Synthesis and antitumor activity of 6- and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones

作     者：Li Ming Zhao Tian Pei Xie YU Qin He De Feng Xu Shao Shun Li 

作者机构：School of Pharmacy Shanghai Jiaotong University 800 Dongchuan Road Shanghai 200240 China Shanghai Standard Biotech Co. Ltd. 1011 Halei Road Shanghai 201203 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2008年第19卷第10期

页      面：1206-1208页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

主　　题：5,8-Dimethoxy-l,4-naphthoquinone derivatives Synthesis Antitumor activity 

摘      要：Sixteen novel 6- and 2-（1-acylsulfanylalkyl）-5,8-dimethoxy-l,4-naphthoquinones were designed and synthesized. Their cytotoxicities were evaluated in vitro against BEL-7402, HT-29 and SPC-Al cell lines. The pharmacological results showed that most of the prepared compounds displayed the excellent selectivity for HT-29 cell line. Compound lab exhibited the most potent antitumor activity among the tested compounds.