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Heterogeneous 2D/3D photonic integrated microsystems

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Microsystems & Nanoengineering 2016年第1期2卷 143-151页

作者： s.j.ben yoo Binbin Guan Ryan P.scott Department of Electrical and Computer Engineering University of CaliforniaDavisCA 95616USA

The continuing trend of exponential growth in data communications and processing are driving the need for large-scale heterogeneous *** to the trend we have observed in electronic integrated circuit development,we are witnessing a growing trend in 3D photonic integrated circuits(PICs)development in addition to that in 2D *** are two main methods for fabricating 3D *** first method,which utilizes ultrafast laser inscription(ULI),offers freeform shaping of waveguides in arbitrary contours and *** second method,which utilizes multilayer stacking and coupling of planar PICs,exploits relatively mature 2D PIC fabrication processes applied to each layer *** the fabrication methods for 3D PICs have advantages and disadvantages such that certain applications may favor one method over the ***,a joining of 2D PICs with 3D PICs can help develop integrated microsystems with new functionalities such as non-mechanical beam steering,spacedivision multiplexing(sDM),programmable arbitrary beam shaping,and photonic signal *** discuss examples of 3D PICs and 2D/3D integrated PICs in two applications:sDM via orbital-angular-momentum(OAM)multiplexing/demultiplexing and optical beam steering using optical phased *** a 2D PIC by itself can function as an OAM multiplexer or demultiplexer,it has limitations in supporting both ***,a 3D PIC fabricated by ULI can easily support both polarizations with low propagation loss.A combination of a 3D PIC and a 2D PIC designed and fabricated for OAM applications has successfully multiplexed and demultiplexed 15 OAM states to demonstrate polarization-diversified sDM coherent optical communications using multiple OAM *** excitation of multi-ring OAM states can allow highly scalable sDM utilizing Laguerre–Gaussian modes or linearly polarized(LP)*** preliminary fabrication of multi-ring OAM multiplexers and demultiplexers using the

关键词： photonic integrated circuits three-dimensional photonics ultrafast laser inscription

Leading Approaches to Vascularize Kidney Constructs in Tissue Engineering

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维普期刊数据库

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Engineering 2022年第12期19卷 117-127页

作者： Diana s.Lim john D.jackson Anthony Atala james.j.yoo Wake Forest Institute for Regenerative Medicine Wake Forest University School of MedicineMedical Center BoulevardNC 27157USA

There is an unprecedented need for new treatments for renal failure,as the incidence of this disease is increasing disproportionately to advancements in *** treatments are limited by the availability of viable organs,for which there is a worldwide *** treatment modalities also require a substantial amount of infrastructure,significantly limiting the access to care in most *** tissue engineering approaches promise to develop alternative solutions that address many of the inadequacies in current *** many advancements have been made—primarily in the past decade—in biofabrication and whole-organ tissue engineering,many challenges *** major hindrance to the progress of current tissue engineering approaches is establishing successful vascularization of developed engineered tissue *** review focuses on the recent advancements that address the vascular challenge,including the biofabrication of vasculature,whole-organ engineering through decellularization and recellularization approaches,microscale organogenesis,and vascularization using organoids in the context of kidney tissue *** also highlight the specific challenges that remain in developing successful strategies capable of clinical translation.

关键词： Kidney Vascularization Tissue engineering Biofabrication Organoids

Mid/far-infrared photo-detectors based on graphene asymmetric quantum wells

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Chinese Physics B 2016年第9期25卷 573-580页

作者： E ben salem R Chaabani s.j.ziri Institut Preparatoire aux Etudes d'Ingenieurs de Tunis 2 Rue Jawaher Lel Nahrou Monfleury 1089 Tunisie Laboratoire de Physique de la Matiere Condensee Departement de Physique Faculte des Sciences de Tunis Campus Universitaire 2092 Tunisie Departement de Physique Faculte des Sciences de Bizerte Jarzouna 7021 Bizerte

We conducted a theoretical study on the electronic properties of a single-layer graphene asymmetric quantum *** of energy levels is limited by electron–hole conversion at the barrier interfaces and free-electron ***–hole conversion at the barrier interfaces can be controlled by introducing an asymmetry between barriers and taking into account the effect of the interactions of the graphene sheet with the *** interaction with the substrate induces an effective mass to carriers,allowing observation of Fabry–P′erot resonances under normal incidence and extinction of Klein *** asymmetry,between barriers creates a transmission gap between confined states and free-electron continuum,allowing the large graphene asymmetric quantum well to be exploited as a photo-detector operating at mid-and far-infrared frequency regimes.

关键词： graphene quantum wells reflection coefficient photo-detector

spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice

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Light(science & Applications) 2016年第1期5卷 104-111页

作者： X Luís Deán-ben Thomas F Fehm steven j Ford sven Gottschalk Daniel Razansky Institute for Biological and Medical Imaging(IBMI) Helmholtz Center Munich85764 NeuherbergGermany school of Medicine and school of Bioengineering Technical University of Munich81675 MunichGermany

Imaging dynamics at different temporal and spatial scales is essential for understanding the biological complexity of living organisms,disease state and *** imaging has been shown to offer exclusive applicability across multiple scales with excellent optical contrast and high resolution in deep-tissue ***,efficient visualization of multi-scale dynamics remained difficult with state-of-the-art systems due to inefficient trade-offs between image acquisition time and effective field of ***,we introduce the spiral volumetric optoacoustic tomography technique that provides spectrally enriched highresolution contrast across multiple spatiotemporal *** vivo experiments in mice demonstrate a wide range of dynamic imaging capabilities,from three-dimensional high-frame-rate visualization of moving organs and contrast agent kinetics in selected areas to whole-body longitudinal studies with unprecedented image *** newly introduced paradigm shift in imaging of multi-scale dynamics adds to the multifarious advantages provided by the optoacoustic technology for structural,functional and molecular imaging.

关键词： multi-scale dynamics multi-spectral imaging optoacoustic tomography real-time imaging whole-body imaging

stability Analysis and Performance Evaluation of Additive Mixed-Precision Runge-Kutta Methods

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Communications on Applied Mathematics and Computation 2024年第1期6卷 705-738页

作者： ben Burnett sigal Gottlieb Zachary j.Grant Center for scientific Computing and Data science Research UMass DartmouthNorth DartmouthMassachusettsUSA CsME Michigan State UniversityEast LansingMichiganUSA

Additive Runge-Kutta methods designed for preserving highly accurate solutions in mixed-precision computation were previously proposed and *** specially designed methods use reduced precision for the implicit computations and full precision for the explicit *** this work,we analyze the stability properties of these methods and their sensitivity to the low-precision rounding errors,and demonstrate their performance in terms of accuracy and *** develop codes in FORTRAN and julia to solve nonlinear systems of ODEs and PDEs using the mixed-precision additive Runge-Kutta(MP-ARK)*** convergence,accuracy,and runtime of these methods are *** show that for a given level of accuracy,suitably chosen MP-ARK methods may provide significant reductions in runtime.

关键词： Mixed precision Runge-Kutta methods Additive methods Accuracy

EFFECT OF CARBON AND BORON ON MICROsTRUCTURE AND MECHANICAL PROPERTIEs OF A sINGLE CRYsTAL sUPERALLOY RR 2072

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Acta Metallurgica sinica(English Letters) 2005年第1期18卷 33-38页

作者： D.H.Kim D.H.Ye j.H.Lee Y.s.yoo C.Y.jo High Temperature Materials Laboratory Korea Institute of Machinery&Materials 66 SangnamChangwonKyungnam 640-010S.Korea Dept.of Metallurgy Changwon National Univerisity 9 SarimChagwonKyungnam 640-773S.Korea

Carbon and boron have been considered to strengthen grain boundaries that might form during single crystal *** this study the effect of boron on solidification behavior and creep properties of the carbon doped single crystal RR 2072 has been *** order to understand solidification behavior with boron addition,the solid/liquid interface morphology and solidification microstructure were examined with solidification *** relationship between mi-crostructural evolution and creep properties of the carbon and boron modified single crystal has been also investigated.

关键词： single crystal superalloy defect tolerance directional solidification creep rupture

Adenosine-treated bioprinted muscle constructs prolong cell survival and improve tissue formation

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Bio-Design and Manufacturing 2021年第3期4卷 441-451页

作者： Dongxu Ke Adam M.jorgensen sang j.Lee james.j.yoo sean V.Murphy Wake Forest Institute for Regenerative Medicine Wake Forest School of MedicineWinston-SalemNCUSA Novaprint Therapeutics suzhou Co. LtdSuzhouJiangsuChina

It is crucial to maintaining the viability of biofabricated human-sized tissues to ensure their successful survival and function after *** is a purine nucleoside that has the function to suppress cellular metabolism and has been previously proposed as a method to prolong cell viability under *** this study,we optimized the dose concentration of adenosine for incorporation into bioprinted constructs to preserve long-term cell viability in *** results showed that muscle cells(C2C12)containing 6,7,or 8 mM adenosine maintained high cell viability for 20 days under hypoxic conditions(0.1%O2),whereas cells without adenosine treatment showed 100%cell death after 11 *** 20 days under hypoxic conditions,muscle cells treated with adenosine proliferated and differentiated when transferred to normoxic *** these adenosine concentrations,6 mM was picked as the optimized adenosine concentration for further investigations due to its most effective results on improving cell *** bioprinted muscle constructs containing adenosine(6 mM)maintained high cell viability for 11 days under hypoxic conditions,while the control constructs without adenosine had no live *** in vivo validation,the bioprinted constructs with adenosine implanted under the dorsal subcutaneous space in mice,showed the enhanced formation of muscle tissue with minimal central necrosis and apoptosis,when compared to the constructs without *** positive in vitro and in vivo results demonstrate that the use of adenosine is an effective approach to preventing the challenge of hypoxia-induced necrosis in bioprinted tissues for clinical translation.

关键词： Bioprinting Hypoxia Adenosine Cell viability In vivo

Experimental study of the effects of a transversal air-flow deflector in electronics air-cooling

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journal of Thermal science 2011年第1期20卷 76-81页

作者： M.REBAY A.ARFAOUI j.PADET R.ben MAAD Université de Reims GRESPI/lab.de ThermomécaniqueFaculté des sciencesBP 103951687 ReimsFrance Laboratoire d'Energétique et Transferts Thermique et Massique Faculté des sciences2092 Manar IITunisia

This paper presents an experimental investigation of the influence of a transversal flow deflector on the cooling of a heated block mounted on a flat *** deflector is inclined and therefore it guides the air flow to the upper surface of the *** configuration is simulating the air-cooling of a rectangular integrated circuit or a current converter mounted on an electronic *** electronic component is assumed dissipating low heat power,as such,air forced convection is still a sufficient cooling way even without fan or heat sink on the *** measurements are given by hot and cold wires anemometers and by an InfraRed *** results give details of the effects of the deflection on the hydrodynamic and the thermal fields on and over the block for different inclination *** show that the deviation caused by the deflector may significantly enhance the heat transfer from the *** is also able to avoid local overheating of the electronic *** heat transfer rate and homogenised temperature are shown to be obtained with an inclination angle =30°.

关键词： Electronic cooling infrared imaging hot wire anemometer upward facing step backward facing step

Zircon U-Pb dating and geochemical study of the Xianggou granite in the Ma'anqiao gold deposit and its relationship with gold mineralization

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science China Earth sciences 2010年第2期53卷 220-240页

作者： LEE ben state Key Laboratory of Continental Dynamics Department of GeologyNorthwest University

single zircon LA-ICP-Ms U-Pb dating and lithogeochemical studies have been performed on the Xianggou monzonitic granitic porphyry outcropped in the Ma’anqiao gold deposit.A weighted average U-Pb age of 242.0±0.8 Ma for Xianggou monzonitic porphyry has been *** corresponds with the conclusions of previous studies indicating a syn-orogenic age (242±21 Ma) of the Qinling Orogenic Belt,suggesting that the formation of the Xianggou granite should be associated with the collisional event of the North China Plate and the Yangtze Plate in the Indosinian *** Xianggou granite is characterized by the high silicon and alkali of high K calc-alkaline series *** is rich in Al (Al2O3=14.49%-15.61%) and sr (457.10-630.82 ppm),poor in Y (s high ratios of sr/Y (76.24-97.34) and (La/Yb)N (29.65-46.10),as well as strongly fractionated REE *** geochemical characteristics suggest the Xianggou granite can be classified as C-type adakitic *** initial sr isotope ratios for the Xianggou granite vary from 0.70642 to 0.70668,εNd(t) values from -4.54 to -3.98,and TDM values from 1152 Ma to 1220 *** low εNd(t) and Isr and high TDM values,as well as Na2O/K2O ratios of the Xianggou granite are close to 1 (Na2O/K2O=0.95-1.10),indicating that it is not an I-type adakite formed by partial melting of the subducting oceanic crust,nor adakitic rock formed by melting of the underplated basaltic lower crust,but the product of partial melting of the nonunderplated basaltic thickened lower *** from the Xianggou pluton have a homogeneous Hf isotopic composition with negative εHf(t) values (between -9.7 and -5.9,with an average of -6.9),indicating that the rock-forming materials were mostly extracted from the ancient crust,not from the depleted *** Xianggou monzonitic granitic porphyry is rich in LILE and LREE and depleted in HsFE,HREE and Y;the composition of trace element and REE are similar to those

关键词： zircon U-Pb dating Xianggou monzonitic granitic porphyry Carlin type and Carlin-like type gold deposits petrologenic and metallogenic dynamic background