From Mutation Signature to Molecular Mechanismin the RNA World: A Case of SARS-CoV-2

作     者：Jun Yu Jun Yu

作者机构：China National Center for BioinformationBeijing 100101China CAS Key Laboratory of Genome Sciences and InformationBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of SciencesBeijing 100190China 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2020年第18卷第6期

页      面：627-639页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 0714[理学-统计学（可授理学、经济学学位）] 0703[理学-化学] 0701[理学-数学] 10[医学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：This work is supported by the National Natural Science Foundation of China(NSFC,Grant No.31671350) Key programs of the Chinese Academy of Sciences(Grant No.QYZDY-SSW-SMC017). 

主　　题：details harmony sizes 

摘      要：As a positive-sense single-strand RNA virus,coronavirus(CoV)possesses some of the largest genomes among RNA viruses,∼30 Kb in size and encodes more than two-dozen proteins that ensure a long-lasting parasitic cellular life leveraging on both informational inheritability and operational integrity by constantly changing the underlying molecular constituents toward harmony with those of the hosts whose genomes harbor over 20,000 genes and 2–3 Gb in sizes.We,taking the advantage of the unprecedented accumulation of genomic sequences,interrogate mutation spectra of SARS-CoV-2 as a whole or of the major clades in details using comprehensive genomic tools and structure chemistry principles.