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A VASUALIZATION FOR THE DYNAMIC BEHAVIORS OF THE MIXTURE OF WATER MASS FOR NORTHWESTERN PACIFIC NEAR JAPAN

International Journal of Modeling, Simulation, and Scientific Computing 2013年第S1期4卷 86-103页

作者： KUN ZHAO SATOSHI NAKADA NAOHISA SAKAMOTO KOJI KOYAMADA CHANDRAJIT BAJAJ yoichi ishikawa TOSHIYUKI AWAJI TEIJI IN SEI-ICHI SAITOH Graduate School of Engineering Kyoto University KyotoKyoto Prefecture606-8501Japan Institute for the Promotion of Excellence in Higher Education Kyoto University KyotoKyoto Prefecture606-8501Japan Department of Computer Science The Institute for Computational Engineering and Sciences University of Texas at Austin AustinTexas78712USA Department of Geophysics Division of Earth and Planetary Sciences Kyoto University KyotoKyoto Prefecture606-8501Japan Data Research Center for Marine-Earth Sciences Japan Agency for Marine-Earth Science and Technology Yokosuka Kanakawa Prefecture237-0061Japan Japan Marine Science Foundation Tokyo Tokyo Metropolis110-0008Japan Laboratory of Marine Bioresource and Environment Sensing Faculty of Fisheries Sciences Hokkaido University SapporoHokkaido Prefecture060-0808Japan

Recent studies are focusing on the distribution of water mass because the mixture region of water mass is highly related to the rich fishing grounds[Yasuda I.,Watanabe Y.,***.3(3):172–181,1994].Due to the large data size and time-varying property,efficient exploration and visualization of the ocean data is always extremely *** extract the dynamic behaviors of the water mass and its mixture from a large-scale simulated ocean dataset,we developed an efficient visualization system by applying our volume compression method and our volume rendering *** system allows us to investigate the time-varying distributions of ocean physical properties,additionally from the user’s perspective and *** the experiments,we show the generality and expressiveness by applying our system for single-and multi-property visualizations to find some significant ocean water ***,we could obtain a clear visualization result to show the dynamic behaviors of the mixture of water mass for simulation data regarding a location in the northwestern Pacific near Japan.

关键词： Oceanography water mass visualization.

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A visualization for the dynamic behaviors of the mixture of water mass for northwestern pacific near Japan

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International Journal of Modeling, Simulation, and Scientific Computing 2015年第2期6卷 213-214页

作者： Kun Zhao Satoshi Nakada Naohisa Sakamoto Koji Koyamada Chandrajit Bajaj yoichi ishikawa Toshiyuki Awaji Teiji In Sei-Ichi Saitoh Graduate School of Engineering Kyoto University KyotoKyoto Prefecture606-8501Japan Institute for the Promotion of Excellence in Higher Education Kyoto University KyotoKyoto Prefecture606-8501Japan Department of Computer Science The Institute for Computational Engineering and Sciences University of Texas at Austin AustinTexas78712USA Department of Geophysics Division of Earth and Planetary Sciences Kyoto University KyotoKyoto Prefecture606-8501Japan Data Research Center for Marine-Earth Sciences Japan Agency for Marine-Earth Science and Technology Yokosuka Kanakawa Prefecture237-0061Japan Japan Marine Science Foundation Tokyo Tokyo Metropolis110-0008Japan Laboratory of Marine Bioresource and Environment Sensing Faculty of Fisheries Sciences Hokkaido University SapporoHokkaido Prefecture060-0808Japan

(1)This article,published on 20 June 2013,had the following title:A VASUALIZATION FOR THE DYNAMIC BEHAVIORS OF THE MIXTURE OF WATER MASS FOR NORTHWESTERN PACIFIC NEAR JAPAN Here“VASUALIZATION”should be“VISUALIZATIO... 详细信息

关键词： northwestern dynamic NORTH

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HsfAld, a Protein Identified via FOX Hunting Using Thellungiella salsuginea cDNAs Improves Heat Tolerance by Regulating Heat-Stress-Responsive Gene Expression

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Molecular Plant 2013年第2期6卷 411-422页

作者： Yukari Higashi Naohiko Ohama Tomoko ishikawa Taku Katori Ayaka Shimura Kazuya Kusakabe Kazuko Yamaguchi-Shinozaki Junko Ishida Maho Tanaka Motoaki Seki Kazuo Shinozaki yoichi Sakata Takahisa Hayashi Teruaki Taji Department of Bio-Science Tokyo University of Agriculture 1-1-1 Sakuragaoka Setagaya Tokyo 156-8502 Japan Graduate School of Agriculture and Life Sciences University of Tokyo Tokyo 113-8657 Japan RIKEN Yokohama Institute 1-7-22 Suehiro-cho Tsururni-ku Yokohama 230-0045 Japan

Thellungiella salsuginea （formerly T. halophila）, a species closely related to Arabidopsis （Arabidopsis thali-ana）, is tolerant not only to high salt levels, but also to chilling, freezing, and ozone. Here, we report that T. salsuginea also shows greater heat tolerance than Arabidopsis. We identified T. salsuginea HsfAld （TsHsfAld） as a gene that can confer marked heat tolerance on Arabidopsis. TsHsfAld was identified via Full-length cDNA Over-eXpressing gene （FOX） hunt-ing from among a collection of heat-stress-related T. salsuginea cDNAs. Transgenic Arabidopsis overexpressing TsHsfAld showed constitutive up-regulation of many genes in the Arabidopsis AtHsfA1 regulon under normal growth tempera-ture. in Arabidopsis mesophyll protoplasts, TsHsfAld was localized in both the nucleus and the cytoplasm. TsHsfAld also interacted with AtHSP90, which negatively regulates AtHsfAls by forming HsfA1-HSP90 complexes in the cytoplasm. It is likely that the partial nuclear localization of TsHsfAld induced the expression of the AtHsfAld regulon in the transgenic plants at normal temperature. We also discovered that transgenic Arabidopsis plants overexpressing AtHsfAldwere more heat-tolerant than wild-type plants and up-regulated the expression of the HsfAld regulon, as was observed in TsHsfAld-overexpressing plants. We propose that the products of both TsHsfAld and AtHsfAld function as positive regulators of Arabidopsis heat-stress response and would be useful for the improvement of heat-stress tolerance in other plants.

关键词： Thellungiella salsuginea heat-stress tolerance HsfA1 FOX hunting.

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Eosinophilic Granuloma Arising from the Sacrum: A Case Report

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Open Journal of Orthopedics 2011年第2期1卷 5-8页

作者： Yuji Kasukawa Naohisa Miyakoshi Michio Hongo Shigeru Ando Yoshinori ishikawa yoichi Shimada 不详

Introduction: Osseous eosinophilic granulomas commonly occur in the skull, pelvis, vertebrae, mandible, and ribs. However, the eosinophilic granuloma in the sacrum is rare. Case presentation: We present the case of a 13-year-old Japanese boy, who presented with left low-back pain, and was diagnosed with eosinophilic granuloma arising in the sacrum. Computed tomography (CT) and magnetic resonance imaging demonstrated an osteolytic lesion with interruption of the cortex, and signal intensity changes at the left sacral body and wing. Histologic examination indicated an eosinophilic granuloma. Two years after CT-guided biopsy, the tumor had spontaneously healed completely, with no residual ***: The present case was eosiophilic granuloma arising from the rare site of sacrum. The tumor was completely remodeled two years after biopsy.

关键词： Eosinophilic granuloma Sacrum Biopsy

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Evaluation with Heart Rate Variability for the Treatment Effect of Aminophylline in Patients with Bradycardia after Cervical Spinal Cord Injury: A Preliminary Study

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Open Journal of Orthopedics 2013年第1期3卷 10-13页

作者： Noriyuki ishikawa Naohisa Miyakoshi Tetsuya Suzuki Akiko a Misaw Yuichi Takano yoichi Shimada Department of Orthopedic Surgery Akita Prefectural Center on Development and Disa- bility Akita Japan Department of Orthopedic Surgery Akita Red Cross Hospital Akita Japan Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan Iwai Orthopaedic Medical Hospital Tokyo Japan

After cervical spinal cord injury (SCI), the autonomic nervous system (ANS) becomes impaired and then, bradycardia can develop. In view of this, we performed to prescribe aminophylline as pharmacotherapy for bradycardia. The study population consisted of 36 patients with cervical SCI. Bradycardia developed in 20 patients (55.6%), of these patients, 8 showed spontaneous recovery. Twelve patients had persistent bradycardia, therefore, aminophylline was administered at 0.5 mg/kg/hr by intravenous infusion. Their average heart rate increased within 24 hours after the start of infusion. In heart rate variability analysis for 7 preliminarily selected patients, the spectral waveforms of “oligowave type” indicating ANS impairment tended to appear in relatively early phase after injury (i.e., 2 days to 2 weeks after injury), whereas “normal type” was observed in the late phase (i.e., at 4 weeks). “Sympathetic block type” was observed throughout the follow-up period (2 days to 4 weeks). “Sympathetic block type” was also observed in a non-bradycardic patient on day 2. These results underscore the importance of treating ANS impairment with aminophylline while keeping in mind that bradycardia can occur even in post-SCI patients without clinical manifestations.

关键词： Spinal Cord Injury Aminophylline Heart Rate Variability Autonomic Nervous System Bradycardia

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Spinal Epidural Myeloid Sarcoma with Paraplegia in Acute Myeloid Leukemia Treated with Radiation and Chemotherapy: A Case Report

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Open Journal of Orthopedics 2019年第6期9卷 131-136页

作者： Chiaki Sato Naohisa Miyakoshi Michio Hongo Yuji Kasukawa Yoshinori ishikawa Daisuke Kudo yoichi Shimada Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan

Myeloid sarcoma occurs in 1% - 9% of patients with myelogenous leukemia. Spinal epidural myeloid sarcoma is particularly rare, and its treatment has not been established. A 27-year-old woman complained of pain on her left chest, back around the scapula, and neck. Magnetic resonance imaging (MRI) showed a thoracic epidural tumor. One week after her visit, she developed motor weakness of her lower extremities and dysuria, and she was diagnosed with acute myelogenous leukemia (AML) on peripheral blood analysis. The epidural tumor was strongly suspected to be myeloid sarcoma. The paralysis of the lower extremities and bladder dysfunction were not progressive, and chemotherapy and local radiation therapy to the spine were performed. Improvement of paralysis and complete reduction of tumor volume were achieved by the combination of local low-dose radiation therapy and chemotherapy.

关键词： Myeloid Sarcoma Acute Myeloid Leukemia Spinal Cord Compression

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Pediatric Primary Malignant Lymphoma of the Spine: A Case Report

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Open Journal of Orthopedics 2012年第3期2卷 85-89页

作者： Daisuke Kudo Naohisa Miyakoshi Michio Hongo Yuji Kasukawa Yoshinori ishikawa Hiroshi Aonuma yoichi Shimada Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan

Background: Cases of primary malignant lymphomas of the bone are rare and account for about <1% of all lymphomas and 5% of extranodal non-Hodgkin’s lymphomas. Furthermore, most reports have described the occurrence of this disease in the middle-aged population, pediatric malignant lymphomas originating in the bone, particularly in the spine is rare. Methods: A 10-year-old boy presented with low back pain caused by T12 vertebral compression fracture due to sustaining a fall. A month later, he still presented with prolonged low back pain that intensified after exercise. A neoplastic lesion in T12 vertebral body was identified after spine computed tomography (CT) and magnetic resonance imaging. Results: We performed CT-guided biopsy, and he was diagnosed with primary malignant lymphoma of the vertebral body. He was treated with multiagent chemotherapy without irradiation, and complete remission was maintained at the 5-year follow-up. Moreover, the height of the deformed vertebral body improved as he grew. Conclusions: Herein, we report a rare case of pediatric primary malignant lymphoma of the spine with successful clinical and radiological outcome.

关键词： Malignant Lymphoma Pediatrics CT Guided Biopsy Wrap around Sign Chemotherapy Irradiation

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Glycosylation engineering of therapeutic IgG antibodies： challenges for the safety, functionality and efficacy

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Protein & Cell 2018年第1期9卷 47-62页

作者： Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto Pauline M. Rudd Department of Clinical Research NHO Yamaguchi-Ube Medical Center 685 Higashi-Kiwa Ube 755-0241 Japan Laboratory of Molecular Biology and Bioresponse Division of Integrated Life Science Graduate School of Biostudies KyotoUniversity Kitashirakawa Oiwake-Cho Sakyo-Ku Kyoto 606-8502 Japan NIBRT GlycoScience Group National Institute for Bioprocessing Research and Training Mount Merrion Blackrock Dublin 4Ireland Center for Regenerative Medicine Yamaguchi University Graduate School of Medicine 1-1-1 Minami Kogushi Ube 755-8505 Japan Center for Gene Research Yamaguchi University 1-1-1 Minami-Kogushi Ube 755-8505 Japan Research Institute for Bioresources and Biotechnology Ishikawa Prefectural University 1-308 Suematsu Nonoichi Ishikawa 921-8836 Japan

Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary *** oligosaccharide attached to Asn297 of the Fc is essen- tial for antibody effector functions, fucose and outer-arm sugars attached to the core heptasaccharide that gen- erate structural heterogeneity （glycoforms） exhibit unique biological activities. Hence, efficient and quan- titative glycan analysis techniques have been increas- ingly important for the development and quality control of therapeutic antibodies, and g｜ycan profiles of the Fc are recognized as critical quality attributes. In the past decade our understanding of the influence of glycosy- lation on the structure/function of IgG-Fc has grown rapidly through X-ray crystallographic and nuclear magnetic resonance studies, which provides possibili- ties for the design of novel antibody therapeutics. Fur- thermore, the chemoenzymatic glycoengineering approach using endoglycosidase-based glycosyn- thases may facilitate the development of homogeneous IgG glycoforms with desirable functionality as next- generation therapeutic antibodies. Thus, the Fc glycans are fertile ground for the improvement of the safety,functionality, and efficacy of therapeutic IgG antibodies in the era of precision medicine.

关键词： chemoenzymatic glycoengineering crysta structure endoglycosidase fucose glycosylation,intravenous immunoglobulin sialic acid transglycosylation,ultra performance liquid chromatography

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New Alleles of Rice <i>ebisu dwarf</i>(<i>d</i>2) Mutant Show both Brassinosteroid-Deficient and -Insensitive Phenotypes

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American Journal of Plant Sciences 2012年第12期3卷 1699-1707页

作者： Tomoaki Sakamoto yoichi Morinaka Hidemi Kitano Shozo Fujioka Bioscience and Biotechnology Center Nagoya University Nagoya Japan Faculty of Bioresources and Environmental Sciences Ishikawa Prefectural University Nonoichi Japan RIKEN Advanced Science Institute Wako Japan

ebisu dwarf (d2) is a mutant caused by mutation in a rice brassinosteroid biosynthetic enzyme gene, CYP90D2/D2, thereby conferring a brassinosteroid-deficient dwarf phenotype. Three newly isolated d2 alleles derived from a Nippon- bare mutant library (d2-3, d2-4, and d2-6) produced more severe dwarf phenotypes than the previously characterized null allele from a Taichung 65 mutant library, d2-1. Linkage analysis and a complementation test clearly indicated that the mutant phenotypes in d2-6 were caused by defects in CYP90D2/D2, and exogenous treatment with brassinolide, a bioactive brassinosteroid, rescued the dwarf phenotype of three Nipponbare-derived d2 mutants. However, the content of endogenous bioactive brassinosteroid, castasterone, and the expression of brassinosteroid-response genes indicated that partial suppression of the brassinosteroid response in addition to a brassinosteroid deficiency has occurred in the Nipponbare-derived d2 mutants. Based on these results, we discuss the possibility that wild-type Nipponbare has some defects in an unknown factor or factors related to the brassinosteroid response in rice.

关键词： Brassinosteroids Brassinosteroid Biosynthetic Enzymes Brassinosteroid Sensitivity Cytochrome P450 Monooxygenase Mutant Allele Rice

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Therapeutic efficacy of ramucirumab after lenvatinib for post-progression treatment of unresectable hepatocellular carcinoma

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Gastroenterology Report 2021年第2期9卷 133-138,I0002页

作者： Atsushi Hiraoka Takashi Kumada Toshifumi Tada Chikara Ogawa Joji Tani Shinya Fukunishi Masanori Atsukawa Masashi Hirooka Kunihiko Tsuji Toru ishikawa Koichi Takaguchi Kazuya Kariyama Ei Itobayashi Kazuto Tajiri Noritomo Shimada Hiroshi Shibata Hironori Ochi Kazuhito Kawata Hidenori Toyoda Hideko Ohama Kazuhiro Nouso Akemi Tsutsui Takuya Nagano Norio Itokawa Korenobu Hayama Taeang Arai Michitaka Imai Yohei Koizumi Shinichiro Nakamura Kojiro Michitaka yoichi Hiasa Masatoshi Kudo Gastroenterology Center Ehime Prefectural Central HospitalEhimeJapan Department of Gastroenterology and Hepatology Ogaki Municipal HospitalGifuJapan Department of Internal Medicine Himeji Red Cross HospitalHyogoJapan Department of Gastroenterology and Hepatology Takamatsu Red Cross HospitalTakamatsuJapan Department of Gastroenterology and Hepatology Kagawa universityKagawaJapan Department of Gastroenterology Osaka Medical CollegeOsakaJapan Division of Gastroenterology and Hepatology Department of Internal MedicineNippon Medical SchoolTokyoJapan Department of Gastroenterology and Metabology Ehime University Graduate School of MedicineEhimeJapan Center of Gastroenterology Teine Keijinkai HospitalSapporoJapan Department of Gastroenterology Saiseikai Niigata HospitalNiigataJapan Department of Hepatology Kagawa Prefectural Central HospitalTakamatsuJapan Department of Gastroenterology Okayama City HospitalOkayamaJapan Department of Gastroenterology Asahi General HospitalAsahiJapan Department of Gastroenterology Toyama University HospitalToyamaJapan Division of Gastroenterology and Hepatology Otakanomori HospitalKashiwaJapan Department of Gastroenterology Tokushima Prefectural Central HospitalTokushimaJapan Hepato-biliary Center Matsuyama Red Cross HospitalMatsuyamaJapan Department of Hepatology Hamamatsu University School of MedicineHamamatsuJapan Department of Gastroenterology Kindai UniversityOsakaJapan

Background:Lenvatinib is used for unresectable hepatocellular carcinoma(u-HCC)as first-line,as well as second-and third-line therapy in *** evaluated the therapeutic efficacy of newly developed ramucirumab when given after lenvatinib for post-progression ***:Of 385 patients with u-HCC and treated with lenvatinib at 16 different institutions in Japan between May 2018 and January 2020,28 who received ramucirumab as the next treatment were enrolled and therapeutic responses were evaluated in a retrospective ***:The median age of the 28 patients given ramucirumab was 70 years and the median albumin-bilirubin score *** the 28 patients,23 were male,21 were classified as Child-Pugh A and 7 as Child-Pugh B,and 25 were Barcelona Clinic Liver Cancer Stage *** was given as second-line therapy in 14,third-line in 9,and fourth-line in *** response was obtained in only 26 patients;the objective response rate was 3.8%(1/26)and the disease-control rate was 42.3%(11/26),with a median period to progression of 2.0 *** reasons for discontinuation of ramucirumab were progression of disease in 16 and Grade 3 adverse events(gastrointestinal bleeding,ascites)in ***:The anticipated therapeutic efficacy of ramucirumab for post-progression treatment following lenvatinib was not seen in our early experience.

关键词： hepatocellular carcinoma ramucirumab lenvatinib sorafenib

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