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The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop

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Chinese Journal of Natural Medicines 2021年第11期19卷 815-824页

作者： CHEN Yao-dong CAI Fang-yu mao yu-Ze YANG Yong-sheng XU Kun LIU xiao-Fang FAN Wen-Wen CHEN Wu JIANG Feng-Qi zhang Hui Department of Ultrasonic Imaging the First Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Radiology the First Clinical Medical CollegeShanxi Medical UniversityTaiyuan 030001China Department of Thoracic Surgery the General Hospital of Heilongjiang Province Land Reclamation BureauHarbin 150088China Department of Cardio-Thoracic Surgery the First Affiliated Hospital of Jiamusi UniversityJiamusi 154000China Department of General Surgery Heilongjiang Provincial HospitalHarbin 150001China

Cervical cancer(CC)is recognized as the most common neoplasm in the female reproductive system *** lack of chemotherapeutic agents with outstanding effectiveness and safety severely compromises the anti-cipated prognosis of ***(ALO)is a natural quinolizidine alkaloid with marked anti-cancer effects on multiple malignancies as well as favorable activity in relieving inflammation,allergies and ***,its therapeutic efficacy and underlying mechanism in CC are still *** the current study,MTT assay was employed to evaluate the viability of HeLa cells exposed to ALO to preliminarily estimate the effectiveness of ALO in ***,the effects of ALO on the proliferation and apoptosis of HeLa cells were further investigated by plate colony formation and flow cytometry,respectively,while the migration and invasion of ALO-treated HeLa cells were evaluated using Transwell ***,nude mice were subcutaneously inoculated with HeLa cells to demonstrate the anti-CC properties of ALO in *** molecular mechanisms underlying these effects of ALO were evaluated by Western blot and immunohistochemical *** study experimentally demonstrated that ALO inhibited the proliferation of HeLa cells via G2 phase cell cycle ***,ALO promoted an increase in the percentage of apoptotic HeLa cells by increasing the Bax/Bcl-2 ***,the migration and invasion of HeLa cells were attenuated by ALO treatment,which was considered to result from inhibition of epithelial-to-mesenchymal *** molecular mechanisms,the expression and activation of the IL-6-JAK1-STAT3 feedback loop were markedly suppressed by ALO *** study indicated that ALO markedly suppresses the proliferation,migration and invasion and enhances the apoptosis of HeLa *** addition,these prominent anti-CC properties of ALO are associated with repression of the IL-6-JAK1-STAT3 feedback loop.

关键词： Cervical cancer Chemotherapy Aloperine Epithelial-mesenchymal transition IL-6-JAK1-STAT3 feedback loop

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EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma

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Signal Transduction and Targeted Therapy 2022年第3期7卷 746-757页

作者： Qu-Jing Gai Zhen Fu Jiang He Min mao xiao-Xue Yao Yan Qin Xi Lan lin zhang Jing-Ya Miao Yan-Xia Wang Jiang Zhu Fei-Cheng Yang Hui-Min lu Ze-Xuan Yan Fang-lin Chen yu shi Yi-Fang Ping You-hong Cui Xia zhang xindong Liu xiao-hong Yao sheng-Qing Lv Xiu-Wu Bian Yan Wang Institute of Pathology and Southwest Cancer Center Southwest HospitalArmy Medical University(Third Military Medical University)ChongqingChina Biobank of Institute of Pathology Southwest HospitalArmy Medical University(Third Military Medical University)ChongqingChina Institute of Cancer Xinqiao HospitalArmy Medical University(Third Military Medical University)ChongqingChina Department of Neurosurgery Xinqiao HospitalArmy Medical University(Third Military Medical University)ChongqingChina

Platelet-derived growth subunit A(PDGFA)plays critical roles in development of glioblastoma(GBM)with substantial evidence from TCGA database analyses and in vivo mouse *** far,only platelet-derived growth receptor a(PDGFRA)has been identified as receptor for ***,PDGFA and PDGFRA are categorized into different molecular subtypes of GBM in TCGA_GBM database.

关键词： PDGFRA Platelet glioblastoma

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A Meloidogyne incognita effector Minc03329 suppresses plant immunity and promotes parasitism

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Journal of Integrative Agriculture 2023年第3期22卷 799-811页

作者： ZHOU Jing-jing zhang xiao-ping LIU Rui linG Jian LI Yan YANG yu-hong xie Bing-yan ZHAO Jian-long mao Zhen-chuan State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081P.R.China

Meloidogyne incognita is a devastating plant-parasitic *** play important roles during the stages of nematodes infection and parasitism,but their molecular functions remain largely *** this study,we characterized a new effector,Minc03329,which contains signal peptide for secretion and a C-type lectin *** yeast signal sequence trap experiments indicated that the signal peptide of Minc03329 is *** situ hybridization showed that Minc03329 was specifically expressed in the subventral esophageal ***-time qPCR confirmed that the expression level of Minc03329 transcript was significantly increased in pre-parasitic and parasitic second-stage juveniles(pre-J2s and par-J2s).Tobacco rattle virus(TRV)-mediated gene silencing of Minc03329 in host plants largely reduced the pathogenicity of *** the contrary,ectopic expression of Minc03329 in Arabidopsis thaliana significantly increased plant susceptibility to *** expression of Minc03329 in Nicotiana benthamiana leaves suppressed the programmed cell death triggered by the pro-apoptotic protein ***,the transcriptome analysis of Minc03329-transgenic Arabidopsis and wild type revealed that many defense-related genes were significantly ***,some different expressed genes were involved in the formation of nematode feeding *** results revealed that Minc03329 is an important effector for ***,suppressing host defense response and promoting pathogenicity.

关键词： Meloidogyne incognita effector C-type lectin pathogenicity plant immunity

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清末民初踢毽运动发展述论

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山西大同大学学报（社会科学版） 2024年第5期38卷 26-30页

作者：唐彦张钰菁谢维俊张德顺毛俊生北京大学体育教研部北京100871 北京大学历史学系北京100871 南京邮电大学体育部江苏南京210023 淮阴师范学院历史文化旅游学院江苏淮阴223001 天津体育学院运动训练科学学院天津300211

传统踢毽作为中华民族传统运动,自发明之始便受到大众的喜爱。由于踢毽制作的随手可得和对不同身体素质的兼容,民国时期的教育部把踢毽在大学教学纲要中列为和缓运动,提倡踢毽还具有着推广民族运动,宣传尚武精神,增强民族凝聚力的重要... 详细信息

传统踢毽作为中华民族传统运动,自发明之始便受到大众的喜爱。由于踢毽制作的随手可得和对不同身体素质的兼容,民国时期的教育部把踢毽在大学教学纲要中列为和缓运动,提倡踢毽还具有着推广民族运动,宣传尚武精神,增强民族凝聚力的重要作用。本篇文章以文献分析法为主,选取民国报纸为主要史料,对清末民初传统毽球运动在国内的发展深度还原,以填补相关历史叙述之空缺,亦为当代传统踢毽等民族传统体育项目的发展、复兴提供借鉴。

关键词：传统踢毽毽球运动民族运动

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Application of Virtual Reality Technology in Disaster Medicine

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Current Medical Science 2019年第5期39卷 690-693页

作者： yu-yu DUAN Jia-yao zhang mao xie xiao-bo FENG Song XU Zhe-wei YE The Clinical School of Chinese Medicine Hubei University of Chinese MedicineWuhan 430065China Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

The occurrence of major emergencies often leads to environmental damage,property damage,health challenges and life *** the tremendous progress we have made in responding to the many challenges posed by disasters in recent years,there are still many *** an emerging technology widely used in recent years,virtual reality(VR)technology is very suitable for many fields of disaster medicine,such as basic education,professional training,psychotherapy,*** purpose of this review article is to introduce the application of VR technology in the disaster medical field and prospect its trend in the future.

关键词： virtual reality disaster medicine education psychotherapy

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巴戟天寡糖胶囊用于轻、中度抑郁症患者巩固期治疗的临床研究

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中国临床药理学杂志 2024年第6期40卷 815-819页

作者：周书喆韩祖成王秀珍陈燕清呼亚玲余雪芹王斌红樊国珍桑红海英贾智捷王占敏魏琰朱建国宋学勤刘志东况利王洪明田峰李玉欣张玲林海吴斌王超英刘畅孙佳凡闫少校刘君谢守付房茂胜宓为峰张鸿燕北京大学第六医院北京大学精神卫生研究所国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院)国家药物临床试验机构办公室北京100191 陕西省中医医院精神科陕西西安710003 沈阳市精神卫生中心精神科辽宁沈阳110168 山西中医学院附属医院精神科山西太原030024 山西大医院中医科山西大同037046 重庆市精神卫生中心精神科重庆400036 太原市精神病医院精神科山西太原030045 吉林省神经精神病医院精神科吉林松原138001 长春市第六医院精神科吉林长春130052 辽宁中医药大学附属医院精神科辽宁沈阳110033 河北省荣军医院精神科河北石家庄050899 衡水人民医院神经科河北衡水053099 郑州大学第一附属医院精神科河北郑州450052 天津市第四中心医院精神科天津300142 重庆医科大学附属第一医院精神科重庆400042 成都市第四人民医院精神科四川成都610036 山西医科大学第二医院精神科山西太原030001 河北省精神卫生中心精神科河北保定071030 首都医科大学附属北京安定医院精神科北京100120 西安市中医医院精神科陕西西安710021 西安市精神卫生中心精神科陕西西安710061 湖南省脑科医院精神科湖南长沙410021 吉林大学第一医院精神科吉林长春130061 山西省中西医结合医院精神科山西太原030013 北京回龙观医院精神科北京102208 辽宁中医药大学附属第二医院精神科辽宁沈阳110034 大连市第七人民医院精神科辽宁大连116086 武汉市精神卫生中心精神科湖北武汉430012

目的观察巴戟天寡糖胶囊用于治疗轻、中度抑郁症患者的24周巩固期的疗效和安全性。方法本研究采用开放、单臂、多中心设计,纳入已完成巴戟天寡糖急性期治疗的成人轻、中度抑郁症患者,继续给予巴戟天寡糖胶囊24周,巩固期维持治疗剂量不变... 详细信息

目的观察巴戟天寡糖胶囊用于治疗轻、中度抑郁症患者的24周巩固期的疗效和安全性。方法本研究采用开放、单臂、多中心设计,纳入已完成巴戟天寡糖急性期治疗的成人轻、中度抑郁症患者,继续给予巴戟天寡糖胶囊24周,巩固期维持治疗剂量不变,用汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)、临床总体印象量表-严重度(CGI-S)和亚利桑那性体验量表(ASEX)评估治疗前后的变化,评估患者的缓解率、复燃率及复燃时间,观察患者治疗相关不良事件的发生情况。结果治疗前后患者的HAMD-17评分分别为(6.60±1.87)和(5.85±4.18)分,HAMA评分分别为(6.36±3.02)和(4.93±3.09)分,CGI-S评分分别为(1.49±0.56)和(1.29±0.81)分,ASEX评分分别为(15.92±4.72)和(15.57±5.26)分,在统计学上差异均有统计学意义(均P<0.05)。用药24周末,患者的缓解率为54.59%(202例/370例),复燃率为6.49%(24例/370例),复燃时间为(64.67±42.47)d。巴戟天寡糖胶囊药物不良反应发生率为15.35%(64例/417例)。结论巴戟天寡糖胶囊能用于轻、中度抑郁症患者的巩固期治疗,且具有良好的耐受性和安全性。

关键词：巴戟天寡糖胶囊抑郁症疗效安全性

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猪链球菌3型的分离鉴定及耐药性分析

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黑龙江畜牧兽医 2024年第14期 74-80,126页

作者：毛从剑曹冶于吉锋吴学婧谢晶肖璐叶勇刚叶健强林毅潘梦魏勇李兴玉张先慧曾凯康润敏四川省畜牧科学研究院动物遗传育种四川省重点实验室成都610066

为查明四川地区某规模化猪场猪发病死亡原因并进行有效防控,试验采集病死猪肺脏组织样本4份进行细菌的分离,并对分离菌株进行菌落形态观察、革兰氏染色和镜检、猪链球菌的PCR鉴定、血清型鉴定、主要毒力基因检测、药敏试验和耐药基因检... 详细信息

为查明四川地区某规模化猪场猪发病死亡原因并进行有效防控,试验采集病死猪肺脏组织样本4份进行细菌的分离,并对分离菌株进行菌落形态观察、革兰氏染色和镜检、猪链球菌的PCR鉴定、血清型鉴定、主要毒力基因检测、药敏试验和耐药基因检测。结果表明:从病料中共分离到4株菌,4株分离菌株在胰酪大豆胨琼脂培养基(TSA)中均呈灰白色、针尖状、圆形的菌落,革兰氏染色后镜检可见呈蓝紫色、圆形或卵圆形、链状排列的革兰氏阳性菌,符合猪链球菌的形态特征,分别命名为SYS9、SYS14、SYS15和SYS16。经猪链球菌的PCR鉴定和血清型鉴定确定4株分离菌株均为猪链球菌3型。4株猪链球菌分为2种毒力基因型,SYS9株的毒力基因型为mrp+epf+sly+fbps+cps-orf2+,SYS14、SYS15和SYS16的毒力基因型为mrp+epf+sly+fbps+cps+orf2+;4株猪链球菌均对四环素和泰乐菌素耐药,且均对阿莫西林(青霉素类药物),氟苯尼考和氯霉素(酰胺醇类药物),利奈唑胺(口恶唑烷酮类药物),头孢匹罗、头孢氨苄和头孢拉定(头孢菌素类药物),环丙沙星和左氟沙星(喹诺酮类药物)敏感。除SYS9株仅对四环素和泰乐菌素耐药外,其余3株菌均为3重或3重以上耐药菌株,其中SYS15株为6重耐药菌株。4株猪链球菌均未检出耐药基因ermA、mefA、msrD、fexA、fexB、aph(3′)-Ⅲa、ant(6′)-Ⅰa、aph(2′)-Ⅰb;SYS9株检出耐药基因tetO和ermB,SYS14株检出耐药基因tetM、tetO、ermB、aac(6′)-aph(2″)和optrA,SYS15株检出耐药基因tetM、tetO、tetL、ermB、aac(6′)-aph(2″)和optrA,SYS16株检出耐药基因tetM、tetO、tetL、ermB、aac(6′)-aph(2″)、optrA和Lsa(E)。说明该规模化猪场猪发病死亡原因为猪链球菌3型感染,可使用青霉素类、酰胺醇类、口恶唑烷酮类、头孢菌素类、喹诺酮类药物进行治疗。

关键词：猪链球菌3型细菌分离鉴定耐药性耐药基因

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Y-box binding protein 1 augments sorafenib resistance via the PI3K/Akt signaling pathway in hepatocellular carcinoma

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World Journal of Gastroenterology 2021年第28期27卷 4667-4686页

作者： Ting Liu xiao-Li xie Xue Zhou sheng-Xiong Chen Yi-Jun Wang lin-Ping shi Shu-Jia Chen Yong-Juan Wang Shu-ling Wang Jiu-Na zhang shi-Ying Dou xiao-yu Jiang Ruo-lin Cui Hui-Qing Jiang Department of Gastroenterology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Hepatobiliary Surgery The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Gastroenterology Hebei General HospitalShijiazhuang 050000Hebei ProvinceChina Department of Gastroenterology Shijiazhuang People’s HospitalShijiazhuang 050000Hebei ProvinceChina Department of Infectious Diseases The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Sorafenib is the first-line treatment for patients with advanced hepatocellular carcinoma(HCC).Y-box binding protein 1(YB-1)is closely correlated with tumors and drug ***,the relationship between YB-1 and sorafenib resistance and the underlying mechanism in HCC remain *** To explore the role and related mechanisms of YB-1 in mediating sorafenib resistance in *** The protein expression levels of YB-1 were assessed in human HCC tissues and adjacent nontumor ***,we constructed YB-1 overexpression and knockdown hepatocarcinoma cell lines with lentiviruses and stimulated these cell lines with different concentrations of ***,we detected the proliferation and apoptosis in these cells by terminal deoxynucleotidyl transferase dUTP nick end labeling,flow cytometry and Western blotting *** also constructed a xenograft tumor model to explore the effect of YB-1 on the efficacy of sorafenib in ***,we studied and verified the specific molecular mechanism of YB-1 mediating sorafenib resistance in hepatoma cells by digital gene expression sequencing(DGE-seq).RESULTS YB-1 protein levels were found to be higher in HCC tissues than in corresponding nontumor ***-1 suppressed the effect of sorafenib on cell proliferation and ***,the efficacy of sorafenib in vivo was enhanced after YB-1 was knocked ***,KEGG pathway enrichment analysis of DGEseq demonstrated that the phosphoinositide-3-kinase(PI3K)/protein kinase B(Akt)signaling pathway was essential for the sorafenib resistance induced by ***,YB-1 interacted with two key proteins of the PI3K/Akt signaling pathway(Akt1 and PIK3R1)as shown by searching the BioGRID and HitPredict ***,YB-1 suppressed the inactivation of the PI3K/Akt signaling pathway induced by sorafenib,and the blockade of the PI3K/Akt signaling pathway by LY294002 mitigated YB-1-induced sorafenib *** Overall,we con

关键词： Y-box binding protein 1 Hepatocellular carcinoma Sorafenib Drug resistance Phosphoinositide-3-kinase/protein kinase B

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Clinical Research Regarding the Ratio of Lymph Node Metastasis and the Reasonable Extent of Lymphadenectomy in Middle Third Thoracic Esophageal Squamous Cell Carcinoma

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Clinical oncology and cancer researeh 2010年第1期7卷 33-38页

作者： Ming-ran xie Peng lin Xu zhang Jie-xin CHEN Yong-bin lin Zhe-sheng WEN Tie-hua RONG xiao-dong LI Jun-ye WANG Hui yu State Key Laboratory of Oncology in SouthChina Department of Thoracic OncologyCancer Center Sun Yat-sen UniversityGuangzhou 510060 Guangdong ProvinceChina.

OBJECTIVE To explore the extent of lymphadenectomy deemed reasonable by analyzing the influence of the regular pattern and ratio of lymph node metastasis on the prognosis of the patients with middle third thoracic esophageal squamous cell carcinoma. METHODS Clinical data from 129 patients with middle third thoracic esophageal squamous cell carcinoma who underwent curative esophagectomy with modem two-field lymphadenectomy were retrospectively analyzed. RESULTS The rate of lymphatic metastasis in EC patients was 56.6% in all groups, and the ratio of lymph node metastasis （RLNM, i.e. positive nodes/total dissected nodes） was 11.3%, with a lymphatic metastasis rate of 43.4% in the superior mediastinum. The most commonly involved regions included the sites around the esophagus, the right recurrent laryngeal nerve and the left- sided blood vessels of stomach, as well as the cardia and the inferior tracheal protuberance. The main factors influencing lymphatic metastasis were the depth of tumor infiltration, differentiation of tumor cells and the size of the tumor. The 5-year survival rate for patients in the groups without lymphatic metastasis, with a RLNM 〈 20%, and a metastasis ratio 〉 20% was 50.4%, 31.0% and 6.8%, respectively. The differences were statistically significant among the groups （P = 0.000）. CONCluSION The RLNM is one of the key factors affecting the prognosis of EC patients. For conventional therapy for patients with middle third thoracic esophageal carcinoma, modern 2-field lymphadenectomy, including node dissection in the bilateral superior mediastinum, should be performed.

关键词： esophagus cancer lymph nodes metastasis lymphadenectomy.

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Structural and optical investigation of nonpolar a-plane GaN grown by metal-organic chemical vapour deposition on r-plane sapphire by neutron irradiation

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Chinese Physics B 2012年第2期21卷 531-535页

作者： Xu sheng-Rui zhang Jin-Feng Gu Wen-Ping Hao yue zhang Jin-Cheng Zhou xiao-Wei lin Zhi-yu mao Wei National Key Laboratory of Fundamental Science for Wide Band-Gap Semiconductor Technology School of MicroelectronicsXidian UniversityXi'an 710071China

Nonpolar （1150） a-plane GaN films are grown by metal-organic chemical vapour deposition （MOCVD） on r-plane （1102） sapphire. The samples are irradiated with neutrons under a dose of 1× 1015 cm-2. The surface morphology, the crystal defects and the optical properties of the samples before and after irradiation are analysed using atomic force microscopy （AFM）, high resolution X-ray diffraction （HRXRD） and photoluminescence （PL）. The AFM result shows deteriorated sample surface after the irradiation. Careful fitting of the XRD rocking curve is carried out to obtain the Lorentzian weight fraction. Broadening due to Lorentzian type is more obvious in the as-grown sample compared with that of the irradiated sample, indicating that more point defects appear in the irradiated sample. The variations of line width and intensity of the PL band edge emission peak are consistent with the XRD results. The activation energy decreases from 82.5 meV to 29.9 meV after irradiation by neutron.

关键词： GaN neutron nonpolar photoluminescence

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