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Synthesis of Obyanamide, a Marine Cytotoxic Cyclic Depsipeptide

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Chinese Chemical Letters 2006年第3期17卷 285-288页

作者： Wei ZHANG Ni SONG Zhong Zhen li ying xia li Key Laboratory of Marine Drugs the Ministry of Education of China Marine Drug and Food Institute Ocean University of China Qingdao 266003

The synthesis of a marine cytotoxic cyclic depsipeptide obyanamide has been accomplished. The key steps include assembling liner pentapeptide via Yamaguchi esterification and HATU-promoted ring closing. The structure of the synthetic sample was identified by ^1H and ^13C NMR, H-H COSY, HMQC, HMBC, and HRESIMS, but appears to be different from that of the marine natural product.

关键词： Obyanamide synthesis cyclic depsipeptide natural product.

Laser Alloyed Coatings of TiB_2/Graphite on 9Cr18 Stainless Steel Surface

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Journal of Iron and Steel Research International 2007年第3期14卷 69-72页

作者： ying li-xia WANG li-qin JIA xiao-mei GU Le School of Mechatronics Engineering Harbin Engineering University Harbin 150001 Heilongjiang China School of Mechatronics Engineering Harbin Institute of Technology Harbin 150001 Heilongjiang China

Modified coatings including carbide of iron, nickel, chromium, silicon, and titanium are obtained on 9Cr18 stainless steel surface by laser alloying. The processing method, the microstructure, the interface, the tribological properties, and the forming mechanisms of the coatings are analyzed. The results show that the microstructure of the alloyed coatings is mainly irregular FeC crystals. Carbides of chromium and iron are around the FeC crystals. Small granular TiC disperses in the alloyed coatings. The microhardness of the alloyed coatings is greatly improved because of the occurrence of carbide with high hardness. At the same time, the wear resistance of the alloyed coatings are higher than that of 9Cr18 stainless steel.

关键词： laser alloying TiB2 graphite carbide

Stereoselective Synthesis of Novel C-Disaccharides via Suzuki Cross-Coupling Reaction

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Chinese Journal of Chemistry 2005年第11期23卷 1564-1568页

作者： li, xiao-liu XU, xiao-Ming TIAN, Jun li, ying-xia School of Chemistry and Environmental Sciences Hebei University Baoding Hebei 071002 China Department of Pharmaceutical Sciences Ocean University of China Qingdao Shandong 266003 China

Novel β-C-disaccharides containing a three carbon linkage using exo-glycal as the precursor were prepared stereoselectively. The synthesis was achieved by the tandem reactions of the stereoselective hydroboration of exo-glycal and Suzuki cross-coupling reaction with an iodovinyl sugar, and followed by hydrogenated deprotection under the catalysis of Pd（OH）2/C.

关键词： exo-glycal Suzuki coupling reaction C-disaccharide

The Synthesis of Glycoglycerolipids

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Chinese Chemical Letters 2003年第8期14卷 776-778页

作者： Chun xia li ying xia li ling Bo YU Hua ZHANG Shi Dong CHU Hua Shi GUAN Institute of Marine Drugs and food Ocean University of ChinaQingdao 266003

A convenient synthetic route was developed for the synthesis of the novel glycolipids: 1, 2-di-O-acyl-3-O-(2-acylamide-2-deoxy-a-D-glucopyranosyl)-sn-glycerols. 10 new compounds of glycolipids with different acyl grou... 详细信息

关键词： N-Acetamide-glucose glycolipids glycoglycerolipids.

Synthesis and Pharmacological Evaluation of Novel Conjugates of Indomethacin with Antioxidant Activity

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Chinese Journal of Chemistry 2005年第11期23卷 1523-1529页

作者： ZHANG, Yi-Chun CHEN, Ping-Tao GUAN, Hua-Shi li, ying-xia Key Laboratory of Marine Drugs The Ministry of Education of China Marine Drug and Food Institute Ocean University of China Qingdao Shandong 266003 China

A series of new conjugates of indomethacin with phenolic anfioxidants were synthesized for enhanced antiinflammatory activity as well as reduced ulcerogenic potency. It was found that all conjugates were very potent antioxidants in vitro. They could inhibit lipid peroxidafion significantly, while 11b-11e and 13b-13e could also interact with DPPH. However these conjugates showed little inhibition against croton oil induced mouse ear swelling.

关键词： antioxidant indomethacin antiinflammation conjugate nonsteroidal antiinflammatory drugs (NSAID)

Adsorption of Benzene and Propylene in Zeolite ZSM-5:Grand Canonical Monte Carlo Simulations

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Chemical Research in Chinese Universities 2009年第3期25卷 377-382页

作者： SUN xiao-yan li Jian-wei li ying-xia YAN Shi-cheng CHEN Biao-hua State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China Jilin Vocational College of lndustry and Technology Jilin 132000 P. R. China

The adsorption behavior of benzene and propylene in zeolite ZSM-5 was studied by Grand Canonical Monte Carlo（GCMC） simulations. It could be found that benzene and propylene molecules showed different adsorption behavior in the zeolite cavities. The loadings of propylene were significantly larger than those of benzene at 100 kPa. From the figures of potential energy distribution, the potential energy of benzene/zeolite was more negative than that of propylene/zeolite, so benzene could be adsorbed more stably than propylene. When the temperature was in- creased from 298 to 443 K at 100 kPa, the loading ofpropylene was reduced from 99 to 82 molecules, whereas that of benzene changed little. When benzene and propylene were adsorbed in zeolite simultaneously, the competitive adsorption of them occurred; therefore, the potential energy distribution could be changed significantly. Besides, the adsorption isotherms of benzene and propylene in ZSM-5 at 298 and 443 K were simulated. The results exhibit that the different factors influenced the molecular adsorption at various temperatures and pressures, leading to the diffe- rent rules for the adsorption of benzene and propylene molecules in the zeolite. At a low pressure, the unfavorable energy of propylene/zeolite and the ＂commensurate freezing＂ phenomenon of benzene would make the loadings of itself higher than those of propylene. When pressure was higher than 5 kPa, the adsorption of benzene in ZSM-5 would nearly reach saturation.

关键词： ZSM-5 zeolite Adsorption Grand canonical monte carlo

Synthesis and biological evaluation of a series of novel salicylanilides as inhibitors of EGFR protein tyrosine kinases

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Chinese Chemical Letters 2012年第5期23卷 529-532页

作者： Ning Ding Wei Zhang Hua ling xiao Peng Wang ying xia li Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China

The synthesis and biological evaluation of two series of salicylanilide derivatives on the EGFR and ErbB-2 tyrosine kinases inhibitory activities were *** the tested compounds those having an additional aryl group substituted on the anilino ring were active on the EGFR tyrosine kinase inhibition（7a-c and 13a,13c,13d,13f）.The inhibitory activities were all in the low micromolar or submicromolar *** addition,compound 13a was found to have dual inhibitory activities both on EGFR and ErbB-2 tyrosine kinases（1.654±1.280 and 7.134±1.265μmol/L）.

关键词： Salicylanilides EGFR HER2 Tyrosine kinase inhibitor

Synthesis of Nonionic Oligomeric Manganese(Ⅱ) Complexes and Investigation of Their Toxicity andΤ_1-Relaxation Enhancement

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Chemical Research in Chinese Universities 2005年第5期21卷 512-516页

作者： YU Kai-chao li ying-xia ZHOU Jin-lan DING Shang-wu YE Chao-hui State Key Laboratory of Magnetic Resonance ＆ Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics the Chinese Academy of Sciences Wuhan 430071 P. R. China Department of Chemistry Huazhong University of Sciertce and Technology Wuhan 430074 P. R. China Department of Chemistry and Center for Nano Science ＆ Nano Technology National Sun Yat-Sen University Kaohsiung 80424 Taiwan China

Six nonionic oligomeric manganese （ Ⅱ ） complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. The longitudinal relaxivities of these complexes were measured. One of these complexes, which showed the highest relaxivity, was chosen to be used in the acute toxicity test and the T1-weighted imaging experiment. It has been found that compared to Gd-DTPA, this nonionic oligomeric Mn（ Ⅱ ） complex exhibits no acute toxicity, generates highly enhanced MRI signals and increases the intention time in the rat liver tissue.

关键词： Magnetic resonance imaging( MRI) Oligomeric contrast agent Nonionic Mn( Ⅱ ) complex Relaxivity,Acute toxicity Relaxation enhancement

Synthesis of protected (2S,4R)-2-amino-4-methyldecanoic acid, a proposed component of culicinins

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Chinese Chemical Letters 2008年第9期19卷 1068-1070页

作者： Wei Zhang Tian Tian Sun Duo Mei Jun Fei Wang ying xia li Key laboratory of Marine Drugs The Ministry of Education of China School of Pharmacy Ocean University of China Qingdao 266003 China

The protected （2S,4R）-2-amino-4-methyldecanoic acid, a proposed component of culicinins has been synthesized over 10 steps and in total 28% yields using Wittig reaction and Schollkopf amino acid synthesis as key steps.

关键词： Synthesis Amino acid Schollkopf methodology Culicinins