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Targeting the mammalian target of rapamycin pathway in osteosarcoma using combinative chemotherapy

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Chinese Medical Journal 2013年第10期126卷 1978-1981页

作者： LIU Pei-yi ZHANG Wei-bin WEI yi-yong Department of Orthopedics Ruijin Hospital Shanghai Jiao TongUniversity School of Medicine Shanghai Institute of Traumatologyand Orthopedics Shanghai 200025 China

Osteosarcoma is the most common primary malignant ＇bone sarcoma, and occurs predominantly in childrenand young adults. The overall survival of patients with osteosarcoma remains low at approximately 60%.1 The prognosis of osteosarcoma patients is highly associated with response to chemotherapy. Although multiple chemotherapy regimens have improved the outcome of patients with osteosarcoma, resistance to current regimens has been reported in more than 30% of patients,2 highlighting the need for novel, targeted therapies.

关键词： osteosarcoma mammalian target of rapamycin pathway chemotherapy.

Heterostructure:application of absorption-catalytic center in lithium-sulfur batteries

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Rare Metals 2024年第4期43卷 1461-1487页

作者： Fei Wang Chun-Man Yang yong-Qi Wang Dan You Wen-Hao Yang Rong-Wei Huang Ji-Yue Hou Qian Wang ying-Jie Zhang ying Wang Yue-Jing Zeng yi-yong Zhang Xue Li National Local Joint Engineering Research Center for Lithium-Ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Batteries Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming650093China College of Electrical Information Engineering Panzhihua UniversityPanzhihua617000China State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Centre of Chemistry for Energy MaterialsState-Province Joint Engineering Laboratory of Power Source Technology for New Energy VehicleEngineering Research Center of Electrochemical TechnologyMinistry of EducationCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China

Due to the high theoretical specific capacity(1675 mAh·g^(-1)),low cost,and high safety of the sulfur cathodes,they are expected to be one of the most promising rivals for a new generation of energy storage ***,the shuttle effect,low conductivity of sulfur and its discharge products,volume expansion,and other factors hinder the commercialization of lithium-sulfur batteries(LSBs).The development of sulfur-fixing materials and the design of multifunctional materials to enhance the electrochemical performance of LSBs have been the main research priorities in recent *** of the advantages of high conductivity,built-in electric field,and good synergism,more and more researchers have employed heterostructure into sulfur-fixing materials to enhance the catalytic and absorption ability for *** this review,the principle of heterostructure and the mechanism of enhancing the performance of lithium-sulfur batteries are *** applications of heterostructure in cathode and interlayer of LSBs in the latest years are ***,the cutting-edge troubles and possibilities of heterostructures in LSBs are briefly presented.

关键词： Lithium-sulfur batteries(LSBs) Heterostructure Built-in electric field Catalytic Absorption

Original article：A new diagnostic algorithm for vascular cognitive impairment： the proposed criteria and evaluation of its reliability and validity

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Chinese Medical Journal 2010年第3期 311-319页

作者： ZHAO Qian-lu ZHOU yong WANG yi-long DONG Ke-hui WANG yong-jun Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background Vascular cognitive impairment （VCI） is considered to be the most common pattern of cognitive impairment. We aimed to devise a diagnostic algorithm for VCI, and evaluate the reliability and validity of our proposed criteria. Methods We based our new algorithm on previous literature, a Delphi consensus method, and preliminary testing. First, successive 100 patients with cerebrovascular disease （CVD） in hospital underwent a structured medical examination. Twenty-five case vignettes fulfilled the proposed criteria of diagnosis for probable or possible VCI were divided into three subtype categories： vascular cognitive impairment, no dementia （VCIND）, vascular dementia （VaD） or mixed VCI/Alzheimer＇s disease （AD）. Inter-raters reliability was assessed using a Fleiss kappa analysis. Convergent validity was also evaluated by correlation coefficients （r） between the proposed key points for each subtype and the currently accepted criteria. Forty-five patients with probable VCI were examined to determine the accuracy of identification for each subtype. Results The proposed criteria showed clinical diagnostic validity for VCI, and were able to define probable, possible and definite VCI, three VCI subtypes, and vascular causes. There was good consensus between experts （Cronbach＇s a=0.96 for both rounds）. Significant moderate to good items-total correlations were found for two questionnaires （50-r range, 0.40-0.97 and 0.41-0.99, respectively）. Significant slight and moderate inter-raters reliability were obtained for VCI （k=0.13） and three VCI subtypes （k=0.45）. Furthermore, good convergent validity was observed in a comparison of significant correlations between criteria： good （4-r range, 0.75-0.92） to perfect （3-r=1.00） validity for the VCIND subtype, and moderate to good validity for the VaD subtype （1-r=0.46; 5-r range, 0.76-0.92） and for the mixed VCI/AD subtype （r=0.92 and 1.00; 4-r range, 0.47-0.70）. Importantly, the area under receiver operating characteristic （

关键词： criteria vascular cognitive impairment subtype cerebrovascular disease validity

EFFECTS OF AGRICULTURE RECLAMATION ON THE HYDROLOGIC CHARACTERISTICS IN THE SANJIANG PLAIN, CHINA

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Chinese Geographical Science 2001年第2期11卷 163-167页

作者： WANG yi-yong, YANG yong-xing (Changchun Institute of Geography, the Chinese Academy of Sciences,Changchun 130021,P. R. China) Changchun Institute of Geography the Chinese Academy of Sciences Changchun P. R. China

The Sanjiang Plain is the largest and most concentrated wetland region in China, the total area is about 1.088×107ha with rich marsh resources and biodiversity. Before 1949, the Sanjiang Plain was a large untravelled wild plant and waterfowl habitat, and there were some rare swans, red-crowned cranes and thousands of hydrophytes. From 1950, the local government began to reclaim the marsh in the Sanjiang Plain, built the commodity grain base of Northeast China, and developed the industry of grain processing, animal husbandry, etc. Up to now, there are 54 farms which control 3.5087×106ha agriculture field. The marsh areas are reduced by 1/2; many rare animals and plants are near extinction. The human activities and agriculture reclamation made a great change on the environment, especially made water balance change and regional climate change. So to study and protect the wetland ecosystem and marsh resource are extremely urgent. This paper focus on the hydrology change and climate change before and after marsh reclamation, including evapotranspiration, run off, soil character, micro-climate on both marsh and agriculture field, and the reason that cause seasonal drought, waterlogging and degeneration of marsh.

关键词： marsh agriculture reclamation the Sanjiang Plain

Structural Aberrations of Cellular Sialic Acids and Their Functions in Cancer Metastases

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Journal of Shanghai University(English Edition) 2001年第2期5卷 164-170页

作者： LU Da yong, CAO Jing yi School of Life Sciences, Shanghai University, Shanghai 200436 School of Life Sciences Shanghai University Shanghai

Sialic acids (neuraminic acids) are a special series of 9 carbon ring negatively charged carbohydrates, which has been found to be selectively changed in malignant cells from structures (both synthesis and structure modifications) to functions (up and down regulation in cells). Sialic acids, in single forms or conjugates, have been systematically studied both in lab and in clinics by GC, GC MS, NMR, HPTLC, HPLC and other modern analytical means. Sialic acids and related conjugates are predicted to be used in cancer diagnosis, cancer prognostic forecasting, designing of cancer chemotherapy regimens, uncovering carcinogenetic processes and neoplasm metastasis. Tumor cell regulative systems and pathways are correlated with sialic acids, which can be applied to prognostic evaluation of cancer patients, and antimetastatic chemotherapy by sialic acid derivatives and analogues. Searching for new biological characteristics of sialic acids in cells have also been extensively studied these days. In this paper, main stream discoveries and advancements are provided , also discussions of possible mechanisms and hypotheses are invoked.

关键词： sialic acid neoplasm metastasis cancer diagnosis cancer pathology cancer chemotherapy

Blockade of insulin receptor substrate-1 inhibits biological behavior of choroidal endothelial cells

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1386-1394页

作者： yi-yong Qian Hong-Ya Wu Gao-Qin Liu Chi Ren Pei-Rong Lu Xue-Guang Zhang Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Ophthalmology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Jiangsu Key Laboratory of Clinical Immunology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

AIM: To investigate the effects of blockade of insulin receptor substrate-1(IRS-1) on the bio-function of tube formation of human choroidal endothelial cells(HCECs).METHODS: Quantitative reverse transcriptionpolymerase chain reaction(RT-PCR) and Western blot were performed to determine the expression level of IRS-1 and phospho-IRS-1 in HCECs. Tube formation of HCECs was analyzed using three dimensional in vitro Matrigel assay with or without IRS-1 blockage via IRS-1 inhibitor(GS-101) and vascular endothelial growth factor receptor 2(VEGFR2) inhibitor. In addition, cell counting kit(CCK)-8 and Transwell migration assay were exerted to analyze the effects of blockade of IRS-1 on the bio-function of proliferation and migration of HCECs, respectively. The apoptosis of HCECs was examined using flow cytometry(FCM).RESULTS: RT-PCR and Western blot revealed that IRS-1 phospho-IRS-1 were expressed in HCECs and the expression level was enhanced by stimulation of VEGF-A. The number of tube formation was decreased significantly in GS-101 treated groups compared to phosphate buffered saline(PBS) treated control groups. Furthermore, both cell proliferation and migration of HCECs were decreased in the presence of GS-101. FCM analysis showed that the apoptosis of HCECs was enhanced when the cells were treated with GS-101. Western blot also showed that the expression level of cleaved-caspase 3 in GS-101 treated group was higher than that in control ***: Blockade of IRS-1 can inhibit tube formation of HCECs through reducing cell proliferation and migration and promoting cell apoptosis.

关键词： insulin receptor substrate-1 choroidal endothelial cells neovascularization proliferation

Update on thyroid ultrasound: a narrative review from diagnostic criteria to artificial intelligence techniques

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Chinese Medical Journal 2019年第16期132卷 1974-1982页

作者： Xiao-Wen Liang yong-yi Cai Jin-Sui Yu Jian-yi Liao Zhi-yi Chen Department of Ultrasound Medicine Laboratory of Ultrasound Medicine and Artificial IntelligenceExperimental Center of Liwan HospitalThe Third Affiliated Hospital of Guangzhou Medical UniversityThe Liwan Hospital of the Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510000China.

Objective Ultrasound imaging is well known to play an important role in the detection of thyroid disease, but the management of thyroid ultrasound remains inconsistent. Both standardized diagnostic criteria and new ultrasound technologies are essential for improving the accuracy of thyroid ultrasound. This study reviewed the global guidelines of thyroid ultrasound and analyzed their common characteristics for basic clinical screening. Advances in the application of a combination of thyroid ultrasound and artificial intelligence (AI) were also presented. Data sources An extensive search of the PubMed database was undertaken, focusing on research published after 2001 with keywords including thyroid ultrasound, guideline, AI, segmentation, image classification, and deep learning. Study selection Several types of articles, including original studies and literature reviews, were identified and reviewed to summarize the importance of standardization and new technology in thyroid ultrasound diagnosis. Results Ultrasound has become an important diagnostic technique in thyroid nodules. Both standardized diagnostic criteria and new ultrasound technologies are essential for improving the accuracy of thyroid ultrasound. In the standardization, since there are no global consensus exists, common characteristics such as a multi-feature diagnosis, the performance of lymph nodes, explicit indications of fine needle aspiration, and the diagnosis of special populations should be focused on. Besides, evidence suggests that AI technique has a good effect on the unavoidable limitations of traditional ultrasound, and the combination of diagnostic criteria and AI may lead to a great promotion in thyroid diagnosis. Conclusion Standardization and development of novel techniques are key factors to improving thyroid ultrasound, and both should be considered in normal clinical use.

关键词： Thyroid Ultrasound Guideline Artificial Intelligence Image Classification

CRYSTALLIZATION CHARACTERISTICS OF β-PHASE CRYSTALS IN COPOLYMERS OF POLYPROPYLENE WITH LOW ETHYLENE CONTENT

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Chinese Journal of Polymer Science 2001年第3期19卷 317-322页

作者： Wen-tao Hao yi-yong He Xiao-lie Luo De-zhu Ma Department of Polymer Science and Engineering University of Science and Technology of China Hefei 230026 China Univ Sci & Technol China Dept Polymer Sci & Engn Hefei 230026 Peoples R China

Polypropylene copolymers (CPP) containing β-nucleating agent were investigated by differential scanningcalorimetry (DSC), wide-angle X-ray diffraction (WAXD) and polarizing light microscopy (PLM). The results show thathigh content of β-phase crystals can also be formed for CPPs. Like PP homopolymers, the CPPs also have a most favorabletemperature near 132℃ for β-phase crystal growth. The crystallization rate of CPPs containing β-nucleating agent (β-CPP) ismuch greater than that of PP homopolymer containing β-nucleating agent (β-PP homopolymer). The observation ofspherulite morphology of β-CPP and β-PP homopolymer shows that the spherulites of β-CPP are more imperfect than thoseof β-PP homopolymer.

关键词： Copolymer polypropylene β-Nucleating agent Differential scanning calorimetry Wide angle X-ray diffraction Spherulite

Ordovician integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 971-1004页

作者： Xiang FANG yong yi ZHEN Guangxu WANG Xin WEI Zhongyang CHEN Yan LIANG Xuejin WU Wenjie LI Chao LI Renbin ZHAN Yuandong ZHANG State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Geological Survey of New South Wales W.B.Clarke Geoscience CentreNSW 2753Australia University of Chinese Academy of Sciences Beijing 100049China

The Ordovician rocks on the Qinghai-Tibetan Plateau represent the oldest non-metamorphic strata,and are critical to understanding the history of regional geology and biotic evolution of the entire *** of Floian,Darriwilian,Sandbian,Katian and Hirnantian are represented in the plateau with a hiatus of variable duration occurring underneath the basal Ordovician across the *** stratigraphical regions,including the Himalaya,Gangdise-Zayu,Qiangtang-Qamdo,Songpan-Garze,and Karakoram-Kunlun-Altun,are differentiated for the Ordovician strata,which are correlated with their equivalents in the Sibumasu,Indochina,Qaidam-Qilian,Tarim-Tianshan,and the Yangtze(western margin)stratigraphical *** the QinghaiTibetan Plateau,graptolites,conodonts,and cephalopods are the most common and useful fossils for the Ordovician *** Ordovician biotas of the Qinghai-Tibetan Plateau bear some distinguishable palaeobiogeographical signatures,among which the cephalopods are characterized by the flourishing actinocerids of North China affinity in the Early-Middle Ordovician,and by the thriving lituitids and orthocerids of South China affinity in the Middle-Late *** occurrences and their palaeobiogeographical evolution provide critical evidence bearing on the reconstruction of the geological history of the Qinghai-Tibetan Plateau and surrounding terranes in northeastern *** stratigraphical successions of the Cambrian-Ordovician transition in the Himalaya and Lhasa and nearby Sibumasu terranes were significantly affected by the Kurgiakh Orogeny,which resulted in the extensive unconformity between the Ordovician and the underlying rocks in most areas of the Qinghai-Tibetan *** southern Xizang,a warm-water biota of Middle Ordovician age was recovered from oolitic limestones,suggesting a likely palaeogeographical location in low-latitudes near the *** the Himalaya and Sibumasu regions,the Upper Ordovician was typified by t

关键词： Ordovician Chronostratigraphy Lithostratigraphy Biostratigraphy Palaeobiogeography Qinghai-Tibetan Plateau