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Onset and Recurrence Characteristics of Chinese Patients with Noncardiogenic Ischemic Stroke in Chinese Medicine Hospitals

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Chinese Journal of Integrative Medicine 2022年第6期28卷 492-500页

作者： GAO Yang XIE Yan-ming WANG Gui-qian CAI Ye-feng SHEN Xiao-ming ZHAO De-xi XIE Ying-zhen ZHANG Yin MENG Fan-xing yu hai-qing JIANG Jun-jie WEI Rui-Li Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing100700China Department of Rehabilitation Dongfang HospitalBeijing University of Chinese MedicineBeijing100078China Department of Emergency Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Neurology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China Department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Neurology the Affiliated Hospital of Changchun University of Chinese MedicineChangchun130017China Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Department of Neurology Taiyuan Hospital of Traditional Chinese MedicineTaiyuan140107China

Objective:To delineate the onset and recurrence characteristics of noncardiogenic ischemic stroke patients in China.Methods:A prospective,multicenter and registry study was carried out in 2,558 patients at 7 representative clinical sub-centers during November 3,2016 to February 17,2019.A questionnaire was used to collect information of patients regarding CM syndromes and constitutions and associated risk factors.Additionally,stroke recurrence was defined as a primary outcome indicator.Results:A total of 327(12.78%)patients endured recurrence events,1,681(65.72%)patients were men,and the average age was 63.33±9.45 years.Totally 1,741(68.06%)patients suffered first-ever ischemic stroke,1,772(69.27%)patients reported to have hypertension,and1,640(64.11%)of them reported dyslipidemia,1,595(62.35%)patients exhibited small-artery occlusion by The Trial of Org 10172 in Acute Stroke Treatment(TOAST)classification.Specifically,1,271(49.69%)patients were considered as qi-deficient constitution,and 1,227(47.97%)patients were determined as stagnant blood constitution.There were 1,303(50.94%)patients diagnosed as blood stasis syndrome,1,280(50.04%)patients exhibited phlegm and dampness syndrome and 1,012(39.56%)patients demonstrated qi deficiency syndrome.And 1,033(40.38%)patients declared intracranial artery stenosis,and 478(18.69%)patients reported carotid artery stenosis.The plaque in 1,508(41.36%)patients were of mixed.Particularly,41.09%of them demonstrated abnormal levels of glycated hemoglobin(HbA1 c)levels.Conclusions:Recurrence in minor and small-artery stroke cannot be ignored.Hypertension,dyslipidemia,abnormal HbA1 c,intracranial artery stenosis and carotid plaque were more common in stroke patients.Particularly,phlegm-dampness and blood stasis syndromes,as well as qi deficiency and blood stasis constitutions,were still the main manifestations of stroke.(Trial registration at ClinicalTrials.gov,No.NCT03174535)

关键词： noncardiogenic ischemic stroke Chinese medicine hospital onset characteristics recurrence

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Isogeometric Analysis for the Arbitrary AFG Microbeam with Two-Phase Nonlocal Stress-Driven Model

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Acta Mechanica Solida Sinica 2024年第2期37卷 341-360页

作者： Pei-Liang Bian Zhaowei Liu hai qing Tiantang yu Department of Engineering Mechanics Hohai UniversityNanjing211100China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China

Scale effects play critical roles in the mechanical responses of microstructures.An isogeometric analysis was developed here to investigate the mechanical responses of an axially functionally graded microbeam.The Euler–Bernoulli beam model was utilized,and size effects in the structure were modeled with a stress-driven two-phase local/nonlocal integral constitution.The governing equation of microstructures was given in an equivalent differential form with two additional constitutive boundary conditions.The framework was verified and utilized to analyze the microbeam’s static and dynamic mechanical responses.The present work showed great potential for modeling various types of functionally graded microstructures.

关键词： Isogeometric analysis Size effect Functionally graded material Nonlocal theory Euler-Bernoulli beam

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Learning topological defects formation with neural networks in a quantum phase transition

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Communications in Theoretical Physics 2024年第5期76卷 68-76页

作者： Han-qing Shi hai-qing Zhang Center for Gravitational Physics Department of Space ScienceBeihang UniversityBeijing 100191China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China

Neural networks possess formidable representational power,rendering them invaluable in solving complex quantum many-body systems.While they excel at analyzing static solutions,nonequilibrium processes,including critical dynamics during a quantum phase transition,pose a greater challenge for neural networks.To address this,we utilize neural networks and machine learning algorithms to investigate time evolutions,universal statistics,and correlations of topological defects in a one-dimensional transverse-field quantum Ising model.Specifically,our analysis involves computing the energy of the system during a quantum phase transition following a linear quench of the transverse magnetic field strength.The excitation energies satisfy a power-law relation to the quench rate,indicating a proportional relationship between the excitation energy and the kink numbers.Moreover,we establish a universal power-law relationship between the first three cumulants of the kink numbers and the quench rate,indicating a binomial distribution of the kinks.Finally,the normalized kink-kink correlations are also investigated and it is found that the numerical values are consistent with the analytic formula.

关键词： neural networks machine learning transverse-field quantum Ising model kibble-zurek mechanism

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Dual template-induced construction of three-dimensional porous SiO2/NC/Co-CNTs heterostructure with highly dispersed active sites for efficient oxygen evolution reaction

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Tungsten 2024年第3期6卷 585-595页

作者： hai-Qi Zhang Xiao-Jun Zeng qing-qing Zhang Zu-Liang Zhang Chu-Long Jin Rong-hai yu School of Materials Science and Engineering Jingdezhen Ceramic University School of Materials Science and Engineering Beihang University

The development and exploration of efficient and economical electrocatalysts for oxygen evolution reaction（OER） represents the main bottleneck to unlocking a sustainable energy scenario based on elec trocataly tic water splitting.Nano scale integration of three-dimensional（3D） porous heterostructure with highly dispersed active sites and good structural stability is challenging.Herein,a dual template route is developed to construct the 3D porous SiO2/nitrogen-doped carbon（NC）/Co-carbon nano tubes（CNTs） hetero structure.Importantly,the hard template（SiO2nano spheres） contributes to 3D porous structure,increases the specific surface area,and promotes the contact area of the electrolyte.At the same time,the soft template（basic zinc carbonate） can control the growth of 1D CNTs and facilitate the exposure of the active sites.Apparently,3D porous SiO2/NC/Co-CNTs hetero structure inherits highly dispersed Co nanoparticles coated by NC.CNTs conductive channels and abundant N hetero atoms doping are reasonably constructed by a dual template strategy.Therefore,SiO2/NC/Co-CNTs catalyst provides an extraordinary activity for the OER in alkaline media,with a low overpotential of 298 mV at a current density of 10 mA·cm-2.Furthermore,SiO2/NC/Co-CNTs hetero structure enables excellent long-term durability with a 10 mV decay in overpotential after 3000 cyclic voltammetry cycles,and 97% remain in current density over 20 h.It is believed that this dual template strategy can provide a new and simple way to construct a highly dispersed active site in electrocatalysts.

关键词： Dual template High dispersion Porous heterostructure Conductive channels Oxygen evolution reaction

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Mediating role of social support in dysphoria,despondency,and quality of life in patients undergoing maintenance hemodialysis

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World Journal of Psychiatry 2024年第3期14卷 409-420页

作者： Xiang Zhou Hong Jiang Yi-Peng Zhou Xiao-yu Wang hai-Yan Ren Xue-Fei Tian qing-qing Zhang Department of Nephrology People’s Hospital of Xinjiang Uygur Autonomous RegionXinjiang Clinical Research Center for Kidney DiseaseUrumqi 832000Xinjiang Uygur Autonomous RegionChina Department of Endocrinology and Metabolism People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 832000Xinjiang Uygur Autonomous RegionChina Section of Nephrology Department of Internal MedicineYale University School of MedicineNew HavenCT 06510United States

BACKGROUND Dysphoria and despondency are prevalent psychological issues in patients undergoing Maintenance Hemodialysis(MHD)that significantly affect their quality of life(QOL).High levels of social support can significantly improve the physical and mental well-being of patients undergoing MHD.Currently,there is limited research on how social support mediates the relationship between dysphoria,despondency,and overall QOL in patients undergoing MHD.It is imperative to investigate this mediating effect to mitigate dysphoria and despondency in patients undergoing MHD,ultimately enhancing their overall QOL.AIM To investigate the mediating role of social support in relationships between dysphoria,despondency,and QOL among patients undergoing MHD.METHODS Participants comprised 289 patients undergoing MHD,who were selected using a random sampling approach.The Social Support Rating Scale,Self-Rating Anxiety Scale,Self-Rating Depression Scale,and QOL Scale were administered.Correlation analysis was performed to examine the associations between social support,dysphoria,despondency,and QOL in patients undergoing MHD.To assess the mediating impact of social support on dysphoria,despondency,and QOL in patients undergoing MHD,a bootstrap method was applied.RESULTS Significant correlations among social support,dysphoria,despondency,and quality in patients undergoing MHD were observed(all P<0.01).Dysphoria and despondency negatively correlated with social support and QOL(P<0.01).Dysphoria and despondency had negative predictive impacts on the QOL of patients undergoing MHD(P<0.05).The direct effect of dysphoria on QOL was statistically significant(P<0.05).Social support mediated the relationship between dysphoria and QOL,and this mediating effect was significant(P<0.05).Similarly,the direct effect of despondency on QOL was significant(P<0.05).Moreover,social support played a mediating role between despondency and QOL,with a significant mediating effect(P<0.05).CONCLUSION These findings suggest that social support plays a signifi

关键词： Maintenance hemodialysis Social support Dysphoria Despondency Quality of life Mediating effect

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Mesenteric adipose tissue B lymphocytes promote intestinal injury in severe acute pancreatitis by mediating enteric pyroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 300-309页

作者： qing Huang Jia-Wen Liu hai-Bin Dong Zheng-Jie Wei Jin-Zhe Liu yu-Tang Ren Xuan Jiang Bo Jiang Department of Gastroenterology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

Background:Visceral adipose tissue(VAT)has been linked to the severe acute pancreatitis(SAP)prognosis,although the underlying mechanism remains unclear.It has been reported that pyroptosis worsens SAP.The present study aimed to verify whether mesenteric adipose tissue(MAT,a component of VAT)can cause secondary intestinal injury through the pyroptotic pathway.Methods:Thirty-six male Sprague Dawley(SD)rats were divided into six different groups.Twelve rats were randomly divided into the SAP and control groups.We monitored the changes of MAT and B lymphocytes infiltration in MAT of SAP rats.Twelve SAP rats were injected with MAT B lymphocytes or phosphate buffer solution(PBS).The remaining twelve SAP rats were first injected with MAT B lymphocytes,and then with MCC950(NLRP3 inhibitor)or PBS.We collected blood and tissue samples from pancreas,gut and MAT for analysis.Results:Compared to the control rats,the SAP group showed inflammation in MAT,including higher expression of tumor necrosis factor(TNF-α)and interleukin-6(IL-6),lower expression of IL-10,and histological changes.Flow cytometry analysis revealed B lymphocytes infiltration in MAT but not T lymphocytes and macrophages.The SAP rats also exhibited intestinal injury,characterized by lower expression of zonula occludens-1(ZO-1)and occludin,higher levels of lipopolysaccharide and diamine oxidase,and pathological changes.The expression of NLRP3 and n-GSDMD,which are responsible for pyroptosis,was increased in the intestine of SAP rats.The injection of MAT B lymphocytes into SAP rats exacerbated the inflammation in MAT.The upregulation of pyroptosis reduced tight junction in the intestine,which contributed to the SAP progression,including higher inflammatory indicators and worse histological changes.The administration of MCC950 to SAP+MAT B rats downregulated pyroptosis,which subsequently improved the intestinal barrier and ameliorated inflammatory response of SAP.Conclusions:In SAP,MAT B lymphocytes aggravated local inflammation,and promoted the injury to the int

关键词： Acute pancreatitis Mesenteric adipose tissue B lymphocyte Intestinal barrier Pyroptosis

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One-step conversion of methane and formaldehyde to ethanol over SA-FLP dual-active-site catalysts: A DFT study

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Chinese Chemical Letters 2024年第4期35卷 544-548页

作者： Tao Ban Xi-Yang yu hai-Kuo Tian Zheng-qing Huang Chun-Ran Chang Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and TechnologyXi'an Jiaotong UniversityXi'an 710049China Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization School of Chemistry and Chemical EngineeringYulin UniversityYulin 719000China

One-step conversion of methane and formaldehyde into ethanol is a 100% atom-efficient process for carbon resources utilization and environment protection but still faces eminent challenges due to the lacking of efficient catalysts. Therefore, developing active and stable catalysts is crucial for the co-conversion of methane and formaldehyde. Herein, twelve kinds of “Single-Atom”-“Frustrated Lewis Pair”(SA-FLP)dual-active-site catalysts are designed for the direct conversion of methane and formaldehyde to ethanol based on density functional theory(DFT) calculations and microkinetic simulations. The results show that the SA-FLP dual active sites can simultaneously activate methane at the SA site and activate formaldehyde at the FLP site. Among the twelve designed SA-FLP catalysts, Fe1-FLP shows the best performance in the co-conversion of methane and formaldehyde to ethanol with the rate-determining barrier of 1.15 e V.Ethanol is proved as the main product with the turnover frequency of 1.32 × 10^(-4)s^(-1)at 573 K and 3 bar.This work provides a universal strategy to design dual active sites on metal oxide materials and offers new insights into the effective conversion of methane and formaldehyde to desired C_(2) chemicals.

关键词： Single-atom Frustrated Lewis pairs Methane conversion Dual active sites Ethanol synthesis

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Cascade electrolysis and thermocatalysis: a reliable system for upgrading C1 to C4 hydrocarbons

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Rare Metals 2024年第1期43卷 410-412页

作者： Chao-yue Sun Wen Li hai-qing Wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

The carbon cycle is important for maintaining a stable climate and carbon balance on Earth. Renewable-electricitydriven upcycling of carbon dioxide (CO_(2)) into value-added multi-carbon molecules is a potentially sus... 详细信息

关键词： cycling hydrocarbons enable

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Features and formulae of sediment incipient motion in vegetated flow environment

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Journal of Hydrodynamics 2024年第2期36卷 331-339页

作者： yu-xuan Xu Wei-jie Wang Shi-bao Zhang Han-qing Zhao Xue-kai Chen hai-ping Zhang School of Water Conservancy North China University of Water Resources and Electric PowerZhengzhou450045China State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower ResearchBeijing100038China China Three Gorges Corporation Wuhan430010China

Aquatic vegetation is a vital component of natural river ecosystems,playing a crucial role in maintaining ecological balance,providing habitat and improving water quality.However,the presence of vegetation results in increased resistance in vegetated channels compared with non-vegetated channels,rendering traditional sediment movement predictions inadequate for the latter.Consequently,the concept of a vegetation influence factor,denoted by CDah,has been proposed by previous researchers to represent the effect of vegetation on sediment movement in watercourses.In this study,we focus on exploring the vegetation resistance coefficient(CD)among the vegetation influence factors,evaluating two different calculation methods for vegetation resistance coefficient,and presenting two expressions through genetic algorithm analysis to predict the incipient flow velocity of sediment in vegetated watercourses.The predicted values from the new formulae show excellent agreement with measured data,highlighting the high accuracy of the proposed methods in predicting the incipient flow velocity of sediment.Our results provide a solid theoretical basis for understanding the influence of aquatic vegetation on sediment particle movement.

关键词： Vegetation flow vegetation resistance coefficient genetic algorithm sediment initiation

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Facile preparation of Fe/N-based biomass porous carbon composite towards enhancing the thermal decomposition of DAP-4

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Defence Technology（防务技术） 2024年第1期31卷 288-294页

作者： Er-hai An Xiao-xia Li Cun-juan yu Ying-xin Tan Zi-jun Fan qing-xia Li Peng Deng Xiong Cao School of Environment and Safety Engineering North University of ChinaTaiyuan030051PR China College of Safety and Emergency Management Engineering Taiyuan University of Science and TechnologyTaiyuan030024PR China

Fe/N-based biomass porous carbon composite(Fe/N-p Carbon) was prepared by a facile high-temperature carbonization method from biomass,and the effect of Fe/N-p Carbon on the thermal decomposition of energetic molecular perovskite-based material DAP-4 was studied.Biomass porous carbonaceous materials was considered as the micro/nano support layers for in situ deposition of Fe/N precursors.Fe/Np Carbon was prepared simply by the high-temperature carbonization method.It was found that it showed the inherent catalysis properties for thermal decomposition of DAP-4.The heat release of DAP-4/Fe/N-p Carbon by DSC curves tested had increased slightly,compared from DAP-4/Fe/N-p Carbon-0.The decomposition temperature peak of DAP-4 at the presence of Fe/N-p Carbon had reduced by 79°C from384.4°C(pure DAP-4) to 305.4°C(DAP-4/Fe/N-p Carbon-3).The apparent activation energy of DAP-4thermal decomposition also had decreased by 29.1 J/mol.The possible catalytic decomposition mechanism of DAP-4 with Fe/N-p Carbon was proposed.

关键词： Biomass materials Porous carbon DAP-4 Thermal decomposition Facile method

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