17×10^(5)tCO_(2)e,秸秆露天焚烧所导致的温室气体排放量为8.8×10^(5)tCO_(2)e;肥料化和燃料化利用方式的减排量最高,减排量分别为1.1×10^(5)tCO_(2)e和5.1×10^(4)tCO_(2)e。由此提出提升肥料及燃料化利用水平,并加大对减排贡献较大的利用技术支持力度等建议,为中国实现“双碳”目标出谋划策。

关键词：农作物秸秆综合利用农业碳排放温室气体碳减排

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Controlled pore size of Pt/KIT-6 used for propane total oxidation

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Rare Metals 2018年第2期37卷 123-128页

作者： yu-sheng chen Yi-Dan Cao Rui Ran Xiao-Dong Wu Duan Weng Key Laboratory of Advanced Materials of Ministry of Education School of Materials Science and EngineeringTsinghua University State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University

Mesoporous silica KIT-6 with different pore sizes was controllably synthesized by hydrothermal meth- ods. The same contents of Pt were loaded on KIT-6 sup- ports to apply for propane total oxidation. Low-angle X-ray diffraction （XRD）, nitrogen adsorption-desorption, CO chemisorption and transmission electron microscopy （TEM） were carried out to investigate the physicochemical properties of the catalysts. The results reveal that different pore sizes of KIT-6 supports could affect the Pt particle sizes on KIT-6. The mesopores on KIT-6-80 and KIT-6- 130 effectively confine the size of the inside Pt nanopar- ticles during calcining. Pt/KIT-6-80 with the appropriate pore size as well as the Pt particle size exhibits the best catalytic performance with T50 （the temperature at which hydrocarbon （HC） conversion reaches 50%） of only 237 ℃. However, Pt particles prefer dispersing on the external surface of KIT-6-40 due to those too small pores.

关键词： Mesoporous silica KIT-6 Pore size Propanetotal oxidation

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Two highly porous single-crystalline zirconium-based metal-organic frameworks

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Science China Chemistry 2016年第8期59卷 980-983页

作者： Wen-Yang Gao Timmy Thiounn Lukasz Wojtas yu-sheng chen shengqian Ma Department of Chemistry University of South Florida Florida 33620 USA ChemMatCARS Center for Advanced Radiation Sources University of Chicago Illinois 60439 USA

Herein we report two highly porous Zr-based metal-organic frameworks （MOFs, 1 and 2） constructed by the truncated octahedral secondary building unit （SBU） of Zr604（OH）4（CO2）12 and the organic linear ligand of 4,4＇-stilbenedicarboxylic acid （H2sbdc） or 4,4＇-azobenezenedicarboxylic acid （H2abdc）. Both Zr-based MOFs are obtained as single crystals of suitable size for single-crystal X-ray diffraction analysis. Furthermore, these two Zr-based MOFs have been fully characterized by powder X-ray diffraction （PXRD） studies, thermogravimetric analysis （TGA）, infrared spectroscopy （IR） and gas adsorption analysis. In particular, their CO2 gas adsorption behaviors have been investigated and discussed.

关键词： metal-organic frameworks zirconium cluster single-crystalline

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Chlorogenic acid prevents acetaminophen-induced liver injury: the involvement of CYP450 metabolic enzymes and some antioxidant signals

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第7期16卷 602-610页

作者： Chun PANG yu-chen sheng Ping JIANG Hai WEI Li-li JI Shanghai Key Laboratory of Complex Prescription the MOE Key Laboratory for Standardization of Chinese MedicinesInstitute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Center for Traditional Chinese Medicine and Systems Biology Shanghai University of Traditional Chinese Medicine Center for Drug Safety Evaluation and Research Shanghai University of Traditional Chinese Medicine

Chlorogenic acid（CGA）, a polyphenolic compound, is abundant in fruits, dietary vegetables, and some medicinal herbs. This study investigated the prevention of CGA against acetaminophen（AP）-induced hepatotoxicity and its engaged mechanisms. CGA reversed the decreased cell viability induced by AP in L-02 cells in vitro. In addition, CGA reduced the AP-induced increased serum levels of alanine/aspartate aminotransferase（ALT/AST） in vivo. The effect of CGA on cytochrome P450（CYP） enzymatic（CYP2E1, CYP1A2, and CYP3A4） activities showed that CGA caused very little inhibition on CYP2E1 and CYP1A2 enzymatic activities, but not CYP3A4. The measurement of liver malondialdehyde（MDA）, reactive oxygen species（ROS）, and glutathione（GSH） levels showed that CGA prevented AP-induced liver oxidative stress injury. Further, CGA increased the AP-induced decreased m RNA expression of peroxiredoxin（Prx） 1, 2, 3, 5, 6, epoxide hydrolase（Ephx） 2, and polymerase（RNA） II（DNA directed） polypeptide K（Polr2k）, and nuclear factor erythroid-2-related factor 2（Nrf2）. In summary, CGA ameliorates the AP-induced liver injury probably by slightly inhibiting CYP2E1 and CYP1A2 enzymatic properties. In addition, cellular important antioxidant signals such as Prx1, 2, 3, 5, 6, Ephx2, Polr2 k, and Nrf2 also contributed to the protection of CGA against AP-induced oxidative stress injury.

关键词： Chlorogenic acid Acetaminophen CYP450 Oxidative stress injury

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ANGPTL2 expression in gastric cancer tissues and cells and its biological behavior

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World Journal of Gastroenterology 2016年第47期22卷 10364-10370页

作者： Wei-Zhong sheng yu-sheng chen Chuan-Tao Tu Juan He Bo Zhang Wei-Dong Gao Department of general surgery Fudan University affiliated zhongshan Hospital Department of Digestion Fudan University affiliated zhongshan Hospital

AIM To explore expression of angiopoietin-like protein 2(ANGpT L2) and its effect on biological behavior such as proliferation and invasiveness in gastric cancer. METHODS Western blotting was used to detect expression of ANGp TL2 in 60 human normal gastric tissues, 60 human gastric cancer tissues and gastric cell lines including GES-1, N87, SGC7901, BGC823 and pA MC82. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) and Transwell assay were used to detect the proliferation and invasive ability of gastric cancer cells. RESULTS Compared to normal tissues, ANGp TL2 protein levels were significantly upregulated in gastric tissues, and this level was closely correlated with gastric tumor grade, clinical stage and lymph node metastasis. Compared to GES-1 cells, ANGpT L2 mR NA and protein levels were significantly increased in gastric cancer cells including N87, SGC7901, BGC823 and p AMC82. The expression of ANGpT L2 in highly malignant gastric cancer cell lines BGC823 and pA MC82 was significantly higher than in low malignancy gastric cancer cell lines N87 and SGC7901. MTT and Transwell experiments indicated that the proliferation rate and invasive ability of stable overexpressed gastric cancer cells was faster than in cells transfected with Lv-NC and blank controlcells, and the invasive ability of stable overexpressed gastric cancer cells was higher than that of cells transfected with Lv-NC and blank control *** ANGp TL2 contributed to proliferation and invasion of gastric cancer cells. In clinical treatment, ANGpT L2 may become a new target for treatment of gastric cancer.

关键词： Gastric cancer Angiopoietin-like protein 2 Cell invasion Cell proliferation

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Micro RNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer

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World Journal of Gastroenterology 2016年第24期22卷 5532-5539页

作者： Wei-Zhong sheng yu-sheng chen Chuan-Tao Tu Juan He Bo Zhang Wei-Dong Gao Department of General Surgery Fudan University affiliated zhongshan Hospital Department of Digestion Fudan University affiliated zhongshan Hospital

AIM: To explore the regulatory mechanism of the target gene of micro RNA-21(mi R-21), phosphatase gene(p TEN), and its downstream proteins, protein kinase B(AKT) and phosphatidylinositol 3-kinase(p I3K), in colorectal cancer(CRC) cells. METHODS: Quantitative real-time p CR(q RT-p CR) and Western blot were used to detect the expression levels of mi R-21 and p TEN in HCT116, HT29, Colo32 and SW480 CRC cell lines. Also, the expression levels of p TEN m RNA and its downstream proteins AKT and p I3 K in HCT116 cells after downregulating mi R-21 were investigated. RESULTS: Comparing the mi R-21 expression in CRC cells, the expression levels of mi R-21 were highest in HCT116 cells, and the expression levels of mi R-21 were lowest in SW480 cells. In comparing mi R-21 and p TEN expression in CRC cells, we found that the protein expression levels of mi R-21 and p TEN were inversely correlated(p 0.05), but the expression levels of its protein significantly increased(p < 0.05). In comparing the levels of p TEN protein and downstream AKT and p I3 K in HCT116 cells after downregulation of mi R-21 expression, the levels of AKT and p I3 K protein expression significantly decreased(p < 0.05). CONCLUSION: p TEN is one of the direct target genesof mi R-21. Thus, phosphatase gene and its downstream AKT and p I3 K expression levels can be regulated by regulating the expression levels of mi R-21, which in turn regulates the development of CRC.

关键词： MicroRNA-21 protein kinase B Colorectal cancer phosphatidylinositol 3-kinase phosphatase and tensin homolog

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Scutellarein alleviates the dysfunction of inner blood-retinal-barrier initiated by hyperglycemia-stimulated microglia cells

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1538-1545页

作者： Han Li Xi-yu Mei Meng-Na Wang Tian-yu Zhang yue Zhang Bin Lu yu-chen sheng The MOE Key Laboratory for Standardization of Chinese Medicines Shanghai Key Laboratory of Compound Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Center for Drug Safety Evaluation and Research Innovation Research Institute of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

AIM:To investigate the alleviation of scutellarein(SN)against inner blood-retinal-barrier(iBRB)dysfunction in microglia cells stimulated by hyperglycemia and to elucidate the engaged ***:Microglia BV2 cells were stimulated by using 25 mmol/L *** same concentration of mannitol(25 mmol/L)was applied as an isotonic ***-time PCR,Western-blot assay and immunofluorescence staining assay was *** dysfunction of iBRB in vitro was detected by using transendothelial electrical resistance(TEER)***,the leakage of fluorescein isothiocyanate(FITC)-conjugated dextran(70 kDa)was ***:SN abrogated microglia BV2 cells activation and reduced the phosphorylated activation of extracellular signal-regulated protein kinase(ERK)1/*** also decreased the transcriptional activation of nuclear factorκB(NFκB)and the elevated expression of tumor necrosis factorα(TNFα),interleukin(IL)-6 and IL-1βin BV2 cells treated with D-glucose(25 mmol/L).SN attenuated iBRB dysfunction in human retinal endothelial cells(HRECs)or choroid-retinal endothelial RF/6 A cells when those cells were treated with TNFα,IL-1βor IL-6,or co-cultured with microglia cells stimulated by ***,SN restored the decreased protein expression of tight junctions(TJs)in TNFα-treated HRECs and RF/6 A ***:SN not only alleviate iBRB dysfunction via directly inhibiting retinal endothelial injury caused by TNFα,IL-1βor IL-6,but also reduce the release of TNFα,IL-1βand IL-6 from microglia cells by abrogating hyperglycemia-mediated the activation of microglia cells.

关键词： scutellarein blood-retinal-barrier tight junctions inflammation tumor necrosis factorα

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The Analysis of Zirconium (Ⅳ) Oxide (ZrO_(2)) Nanoparticles for Peroxidase Activity

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Journal of Analysis and Testing 2019年第3期3卷 246-252页

作者： Christopher W.Smith yu-sheng chen Nidhi Nandu Mahera Kachwala Mehmet V.Yigit Department of Chemistry University at AlbanyState University of New York1400 Washington AvenueAlbanyNY 12222USA The RNA Institute University at AlbanyState University of New York1400 Washington AvenueAlbanyNY 12222USA

In this study,the peroxidase-like activity of zirconium(Ⅳ)oxide nanoparticles(nZr)is *** catalyze the oxidation of their substrate in the presence of peroxide species.3,3′,5,5′-tetramethylbenzidine(TMB)is a peroxidase substrate,and we have demonstrated that nZr oxidizes the TMB in the presence of hydrogen peroxide resulting in a colored(TMBox)*** reaction was tested in various buffers,and sodium acetate with pH 4 was observed to be an ideal buffer for the enzymatic reaction and the dispersity of the nZr in the *** nanozyme behavior was studied systematically at three different temperatures(25,35 and 45℃)and a wide range of H_(2)O_(2) *** dependence of the enzymatic reaction on temperature,nZr content and H_(2)O_(2) concentration was *** enzymatic reaction was tested in different protein solutions and no noticeable interference was observed with these ***,we demonstrate that nZr,which is often used for industrial applications,mimics peroxidase enzyme and catalyzes oxidation of its substrate in the presence of peroxide species.

关键词： Artificial enzyme Nanozyme Peroxidase Sensor Zirconium(Ⅳ)oxide(ZrO_(2))

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Synthesis, Crystal Structure, Antifungal Activity and Computational Study on 4-(((8-Chloro-3-oxo-[1,2,4]-triazolo[4,3-a]pyridin-2(3H)-yl)thio)methyl)benzonitrile

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Chinese Journal of Structural Chemistry 2021年第4期40卷 424-430,405页

作者： MU Jin-Xia yu chen-sheng MIN Li-Jing LIU Xing-Hai Department of Environmental Engineering China Jiliang UniversityHangzhou 310018China College of Life Science Key Laboratory of Vector Biology and Pathogen Control of Zhejiang ProvinceHuzhou UniversityHuzhou Cent HospHuzhou 313000China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China

1,2,4-Triazolo[4,3-a]pyridine(TP) is a key intermediate in pesticides, materials and medicines. The title compound 4-(((8-chloro-3-oxo-[1,2,4]triazolo[4,3-a]pyridin-2(3 H)-yl)thio)methyl)benzonitrile was synthesized via three steps, and its structure was characterized by ^(1)H NMR, HRMS and X-ray diffraction. Single-crystal X-ray diffraction reveals that it crystallizes in the monoclinic system, space group P21/c. Four TP molecules in the symmetric unit are linked through the O–H···O and O–H···N hydrogen bonding interactions via two H2O molecules along with two π-π interactions. The preliminary antifungal activity results indicated that the compound TP exhibited good activities. Theoretical calculation was carried out by DFT method using the 6-31 G basis set.

关键词： 1 2 4-triazolo[4 3-a]pyridine synthesis crystal structure antifungal activity DFT

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