Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer’s disease: a meta-analytic review on potential mechanisms

作     者：Chuan Qin Yalan Lu Kewei Wang Lin Bai Guiying Shi Yiying Huang Yongning Li 

作者机构：Institute of Laboratory Animal SciencesChinese Academy of Medical Sciences&Comparative Medical CenterPeking Union Medical CollegeBeijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases5 Panjiayuan Nanli StBeijing100021China Department of International Medical Service&Department of NeurosurgeryPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShuaifuyuan 1Dong Cheng DistrictBeijing100730China 

出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)

年 卷 期：2020年第9卷第2期

页      面：214-233页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：This work was supported by grants Beijing Natural Science Foundation(No.517100) National Key Research and Development Project(No.2017YFA0105200) CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2M-2-006) 

主　　题：Alzheimer's disease Bone marrow mesenchymal stem cells Meta-analysis Amyloid P peptide Memory loss Cognitive deficits Animal model Neuropathology 

摘      要：Background Alzheimer’s disease is a neurodegenerative ***,a transplantation of bone marrow mesenchymal stem cells(BMMSCs)can play a beneficial role in animal models of Alzheimer’s ***,the relevant mechanism remains to be fully *** body Subsequent to the transplantation of BMMSCs,memory loss and cognitive impairment were significantly improved in animal models with Alzheimer’s disease(AD).Potential mechanisms involved neurogenesis,apoptosis,angiogenesis,inflammation,immunomodulation,*** above mechanisms might play different roles at certain *** was revealed that the transplantation of BMMSCs could alter some gene ***,the differential expression of representative genes was responsible for neuropathological phenotypes in Alzheimer’s disease,which could be used to construct gene-specific *** Multiple signal pathways involve therapeutic mechanisms by which the transplantation of BMMSCs improves cognitive and behavioral deficits in AD *** expression profile can be utilized to establish statistical regression model for the evaluation of therapeutic *** transplantation of autologous BMMSCs maybe a prospective therapy for patients with Alzheimer’s disease.