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Research status and hotspots in transjugular intrahepatic portosystemic shunts based on CiteSpace bibliometric analysis

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2996-3007页

作者： Zeng-Long Que Ming-Song Wu Shu-Jie Lai yu-qin he Yin-Bin Zhou Shun-Ping Gui Liang-Zhi Wen Department of Gastroenterology Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China Department of Infectious Diseases The 960 Hospital of PLAJinan 250031Shandong ProvinceChina Department of Obstetrics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China

BACKGROUND The transjugular intrahepatic portosystemic shunt(TIPS)is an important technique for treating complications related to portal hypertension in patients with cirrhosis,and the number of publications in the TIPS field continues to *** To facilitate an understanding of the research status and hotspots in the field of TIPS using CiteSpace bibliometric *** CiteSpace is a software that depicts the strength of relationships through graphics and connections with diverse functionalities and can be used to analyze the status and hotspots of areas of *** on TIPS in the Web of Science Core Collection were retrieved,and CiteSpace software was used to visualize and analyze the number of publications,journals,countries,institutions,authors,keywords,and *** A total of 985 relevant documents were included in the *** January 2013 to December 2022,the number of publications increased *** journal,institution,and author with the greatest number of publications in the field of TIPS are the Journal of Vascular and Interventional Radiology,the University of Bonn,and Jonel Trebicka,*** main keywords used in this field are“transjugular intrahepatic portosystemic shunt”,“portal hypertension”,“cirrhosis”,“management”,“stent”,“hepatic encephalopathy”,“refractory ascite”,“survival”,“risk”,and“variceal bleeding”.The greatest obstacle to TIPS placement is currently the occurrence of hepatic *** research hotspots are the mechanism,risk factors,management,and control of hepatic *** This bibliometric analysis reported the research status and hotspots of *** on postoperative hepatic encephalopathy is the research hotspot in this field.

关键词： Liver cirrhosis Transjugular intrahepatic portosystemic shunt CiteSpace Visualization Hotspots

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Synthesis and antitumor activity of 6- and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones

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Chinese Chemical Letters 2008年第10期19卷 1206-1208页

作者： Li Ming Zhao Tian Pei Xie yu qin he De Feng Xu Shao Shun Li School of Pharmacy Shanghai Jiaotong University 800 Dongchuan Road Shanghai 200240 China Shanghai Standard Biotech Co. Ltd. 1011 Halei Road Shanghai 201203 China

Sixteen novel 6- and 2-（1-acylsulfanylalkyl）-5,8-dimethoxy-l,4-naphthoquinones were designed and synthesized. Their cytotoxicities were evaluated in vitro against BEL-7402, HT-29 and SPC-Al cell lines. The pharmacological results showed that most of the prepared compounds displayed the excellent selectivity for HT-29 cell line. Compound lab exhibited the most potent antitumor activity among the tested compounds.

关键词： 5,8-Dimethoxy-l,4-naphthoquinone derivatives Synthesis Antitumor activity

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Stress corrosion cracking behavior of buried oil and gas pipeline steel under the coexistence of magnetic field and sulfate-reducing bacteria

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Petroleum Science 2024年第2期21卷 1320-1332页

作者： Jian-yu he Fei Xie Dan Wang Guang-Xin Liu Ming Wu yue qin College of Petroleum Engineering Liaoning Petrochemical UniversityFushun113001LiaoningChina Key Laboratory of Oil and Gas Storage and Transportation Technology in Liaoning Province Fushun113001LiaoningChina State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China PipeChina West East Gas Pipeline Company Shanghai200120China

Magnetic field and microorganisms are important factors influencing the stress corrosion cracking(SCC)of buried oil and gas pipelines. Once SCC occurs in buried pipelines, it will cause serious hazards to the soil environment. The SCC behavior of X80 pipeline steel under the magnetic field and sulfate-reducing bacteria(SRB) environment was investigated by immersion tests, electrochemical tests, and slow strain rate tensile(SSRT) tests. The results showed that the corrosion and SCC sensitivity of X80 steel decreased with increasing the magnetic field strength in the sterile environment. The SCC sensitivity was higher in the biotic environment inoculated with SRB, but it also decreased with increasing magnetic field strength, which was due to the magnetic field reduces microbial activity and promotes the formation of dense film layer. This work provided theoretical guidance on the prevention of SCC in pipeline steel under magnetic field and SRB coexistence.

关键词： Magnetic field Sulfate-reducing bacteria Film layer Stress corrosion cracking Oil and gas pipelines

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Oral delivery of insulin by barbed microneedles actuated by intestinal peristalsis

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Chinese Chemical Letters 2024年第9期35卷 6-8页

作者： qin yu Haisheng he Jianping Qi Yi Lu Wei Wu Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China

Oral formulations are always preferred to injections due to the advantages of high patient compliance,no biohazardous needle waste,and low requirements for administration ***,the presence of multiple gastrointestinal(GI)barriers,including extreme gastric acidity and a broad pH gradient,digestive enzymes,thick and variable mucus layers,and tight junctions in the enteric epithelia,restricts the rate and extent of oral *** active ingredients with favorable physicochemical properties.

关键词： needle extreme formulation

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Corrugated Graphene Paper Reinforced Silicone Resin Composite for Efficient Interface Thermal Management

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Chinese Journal of Polymer Science 2024年第7期42卷 1002-1014,I0010页

作者： Bo-Wen Wang heng Zhang qing-Xia he Hui-Tao yu Meng-Meng qin Wei Feng Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350China International Engineering Institute Tianjin UniversityTianjin300350China

With the rapid development of high-power-density electronic devices,interface thermal resistance has become a critical barrier for effective heat management in high-performance electronic ***,there is an urgent demand for advanced thermal interface materials(TIMs)with high cross-plane thermal conductivity and excellent compressibility to withstand increasingly complex operating *** achieve this aim,a promising strategy involves vertically arranging highly thermoconductive graphene on ***,with the currently available methods,achieving a balance between low interfacial thermal resistance,bidirectional high thermal conductivity,and large-scale production is ***,we prepared a graphene framework with continuous filler structures in in-plane and cross-plane directions by bonding corrugated graphene to planar graphene *** interface interaction between the graphene paper framework and polymer matrix was enhanced via surface functionalization to reduce the interface thermal *** resulting three-dimensional thermal framework endows the polymer composite material with a cross-plane thermal conductivity of 14.4 W·m^(-1)·K^(-1)and in-plane thermal conductivity of 130W·m^(-1)·K^(-1)when the thermal filler loading is 10.1 wt%,with a thermal conductivity enhancement per 1 wt%filler loading of 831%,outperforming various graphene structures as *** its high thermal conductivity,low contact thermal resistance,and low compressive modulus,the developed highly thermoconductive composite material demonstrates superior performance in TIM testing compared with TFLEX-700,an advanced commercial TIM,effectively solving the interfacial heat transfer issues in electronic *** novel filler structure framework also provides a solution for achieving a balance between efficient thermal management and ease of processing.

关键词： Graphene paper Vertically aligned structure Cross-plane thermal conductivity Low compressive modulus Thermal interface material

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Novel sandwich structured glass fiber Cloth/Poly(ethylene oxide)-MXene composite electrolyte

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Nano Materials Science 2024年第1期6卷 60-67页

作者： yu-qin Mao Guang-he Dong Wei-Bin Zhu yuan-qing Li Pei Huang Shao-yun Fu College of Aerospace Engineering Chongqing UniversityChongqing400044China State Key Laboratory of Power Transmission Equipment and System Security and New Technology Chongqing UniversityChongqing400044China

Recently,poly(ethylene oxide)(PEO)-based solid polymer electrolytes have been attracting great attention,and efforts are currently underway to develop PEO-based composite electrolytes for next generation high performance all-solid-state lithium metal *** this article,a novel sandwich structured solid-state PEO composite electrolyte is developed for high performance all-solid-state lithium metal *** PEO-based composite electrolyte is fabricated by hot-pressing PEO,LiTFSI and Ti_(3)C_(2)T_(x) MXene nanosheets into glass fiber cloth(GFC).The as-prepared GFC@PEO-MXene electrolyte shows high mechanical properties,good electrochemical stability,and high lithium-ion migration number,which indicates an obvious synergistic effect from the microscale GFC and the nanoscale *** as,the GFC@PEO-1 wt%MXene electrolyte shows a high tensile strength of 43.43 MPa and an impressive Young's modulus of 496 MPa,which are increased by 1205%and 6048%over those of ***,the ionic conductivity of GFC@PEO-1 wt%MXene at 60℃ reaches 5.01×10^(-2) S m^(-1),which is increased by around 200%compared with that of GFC@PEO *** addition,the Li/Li symmetric battery based on GFC@PEO-1 wt%MXene electrolyte shows an excellent cycling stability over 800 h(0.3 mA cm^(-2),0.3 mAh cm^(-2)),which is obviously longer than that based on PEO and GFC@PEO electrolytes due to the better compatibility of GFC@PEO-1 wt%MXene electrolyte with Li ***,the solid-state Li/LiFePO_(4) battery with GFC@PEO-1 wt%MXene as electrolyte demonstrates a high capacity of 110.2–166.1 mAh g^(-1) in a wide temperature range of 25–60C,and an excellent capacity retention *** developed sandwich structured GFC@PEO-1 wt%MXene electrolyte with the excellent overall performance is promising for next generation high performance all-solid-state lithium metal batteries.

关键词： Solid polymer electrolyte Ti_(3)C_(2)T_(x)MXene Poly(ethylene oxide) Glass fiber cloth All-solid-state Li metal Battery

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Learning in games:a systematic review

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Science China(Information Sciences) 2024年第7期67卷 133-159页

作者： Rong-Jun qin Yang yu National Key Laboratory for Novel Software Technology Nanjing University Polixir Technologies

Game theory studies the mathematical models for self-interested individuals. Nash equilibrium is arguably the most central solution in game theory. While finding the Nash equilibrium in general is known as polynomial parity arguments on directed graphs(PPAD)-complete, learning in games provides an alternative to approximate Nash equilibrium, which iteratively updates the player's strategy through interactions with other players. Rules and models have been developed for learning in games, such as fictitious play and no-regret learning. Particularly, with recent advances in online learning and deep reinforcement learning,techniques from these fields greatly boost the breakthroughs in learning in games from theory to *** a result, we have witnessed many superhuman game AI systems. The techniques used in these systems evolve from conventional search and learning to purely reinforcement learning(RL)-style learning methods,gradually getting rid of the domain knowledge. In this article, we systematically review the above techniques,discuss the trend of basic learning rules towards a unified framework, and recap applications in large ***, we discuss some future directions and make the prospect of future game AI systems. We hope this article will give some insights into designing novel approaches.

关键词： non-cooperative games learning in games no-regret learning reinforcement learning superhuman AI

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Hydrocarbon gas huff-n-puff optimization of multiple horizontal wells with complex fracture networks in the M unconventional reservoir

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Petroleum Science 2024年第2期21卷 1018-1031页

作者： Hao-Chuan Zhang Yong Tang You-Wei he Yong qin Jian-Hong Luo yu Sun Ning Wang De-Qiang Wang State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina CNPC Research Institute of Petroleum Exploration&Development Beijing100083China Southwest Oil&Gas Field Company PetroChinaChengdu610051SichuanChina State Key Laboratory of Offshore Oil Exploitation CNOOC Research Institute Co.LtdBeijing100027China

The oil production of the multi-fractured horizontal wells(MFHWs) declines quickly in unconventional oil reservoirs due to the fast depletion of natural energy. Gas injection has been acknowledged as an effective method to improve oil recovery factor from unconventional oil reservoirs. Hydrocarbon gas huff-n-puff becomes preferable when the CO_(2) source is limited. However, the impact of complex fracture networks and well interference on the EOR performance of multiple MFHWs is still unclear. The optimal gas huff-n-puff parameters are significant for enhancing oil recovery. This work aims to optimize the hydrocarbon gas injection and production parameters for multiple MFHWs with complex fracture networks in unconventional oil reservoirs. Firstly, the numerical model based on unstructured grids is developed to characterize the complex fracture networks and capture the dynamic fracture ***, the PVT phase behavior simulation was carried out to provide the fluid model for numerical simulation. Thirdly, the optimal parameters for hydrocarbon gas huff-n-puff were obtained. Finally, the dominant factors of hydrocarbon gas huff-n-puff under complex fracture networks are obtained by fuzzy mathematical method. Results reveal that the current pressure of hydrocarbon gas injection can achieve miscible displacement. The optimal injection and production parameters are obtained by single-factor analysis to analyze the effect of individual parameter. Gas injection time is the dominant factor of hydrocarbon gas huff-n-puff in unconventional oil reservoirs with complex fracture networks. This work can offer engineers guidance for hydrocarbon gas huff-n-puff of multiple MFHWs considering the complex fracture networks.

关键词： Unconventional oil reservoir Complex fracture network Hydrocarbon gas huff-n-puff Parameter optimization Numerical simulation

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Effect of Iron on the Stability of Rhodochrosite at the Topmost Lower Mantle Conditions

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Journal of Earth Science 2024年第2期35卷 504-513页

作者： Tianlei Zhai Fei qin Shengxuan Huang Shan qin yu Gong Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing100871China School of Earth Sciences and Resources China University of GeosciencesBeijing100083China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China

Carbonates are viewed as the principal oxidized carbon carriers during subduction,and thus the stability of subducted carbonates has significant implications for the deep carbon *** we investigate the high pressure-temperature behaviors of rhodochrosite in the presence of iron up to∼34 GPa by in-situ X-ray diffraction and ex-situ Raman *** relatively low temperature below∼1500 K,MnCO_(3)breaks down into MnO and CO_(2).Upon heating to∼1800 K,however,the MnCO_(3)-Fe^(0)reactions occur with the formation of Mn_(3)O_(4),Fe^(O)and reduced carbon.A'three-stage'reaction mechanism is proposed to understand the kinetics of the carbon-iron-manganese redox *** results suggest that Fe^(0)can serve as a reductant to greatly affect the stability of rhodochrosite,which implies that the effect of Fe-metal should be seriously considered for the high pressure-temperature behaviors of other predominant carbonates at Earth's mantle conditions,particularly at depths greater than∼250 km.

关键词： deep carbon cycle rhodochrosite reduced mantle diamond formation high pressure tectonics geochemistry

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Comparison of Ex‑PRESS implantation versus trabeculectomy combined with phacoemulsification in primary open‑angle glaucoma:a retrospective in vivo confocal microscopy study

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Eye and Vision 2024年第2期10卷 1-11页

作者： yuqiao Zhang Beiting he yulin Zhang Jin Zeng Yanlei Chen Yongyi Niu Honghua yu Yongjie qin Hongyang Zhang Department of Ophthalmology Guangdong Eye InstituteGuangdong Academy of Medical SciencesGuangdong Provincial People’s HospitalNo.106 Zhongshan Er RoadGuangzhou 510080China Shantou University Medical College ShantouChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhouChina Department of Ophthalmology School of MedicineSouth China University of TechnologyGuangzhouChina

Background:To compare the efficacy of Ex-PRESS implantation versus trabeculectomy combined with ***:A retrospective 12-month study on patients with coincident primary open-angle glaucoma(POAG)and *** patients underwent combined phacoemulsification and Ex-PRESS implant(Phaco-ExPRESS,n=35)or phacotrabeculectomy(Phaco-Trab,n=35).The morphological structures of the filtering bleb were examined by slitlamp,anterior segment optical coherence tomography(AS-OCT)and in vivo confocal microscopy(IVCM).Complete success was defined as postoperative intraocular pressure(IOP)he use of anti-glaucoma *** success was defined as postoperative IOPhe variables such as age,IOP and perimetry was found between the groups of Phaco-ExPRESS and *** the one-year postoperative visit for filtering blebs,Phaco-ExPRESS increased the mean area of epithelial microcysts significantly from 0.10±0.05 to 0.20±0.09μm^(2)perμm^(2),while Phaco-Trab decreased the mean area significantly from 0.08±0.04 to 0.04±0.06μm^(2)perμm^(2).Notably,the hyperreflective dots detected by IVCM decreased by 84.9%in Phaco-ExPRESS but increased by 36.3%in *** hyperreflective dots were further identified as neutrophil-and monocyte-like *** number of these cells were negatively correlated with the microcysts area(r=−0.7,Phe grade of connective tissue(r=0.5,Phe filtering blebs,Phaco-ExPRESS produced a higher complete success rate(84.9%vs.41.2%,Phe number of anti-glaucoma medications(Phen compared with those in ***,the qualified success showed no significant difference between the two groups(

关键词： POAG Ex-PRESS Phacoemulsification Confocal microscopy

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