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Detection and Estimation of False Data Injection Attacks for Load Frequency Control Systems

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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 861-870页

作者： jun Ye Xiang yu Hangzhou Innovation Institute Beihang UniversityHangzhouChina School of Automation Science and Electrical Engineering Beihang UniversityBeijingChina

False data injection attacks(FDIAs)against the load frequency control(LFC)system can lead to unstable operation of power systems.In this paper,the problems of detecting and estimating the FDIAs for the LFC system in the presence of external disturbances are investigated.First,the LFC system model with FDIAs against frequency and tie-line power measurements is established.Then,a design procedure for the unknown input observer(UIO)is presented and the residual signal is generated to detect the FDIAs.The UIO is designed to decouple the effect of the unknown external disturbance on the residual signal.After that,an attack estimation method based on a robust adaptive observer(RAO)is proposed to estimate the state and the FDIAs simultaneously.In order to improve the performance of attack estimation,the H¥technique is employed to minimize the effect of external disturbance on estimation errors,and the uniform boundedness of the state and attack estimation errors is proven using Lyapunov stability theory.Finally,a two-area interconnected power system is simulated to demonstrate the effectiveness of the proposed attack detection and estimation algorithms.

关键词： External disturbance false data injection attacks load frequency control robust adaptive observer unknown input observer

From Mutation Signature to Molecular Mechanismin the RNA World: A Case of SARS-CoV-2

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Genomics, Proteomics & Bioinformatics 2020年第6期18卷 627-639页

作者： jun yu China National Center for Bioinformation Beijing 100101China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100190China

As a positive-sense single-strand RNA virus,coronavirus(CoV)possesses some of the largest genomes among RNA viruses,∼30 Kb in size and encodes more than two-dozen proteins that ensure a long-lasting parasitic cellular life leveraging on both informational inheritability and operational integrity by constantly changing the underlying molecular constituents toward harmony with those of the hosts whose genomes harbor over 20,000 genes and 2–3 Gb in sizes.We,taking the advantage of the unprecedented accumulation of genomic sequences,interrogate mutation spectra of SARS-CoV-2 as a whole or of the major clades in details using comprehensive genomic tools and structure chemistry principles.

关键词： details harmony sizes

A Privacy-preserving Algorithm for AC Microgrid Cyber-physical System Against False Data Injection Attacks

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Journal of Modern Power Systems and Clean Energy 2023年第5期11卷 1646-1658页

作者： jun Yang yu Zhang College of Information Science and Engineering Northeastern UniversityShenyangChina Liaoning Provincial Transportation Planning and Design Institute Co. Ltd.ShenyangChina

A new privacy-preserving algorithm based on the Paillier cryptosystem including a new cooperative control strategy is proposed in this paper, which can resist the false data injection(FDI) attack based on the finite-time control theory and the data encryption strategy. Compared with the existing algorithms, the proposed privacy-preserving algorithm avoids the direct transmission of the ciphertext of frequency data in communication links while avoiding complex iterations and communications. It builds a secure data transmission environment that can ensure data security in the AC microgrid cyber-physical system(CPS). This algorithm provides effective protection for AC microgrid CPS in different cases of FDI attacks. At the same time, it can completely eliminate the adverse effects caused by the FDI attack. Finally, the effectiveness, security, and advantages of this algorithm are verified in the improved IEEE 34-node test microgrid system with six distributed generators(DGs) in different cases of FDI attacks.

关键词： AC microgrid cyber-physical system(CPS) distributed cooperative control false data injection(FDI)attack Paillier cryptosystem

Probiotics intervention in colorectal cancer:From traditional approaches to novel strategies

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Chinese Medical Journal 2024年第1期137卷 8-20页

作者： Suki Ha Xiang Zhang jun yu Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina

The intestine harbors a large population of microorganisms that interact with epithelial cells to maintain host healthy physiological status.These intestinal microbiota engage in the fermentation of non-digestible nutrients and produce beneficial metabolites to regulate host homeostasis,metabolism,and immune response.The disruption of microbiota,known as dysbiosis,has been implicated in many intestinal diseases,including colorectal cancer(CRC).As the third most common cancer and the second leading cause of cancer-related death worldwide,CRC poses a significant health burden.There is an urgent need for novel interventions to reduce CRC incidence and improve clinical outcomes.Modulating the intestinal microbiota has emerged as a promising approach for CRC prevention and treatment.Current research efforts in CRC probiotics primarily focus on reducing the incidence of CRC,alleviating treatment-related side effects,and potentiating the efficacy of anticancer therapy,which is the key to successful translation to clinical practice.This paper aims to review the traditional probiotics and new interventions,such as next-generation probiotics and postbiotics,in the context of CRC.The underlying mechanisms of probiotic anti-cancer effects are also discussed,including the restoration of microbial composition,reinforcement of gut barrier integrity,induction of cancer cell apoptosis,inactivation of carcinogens,and modulation of host immune response.This paper further evaluates the novel strategy of probiotics as an adjuvant therapy in boosting the efficacy of chemotherapy and immunotherapy.Despite all the promising findings presented in studies,the evaluation of potential risks,optimization of delivery methods,and consideration of intra-patient variability of gut microbial baseline must be thoroughly interpreted before bench-to-bedside translation.

关键词： colorectal cancer probiotics gut microbiota dysbiosis adjuvant therapy immune modulation gut barrrier

Estimation of Treatment Effects in Nonlinear Models with Unobserved Confounding

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Acta Mathematicae Applicatae Sinica 2023年第2期39卷 320-336页

作者： yu-ling LI jun WANG Research Center for Applied Mathematics and Interdisciplinary Sciences Beijing Normal UniversityZhuhai 519087China yunnan Key Laboratory of Statistical Modeling and Data Analysis Yunnan UniversityKunming 650091China

Estimation of treatment effects is one of the crucial mainstays in economics and sociology studies.The problem will become more serious and complicated if the treatment variable is endogenous for the presence of unobserved confounding.The estimation and conclusion are likely to be biased and misleading if the endogeny of treatment variable is ignored.In this article,we propose the pseudo maximum likelihood method to estimate treatment effects in nonlinear models.The proposed method allows the unobserved confounding and random error terms to exist in an arbitrary relationship(such as,add or multiply),and the unobserved confounding have different influence directions on treatment variables and outcome variables.The proposed estimator is consistent and asymptotically normally distributed.Simulation studies show that the proposed estimator performs better than the special regression estimator,and the proposed method is stable for various distribution of error terms.Finally,the proposed method is applied to the real data that studies the influence of individuals have health insurance on an individual’s decision to visit a doctor.

关键词： nonlinear models quasi likelihood estimator stable treatment effects unobserved confounding

Equivalence between the internal observability and equation

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 89-97页

作者： LIU Wen-jun TU Zhi-yu School of Mathematics and Statistics Nanjing University of Information Science and TechnologyNanjing 210044China

This paper is concerned with a third order in time linear Moore-Gibson-Thompson equation which describes the acoustic velocity potential in ultrasound wave program.Influenced by the work of Kaltenbacher,Lasiecka and Marchand(Control Cybernet.2011,40:971-988),we establish an observability inequality of the conservative problem,and then discuss the equivalence between the exponential stabilization of a dissipative system and the internal observational inequality of the corresponding conservative system.

关键词： Moore-Gibson-Thompson equation internal observability exponential stability

A Simple Proof of ACC for Minimal Log Discrepancies for Surfaces

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Acta Mathematica Sinica,English Series 2024年第2期40卷 425-434页

作者： Jing jun HAN yu Jie LUO Shanghai Center for Mathematical Sciences Fudan UniversityJiangwan CampusShanghai 200438P.R.China Department of Mathematics Johns Hopkins UniversityBaltimoreMD 21218USA

Following Shokurov's idea,we give a simple proof of the ACC conjecture for minimal log discrepancies for surfaces.

关键词： Ascending chain condition minimal log discrepancies minimal model program surface

MHC class I-LILRB3 delivers a punch to eliminate precancerous cells

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Cellular & Molecular Immunology 2022年第6期19卷 655-656页

作者： Chi Chun Wong jun yu Institute of Digestive Disease Department of Medicine and TherapeuticsState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina

In the study by Ayukawa et al.[1],the authors presented an innate defense mechanism whereby normal epithelial cells actively remove precancerous cells from the epithelium via mechanical extrusion(Fig.1).

关键词： precancerous epithelium

Uncovering novel human gut virome using ultra-deep metagenomic sequencing

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Chinese Medical Journal 2022年第20期135卷 2395-2397页

作者： Harry Cheuk Hay Lau jun yu Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health Sciencesthe Chinese University of Hong KongHong Kong SARChina

Human gastrointestinal tract harbors trillions of commensal microbes including bacteria,viruses,and fungi to form an ecological community,commonly known as the gut microbiome.Being the second most dominant taxonomic kingdom in the gut(5.8%of total microbiome DNA),enteric viruses are increasingly acknowledged for their roles in shaping the overall composition of the gut microbiome and maintaining human health.[1,2]Recent advancements in metagenomic sequencing have brought breakthrough in deciphering the features and functions of the gut virome.

关键词： breakthrough harbor gut