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Oncology Research 2024年第4期32卷 643-658页

作者： LEI LIU NA GUO XIANGLING LI QIAN XU RUILONG HE LIMIN CHENG CHUNYAN DANG XINYU bai yiying bai XIN WANG QIANHUI CHEN LI ZHANG Department of Immunology Chengde Medical UniversityChengde067000China Department of Pathology Chengde Medical UniversityChengde067000China Department of Oncology The Affiliated Hospital of Chengde Medical UniversityChengde067000China Department of Hepatobiliary Surgery The Affiliated Hospital of Chengde Medical UniversityChengde067000China

The platinum-based chemotherapy is one of the most frequently used treatment protocols for lung adenocarcinoma(LUAD),and chemoresistance,however,usually results in treatment failure and limits its application in the *** has been shown that microRNAs(miRNAs)play a significant role in tumor *** this study,miR-125b was identified as a specific cisplatin(DDP)-resistant gene in LUAD,as indicated by the bioinformatics analysis and the real-time quantitative PCR *** decreased serum level of miR-125b in LUAD patients was correlated with the poor treatment response rate and short survival ***-125b decreased the A549/DDP proliferation,and the multiple drug resistance-and autophagy-related protein expression levels,which were all reversed by the inhibition of *** addition,xenografts of human tumors in nude mice were suppressed by miR-125b,demonstrating that through autophagy regulation,miR-125b could reverse the DDP resistance in LUAD cells,both in vitro and in *** mechanistic studies indicated that miR-125b directly repressed the expression levels of RORA and its downstream BNIP3L,which in turn inhibited autophagy and reversed *** on these findings,miR-125b in combination with DDP might be an effective treatment option to overcome DDP resistance in LUAD.

关键词： Lung adenocarcinoma miRNAs Cisplatin Resistance Autophagy

Expression and Clinical Significance of Ki67 in Common Gastrointestinal Tumours

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Open Journal of Gastroenterology 2021年第12期11卷 295-306页

作者： Fangyu Shi Yunnan Dai yiying bai Qingshan Li Affiliated Hospital of Chengde Medical University Chengde China

Ki67 is a marker of cell proliferation that is expressed in the S, G2 and M phases but not in the G0 phase of the cell cycle. Several recent studies showed that the expression of Ki67 is closely related to the occurrence and development of gastrointestinal tumours. The Ki67 index is closely related to the degree of differentiation, invasion, metastasis and prognosis of gastrointestinal tumours. This review describes the relationship between the Ki67 index and degree of malignancy, therapeutic effect and prognosis of gastrointestinal tumours.

关键词： Gastrointestinal Neoplasms Ki67 Pathological Features Prognosis

Positive Correlation between PMS2 Deficiency and PD-L1 Expression in Pancreatic Cancer

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Advances in Bioscience and Biotechnology 2023年第2期14卷 74-90页

作者： Cailing Jiang Chunyan Dang Ruilong He Limin Cheng yiying bai Xinyu bai Xin Wang Qianhui Chen Hongbin Yang Zhengxin Zhang Xiaotong Zhang Yan Chen Qian Xu Lei Liu Li Zhang Department of Oncology The Affiliated Hospital of Chengde Medical University Chengde China Department of Hepatobiliary Surgery The Affiliated Hospital of Chengde Medical University Chengde China Department of Immunology Chengde Medical University Chengde China Department of Pathology Chengde Medical University Chengde China

Background: Pancreatic cancer is one of the most lethal types of cancer, and immunotherapy has become a promising remedy with advancements in tumor immunology. However, predicting the clinical response to immunotherapy in pancreatic cancer remains a dilemma for clinicians. Methods: GEPIA database was used to analyze the differential expression of MMR and PD-L1 genes in 33 common cancer types including pancreatic cancer. The expression levels of MMR and PD-L1 genes were downloaded from the GEPIA and GEO databases to analyze the correlation between MMR genes and PD-L1, and the clinicopathological and survival information were downloaded from the TCGA databases to analyze the relationship between the expression of MMR, PD-L1 and clinicopathological characteristics, prognosis. Meanwhile, the tumor tissue samples of 41 patients with pancreatic cancer were collected, and the protein expression levels of MMR and PD-L1 were detected by immunohistochemical assay. Furthermore, we analyzed the correlation between MMR and PD-L1, and the correlation between the expression of MMR, PD-L1 and clinicopathological characteristics, prognosis of pancreatic cancer patients. Results: Bioinformatics analysis showed that MLH1, MLH3, MSH2, MSH3, and PMS2 were highly expressed in most cancer types including pancreatic cancer (P P = 0.012), clinical stage (I vs II: P = 0.016), MSH2 expression was related to clinical stage (P < 0.05), T stage (T3 vs T4: P = 0.039), and MSH3 expression was related to T stage (P < 0.05). Besides, both MSH2 expression (P P = 0.044) were significantly associated with prognosis. GEPIA data also showed that MSH2 expression was related to prognosis (P = 0.008). The correlation analysis revealed that the expressions MSH2, MLH1, PMS2 had strong correlations with PD-L1 both in GEPIA and GEO databases. Real-world data indicated that of the 41 pancreatic cancer patients, 5 cases had MLH1 deletion, 5 cases had MSH2 deletion, 4 cases had PMS2 deletion, and 12 cases had PD-L

关键词： Pancreatic Cancer PD-L1 PMS2 Mismatch Repair Protein Correlation

“房住不炒”下地方政府、开发商与投机者的博弈研究

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财经理论与实践 2023年第4期44卷 121-128页

作者：鞠方阿月荷白怡颖湘潭大学商学院湖南湘潭411105

构建地方政府、开发商和投机者的三方演化博弈模型,运用Matlab仿真,考量“房住不炒”定位下各主体决策行为与演化稳定均衡。结果表明:地方政府选择“积极调控”、开发商选择“原价或降价”和投机者选择“观望”时有利于进化稳定策略实现... 详细信息

构建地方政府、开发商和投机者的三方演化博弈模型,运用Matlab仿真,考量“房住不炒”定位下各主体决策行为与演化稳定均衡。结果表明:地方政府选择“积极调控”、开发商选择“原价或降价”和投机者选择“观望”时有利于进化稳定策略实现;在当前房产税试点税率下,调控政策效果未达到预期;调控执行成本、开发商寻租成本和投机者房价预期会显著影响各主体的策略选择。鉴于此,“房住不炒”定位下应兼顾多方利益需求,深化房产税改革、降低调控执行成本等,促进调控目标实现。

关键词：房住不炒三方演化博弈演化稳定策略

“租购同权”政策对我国大中城市房价的影响研究

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财经理论与实践 2021年第5期42卷 124-131页

作者：鞠方白怡颖许依玲湘潭大学商学院湖南湘潭411105

根据2014年1月至2019年12月我国35个大中城市的面板数据,运用双重差分模型考量了“租购同权”政策对房价的影响。结果显示:“租购同权”政策不仅能直接有效地抑制试点城市新建商品住房及二手住房房价的增长,还能通过降低房价上涨预期间... 详细信息

根据2014年1月至2019年12月我国35个大中城市的面板数据,运用双重差分模型考量了“租购同权”政策对房价的影响。结果显示:“租购同权”政策不仅能直接有效地抑制试点城市新建商品住房及二手住房房价的增长,还能通过降低房价上涨预期间接平抑房价增长速度,且该政策对不同属性的住房市场及不同建筑面积的住房影响也不同。鉴此,应继续落实“租购同权”政策,大力发展住房租赁市场,增加优质教育资源的供给。

关键词：房价租购同权双重差分

我国云计算在图书馆领域应用研究成果综述——基于CNKI的计量分析

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图书馆学刊 2021年第3期43卷 73-81页

作者：柏艺莹天津社会科学院图书馆天津300191

大数据时代,图书馆数字化资源建设是图书馆长期发展的需求。云计算新兴技术的应用,是现代数字化资源建设的重要推动力。以我国有关云计算在图书馆领域应用的研究成果为对象,利用文献计量学的方法,从文献总体特征、作者合著现象、高频关... 详细信息

大数据时代,图书馆数字化资源建设是图书馆长期发展的需求。云计算新兴技术的应用,是现代数字化资源建设的重要推动力。以我国有关云计算在图书馆领域应用的研究成果为对象,利用文献计量学的方法,从文献总体特征、作者合著现象、高频关键词耦合现象3个方面进行计量分析,以期揭示我国云计算技术在图书馆领域应用研究成果的现状、焦点以及未来发展方向。

关键词：云计算数字图书馆计量分析

Effectiveness and mechanisms of adiposederived stem cell therapy in animal models of Parkinson’s disease:a systematic review and meta-analysis

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Translational Neurodegeneration 2021年第2期10卷 166-177页

作者： Keya Li Xinyue Li Guiying Shi Xuepei Lei yiying Huang Lin bai Chuan Qin NHC Key Laboratory of Human Disease Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China

Animal models provide an opportunity to assess the optimal treatment way and the underlying mechanisms of direct clinical application of adipose-derived stem cells(ADSCs).Previous studies have evaluated the effects of primitive and induced ADSCs in animal models of Parkinson’s disease(PD).Here,eight databases were systematically searched for studies on the effects and in vivo changes caused by ADSC *** assessment was conducted using a 10-item risk of bias *** the subsequent meta-analysis,study characteristics were extracted and effect sizes were *** out of 2324 published articles(n=169 animals)were selected for further *** ADSC therapy,the rotation behavior(10 experiments,n=156 animals)and rotarod performance(3 experiments,n=54 animals)were improved(P<0.00001 and P=0.0003,respectively).The rotation behavior test reflected functional recovery,which may be due to the neurogenesis from neuronally differentiated ADSCs,resulting in a higher pooled effect size of standard mean difference(SMD)(−2.59;95%CI,−3.57 to−1.61)when compared to that of primitive cells(−2.18;95%CI,−3.29 to−1.07).Stratified analyses by different time intervals indicated that ADSC intervention exhibited a long-term *** the transplantation of ADSCs,tyrosine hydroxylase-positive neurons recovered in the lesion area with pooled SMD of 13.36[6.85,19.86].Transplantation of ADSCs is a therapeutic option that shows long-lasting effects in animal models of *** potential mechanisms of ADSCs involve neurogenesis and neuroprotective *** standardized induction of neural form of transplanted ADSCs can lead to a future application in clinical practice.

关键词： Parkinson’s disease Adipose-derived stem cells Animal model Stem cell therapy Meta-analysis Neurogenesis Neuroprotection

Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer’s disease: a meta-analytic review on potential mechanisms

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Translational Neurodegeneration 2020年第2期9卷 214-233页

作者： Chuan Qin Yalan Lu Kewei Wang Lin bai Guiying Shi yiying Huang Yongning Li Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences&Comparative Medical CenterPeking Union Medical CollegeBeijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases5 Panjiayuan Nanli StBeijing100021China Department of International Medical Service&Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShuaifuyuan 1Dong Cheng DistrictBeijing100730China

Background Alzheimer’s disease is a neurodegenerative ***,a transplantation of bone marrow mesenchymal stem cells(BMMSCs)can play a beneficial role in animal models of Alzheimer’s ***,the relevant mechanism remains to be fully *** body Subsequent to the transplantation of BMMSCs,memory loss and cognitive impairment were significantly improved in animal models with Alzheimer’s disease(AD).Potential mechanisms involved neurogenesis,apoptosis,angiogenesis,inflammation,immunomodulation,*** above mechanisms might play different roles at certain *** was revealed that the transplantation of BMMSCs could alter some gene ***,the differential expression of representative genes was responsible for neuropathological phenotypes in Alzheimer’s disease,which could be used to construct gene-specific *** Multiple signal pathways involve therapeutic mechanisms by which the transplantation of BMMSCs improves cognitive and behavioral deficits in AD *** expression profile can be utilized to establish statistical regression model for the evaluation of therapeutic *** transplantation of autologous BMMSCs maybe a prospective therapy for patients with Alzheimer’s disease.

关键词： Alzheimer's disease Bone marrow mesenchymal stem cells Meta-analysis Amyloid P peptide Memory loss Cognitive deficits Animal model Neuropathology

Overexpression of ZxABCG11 from Zygophyllum xanthoxylum enhances tolerance to drought and heat in alfalfa by increasing cuticular wax deposition

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The Crop Journal 2023年第4期11卷 1140-1151页

作者： Linbo Liu Aike Bao Hujun Li Wanpeng bai Haishuang Liu Ye Tian yiying Zhao Fangchen Xia Suomin Wang State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou 730020GansuChina College of Biology Hunan UniversityChangsha 410008HunanChina

Drought and heat stresses cause yield losses in alfalfa,a forage crop cultivated *** its drought and heat tolerance is desirable for maintaining alfalfa productivity in hot,arid *** wax forms a protective barrier on aerial surfaces of land plants against environmental ***11encodes an ATP binding cassette(ABC) transporter that functions in the cuticular wax transport *** this study,Zx ABCG11 from the xerophyte Zygophyllum xanthoxylum was introduced into alfalfa by Agrobacterium tumefaciens-mediated *** to the wild type(WT),transgenic alfalfa displayed faster growth,higher wax crystal density,and thicker cuticle on leaves under normal *** either drought or heat treatment in greenhouse conditions,the plant height and shoot biomass of transgenic lines were significantly higher than those of the *** alfalfa showed excellent growth and 50% greater hay yield than WT under field conditions in a hot,arid *** of Zx ABCG11 up-regulated wax-related genes and resulted in more cuticular wax deposition,which contributed to reduction of cuticle permeability and thus increased water retention and photosynthesis capacity of transgenic ***,overexpression of Zx ABCG11 can simultaneously improve biomass yield,drought and heat tolerance in alfalfa by increasing cuticular wax *** study provides a promising avenue for developing novel forage cultivars suitable for planting in hot,arid,marginal lands.

关键词： Alfalfa ZxABCG11 Cuticular wax Yield Stress tolerance

End-to-End Fusion of Hyperspectral and Chlorophyll Fluorescence Imaging to Identify Rice Stresses

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Plant Phenomics 2022年第1期4卷 142-155页

作者： Chu Zhang Lei Zhou Qinlin Xiao Xiulin bai Baohua Wu Na Wu yiying Zhao Junmin Wang Lei Feng School of Information Engineering Huzhou UniversityHuzhou 313000China College of Mechanical and Electronic Engineering Nanjing Forestry UniversityNanjingChina College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China Key Laboratory of Spectroscopy Sensing Ministry of Agriculture and Rural AffairsHangzhou 310058China Institute of Digital Agriculture Zhejiang Academy of Agricultural SciencesHangzhou 310021China Institute of Crop Science and Nuclear Technology Utilization Zhejiang Academy of Agricultural SciencesHangzhou 310021China

Herbicides and heavy metals are hazardous substances of environmental pollution,resulting in plant stress and harming humans and *** of stress types can help trace stress sources,manage plant growth,and improve stress-resistant *** this research,hyperspectral imaging(HSI)and chlorophyll fluorescence imaging(Chl-FI)were adopted to identify the rice plants under two types of herbicide stresses(butachlor(DCA)and quinclorac(ELK))and two types of heavy metal stresses(cadmium(Cd)and copper(Cu)).

关键词： breeding. Fluorescence pollution