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Evaluation of optic nerve head vessels density changes after phacoemulsification cataract surgery using optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2023年第6期16卷 884-890页

作者： Ze-Hui Zhu yin-ying zhao Rui Zou Han Zou Jia-Yan Fang Ping-Jun Chang Yun-E zhao Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Wenzhou 325000Zhejiang ProvinceChina Eye Hospital of Wenzhou Medical University Hangzhou Branch Hangzhou 310000Zhejiang ProvinceChina

·AIM:To evaluate optic nerve head(ONH)vessel density(VD)changes after cataract surgery using optical coherence tomography angiography(OCTA).·METHODS:This was a prospective observational ***-four eyes with mild/moderate cataracts were *** scans were obtained before and 3mo after cataract surgery using *** peripapillary capillary(RPC)density,all VD,large VD and retinal nerve fiber layer thickness(RNFLT)in total disc,inside disc,and different peripapillary sectors were assessed and *** quality score(QS),fundus photography grading and bestcorrected visual acuity(BCVA)were also collected,and correlation analyses were performed between VD change and these parameters.·RESULTS:Compared with baseline,both RPC and all VD increased in inside disc area 3mo postoperatively(from 47.5%±5.3%to 50.2%±3.7%,and from 57.87%±4.30%to 60.47%±3.10%,all P<0.001),but no differences were observed in peripapillary ***,large VD increased from 5.63%±0.77%to 6.47%±0.72%in peripapillary ONH region(P<0.001).RPC decreased in inferior and superior peripapillary ONH parts(P=0.019,<0.001 respectively).There were obvious negative correlations between RPC change and large VD change in inside disc,superior-hemi,and inferior-hemi(r=-0.419,-0.370,and-0.439,P=0.017,0.044,and 0.015,respectively).No correlations were found between VD change and other parameters including QS change,fundus photography grading,postoperative BCVA,and postoperative peripapillary RNFLT.·CONCLUSION:RPC density and all VD in the inside disc ONH region increase 3mo after surgery in patients with mild to moderate *** obvious VD changes are found in peripapillary area postoperatively.

关键词： phacoemulsification cataract optical coherence tomography angiography vessel density optic nerve head

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Abdominal Obesity and Its Attribution to All-cause Mortality in the General Population with 14 Years Follow-up:Findings from Shanxi Cohort in China

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Biomedical and Environmental Sciences 2020年第4期33卷 227-237页

作者： ZHAI Yi REN Ze Ping ZHANG Mei ZHANG Jian JIANG Yong MI Sheng Quan WANG Zhuo Qun zhao Yan Fang SONG Peng Kun yin zhao Xue zhao Wen Hua Beijing Tian Tan Hospital Capital Medical UniversityChina National Clinical Research Center for Neurological DiseasesBeijing 100070China Division for Non-Communicable Disease Control Shanxi Provincial Center for Disease Control and PreventionTaiyuan 030012ShanxiChina National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China Food Science Department College of Biochemical EngineeringBeijing Union UniversityBeijing 100023China Division of Non-communicable Disease Control and Ageing Health Chinese Center for Disease Control and PreventionBeijing 102206China

Objective This study aimed to assess the association of waist circumference(WC)with all-cause mortality among Chinese *** The baseline data were from Shanxi Province of 2002 China Nutrition and Health *** death investigation and follow-up visit were conducted from December 2015 to March *** visits covered up to 5,360 of 7,007 participants,representing a response rate of 76.5%.The Cox regression model and floating absolute risk were used to estimate hazard ratio and 95%floating CI of death by gender and age groups(≥60 and<60 years old).Sensitivity analysis was performed by excluding current smokers;participants with stroke,hypertension,and diabetes;participants who accidentally died;and participants who died during the first 2 years of *** This study followed 67,129 person-years for 12.5 years on average,including 615 *** mortality density was 916 per 100,000 *** WC was associated with all-cause mortality among ***-adjusted hazard ratios(HR)were 1.60(1.35–1.90)for WC<75.0 cm and 1.40(1.11–1.76)for WC ranging from 75.0 cm to 79.9 *** WC(<70.0 cm and 70.0–74.9 cm)and high WC(≥95.0 cm)groups had a high risk of mortality among *** adjusted HRs of death were 1.43(1.11–1.83),1.39(1.05–1.84),and 1.91(1.13–3.22).Conclusion WC was an important predictor of death independent of body mass index(BMI).WC should be used as a simple rapid screening and predictive indicator of the risk of death.

关键词： Waist circumference All-cause mortality Cohort study

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LRP5 polymorphism—A potential predictor of the clinical outcome in advanced gastric cancer patients treated with EOF regimen

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Chinese Journal of Cancer Research 2014年第4期26卷 478-485页

作者： Xin Liu Ming-Zhu Huang Zhi-Yu Chen Xiao-yin zhao Chen-Chen Wang Wei Peng Ji-Liang yin Jin Li Xiao-Dong Zhu Department of Medical Oncology Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical CollegeFudan University

Purpose： Wnt pathways control key biological processes that potentially impact on tumor progression and patient survival. The present study analyzed the polymorphism of lipoprotein-related receptor 5 （LRPS）（gene with key functions in Wnt signaling） and its impact on the response to chemotherapy and survival of patients with advanced gastric cancer （AGC）. Methods： A total of 107 consecutive patients with AGC treated with first-line chemotherapy of EOF regimen were enrolled in the present retrospective study. The association between single nucleotide polymorphism （SNP） of rs3736228 in LRP5 and the clinical outcomes of the patients was studied. Results： The CC genotype of rs3736228 was significantly correlated with a higher disease control rate when compared to the CT and TT genotypes （89.3% and 61.8%, respectively, P〈0.001）. A univariate survival analysis also showed that the progression free survival （PFS） and overall survival （OS） for the patients with the TC and TF genotypes of rs3736228 were worse than for the patients with the CC genotype （PFS： 3.3 and 6.7 months, respectively, HR =0.454, P〈0.001; OS： 8.1 months and 18.8 months, respectively, HR =3.056, P〈0.001）. A multivariate Cox model incorporates rs3736228 and clinical features, also identified rs3736228 was significantly associated with the PFS and OS. Conclusions： Our results firstly highlight the importance of LRPY gene of Wnt pathway in the treatment of AGC and identify polymorphism of rs3736228 as independent predictor of disease control rate, PFS and OS in AGC patients treated with first-line chemotherapy of EOF regimen in the Chinese Han population.

关键词： Gastric cancer chemotherapy biomarker lipoprotein-related receptor 5 (LRP5) rs3736228

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Engineering Rubisco to enhance CO_(2) utilization

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Synthetic and Systems Biotechnology 2024年第1期9卷 55-68页

作者： Lei zhao Zhen Cai yin Li Yanping Zhang CAS Key Laboratory of Microbial Physiological and Metabolic Engineering State Key Laboratory of Microbial ResourcesInstitute of MicrobiologyChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China Seeds Research Syngenta Biotechnology ChinaZhong Guan Cun Life Science ParkBeijingChina

Ribulose-1,5-bisphosphate carboxylase/oxygenase(Rubisco)is a pivotal enzyme that mediates the fixation of CO_(2).As the most abundant protein on earth,Rubisco has a significant impact on global carbon,water,and nitrogen ***,the significantly low carboxylation activity and competing oxygenase activity of Rubisco greatly impede high carbon fixation *** review first summarizes the current efforts in directly or indirectly modifying plant Rubisco,which has been challenging due to its high conservation and limitations in chloroplast transformation ***,recent advancements in understanding Rubisco biogenesis with the assistance of chaperones have enabled successful heterologous expression of all Rubisco forms,including plant Rubisco,in *** breakthrough facilitates the acquisition and evaluation of modified proteins,streamlining the measurement of their ***,the establishment of a screening system in *** opens up possibilities for obtaining high-performance mutant enzymes through directed ***,this review emphasizes the utilization of Rubisco in microorganisms,not only expanding their carbon-fixing capabilities but also holding significant potential for enhancing biotransformation processes.

关键词： Rubisco Plant CO_(2)fixation Microbial Carbon fixation pathway Synthetic biology Enzyme engineering

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UPLC-MS/MS测定特殊医学用途配方乳粉中姜黄素类化合物

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中国乳品工业 2024年第1期52卷 59-64页

作者：公丕学戴琨薛霞徐大玮赵寅王骏胡梅张喜琦刘艳明山东省食品药品检验研究院国家市场监管重点实验室(肉及肉制品监管技术)产业技术基础公共服务平台山东省特殊医学用途配方食品质量控制工程技术研究中心济南250101

建立基于通过式固相萃取净化检测特殊医学用途配方乳粉中姜黄素的超高效液相色谱串联质谱检测方法。样品经80%乙腈提取,通过Oasis PRiME HLB固相萃取柱净化后,以乙腈-0.1%甲酸溶液作为流动相,在acquity UPLC HSS T_(3)色谱柱上进行梯度... 详细信息

建立基于通过式固相萃取净化检测特殊医学用途配方乳粉中姜黄素的超高效液相色谱串联质谱检测方法。样品经80%乙腈提取,通过Oasis PRiME HLB固相萃取柱净化后,以乙腈-0.1%甲酸溶液作为流动相,在acquity UPLC HSS T_(3)色谱柱上进行梯度洗脱,经超高效液相色谱仪进行分离后,通过电喷雾正离子模式电离,多反应监测模式进行检测分析,外标法定量。对目标物进行稳定性研究,对样品中目标物提取、净化方式、色谱分离条件、质谱条件等关键因素进行了优化。结果表明,3种姜黄素类化合物在25~2 500 ng/mL范围内线性关系好,相关系数高于0.99,加标回收率在87.9%~102.8%之间,精密度在1.31%~4.94%之间,3种姜黄素类化合物的检出限为10μg/kg,定量限为25μg/kg。该方法定性定量结果准确、稳定性好、灵敏度高,能够对特殊医学用途配方乳粉中姜黄素类化合物进行定性分析与定量检测。

关键词：姜黄素类化合物 Oasis PRiME HLB 特殊医学用途配方乳粉液相色谱串联质谱法

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RNA interference of pax2 inhibits growth of transplanted human endometrial cancer cells in nude mice

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Chinese Journal of Cancer 2011年第6期30卷 400-406页

作者： Li-Ping Zhang Xiao-Yan Shi Chang-yin zhao Yong-Zhen Liu Ping Cheng Department of Gynecology and Obstetrics Taihe Hospital Hubei Medical University Shiyan Hubei 442000 P. R. China Central Laboratory Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430014 P. R. China.

The development of human endometrial carcinoma(HEC) is a complex pathologic process involves several oncogenes and tumor suppressor *** full-length paired-box gene 2(pax2),a recently discovered oncogene,promotes cell proliferation and growth and inhibits apoptosis of HEC ***,we examined the effect of pax2 small interfering RNA(siRNA) on the growth of transplanted HEC cells in nude *** expression of Pax2 in 21 cases of normal endometrium and 38 cases of HEC was examined by immohistochemistry(IHC).HEC models were developed by subcutaneously transferring HEC cells into nude mice,followed by treatment with empty lentivirus vector,lentivirus vector-based pax2 siRNA,and phosphate buffered saline,*** weeks later,tumor size was measured,tumor inhibition rate was calculated,and histological analyses were conducted after staining with hematoxylin and *** expression of Pax2 and Bcl-2 was detected by Western blot;proliferating cell nuclear antigen(PCNA) was detected by *** differences were observed in the positive rate of Pax2 between normal endometrium and HEC(14.2% vs.60.5%,P<0.01).The expression index of Pax2 in well differentiated tumors was 1.88±1.68,much lower than that in tumors of moderate(3.07±1.96,P<0.05) or poor differentiation(5.45±2.76,P<0.01).Tumor necrosis increased,nuclear basophilia stain decreased,tumor growth was inhibited,and PCNA,Pax2,and Bcl-2 expression was reduced in HEC models treated with pax2 *** results indicate that Pax2 expression is related to HEC tumor biology with the increased expression of Pax2 correlated to ***2 siRNA down-regulates Pax2 expression and inhibits tumorigenesis of HEC in nude mice,possibly due to cell apoptosis and the inhibition of tumor proliferation induced by down-regulation of Bcl-2.

关键词： siRNA 子宫内膜癌小干扰RNA 肿瘤生长细胞移植癌细胞裸鼠免疫组化检测

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粒子群自进化算法求解物流装箱问题

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物流技术 2024年第3期43卷 52-69页

作者：赵崟王小平臧铁钢金将姜世阔南京航空航天大学机电学院江苏南京210016

为了解决当今物流行业中装载货物类型为强异构的情况,提高装载填充率和效率,提出了一种求解三维装箱问题的元启发式算法——粒子群自进化算法。算法包含两部分:极限点构造启发式算法和粒子群自进化规则。极限点构造启发式算法引入了极... 详细信息

为了解决当今物流行业中装载货物类型为强异构的情况,提高装载填充率和效率,提出了一种求解三维装箱问题的元启发式算法——粒子群自进化算法。算法包含两部分:极限点构造启发式算法和粒子群自进化规则。极限点构造启发式算法引入了极限点的概念,利用新的极值点思想推导出了三维装箱问题的启发式算法。粒子群自进化规则提出了在货物装载序列中表示粒子的方法,推导了粒子间交叉、变异算子,在极限点构造启发式算法的基础上不断迭代进化完成货物的装载。通过不同结果的比对,证明该算法显著提高了物流装载的空间利用率,强异构货物的平均装载率达到了85%,验证了算法在强异构货物下的有效性与优越性,并给出了货物装载的三维模型。由于实际测试集的缺少,分别为机腹仓装载类和集装板类模型提出了实例生成器,通过生成器的测试集验证了算法在实际应用中的紧凑性、实用性和快捷性。

关键词：三维装箱问题强异构装载物流运输极点法粒子群算法启发式算法

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Space-Cheirge-Limiting Current of a Relativistic Electron Beam Propagating in a Rippled-Wall Waveguide

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Chinese Physics Letters 2000年第3期17卷 212-214页

作者： QIAN Bao-Liang LEI yin-zhao LIU Yong-Gui LI Chuan-Lu Department of Applied Physics National University of Defense TechnologyChangsha 410073 Center for Electromagnetics Research Zhengzhou University of TechnologyZhengzhou 450002

A Quid model is used to derive the space-charge-limiting current of a relativistic electron beam drifting in a rippled-wall cylindrical *** is found that an enhancement of the space-charge-liniiting current is found as long as optimum values of the ripple wavelength and amplitude are ***,a very small ripple wavelength of the waveguide may reduce the space-charge-limiting current *** result should be of interest to the operation of backward-wave oscillators.

关键词： waveguide Waveguide charge

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A Liouville-Type Theorem for Higher-Order Parabolic Inequalities and Its Applications

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Journal of Mathematical Research and Exposition 2011年第5期31卷 930-936页

作者： Yu Lan WANG ying WANG zhao yin XIANG School of Mathematics and Computer Engineering Xihua University Sichuan 610039 P. R. China School of Mathematical Science University of Electronic Science and Technology of China Sichuan 610054 P. R. China

In this paper, we establish a Liouville-type theorem for a system of higher-order parabolic inequalities by using the method of test functions and an integral estimate. As an application, we observe the Fujita blow-up phenomena for the corresponding parabolic system, which in particular fills up the gap in the recent result of Pang et. al. （Existence and nonexistence of global solutions for a higher-order semilinear parabolic system, Indiana Univ. Math. J., 55（2006）, 1113-1134）. Moreover, the importance of this observation is that we do not impose any regularity assumption on the initial data.

关键词： Liouville theorem parabolic inequalities Fujita phenomena.

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TGF-βchanges cyto/mito-ribosome balance to target respiratory chain complex V biogenesis in pulmonary fibrosis therapy

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1384-1387页

作者： Na Zhang Zunling zhao yin zhao Lei Yang Yanhong Xue Yun Feng Jianjun Luo Runsheng Chen Wei Wei Yan Qin Department of Rheumatology and Immunology Tianjin Medical University General Hospital300052 TianjinChina CAS Center for Excellence in Biomacromolecules Institute of BiophysicsChinese Academy of Sciences15 Datun RoadChaoyang District100101 BeijingChina University of Chinese Academy of Sciences 100049 BeijingChina

Dear Editor,Pulmonary fibrosis(PF)is characterized by failed alveolar reepithelialization and fibroblast activation.1 A continuing struggle in the field has been how to diagnose and treat the disease early and effectively on the basis of shared pathogenetic *** growth factor-β(TGF-β)signaling and mitochondria are involved in PF pathogenesis.2 Mitochondrial respiratory chain complexes(RCCs)I,III,IV,and V comprise both nuclear DNA(nDNA)-and mitochondrial DNA(mtDNA)-encoded subunits,and their biogenesis depends on the cooperation of cytoplasmic(cyto)and mitochondrial(mito)translation(Supplementary Fig.1).3 To date,a correlation between PF and RCC biogenesis has not been reported.

关键词： respiratory genesis struggle

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