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Suppression of pancreatic carcinoma growth by activating peroxisome proliferator-activated receptor γ involves angiogenesis inhibition

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World Journal of Gastroenterology 2009年第4期15卷 441-448页

作者： yu-wei dong Xing-Peng Wang Kai Wu Department of Gastroenterology Shanghai First-People's Hospital Shanghai Jiaotong UniversityShanghai 200080 China Department of Gastroenterology The Tenth People's Hospital of Tongji University Yanchang Road (M)Shanghai 200072 China

AIM： TO Study the possible actions and mechanisms or peroxisome proliferator-activated receptor γ （PPARγ）, a ligand-activated transcription factor, in pancreatic car- cinogenesis, especially in angiogenesis. METHODS： Expressions of PPARy and retinoid acid receptor （RXRα） were examined by reverse-transcription polymerase chain reaction （RT-PCR） with immunocyto- chemical staining. Pancreatic carcinoma cells, PANC-1, were treated either with 9-cis-RA, a ligand of RXRα, or with 15-deoxy-△12,14 prostaglandin J2 （15d-PGJ2）, a ligand of PPART, or both. Antiproliferative effect was evaluated by cell viability using methyltetrazolium （MTT） assay. A pancreatic carcinoma xenograft tumor model of nude mice was established by inoculating PANC-1 cells subcutaneously. Rosiglitazone, a specific ligand of PPARy, was administered via water drinking in experimental group of nude mice. After 75 d, all mice were sacrificed. Expression of proliferating cell nuclear antigen （PCNA） in tumor tissue was examined with immunohistochemical staining. Expression of vascular endothelial growth factor （VEGF） mRNA in PANC-1 cells, which were treated with 15d-PGJ2 or 9-cis-RA at various concentrations or different duration, was detected by semi-quantitative RT-PCR. Effects of Rosi- glitazone on changes of microvascular density （MVD） and VEGF expression were investigated in xenograft tumor tissue. Neovasculature was detected with immu- nohistochemistry staining labeled with anti-Ⅳ collagen antibody, and indicated by MVD. RESULTS： RT-PCR and immunocytochemical stain- ing showed that PPARγ and RXRα were expressed in PANC-1 cells at both transcription level and translation level. MTT assay demonstrated that 15d-PGJ2, 9-cis-RA and their combination inhibited the growth of PANC-1 cells in a dose-dependent manner. 9-cis-RA had a com- bined inhibiting action with 15d-PGJ2 on the growth of pancreatic carcinoma. In vivo studies revealed that Rosiglitazone significantly suppressed the growth of pancreatic carci

关键词： Pancreatic carcinoma Peroxisome prolifer-ator-activated receptor γ Angiogenesis Vascular en-dothelial growth factor

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EXTRACTION OF INTERNAL TIDE FROM CURRENT

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Journal of Hydrodynamics 2001年第3期13卷 138-142页

作者： Pan, Zeng-Di Han, Chun-Ming yu, wei-dong Key Lab. of Mar. Sci. and Numl. Mode First Inst. of Oceanography State Oceanic Administration Qingdao 266061 China

In order to extract the internal tidal current from the current data which is not measured from the sea surface to the bottom, a data processing method is developed. It is based on the fact that the internal wave currents above and below the sharp thermocline are inverse in direction. This method is a practical extension to that proposed by Shu (1985) that can be only used to quite ideal current data. The ADCP data collected on the South China Sea is then processed by this method. The internal tidal current is successfully extracted.

关键词： Data processing Thermal gradients Tides

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Dmrt1 regulates the immune response by repressing the TLR4 signaling pathway in goat male germline stem cells

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Zoological Research 2021年第1期42卷 14-27页

作者： yu-dong wei Xiao-Min Du dong-Hui Yang Fang-Lin Ma Xiu-wei yu Meng-Fei Zhang Na Li Sha Peng Ming-Zhi Liao Guang-Peng Li Chun-Ling Bai wei-Shuai Liu Jin-Lian Hua College of Veterinary Medicine Northwest A&F UniversityShaanxi Centre of Stem Cells Engineering&TechnologyYanglingShaanxi 712100China College of Life Sciences Northwest A&F UniversityYanglingShaanxi 712100China State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock School of Life SciencesInner Mongolia UniversityHohhotInner Mongolia 010021China Department of Pathology Yangling Demonstration Zone HospitalYangling Shaanxi 712100China

Double sex and mab-3-related transcription factor 1(Dmrt1),which is expressed in goat male germline stem cells(mGSCs)and Sertoli cells,is one of the most conserved transcription factors involved in sex *** this study,we highlighted the role of Dmrt1 in balancing the innate immune response in goat ***1 recruited promyelocytic leukemia zinc finger(Plzf),also known as zinc finger and BTB domain-containing protein 16(Zbtb16),to repress the Toll-like receptor 4(TLR4)-dependent inflammatory signaling pathway and nuclear factor(NF)-κ*** of Dmrt1 in seminiferous tubules resulted in widespread degeneration of germ and somatic cells,while the expression of proinflammatory factors were significantly *** also demonstrated that Dmrt1 stimulated proliferation of mGSCs,but repressed apoptosis caused by the immune ***,Dmrt1 is sufficient to reduce inflammation in the testes,thereby establishing the stability of spermatogenesis and the testicular microenvironment.

关键词： Male germline stem cells(mGSCs) Goat Dmrt1 Plzf Immune response

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The Kelvin Wave Processes in the Equatorial Indian Ocean during the 2006-2008 IOD Events

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Atmospheric and Oceanic Science Letters 2012年第4期5卷 324-328页

作者： DU Yan LIU Kai ZHUANG wei yu wei-dong State Key Laboratory of Tropical Oceanography South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 China First Institute of Oceanography State Oceanic Administration Qingdao 266061 China

The present study investigates the role of Kelvin wave propagations along the equatorial Indian Ocean during the 2006-2008 Indian Ocean Dipole(IOD).The 2006 IOD lasted for seven months,developing in May and reaching its peak in December,while the 2007 and 2008 IODs were short-lived events,beginning in early May and ending abruptly in September,with much weaker *** with the above IODs,the impulses of the sea surface height(SSH) anomalies reflect the forcing from an intraseasonal time scale,which was important to the evolution of IODs in 2007 and *** the thermocline depth,dominated by the propagation of Kelvin waves,the warming/cooling temperature signals could reach the surface at a particular *** the force is strong and the local thermocline condition is favorable,the incoming Kelvin waves dramatically impact the sea surface temperature(SST) in the eastern equatorial Indian *** July 2007 and late July 2008,the downwelling Kelvin waves,triggered by the Madden-Julian Oscillation(MJO) in the eastern and central equatorial Indian Ocean,suppressed the thermocline in the Sumatra and the Java coast and terminated the IOD,which made those events short-lived and no longer persist into the boreal fall season as the canonical IOD does.

关键词： Kelvin wave IOD equatorial Indian Ocean MJO

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Experimental Realization of Degenerate Fermi Gases of ^(87)Sr Atoms with 10 or Two Spin Components

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Chinese Physics Letters 2019年第9期36卷 18-22页

作者： wei Qi Ming-Cheng Liang Han Zhang yu-dong wei Wen-wei Wang Xu-Jie Wang Xibo Zhang International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871 Collaborative Innovation Center of Quantum Matter Beijing 100871 Beijing Academy of Quantum Information Sciences Beijing 100193

We report the experimental realization of quantum degenerate Fermi gases of87Sr atoms under controlled 10-and dual-nuclear-spin *** on laser cooling and evaporative cooling,we achieve an ultracold Fermi gas of 10^(5)atoms equally distributed over 10 spin states,with a temperature of T/T_(F)=*** further prepare a dual-spin gas by optically pumping atoms to the m_(F)=9/2 and m_(F)=7/2 states and observe a slightly lower T/T_(F)than that for a 10-spin gas under the same trapping condition,showing efficient evaporative cooling under a decreasing number N of spin states(N≥2)despite the increasing importance of Pauli *** that rethermalization becomes less efficient with N approaching unity,we evaporatively cool an almost polarized gas to 130 *** simple and efficient preparation of ultracold Fermi gases of^(87)Sr with tunable spin configurations provides a first step towards engineering topological quantum systems.

关键词： Atoms

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Hydrodynamical Basis for Interpreting the Features of a Kind of Ocean Objects on Synthetic Aperture Radar Images

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Chinese Physics Letters 1998年第12期15卷 931-933页

作者： yu wei-dong HUA Feng JIN Mei-bing PAN Zeng-di yuAN Ye-li First Institute of Oceanography State Oceanic AdministrationQingdao 266003

A new hydrodynamical model interpreting the synthetic aperture radar(SAR)imaging of a kind of ocean objects is *** is based on the perturbation analysis of the wave height spectrum balance *** appropriate form of equilibrium wave height spectrum is deduced and then used to obtain the relative variation rate of the spectrum perturbation to its equilibrium *** variation rate reflects directly the features of a kind of ocean objects on the SAR images.

关键词： spectrum Synthetic equilibrium

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Crystallization of NiTi shape memory alloy sputtering-deposition film

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中国有色金属学会会刊：英文版 2000年第3期10卷 320-323页

作者： QIU Ping shan(邱平善) SONG Run bin(宋润滨) HUANG wei xin(黄渭馨) LI yun xi(李运稀) WANG Gui song(王桂松) yu wei dong(于伟东) Harbin Univ Sci & Technol Coll Mech & Power Engn Harbin 150080 Peoples R China

The crystallization of NiTi shape memory alloy sputter deposition film in the course of sputtering deposition and that after heat treated were studied. The relationship between the process factors, such as substrate type, temperature, as well as the crystallization when heat treated after plating was investigated. The results show that a new phase precipitates during heat treatment after sputtering deposition and the degree of crystallization among different layers and the stress in grains are obviously different.

关键词： sputtering deposition films crystallization shape memory alloys

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THE VERTICAL THERMAL STRUCTURE OF THE INDIAN OCEAN DIPOLE MODE FROM WOCE DATA

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Journal of Hydrodynamics 2001年第3期13卷 24-27页

作者： yu wei-dong Key Laboratory of Marine Science and Numerical Modeling, State Oceanic Administration, First Institute of Oceanography, Qingdao 266061, China First Inst. of Oceanography State Oceanic Administration Qingdao 266061 China

The Dipole Mode in tropical Indian Ocean (DMI) is a newly verified independent internal mode of atmosphere ocean system in Indian Ocean. Its surface manifestation is illustrated in detail with the aid of the historical data sets. But relatively few is known about its vertical characteristics. Here the vertical thermal structure of DMI is analyzed using the newly released WOCE GLOBAL DATA (V2.0). Attention is focused on the comparison of the abnormal upper ocean thermal structure along one section with the normal state in year 1990 respectively in two cases: in year 1994 when there was IDM but no E1 Nino and in year 1997 when there were DMI and also E1 Nino. This may shed light on the further theoretical and numerical study of IDM.

关键词： DMI thermal structure

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STUDY ON THE WIND AND WAVE EXTREME PARAMETERS OF TONKIN GULF IN THE SOUTH CHINA SEA-THE APPLICATIONS OF LAGFD NUMERICAL MODELS

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Journal of Hydrodynamics 1997年第1期9卷 75-86页

作者： Qiao Fang-li, yu wei-dong, Pan Zeng-diThe First Institute of Oceanography, SOA,Qingdao 266003,P. R. China The First Inst of Oceanography Qingdao China

Based on the hindcast of the severest 75 tropical cyclones (hereafter is called TCs) which affected Tonkin Gulf in history, the present paper gives sea surface wind and wave extreme parameters at 38 points corresponding to (1/2)×(1/2)?grid in the Gulf. The research increases our understanding of the meteo-ocean conditions on the whole area and provides basic data for ocean environmental research and engineering design.

关键词： wind,wave,gulf,ocean environmental research extreme parameters

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The Onset of the Monsoon over the Bay of Bengal:The Year-to-Year Variations

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Atmospheric and Oceanic Science Letters 2012年第4期5卷 342-347页

作者： yu wei-dong LI Kui-Ping SHI Jian-wei LIU Lin WANG Hui-Wu LIU Yan-Liang Center for Ocean and Climate Research First Institute of OceanographyState Oceanic AdministrationQingdao 266061China

In situ buoy observation data spanning four years(2008-2011) were used to demonstrate the year-to-year variations of the monsoon onset processes in the Bay of Bengal(BoB).A significant early(late) monsoon onset event in 2009(2010) was analyzed in *** is found that the year-to-year variations of monsoon onset can be attributed to either the interannual variability in the BoB SST or the irregular activities of the intra-seasonal oscillation(ISO).This finding raises concern over the potential difficulties in simulating or predicting the monsoon onset in the BoB *** uncertainty largely comes from the unsatisfactory model behavior at the intra-seasonal time scale.

关键词： monsoon onset interannual variations Bay of Bengal SST

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