Tong-Luo-San-Jie Formula External Application on Bone Cancer Pain
作者单位：Longhua HospitalShanghai University of Traditional Chinese Medicine
会议名称：《第十四届全国中药和天然药物学术研讨会》
会议日期：2014年
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by the National Natural Science Foundation of China(No.81173225 81373622) Shanghai University of Traditional Chinese medicine 085 Program(No.085ZY1208) Longhua Medical Project (No.LYTD-02)
关 键 词：Tong-Luo-San-Jie Formula Chinese herbs bone cancer pain.
摘 要：Objective To exploring the effects and mechanisms of TLSJ Formula on bone cancer pain in rat *** The Walker 256 cells(1x10 cells/ml) were injected into the abdominal cavities of the rats(70-90 g).After seven days,the cells collected from ascitic fluid were injected into the rats’ bone cavity in the right pelvic *** the mechanisms of TLSJ Formula’s action on cancer pain by assessing both mechanical and thermal sensitivity,the time course of bone mineral density(BMD),and the conditioned place preference(CPP) *** TLSJ treatment significantly restored bone cancer-induced decreasing of PWL and mechanical threshold compared to vehicle *** also significantly repaired cancer-induced decreasing of BMD levels and decreased the destruction such as bone marrow and bone ***,it showed that TLSJ Formula produced CPP effects to the bone cancer pain *** These results suggests that TLSJ Formula not only can inhibit cancer induced bone destruction and hyperalgesia but also produced CPP *** suggests that this formula may be useful in managing cancer pain and that it may act by decreased the destruction such as bone marrow and bone loss.