检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

梢涡空化CFD数值方法

哈尔滨工程大学学报 2011年第6期32卷 702-707页

作者：韩宝玉熊鹰刘志华海军工程大学船舶与动力学院湖北武汉430033

针对梢涡空化问题,应用雷诺平均的N-S方程并结合改进VOF(volume fraction)模型,对椭圆形水翼梢涡空化特性进行了研究,采用的湍流模型为代数雷诺应力模型.为减小网格离散误差,计算中对梢涡处的网格进行了加密.对未发生空化时梢涡内轴向... 详细信息

针对梢涡空化问题,应用雷诺平均的N-S方程并结合改进VOF(volume fraction)模型,对椭圆形水翼梢涡空化特性进行了研究,采用的湍流模型为代数雷诺应力模型.为减小网格离散误差,计算中对梢涡处的网格进行了加密.对未发生空化时梢涡内轴向速度和切向速度分布进行计算,为了准确模拟梢涡涡核内系统旋转和流线曲率影响,将旋转和曲率修正方法应用于湍流模型中,发现经过修正的湍流模型明显提高了预报精度,与实验结果吻合较好,而未经修正的湍流模型过高预报了梢涡内湍流粘性耗散.在此基础上,结合改进VOF模型对梢涡空化的消失空泡数进行了预报,计算结果与实验测量结果相符.

关键词：梢涡空化改进VOF空化模型湍流模型旋转和曲率修正消失空泡数

Activating Transcription Factor 3 Is Essential for Cigarette Smoke-Induced Mucin Expression via Interaction with Activator Protein-1

在线全文

学校读者我要写书评

暂无评论

Activating Transcription Factor 3 Is Essential for Cigarette...

2016（第三十八届）浙江省呼吸系病学术年会

作者： Wu Yanping Wu Yinfang ying Songmin Chen zhihua Shen Huahao Li Wen Department of Respiratory and Critical Care Medicine Second Affiliated HospitalSchool of MedicineZhejiang University

OBJECTIVE:Our study investigated whether ATF3 is involved in the regulation of MUC5AC expression in COPD and explore the molecular *** AND METHODS:CS-induced ATF3 and MUC5AC expression levels were examined in HBE cells,human NCI-H292 cells and ***3 small interfering RNA(siRNA)and plasmid were used to investigate whether ATF3 is involved in CS-induced MUC5AC *** used quantitative real time PCR,Western Blot and immunofluorescence to assess whether the loss or gain of ATF3

关键词：

DNA-PKcs interacting with SIK2 functions in irradiated DNA damage

在线全文

cnki会议

学校读者我要写书评

暂无评论

DNA-PKcs interacting with SIK2 functions in irradiated DNA d...

第八届海峡两岸毒理学研讨会

作者： Yongqing Gu ying Zhang Bin Wang Xiujie Pan zhihua Yang Maoxiang Zhu Beijing Institute of Radiation Medicine School of Medicine Shihezi University School of Life Science Shihezi University

DNA-PKcs is an important molecule of non-homologous end joining repair of double strand *** DNA double strand breaks occurs,DNA-PKcs could be recruited to DNA damaged site within several *** of DNA-PKcs leads to a decreased repair ability of DNA double strand breaks and an increased *** addition to damaged DNA repair,DNA-PKcs plays important role in regulating mitosis process of irradiated cell and is a key molecule to couple damaged DNA repair and mitosis ***-PKcs participates G2 checkpoint of irradiated cell,regulates mitosis process and maintains centrosome and spindle *** is a Serine and threosine kinase belonged to adenosine monophosphate activated protein kinase and sucrose non-fermenting 1（AMPK/SNF1）,originally cloned from adrenal gland of high-salt-fed ***2 expresses highly in adipose tissue,depress synthesis of fat at low energy *** addition,SIK2 is a key molecule to regulate mitosis ***2 is colocolized at centrosome withγactin in intermediate stage and the whole *** of SIK2 can lead to failure of centrosome separation,arrest of prometaphase of mitosis and failure to form bipolar *** the first time we found that DNA-PKcs and SIK2 had interaction by yeast two *** then confirmed their interaction by Co-immunoprecipitation and GST-Pulldown *** we supported evidence of SIK2 being a novel repair protein of irradiated DNA damage.

关键词： DNA-PKcs SIK2 DNA damage response DNA repair

Integrated profiling identifies SLC5A6 and MFAP2 as novel diagnostic and prognostic biomarkers in gastric cancer patients

在线全文

cnki会议

学校读者我要写书评

暂无评论

Integrated profiling identifies SLC5A6 and MFAP2 as novel di...

2019年浙江省检验医学学术大会

作者： Tao Sun Danhua Wang ying Ping Yiwen Sang Weiwei Liu zhihua Tao The Second Affiliated Hospital of Zhejiang University School of Medicine

Background:Gastric cancer(GC) is one of the leading causes of malignancy-related mortality globally. However, the underlying molecular mechanisms of GC are unclear, and the prognosis of GC is miserable. Therefore, it’s important to explore the underlying mechanisms and screen for novel prognostic biomarkers and therapeutic ***:Weighted gene co-expression network analysis(WGCNA) was used to construct free-scale gene co-expression networks to explore the associations between gene sets and clinical features, and to identify hub genes. The gene expression profiles of GSE38749 were selected from the Gene Expression Omnibus(GEO) database. RNA-seq data and clinical information of gastric cancer from the Cancer Genome Atlas(TCGA) were used for validation. Furthermore, the candidate biomarkers expression in gastric tissueswere investigated. Survival analysis was performed with the Kaplan-Meier curve and log-rank test. The predictive role of candidate biomarkers in GC was evaluated by using a receiver operator characteristic(ROC) curve. Gene ontology(GO), gene set enrichment analysis(GSEA), and gene set variation analysis(GSVA) methods were used to interpret the functions of candidate biomarkers in ***:A total of 29 modules were identified via the average linkage hierarchical *** found the significant module consisting of48 genes associated with clinical traits, 3 genes with high connectivity in the clinical significant module were identified as hub genes. Among them, SLC5 A6, and MFAP2 were negatively associated with the overall survival, and their expressionsare elevated in GC compared with that non-tumor samples. Additionally,ROC curves indicated that SLC5 A6 and MFAP2 showed a good diagnostic power in discriminating cancer from normal ***:We identified SLC5 A6 and MFAP2 as novel diagnostic and prognostic biomarkers in GC ***, both of them were first reported in GC and deserved further research.

关键词： Gastric cancer Weighted gene co-expression network analysis The Cancer Genome Atlas Candidate gene Overall survival Prognosis Receiver operating characteristic

Tong-Luo-San-Jie Formula External Application on Bone Cancer Pain

在线全文

cnki会议

学校读者我要写书评

暂无评论

Tong-Luo-San-Jie Formula External Application on Bone Cancer...

第十四届全国中药和天然药物学术研讨会

作者： Fangyuan Wang Juyong Wang Changsheng Dong Qing Wang ying Lin zhihua Du Longhua Hospital Shanghai University of Traditional Chinese Medicine

Objective To exploring the effects and mechanisms of TLSJ Formula on bone cancer pain in rat *** The Walker 256 cells(1x10 cells/ml) were injected into the abdominal cavities of the rats(70-90 g).After seven days,the cells collected from ascitic fluid were injected into the rats’ bone cavity in the right pelvic *** the mechanisms of TLSJ Formula’s action on cancer pain by assessing both mechanical and thermal sensitivity,the time course of bone mineral density(BMD),and the conditioned place preference(CPP) *** TLSJ treatment significantly restored bone cancer-induced decreasing of PWL and mechanical threshold compared to vehicle *** also significantly repaired cancer-induced decreasing of BMD levels and decreased the destruction such as bone marrow and bone ***,it showed that TLSJ Formula produced CPP effects to the bone cancer pain *** These results suggests that TLSJ Formula not only can inhibit cancer induced bone destruction and hyperalgesia but also produced CPP *** suggests that this formula may be useful in managing cancer pain and that it may act by decreased the destruction such as bone marrow and bone loss.

关键词： Tong-Luo-San-Jie Formula Chinese herbs bone cancer pain.

DNA-PKcs interacting with SIK2 functions in irradiated DNA damage

在线全文

cnki会议

学校读者我要写书评

暂无评论

DNA-PKcs interacting with SIK2 functions in irradiated DNA d...

中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛

作者： Yongqing Gu ying Zhang Bin Wang Xiujie Pan zhihua Yang Maoxiang Zhu Beijing Institute of Radiation Medicine School of Medicine Shihezi University School of Life Science Shihezi University

Absract:DNA-PKcs is an important molecule of non-homologous end joining repair of double strand *** DNA double strand breaks occurs,DNA-PKcs could be recruited to DNA damaged site within several *** of DNA-PKcs leads to a decreased repair ability of DNA double strand breaks and an increased *** addition to damaged DNA repair,DNA-PKcs plays important role in regulating mitosis process of irradiated cell and is a key molecule to couple damaged DNA repair and mitosis ***-PKcs participates G2 checkpoint of irradiated cell,regulates mitosis process and maintains centrosome and spindle *** is a Serine and threosine kinase belonged to adenosine monophosphate activated protein kinase and sucrose non-fermenting 1（AMPK/SNF1）,originally cloned from adrenal gland of high-salt-fed ***2 expresses highly in adipose tissue,depress synthesis of fat at low energy *** addition,SIK2 is a key molecule to regulate mitosis ***2 is colocolized at centrosome with y actin in intermediate stage and the whole *** of SIK2 can lead to failure of centrosome separation,arrest of prometaphase of mitosis and failure to form bipolar *** the first time we found that DNA-PKcs and SIK2 had interaction by yeast two *** then confirmed their interaction by Co-immunoprecipitation and GST-Pulldown *** we supported evidence of SIK2 being a novel repair protein of irradiated DNA damage.

关键词： DNA-PKcs SIK2 DNA damage response DNA repair

Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B:a multi-center retrospective cohort study

在线全文

cnki会议

学校读者我要写书评

暂无评论

Frontiers of Medicine 2022年第1期16卷 111-125页

作者： Jing Wang Zequn Lu Meng Jin ying Wang Kunming Tian Jun Xiao Yimin Cai Yanan Wang Xu Zhang Tao Chen Zhi Yao Chunguang Yang Renli Deng Qiang Zhong Xiongbo Deng Xin Chen Xiang-ping Yang Gonghong Wei zhihua Wang Jianbo Tian Xiao-ping Chen Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Epidemiology and Biostatistics Key Laboratory for Environment and HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Respiratory and Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Virology Wuhan Centers for Disease Prevention and ControlWuhan 430024China Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Nursing Zunyi Medical UniversityZunyi 563099China Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department and Institute of Infectious Disease Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Respirology and Tuberculosis Specialty Wuhan Pulmonary HospitalWuhan 430030China The Fifth Affiliated(Zhuhai)Hospital of Zunyi Medical University Zhuhai 519199China Department of Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Radiology Wuhan Jinyintan HospitalWuhan 430048China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Immunology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Biocenter Oulu Faculty of Biochemistry and Molecular MedicineUniversity of OuluOulu 90014Finland Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The coronavirus disease 2019(COVID-19)has spread *** mixed liver impairment has been reported in COVID-19 patients,the association of liver injury caused by specific subtype especially chronic hepatitis B(CHB)with COVID-19 has not been *** this multi-center,retrospective,and observational cohort study,109 CHB and 327 non-CHB patients with COVID-19 were propensity score matched at an approximate ratio of 3:1 on the basis of age,sex,and *** characteristics,laboratory examinations,disease severity,and clinical outcomes were ***,univariable and multivariable logistic and Cox regression models were used to explore the risk factors for disease severity and mortality,respectively.A higher proportion of CHB patients(30 of 109(27.52%))developed into severe status than non-CHB patients(17 of 327(5.20%)).In addition to previously reported liver impairment markers,such as alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,and total bilirubin,we identified several novel risk factors including elevated lactate dehydrogenase(≥245 U/L,hazard ratio(HR)=8.639,95%confidence interval(CI)=2.528–29.523;P<0.001)and coagulation-related biomarker D-dimer(≥0.5μg/mL,HR=4.321,95%CI=1.443–12.939;P=0.009)and decreased albumin(<35 g/L,HR=0.131,95%CI=0.048–0.361;P<0.001)and albumin/globulin ratio(<1.5,HR=0.123,95%CI=0.017–0.918;P=0.041).In conclusion,COVID-19 patients with CHB were more likely to develop into severe illness and *** risk factors that we identified may be helpful for early clinical surveillance of critical progression.

关键词： COVID-19 chronic hepatitis B liver injury coagulation dysfunction

生物基发泡剂泡沫特征及其对泡沫混凝土性能的影响

在线全文

学校读者我要写书评

暂无评论

建筑材料学报 2020年第3期23卷 589-595页

作者：张磊张静张颖荣辉刘志华天津城建大学材料科学与工程学院天津300384 天津城建大学天津市建筑绿色功能材料重点实验室天津300384 河北工业大学土木与交通学院天津300401

以动物蛋白和微生物蛋白类发泡剂为基础发泡剂,分别与十六烷基三甲基溴化铵(CTMAB)复掺来制备生物基发泡剂,探究CTMAB掺量对生物基发泡剂泡沫性能的影响,并在此基础上研究2种生物基发泡剂对泡沫混凝土宏观性能和微观结构的影响.结果表明... 详细信息

以动物蛋白和微生物蛋白类发泡剂为基础发泡剂,分别与十六烷基三甲基溴化铵(CTMAB)复掺来制备生物基发泡剂,探究CTMAB掺量对生物基发泡剂泡沫性能的影响,并在此基础上研究2种生物基发泡剂对泡沫混凝土宏观性能和微观结构的影响.结果表明:掺加适量CTMAB有利于提高泡沫性能,动物蛋白发泡剂(A型)和微生物发泡剂(M型)中CTMAB的最佳掺量分别为0.7%和0.5%;M型发泡剂制得的泡沫孔径分布均匀且尺寸较小,稳定性优于A型;M型泡沫混凝土的孔径分布均匀且尺寸较小,水化生成C-S-H的钙硅比较低,水化产物结构致密,其抗压强度(3.3MPa)高于A型泡沫混凝土(2.1MPa).

关键词：动物蛋白发泡剂微生物发泡剂泡沫特征泡沫混凝土

在线全文

学校读者我要写书评

暂无评论

某集装箱船推进性能的数值预报

武汉理工大学学报（交通科学与工程版） 2011年第4期35卷 670-674页

作者：熊鹰刘志华海军工程大学船舶与动力学院武汉430033

分析了船体兴波作用对推进性能的影响,提出将兴波计算从自航船模流场计算中分离的简化计算模型,并研究了船模预报实船自航点和推进因子的数值方法,同时对KCS缩尺船模推进性能进行了预报,预报结果与试验吻合较好.通过对6条不同缩尺比的KC... 详细信息

分析了船体兴波作用对推进性能的影响,提出将兴波计算从自航船模流场计算中分离的简化计算模型,并研究了船模预报实船自航点和推进因子的数值方法,同时对KCS缩尺船模推进性能进行了预报,预报结果与试验吻合较好.通过对6条不同缩尺比的KCS自航船模的计算,分析了尺度效应对推进性能预报的影响.

关键词：自航船模伴流分数推力减额分数自航点尺度效应 CFD方法