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Bioinformatics comprehensive analysis confirmed the potential involvement of SLC22A1 in lower-grade glioma progression and prognosis

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BIOCELL 2024年第5期48卷 803-815页

作者： JING HUI NANA SUN yong LIU CHUNBO YU yong ke yong CAO ANXIAO YU QINGHONG KONG YUN LIU Guizhou Provincial College-Based key Lab for Tumor Prevention and Treatment with DistinctiveMedicines Zunyi Medical UniversityZunyi563000China College of Basic Medicine Zunyi Medical UniversityZunyi563000China Department of Dermatology Guizhou Province Cosmetic Plastic Surgery HospitalAffiliated Hospital of Zunyi Medical UniversityZunyi563000China School of Forensic Medicine Zunyi Medical UniversityZunyi563000China

Background:Although it has been established that the human Solute Carrier Family 22(SLC22)functions as a cationic transporter,influencing cellular biological metabolism by modulating the uptake of various cations,its impact on cancer prognosis remains ***:We conducted a comprehensive analysis utilizing data from The Cancer Genome Atlas(TCGA)and other databases to assess the prognostic value and functional implications across various *** of SLC22A1 RNA in glioma U251 cells was performed to access the impact of SLC22A1 on lowergrade glioma(LGG)***:Our findings demonstrated a significant correlation between SLC22A1 expression and the survival time of patients with various cancers(p0.8).Cell proliferation and clone formation experiment proved that decreased expression of SLC22A1 in glioma U251 cells inhibited glioma cell ***:Our findings suggest SLC22A1 has huge prospects as a promising biomarker and therapeutic target for LGG ***22A1 has only been proved to support cellular function *** findings demonstrated a robust connection between the tumor microenvironment and functional proteins that maintain basal cell metabolism,which gifts unique tumor immune characteristics of ***,we provide a highly practical prediction model for estimating the survival rate of LGG patients.

关键词： SLC22A1 LGG prognosis immune nomogram

A novel Ce_(0.485)Zr_(0.485)Y_(0.03)O_(2) composite oxide with surface doping of Y and its application in Pd-only three-way catalyst

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Rare Metals 2024年第2期43卷 749-757页

作者： Zheng Zhao Wei-Xin Zhao yong-Qi Zhang Mei-Sheng Cui yong-ke Hou Dong-Ming Chen Juan-Yu Yang Zong-Yu Feng Xiao-Wei Huang National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.GRINM Group Corporation LimitedBeijing100088China Griem Hi-Tech Co.Ltd. Langfang065000China Rare Earth Functional Materials(Xiong’an)Innovation Venter Co.Ltd. Baoding071700China

The ceria-zirconia compound oxide-supported noble metal Pd(Pd@CZ)is widely used in three-way ***,the surface structure of CZ plays an important role in catalytic activity of ***,how to regulate the surface structure of CZ and clarify the structure–activity relationship is still a *** this paper,a strategy is proposed to develop high activity Pd@CZ nanocatalysts by tuning Y doping sites in *** precipitate-deposition method is developed to prepare the novel Ce_(0.485)Zr_(0.485)Y_(0.03)O_(2) composite with surface doping of Y(CZ-Y-S).In addition,the Pd@CZ-Y-S(Pd supported on CZ-Y-S)exhibits superior catalytic activity for HC,CO,and NO oxide,wherein,for CO and C_(3)H_(6) oxidation,the low-temperature activity of Pd@CZ-Y-S is still 20%higher than that of Pd@CZ-Y-B(Y bulk doping)and commercial Pd@CZ after 1000℃/4 h *** effect mechanism is further studied by density functional theory(DFT)*** with Pd@CZ-Y-B,Pd@CZ-Y-S shows the lower CO oxide reaction energy barriers due to the weaker adsorption strength of *** Y surface doping strategy could provide valuable insights for the development of highly efficient Pd@CZ catalyst with extensive applications.

关键词： Rare earth Ceria-zirconia-supported Pd Surface doping Experiment and theory Catalytic application

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无人机非确定性等价自适应容错飞行控制

控制理论与应用 2024年第4期41卷 587-596页

作者：季海宁陈谋雍可南南京航空航天大学自动化学院江苏南京211106

针对存在执行器复合故障的固定翼无人机跟踪控制问题,本文提出一种基于非确定性等价原理的自适应容错飞行控制策略.该策略能够有效地估计无人机纵向动态中执行器的失效及漂移故障,保证故障发生后闭环系统的最优性能指标.在自适应容错飞... 详细信息

针对存在执行器复合故障的固定翼无人机跟踪控制问题,本文提出一种基于非确定性等价原理的自适应容错飞行控制策略.该策略能够有效地估计无人机纵向动态中执行器的失效及漂移故障,保证故障发生后闭环系统的最优性能指标.在自适应容错飞行控制设计中,通过引入辅助系统并动态调节因子,构造非确定性等价原理中偏微分方程的近似解,以简化自适应律设计复杂度.此外,借助Lyapunov稳定性分析方法,证明了在所设计的自适应容错控制器作用下闭环系统的稳定性.最后,仿真验证表明所设计的控制方法能够保证故障无人机的闭环系统性能.

关键词：无人机非确定性等价容错控制

Safety and feasibility of enhanced recovery after surgery-based management model for ambulatory pediatric surgical procedures

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World Journal of Clinical Cases 2024年第22期12卷 4965-4972页

作者： Gui-Quan Fan Xin-Dan Zhang yong-ke He Xiao-Gang Lu Ji-yong Zhong Zong-Yang Pang Xi-Yang Gan Pediatric Surgery The First People’s Hospital of Liangshan Yi Autonomous PrefectureXichang 615000Sichuan ProvinceChina

BACKGROUND There is still some room for optimizing ambulatory pediatric surgical procedures,and the preoperative and postoperative management quality for pediatric patients needs to be *** To discuss the safety and feasibility of the enhanced recovery after surgery(ERAS)-based management model for ambulatory pediatric surgical *** We selected 320 pediatric patients undergoing ambulatory surgery from June 2023 to January 2024 at The First People’s Hospital of Liangshan Yi Autonomous *** these,220 received ERAS-based management(research group)and 100 received routine management(control group).General information,postoperative ambulation activities,surgical outcomes(operation time,postoperative gastro-intestinal ventilation time,and hospital stay),postoperative pain visual analogue scale,postoperative complications(incision infection,abdominal distension,fever,nausea,and vomiting),and family satisfaction were *** The general information of the research group(sex,age,disease type,single parent,family history,etc.)was comparable to that of the control group(P>0.05),but the rate of postoperative(2 h,4 h,and 6 h after surgery)ambulation activities was statistically higher(Pkedly shorter(P<0.05).The research group had lower visual analogue scale scores(P<0.01)at 12 h and 24 h after surgery and a lower incidence of total postoperative complications than the control group(P=0.001).The research group had higher family satisfaction than the control group(P=0.007).CONCLUSION The ERAS-based management model was safe and feasible in ambulatory pediatric surgical procedures and worthy of clinical promotion.

关键词： Ambulatory pediatric surgery Ambulatory surgery Enhanced recovery after surgery Safety Feasibility

Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study

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Journal of Geriatric Cardiology 2024年第7期21卷 751-759页

作者： Shi-Yu ZHOU Fang-Chao LIU Shu-Feng CHEN Jian-Xin LI Jie CAO ke-yong HUANG Zheng-Hao TANG Feng-Chao LIANG Dong-Sheng HU Lian-Cheng ZHAO Ying LI Jian-Feng HUANG Xiang-Feng LU Bin LU Dong-Feng GU Department of Epidemiology&key Laboratory of Cardiovascular Epidemiology State Key Laboratory of Cardiovas-cular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina School of Public Health and Emergency Management School of Medi-cineSouthern University of Science and TechnologyShenzhenChina Department of Epidemiology and Health Stat-istics School of Public HealthZhengzhou UniversityZhengzhouChina Department of Biostatistics and Epidemi-ology School of Public HealthShenzhen University Health Science CenterShenzhenChina Department of Radi-ology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

BACKGROUND Previous studies have demonstrated the benefits of ideal cardiovascular health(CVH) in reducing cardiovascular ***,its role in subclinical atherosclerosis(SA) progression remains *** aim to examine the association of CVH,estimated by the American Heart Association's new Life's Essential 8(LE8),with the progression of *** This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for5.7 *** LE8 score(range,0–100) consisted of blood pressure,lipids,glucose,body mass index,smoking status,diet health,physical activity and sleep health was evaluated in 1998 and 2008–*** of SA was determined by carotid plaque and coronary artery calcification(CAC) in 2008–2009 and 2013–***-binomial regression model was used to estimate the association of LE8 score with SA *** Each 10 points increment in LE8 score was associated with 15.2%(RR:0.848,95% CI:0.797–0.902),17.7%(RR:0.823,95% CI:0.766–0.884) and 12.0%(RR:0.880,95% CI:0.845–0.916) lower risks of carotid plaque,CAC and overall SA progression,*** with participants with non-ideal CVH at both visits,the participants with ideal CVH at both visits had39.1%(RR:0.609,95% CI:0.494–0.752),41.0%(RR:0.590,95% CI:0.456–0.764) and 29.7%(RR:0.703,95% CI:0.598–0.825) lower risks of carotid plaque,CAC and overall SA progression,*** Higher LE8 scores were associated with lower risks of SA ***,long-term maintenance of optimal CVH was more beneficial to prevent SA progression.

关键词： atherosclerosis prospective cardiovascular

英国职业养老金自动加入机制的改革经验与启示

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经济体制改革 2024年第2期 167-175页

作者：董克用周宁林佳钰中国人民大学公共管理学院北京100872

自动加入机制对扩大职业养老金覆盖面具有重要作用。以英国方案为例,其内容特点包括:政策设计上,追求政策宣传与反馈收集相结合;参与环节上,兼顾覆盖广泛与个体差异;运作过程中,明晰不同主体的权利与义务;平台建设上,注重参与便利性与... 详细信息

自动加入机制对扩大职业养老金覆盖面具有重要作用。以英国方案为例,其内容特点包括:政策设计上,追求政策宣传与反馈收集相结合;参与环节上,兼顾覆盖广泛与个体差异;运作过程中,明晰不同主体的权利与义务;平台建设上,注重参与便利性与投资服务有效性。其改革在提高计划参与率、稳定计划退出率、增强计划运作合规性、促进优质职业养老金计划发展等取得良好成效,但在时间成本控制、低收入群体政策倾斜与配套措施推进等方面存在不足。参考英国模式,结合我国企业年金发展现实情况,未来可在政策推广上开展系统化宣教;在参与方式上适度降低准入门槛;在计划运作上优化集合计划发展模式;在系统建设上健全功能版块及互联机制;为自动加入机制改革提供良好氛围、广泛受众、优质载体和坚实保障。

关键词：职业养老金制度自动加入机制英国

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基于句法规则与情感词的隐式特征提取

计算机工程与设计 2024年第3期45卷 740-747页

作者：陈可嘉柯永诚林鸿熙福州大学经济与管理学院福建福州350108 莆田学院商学院福建莆田351100

针对当前句法关系研究存在过多考虑主谓关系、情感词识别能力有限、忽视隐式特征提取等方面的不足,提出一种基于句法规则与情感词的隐式特征提取方法。借助中文情感词典资源,基于外部语料与实验语料训练的词向量分别构建混合情感词典和... 详细信息

针对当前句法关系研究存在过多考虑主谓关系、情感词识别能力有限、忽视隐式特征提取等方面的不足,提出一种基于句法规则与情感词的隐式特征提取方法。借助中文情感词典资源,基于外部语料与实验语料训练的词向量分别构建混合情感词典和产品特征词典,通过词典和定义的句法规则提取显式特征及情感词,根据其共现关系提取隐式特征。在相机评论语料集上进行实验并与现有方法进行对比,实验结果表明,该方法能有效提取显式及隐式特征,在获取全面特征信息上具有较好的性能。

关键词：隐式特征显式特征句法规则情感词词向量共现分析产品评论

体卫融合养老模式的逻辑理路、基本框架与推进方略

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天津体育学院学报 2024年第5期39卷 589-595页

作者：刘振耿涛刘远海柯勇武汉体育学院研究生院湖北武汉430079 湖北科技学院湖北武汉430079 武汉体育学院网球学院湖北武汉430079.

构建体卫融合养老模式是“十四五”时期构建更高质量养老服务体系的应有之义。运用文献归纳、逻辑分析等研究方法,从理论、历史和实践维度阐述体卫融合养老模式的构建逻辑,明确体卫养融合是破解当前我国老龄化困局之需。在积极应对人口... 详细信息

构建体卫融合养老模式是“十四五”时期构建更高质量养老服务体系的应有之义。运用文献归纳、逻辑分析等研究方法,从理论、历史和实践维度阐述体卫融合养老模式的构建逻辑,明确体卫养融合是破解当前我国老龄化困局之需。在积极应对人口老龄化战略指导下,将“积极老龄化”“运动是良医”等理论运用于养老服务,构建体卫融合养老模式基本框架,充分发挥物质、健康、精神三位一体价值功能,进而提出体卫融合养老模式的推进方略:政府兜底,提高体卫融合养老模式协调性;科技助力,提高体卫融合养老模式效益性;环境营造,提高体卫融合养老模式普及性。

关键词：体卫融合养老模式健康养老人口老龄化

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非O1群非O139群霍乱弧菌血流感染的诊疗及防控2例报告

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中国感染控制杂志 2024年第6期23卷 687-691页

作者：马天驰白露解柔刚周柯孙菲田克勇空军军医大学基础医学院学员六大队二十二队陕西西安710032 空军军医大学、西京医院检验科陕西西安710032 空军军医大学基础医学院神经生物学教研室陕西西安710032 空军军医大学、西京医院耳鼻咽喉头颈外科陕西西安710032

目的对2例血流感染患者血培养标本分离的弧菌属进行鉴定和药敏试验,分析非O1群非O139群霍乱弧菌(NOVC)的微生物学特性,为霍乱弧菌感染的诊断和防控提供依据。方法通过基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)、API细菌生化反应... 详细信息

目的对2例血流感染患者血培养标本分离的弧菌属进行鉴定和药敏试验,分析非O1群非O139群霍乱弧菌(NOVC)的微生物学特性,为霍乱弧菌感染的诊断和防控提供依据。方法通过基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)、API细菌生化反应鉴定卡、VITEK 2 Compact鉴定仪和16S rRNA基因测序鉴定2株弧菌分离株,并进行血清学分型、毒力基因分子检测和耐药表型检测。结果2株菌株均鉴定为霍乱弧菌,血清学试验确定为NOVC,毒力基因ctx AB检测阴性;药敏试验显示1株菌对氨苄西林、阿奇霉素、多西环素和氯霉素敏感,对四环素和复方磺胺甲唑耐药,另一菌株对所有检测抗菌药物均敏感。结论NOVC所致的血流感染在中国少有报道,完善血培养标本分离霍乱弧菌的准确鉴定、分型和耐药表型检测,对诊断、治疗和防控霍乱弧菌感染具有重要价值。

关键词：非O1群非O139群霍乱弧菌血流感染血清学分型抗菌药物敏感性感染防控