检索结果-南通市图书馆

Chinese Chemical Letters 2024年第10期35卷 241-243页

作者： yu Pang Min Wang Ning-Hua Yang Min Xue yong Yang School of Science Department of PhysicsKey Laboratory of Optical Field Manipulation of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou 310018China School of Chemistry and Chemical Engineering Key Laboratory of Surface&Interface Science of Polymer Materials of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou310018China

Trifluoroacetic acid(TFA)catalyzed condensation reaction between tetraaminooxacalix[4]arene and N-alkylcarbazole-3,6-dicarbaldehyde in CH_(2)Cl2afforded a single product in 87%–89%***-defined yet undissolvable1H NMR spectra suggested formation of robust and discrete structures in solution.X-ray single crystal analysis further revealed a giant twisted double-layer chiral macrocycle in the solid state,which was formed from[4+8]condensation of the two reactants via 16 imine *** calculations discovered that only the[4+8]twisted product is thermodynamically favorable,which accounts for its highly selective and efficient formation out of a library of many other combinations.

关键词： One-pot synthesis Oxacalixarene Dynamic covalent chemistry Chiral macrocycle X-ray single crystal

Effect of Lightweight Aggregates Incorporation on the Mechanical Properties and Shrinkage Compensation of a Cement-Ground Granulated Blast Furnace Slag-Phosphogypsum Ternary System

在线全文

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2024年第8期20卷 1773-1784页

作者： yu Wang Mengyang Ma yong Long Qingxiang Zhao Zhifei Cheng State Key Laboratory of Bridge Intelligent and Green Construction China Railway Major Bridge Engineering Group Co.Ltd.Wuhan430034China China Railway Bridge Science Research Institute. Ltd.Wuhan430034China

Shrinkage-induced cracking is a common issue in concrete structures,where the formation of cracks not only affects the aesthetic appearance of concrete but also potentially reduces its durability and *** this study,the effect of ceramsite sand addition on the properties of a ternary system of cement-ground granulated blast furnace slag(GGBFS)-phosphogypsum(PG)is *** particular,the fluidity,rheology,hydration heat,compressive strength,autogenous shrinkage,and drying shrinkage of the considered mortar specimens are *** results indicate that an increase in PG content leads to a decrease in fluidity,higher viscosity,lower exothermic peak,and lower compressive ***,the shrinkage of the mortar specimens is effectively *** incorporation of internal curing water from ceramsite sand improves fluidity,decreases both yield stress and viscosity,enhances the degree of hydration,and induces mortar ***,the inferior mechanical properties of the ceramsite sand generally produce a decrease in the compressive strength.

关键词： Phosphogypsum ceramsite sand internal curing mechanical property shrinkage

Transglutaminase 2 serves as a pathogenic hub gene of KRAS mutant colon cancer based on integrated analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2074-2090页

作者： Wei-Bin Peng yu-Ping Li yong Zeng Kai Chen First People’s Hospital of Foshan Foshan 528000Guangdong ProvinceChina Department of Radiation Oncology Cancer Hospital of Shantou University Medical CollegeShantou 515031Guangdong ProvinceChina

BACKGROUND Colon cancer is acknowledged as one of the most common malignancies worldwide,ranking third in United States regarding incidence and ***,approximately 40%of colon cancer cases harbor oncogenic KRAS mutations,resulting in the continuous activation of epidermal growth factor receptor *** To investigate the key pathogenic genes in KRAS mutant colon cancer holds considerable *** Weighted gene co-expression network analysis,in combination with additional bioinformatics analysis,were conducted to screen the key factors driving the progression of KRAS mutant colon ***,various in vitro experiments were also conducted to explore the biological function of transglutaminase 2(TGM2).RESULTS Integrated analysis demonstrated that TGM2 acted as an independent prognostic factor for progression-free *** analysis on tissue microarrays revealed that TGM2 was associated with an elevated probability of perineural invasion in patients with KRAS mutant colon ***,biological roles of the key gene TGM2 was also assessed,suggesting that the downregulation of TGM2 attenuated the proliferation,invasion,and migration of the KRAS mutant colon cancer cell *** This study underscores the potential significance of TGM2 in the progression of KRAS mutant colon *** insight not only offers a theoretical foundation for therapeutic approaches but also highlights the need for additional clinical trials and fundamental research to support our preliminary findings.

关键词： Colon cancer KRAS mutation Transglutaminase 2 Weighted gene co-expression network analysis

Searching for the optimal precondition procedure for mesenchymal stem/stromal cell treatment:Facts and perspectives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第6期16卷 615-618页

作者： yu-Dong Zhao yong-Can Huang Wei-Shi Li Department of Orthopedic Peking University Third HospitalBeijing 100191China Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies Orthopaedic Research CenterPeking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina

Mesenchymal stem/stromal cells are potential optimal cell sources for stem cell therapies,and pretreatment has proven to enhance cell vitality and *** a recent publication,Li et al explored a new combination of pretreatment ***,we present an editorial to comment on their work and provide our view on mesenchymal stem/stromal cell precondition.

关键词： Mesenchymal stem cell Precondition Hypoxia Inflammation

基于法线夹角与面积分布的三维CAD模型检索

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四川大学学报（自然科学版） 2014年第6期51卷 1156-1162页

作者：陈强余永梅唐雁西南大学计算机与信息科学学院重庆400715

三维CAD检索技术对产品设计、重用具有促进作用.经典的三维模型检索算法——形状分布算法SD,适用于全局特征相似的模型检索,但对于全局相似但局部差异明显的模型则无法有效检索.针对这一问题,本文首先提取SD特征,并利用基于法线夹角与... 详细信息

三维CAD检索技术对产品设计、重用具有促进作用.经典的三维模型检索算法——形状分布算法SD,适用于全局特征相似的模型检索,但对于全局相似但局部差异明显的模型则无法有效检索.针对这一问题,本文首先提取SD特征,并利用基于法线夹角与面积分布的特征提取技术来对模型局部特征进行描述,随后通过构造特征矩阵来融合提取到的法线夹角与面积分布两类特征,最后将SD特征与法线夹角与面积分布特征进行组合,形成新的特征并应用于检索.实验结果验证了该方法的有效性.

关键词：三维CAD检索面积分布特征矩阵法线夹角

Enhanced cyclic stability of partially disordered spinel cathodes through direct fluorination with gaseous fluorine

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第4期43卷 1635-1646页

作者： yong-Nian Ma Ling-Chen Kong Shao-Shan Chen yong Wang Li-Dong Sun Cong Peng Meng-Meng Qin yu Li Wei Feng Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin300072China Institute of Advanced Technology and Equipment Beijing University of Chemical TechnologyBeijing100029China

Spinel-type cathodes are considered an optimal substitute for conventional layered oxide cathodes owing to their use of inexpensive and earth-abundant manganese as the redox-active ***,the introduction of cation disorder can effectively suppress the detrimental two-phase reaction to realize high capacities in a wide voltage ***,the continuous capacity decay during cycles has hindered the widespread application of these cathode *** fluorides exhibit excellent electrochemical stability at high voltage;therefore,in this study,the direct F2 gas reaction with a partially disordered spinel cathode(Li_(1.6)Mn_(1.6)O_(3.7)F_(0.3,)LMOF1.6)was initially applied to investigate the impacts of fluorination on the surface structure and electrochemical *** inorganic fluorinated layer,mainly containing LiF,was distributed uniformly on the surface of LMOF1.6nanoparticles after fluorination for an appropriate time without the turbulence caused by the valency of manganese cation,which improved the capacity retention and rate capability by the suppression of structural damage,parasitic reaction,and cation *** LMOF1.6cathode fluorinated for 0.5 h exhibited a capacity of283.6 mAh·g^(-1)at 50 mA·g^(-1)and an enhanced capacity retention of 29.6%after 50 cycles in the voltage range of1.5-4.8 V,as compared to the pristine LMOF1.6 with only27.9%capacity retention.

关键词： Spinel-type cathodes Direct fluorination Capacity retention ability High rate capability

Gas sensor array based on carbon-based thin-film transistor for selective detection of indoor harmful gases

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4401-4411页

作者： Can Liu yu Sun Jia-Yi Guo Xiu-Lei Li Lu Tao Jin-yong Hu Jue-Xian Cao Ping-Hua Tang yong Zhang School of Electrical and Information Engineering Hunan Institute of EngineeringXiangtan 411104China Physics and Optoelectronics&Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China

The identification of indoor harmful gases is imperative due to their significant threats to human health and *** achieve accurate identification,an effective strategy of constructing a sensor array combined with the pattern recognition algorithm is ***-based thin-film transistors are selected as the sensor array unit,with semiconductor carbon nanotubes(CNTs)within the TFT channels modified with different metals(Au,Cu and Ti)for selective responses to NH_(3),H_(2)S and HCHO,*** accurate gas species identification,an identification mode that combines linear discriminant analysis algorithms and logistic regression classifier is *** test results demonstrate that by preprocessing the sensor array’s sensing data with the LDA algorithm and subsequently employing the LR classifier for identification,a 100%recognition rate can be achieved for three target gases(NH3,H2S and HCHO).This work provides significant guidance for future applications of chip-level gas sensors in the realms of the Internet of Things and Artificial Intelligence.

关键词： Carbon-based thin-film transistors Gas sensor arrays Semiconductor carbon nanotubes Multi-gas detection Linear discriminant analysis

Di-and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第6期67卷 1089-1105页

作者： Runfa Chen Meng-Jie Zhao yu-Min Li Ao-Hui Liu Ru-Xin Wang yu-Chao mei Xuefeng Chen Hai-Ning Du Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismHubei Clinical Research Center of Emergency and ResuscitationEmergency Center of Zhongnan HospitalWuhan UniversityWuhan 430072China Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismWuhan UniversityWuhan 430072China

Histone H3 Lys36(H3K36)methylation and its associated modifiers are crucial for DNA double-strand break(DSB)repair,but the mechanism governing whether and how different H3K36 methylation forms impact repair pathways is ***,we unveil the distinct roles of H3K36 dimethylation(H3K36me2)and H3K36 trimethylation(H3K36me3)in DSB repair via non-homologous end joining(NHEJ)or homologous recombination(HR).Yeast cells lacking H3K36me2 or H3K36me3 exhibit reduced NHEJ or HR efficiency.y Ku70 and Rfa1 bind H3K36me2-or H3K36me3-modified peptides and chromatin,*** these interactions impairs y Ku70 and Rfa1 recruitment to damaged H3K36me2-or H3K36me3-rich loci,increasing DNA damage sensitivity and decreasing repair ***,H3K36me2-enriched intergenic regions and H3K36me3-enriched gene bodies independently recruit y Ku70 or Rfa1 under DSB ***,human KU70 and RPA1,the homologs of y Ku70 and Rfa1,exclusively associate with H3K36me2 and H3K36me3 in a conserved *** findings provide valuable insights into how H3K36me2 and H3K36me3 regulate distinct DSB repair pathways,highlighting H3K36 methylation as a critical element in the choice of DSB repair pathway.

关键词： histone H3K36 methylation Ku70 RPA non-homologous end joining homologous recombination

同方期刊数据库

Synthesis of Planar-Chiral[2.2]Paracyclophane-Based Oxazole-Pyrimidine Ligands and Application in Nickel-Catalyzed 1,2-Reduction ofα,β-Unsaturated Ketones

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第7期42卷 705-710页

作者： Juan Wang Qing-Xian Xie Xiang Li Chang-Bin yu yong-Gui Zhou School of Chemistry Dalian University of Technology2 Linggong RoadDalianLiaoning 116024China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning 116023China

The planar-chiral ligands have been widely applied as a class of unique and significant ligands in asymmetric *** them,chiral[2.2]paracycyclophane has emerged as a privileged type of planar-chiral framework and has been utilized as an important toolbox due to their structural ***,we design and synthesize[2.2]paracyclophane-derived oxazole-pyrimidine ligands(abberviated as PYMCOX).These N,N-ligands with stable properties,rigid structure and large steric hindrance performed successfully in nickel-catalyzed asymmetric 1,2-reduction ofα,β-unsaturated ketones,affording the chiral allylic alcohols with up to 99%yield and 99%***,this reduction reaction could be conducted on gram-scale without loss of activity and enantioselectivity,and the chiral ligand could be conveniently recovered with high yield.

关键词： Oxazole-pyrimidine ligands Planar chirality Nickel Hydroboration Asymmetric synthesis

Correlation between Combined Urinary Metal Exposure and Grip Strength under Three Statistical Models:A Cross-sectional Study in Rural Guangxi

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第1期37卷 3-18页

作者： LIANG yu Jian RONG Jia Hui WANG Xue Xiu CAI Jian Sheng QIN Li Dong LIU Qiu mei TANG Xu MO Xiao Ting WEI Yan Fei LIN Yin Xia HUANG Shen Xiang LUO Ting yu GOU Ruo yu CAO Jie Jing HUANG Chu Wu LU yu Fu QIN Jian ZHANG Zhi yong Department of Environmental and Occupational Health School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Tumor Immunology and Microenvironmental Regulation Guilin Medical UniversityGuilin 541199GuangxiChina Department of Environmental Health and Occupational Medicine School of Public HealthGuilin Medical UniversityGuilin 541199GuangxiChina Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Key Laboratory of Environment and Health Research Guangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care Guilin Medical UniversityGuilin 541199GuangxiChina

Objective This study aimed to investigate the potential relationship between urinary metals copper(Cu),arsenic(As),strontium(Sr),barium(Ba),iron(Fe),lead(Pb)and manganese(Mn)and grip *** We used linear regression models,quantile g-computation and Bayesian kernel machine regression(BKMR)to assess the relationship between metals and grip *** In the multimetal linear regression,Cu(β=−2.119),As(β=−1.318),Sr(β=−2.480),Ba(β=0.781),Fe(β=1.130)and Mn(β=−0.404)were significantly correlated with grip strength(P<0.05).The results of the quantile g-computation showed that the risk of occurrence of grip strength reduction was−1.007(95%confidence interval:−1.362,−0.652;P<0.001)when each quartile of the mixture of the seven metals was *** kernel function regression model analysis showed that mixtures of the seven metals had a negative overall effect on grip strength,with Cu,As and Sr being negatively associated with grip strength *** the total population,potential interactions were observed between As and Mn and between Cu and Mn(P_(interactions) of 0.003 and 0.018,respectively).Conclusion In summary,this study suggests that combined exposure to metal mixtures is negatively associated with grip ***,Sr and As were negatively correlated with grip strength levels,and there were potential interactions between As and Mn and between Cu and Mn.

关键词： Urinary metals Handgrip strength Quantile g-computation Bayesian kernel machine regression