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生肌散质控方法的研究

解放军药学学报 2007年第2期23卷 145-147页

作者：申玉飞曹红邢俊波冯作山新疆农业大学食品科学学院新疆乌鲁木齐830052 总后勤部卫生部药品仪器检验所北京100071 不详

目的建立生肌散的质量标准。方法采用TLC法对处方中血竭、冰片进行鉴别，用HPLC法测定方中君药儿茶中儿茶素的含量。结果在TLC色谱中，能检出血竭、冰片。儿茶素在0．1762～3．524μg范围内，浓度与峰面积线性关系良好（r=0．9994）... 详细信息

目的建立生肌散的质量标准。方法采用TLC法对处方中血竭、冰片进行鉴别，用HPLC法测定方中君药儿茶中儿茶素的含量。结果在TLC色谱中，能检出血竭、冰片。儿茶素在0．1762～3．524μg范围内，浓度与峰面积线性关系良好（r=0．9994），样品的平均加样回收率为103．06％，RSD为0．39％（n=6）。结论本文建立的方法对方中3味药材能准确、快速地进行定性、定量检测，可用于生肌散的质量控制。

关键词：生肌散 TLC HPLC 儿茶素

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-Hong Zhou Wei-Hong Jiang Yan Jiang Jing-Wu Sun Qin-Tai Yang Xue-Zhong Li Ya-Nan Sun Li Shi Min Wang Xi-Cheng Song Fu-Quan Chen Xiao-Shu Zhang Hong-Quan Wei Shao-Qing yu Dong-Dong Zhu Luo Ba Zhi-Wei Cao Xu-Ping Xiao Xin Wei Zhi-Hong Lin Feng-Hong Chen Chun-Guang Shan Guang-Ke Wang Jing Ye shen-Hong Qu Chang-Qing Zhao Zhen-Lin Wang Hua-Bin Li Feng Liu Xiao-Bo Cui sheng-Nan Ye Zheng Liu yu Xu Xiao Cai Wei Huang Ru-Xin Zhang yu-Lin Zhao Guo-Dong yu Guang-Gang Shi Mei-Ping Lu Yang shen yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang yu Ye-Hai Liu Shao-Wei Gu yu-Cheng Yang Lei Cheng Jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

Induced pluripotent stem cell technology for spinal cord injury: a promising alternative therapy

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Neural Regeneration Research 2021年第8期16卷 1500-1509页

作者： yu Li Ping-Ping shen Bin Wang Clinical Stem Cell Center the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolSchool of Life ScienceNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and The Comprehensive Cancer Center the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolSchool of Life ScienceNanjing UniversityNanjingJiangsu ProvinceChina Clinical Stem Cell Center the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsu ProvinceChina

Spinal cord injury has long been a prominent challenge in the trauma repair process. Spinal cord injury is a research hotspot by virtue of its difficulty to treat and its escalating morbidity. Furthermore, spinal cord injury has a long period of disease progression and leads to complications that exert a lot of mental and economic pressure on patients. There are currently a large number of therapeutic strategies for treating spinal cord injury, which range from pharmacological and surgical methods to cell therapy and rehabilitation training. All of these strategies have positive effects in the course of spinal cord injury treatment. This review mainly discusses the problems regarding stem cell therapy for spinal cord injury, including the characteristics and action modes of all relevant cell types. Induced pluripotent stem cells, which represent a special kind of stem cell population, have gained impetus in cell therapy development because of a range of advantages. Induced pluripotent stem cells can be developed into the precursor cells of each neural cell type at the site of spinal cord injury, and have great potential for application in spinal cord injury therapy.

关键词： axon regeneration cell therapy functional recovery induced pluripotent stem cell mesenchymal stem cell neural cells neural precursor cell neural stem cell remyelination spinal cord injury stem cells

Characteristic comparison of metal films coated onto the cenosphere by chemical and magnetron sputtering methods

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Rare Metals 2007年第6期26卷 617-624页

作者： XU Zheng yu Xiaozheng CAI Chujiang shen Zhigang General Research Institute For Nonferrous Metals Beijing 100088 China Beijing Key Laboratory for Powder Technology R ＆ D Beijing University of Aeronautics and Astronautics Beijing 100083 China

Metal-coated cenospheres have been widely used in industries. Different coating methods result in different characteristic metal films. The metal film on the cenosphere by chemical coating does not appear to be very smooth, exhibiting metal piled up and pin holes on the surface and leaving some spots uncoated. Meanwhile, the metal film is not tightly absorbed onto cenospheres and is easy to peel off. However, the metal film prepared by magnetron sputtering is compact, smooth and without pin holes. The film has good affinity to the cenosphere surface. Such films do not separate with it even when the cenosphere is crushed. Both the metal t＇rims give the same XRD patterns, indicating that the crystal structure of the metal films by these two methods is the same. Chemical coating is a complex process and harmful to the environment, but it fits ultrafine powder coating （the particle size can be less than 2 μm）. The magnetron sputtering method is environmental friendly and works quickly, but this method requires specially designed equipment and does not work for ultrafine powders. If the particle size is less than 30 μm, the coating process is hard to carry on.

关键词： coating magnetron sputtering chemical coating cenosphere

廉洁文化进课堂的现状及对策分析——以河南财经政法大学的廉洁通识选修课为例

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晋中学院学报 2022年第6期39卷 9-13页

作者：张银霞傅恒锐于慎鸿河南财经政法大学马克思主义学院河南郑州450046

廉洁文化进课堂,开展大学生廉洁教育,培养崇尚廉洁、严于修身的大学生,是高校廉洁教育的重要工作。廉洁文化进课堂,高校应紧密结合自身实际,增强进课堂的执行合力和实际效果;确定统一教材,加强专职教师队伍建设;促进课堂教学方法创新,... 详细信息

廉洁文化进课堂,开展大学生廉洁教育,培养崇尚廉洁、严于修身的大学生,是高校廉洁教育的重要工作。廉洁文化进课堂,高校应紧密结合自身实际,增强进课堂的执行合力和实际效果;确定统一教材,加强专职教师队伍建设;促进课堂教学方法创新,不断优化教学效果;适应时代要求,推进综合型人才培养的教学改革。

关键词：廉洁文化进课堂廉洁教育问题

多学科协作在急诊接收心肌梗死患者的应用研究

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医院管理论坛 2019年第5期36卷 17-19页

作者：沈玉萍刘怀莉谢晓林杭州市第三人民医院

目的探讨多学科协作应急处置流程在急诊接收心肌梗死患者中的应用效果。方法选取2016年1月至2017年12月急诊接收的310例心肌梗死患者为研究对象。对照组采用常规急诊接收方式,实验组采取多学科协作的应急处置流程进行急诊接收。结果实... 详细信息

目的探讨多学科协作应急处置流程在急诊接收心肌梗死患者中的应用效果。方法选取2016年1月至2017年12月急诊接收的310例心肌梗死患者为研究对象。对照组采用常规急诊接收方式,实验组采取多学科协作的应急处置流程进行急诊接收。结果实验组出诊反应时间、首次心电图时间、院前急救耗时等相关时间指标优于对照组,出诊缺陷率和护理缺陷发生率低于对照组,数据比较差异均具有统计学意义(p<0.05)。结论多学科协作应急处置流程能够缩短心肌梗死患者急诊接收时间,降低接收过程中护理缺陷发生率,提高患者生存质量。

关键词：多学科协作应急处置流程心肌梗死急诊接收

高敏感用户供电质量综合提升装置拓扑及参数设计

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电力自动化设备 2020年第11期40卷 219-224页

作者：胡伟沈煜李小平杨帆杨志淳左文平国网湖北省电力有限公司电力科学研究院湖北武汉430077 华中科技大学电气与电子工程学院湖北武汉430074

为满足大容量高敏感用户的供电质量需求,提出了一种含储能的源-荷隔离的级联H桥拓扑结构和一种考虑级联H桥冗余的关键参数设计方法,研制了一套容量为1 MV·A高敏感用户供电质量综合提升装置。基于电网模拟器搭建了装置性能测试平台,测... 详细信息

为满足大容量高敏感用户的供电质量需求,提出了一种含储能的源-荷隔离的级联H桥拓扑结构和一种考虑级联H桥冗余的关键参数设计方法,研制了一套容量为1 MV·A高敏感用户供电质量综合提升装置。基于电网模拟器搭建了装置性能测试平台,测试了电网发生各种供电质量事件时装置的输出性能。测试结果表明:该拓扑能够自动实现电网和储能供电的无缝切换,为高敏感用户综合供电质量的提升提供有效方法;所提参数设计方法能够减少储能投入次数,延长了储能寿命。

关键词：供电质量综合提升拓扑结构冗余参数设计

三种马铃薯病毒多重RT-PCR检测体系建立

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东北农业大学学报 2014年第5期45卷 13-18页

作者：张威白艳菊罗丽环范国权高艳玲申宇张抒孟宪欣黑龙江省农业科学院植物脱毒苗木研究所哈尔滨150086 黑龙江省农业科学院作物育种研究所哈尔滨150086

马铃薯卷叶病毒(PLRV)、马铃薯Y病毒(PVY)和马铃薯S病毒(PVS)是马铃薯生产田中发生率较高、危害较严重的病毒,通常复合侵染。研究通过综合评价和筛选,确定每种病毒的特异性引物,对PCR部分各试剂用量和反应程序进行优化,在同一体系中对... 详细信息

马铃薯卷叶病毒(PLRV)、马铃薯Y病毒(PVY)和马铃薯S病毒(PVS)是马铃薯生产田中发生率较高、危害较严重的病毒,通常复合侵染。研究通过综合评价和筛选,确定每种病毒的特异性引物,对PCR部分各试剂用量和反应程序进行优化,在同一体系中对三种病毒复合侵染的马铃薯材料进行多重RT-PCR扩增,得到长度分别为336、447、729 bp的3条特异性条带,建立能同时检测PLRV、PVY和PVS病毒的多重RT-PCR检测体系。应用该体系对田间样品进行检测,检测结果特异性强、灵敏度高,表明该多重RT-PCR体系能够同时检测三种马铃薯病毒。

关键词：马铃薯 PLRV PVY PVS 多重RT-PCR 检测

冷循环微波天线对人离体曲张大隐静脉作用的实验研究

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四川医学 2011年第11期32卷 1685-1688页

作者：俞慎林雷泽华乔正荣乐山市人民医院普外科四川乐山614004 重庆医科大学附属第一医院重庆400016

目的研究冷循环微波天线对人离体曲张大隐静脉腔内的作用机制。方法术中切取下肢大隐静脉曲张患者的大隐静脉主干,直径(6.5±0.5)cm,将其分成每段长10cm,两端细线结扎,腔内注入5ml生理盐水。对照组2组,每组2段;实验组4组,每组12段。将... 详细信息

目的研究冷循环微波天线对人离体曲张大隐静脉腔内的作用机制。方法术中切取下肢大隐静脉曲张患者的大隐静脉主干,直径(6.5±0.5)cm,将其分成每段长10cm,两端细线结扎,腔内注入5ml生理盐水。对照组2组,每组2段;实验组4组,每组12段。将冷循环微波天线插入静脉腔中,分别以不同输出功率(0W、30W和35W)与不同退出速度(5cm/min和10cm/min)退出。用苏木精-伊红染色和透射电镜观察静脉壁的内膜,弹力纤维、胶原纤维、平滑肌细胞和血管外周围组织的病理改变,用游标卡尺测量管腔外径的变化。结果内膜损伤率:对照组和30W×10cm/min组无内膜损伤,30W×5cm/min组为25%,35W×10cm/min组为91.67%,35W×5cm/min组为100%,后两组与第1组差异均有统计学意义(P0.05)。外膜损伤率:35W×5cm/min组为41.67%,其余组均无外膜损伤,与对照组差异有统计学意义(P<0.05)。管腔缩小率:对照组无管腔缩小,30W×10cm/min组为(31.67%±2.16)%,30W×5cm/min组为(36.44%±2.42)%,35W×10cm/min组为(50.60±0.39)%,35W×5cm/min组为(56.62±1.23)%,各组间差异均有统计学意义(P<0.05)。病理观察和电镜结果显示内膜损伤组的内皮细胞变性坏死、脱落,内膜断裂完整性破坏,肌纤维、胶原纤维变性、挛缩,排列紊乱。结论冷循环微波天线能损伤曲张大隐静脉内膜,内膜损伤率随输出功率的增加而升高,随退出速度减慢而增加。35W×10cm/min为最佳组合,既保持高内膜损伤率又避免了外膜损伤。30W×10cm/min能使静脉管腔缩小约30%,但不损伤内膜。

关键词：微波静脉腔内影响体外