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Quantitative structure-activity relationship study on the biodegradation of acid dyestuffs

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Journal of Environmental Sciences 2007年第7期19卷 800-804页

作者： LI yin xi Dan-li College of Environmental Science and Engineering Dong Hua University Shanghai 201620 China.

Quantitative structure-biodegradability relationships （QSBRs） were established to develop predictive models and mechanistic explanations for acid dyestuffs as well as biological activities. With a total of four descriptors, molecular weight （MW）, energies of the highest occupied molecular orbital （EHOMO）, the lowest unoccupied molecular orbital （ELUMO）, and the excited state （EES）, calculated using quantum chemical semi-empirical methodology, a series of models were analyzed between the dye biodegradability and each descriptor. Results showed that EHOMO and Mw were the dominant parameters controlling the biodegradability of acid dyes. A statistically robust QSBR model was developed for all studied dyes, with the combined application of EHOMO and Mw. The calculated biodegradations fitted well with the experimental data monitored in a facultative-aerobic process, indicative of the reliable prediction and mechanistic character of the developed model.

关键词： quantitative structure-activity relationship (QSAR) acid dyestuff biodegradability decolorization

Diverse and variable sex determination mechanisms in vertebrates

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Science China(Life Sciences) 2018年第12期61卷 1503-1514页

作者： xi-yin Li Jian-Fang Gui State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology College of Modern Agriculture Sciences University of Chinese Academy of Sciences The Innovative Academy of Seed Design Chinese Academy of Sciences

Sex is prevalent in nature and sex determination is one of the most fundamental biological processes, while the way of initiating female and male development exhibits remarkable diversity and variability across vertebrates. The knowledge on why and how sex determination mechanisms evolve unusual plasticity remains limited. Here, we summarize sex determination systems,master sex-determining genes and gene-regulatory networks among vertebrates. Recent research advancements on sex determination system transition are also introduced and discussed in some non-model animals with multiple sex determination mechanisms. This review will provide insights into the origin, transition and evolutionary adaption of different sex determination strategies in vertebrates, as well as clues for future perspectives in this field.

关键词： sex determination sex-determining gene sex chromosome sex transition sex differentiation sex control breeding

An epigenetic regulatory switch controlling temperature-dependent sex determination in vertebrates

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Science China(Life Sciences) 2018年第8期61卷 996-998页

作者： xi-yin Li Jian-Fang Gui State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology The Innovative Academy of Seed Design Chinese Academy of Sciences Wuhan 430072 China University of Chinese Academy of sciences Beijing 100049 China

Most vertebrates present two sexes, and females and males are determined via two diverse strategies including geno-typic sex determination （GSD） and environmental sex de-termination （ESD）（Mei and Gui, 2015; Ma et al., 2016）. The most common form of ESD is temperature-dependent sex determination （TSD）. Although several master sex-de-termining genes and their molecular pathways have been elucidated in vertebrates with GSD, the molecular mechan-ism underlying TSD remains unclear （Bachtrog et al., 2014; Capel, 2017）.

关键词：脊椎动物温度依赖开关控制性别规章环境性 Gui ESD

Study of the structure and the mechanical properties of dynamically cured PP/MAH-g-SEBS/epoxy blends

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Chinese Chemical Letters 2009年第7期20卷 877-880页

作者： Xue Liang Jiang yin xi Zhang School of Materials Science and Engineering Wuhan Institute of Technology Wuhan 430073 China Research Institute of Polymer Materials S-hanghai Jiaotong University Shanghai 200030 China

A new method concerning with the simultaneous reinforcing and toughening of polypropylene （PP） was reported. Dynamical cure of the epoxy resin was successfully applied in the PP/maleic anhydride-grafted styrene-ethylene-butylene-styrene （SEBS） triblock copolymer, and the obtained blends named as dynamically cured PP/MAH-g-SEBS/epoxy blends. The stiffness and toughness of the blends are in a good balance, and MAH-g-SEBS was acted as not only an impact modifier but also a compatibilizer. The structure of the dynamically cured PP/MAH-g-SEBS/epoxy blends is the embedding of the epoxy particles by the MAH-g- SEBS.C2009 Xue Liang Jiang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Dynamical cure Epoxy resin PP MAH-g-SEBS

How Much is the Consumption Potential of Citizenized Migrants?——Based on the Estimation of Migrants' Income Elasticity of Demand in the New Era of China

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Chinese Journal of Urban and Environmental Studies 2020年第2期8卷 59-81页

作者： CHENG Jie yin xi Institute of Population and Labor Economics Chinese Academy of Social Sciences

The economic development and urbanization in China have stepped into a new stage, and the style of migrants’ consumption has changed. We use nationally representative data from China Migrants Dynamic Survey(2010–2017) for the evaluation of migrants’ income elasticity of demand and data from Urban Household Survey for that of local citizens in the new era of *** results show the following:(1) Migrants’ income elasticity of demand has reached 0.67 since the new era, presenting a sharply rising trend. In 2017, this number rose to 0.72, indicating that the overall consumption behavior of migrants tended to be localized.(2) Compared with the average consumption elasticity of local citizens(around 0.8), migrants’ income elasticity of demand was low, and still had room for improvement.(3) Citizenized migrants play a significant role in stimulating consumption. As estimated with consumption function, if citizenized migrants’ income elasticity of demand converges with that of local citizens, the total consumption will reach15.8 trillion in 2030, equivalent to 9.3% of GDP of the year. The consumption growth directly driven by citizenized migrants is about 8 trillion yuan, equivalent to 4.7 percentage points of the GDP. Migrants are not only labor forces but also important consumers for urban areas. Therefore,to expand domestic demands and shift economic development paradigm, it is crucial to citizenize migrants as soon as possible by accelerating the construction of new-type urbanization and the reform of household registration system.

关键词： citizenization consumption potential income elasticity of demand Migrants

Programmed cell death-1 inhibitor combination treatment for recurrent proficient mismatch repair/miscrosatellite-stable type endometrial cancer:A case report

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World Journal of Clinical Cases 2022年第21期10卷 7474-7482页

作者： Chong-Ya Zhai Lu-xi yin Wei-Dong Han Department of Medical Oncology Xiasha CampusSir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou 310020Zhejiang ProvinceChina Department of Medical Oncology Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou 310020Zhejiang ProvinceChina

BACKGROUND Endometrial cancer(EC)is one of the most common cancers of the female reproductive tract,and the incidence is increasing *** using programmed cell death-1(PD-1)inhibitors is an emerging research topic and treatment strategy for refractory gynecological ***,clinical management of EC with checkpoint inhibitors requires ***,we discuss a case of refractory proficient mismatch repair(pMMR)/miscrosatellitestable(MSS)EC treated with a combination of PD-1 and angiogenesis inhibitors and offer a review of the pathophysiology and clinical outcomes based on previous *** SUMMARY A 62-year-old woman diagnosed with invasive or metastatic EC in 2015 was treated with six courses of chemotherapy and refused further *** years later,she developed chest pain,and lung biopsy indicated thyroid transcription factor-1(-),Napsin A(-),estrogen receptor(+),progesterone receptor(+),anaplastic lymphoma kinase(D5F3)(-),and receptor tyrosine kinase(D4D6)(-)metastatic *** testing results showed low tumor mutation burden,pMMR,PD ligand 1(-),MSS,and HLA-class 1 heterogeneous *** patient was started on toripalimab combined with nab-paclitaxel for seven cycles(every 3 wk),but this regimen was terminated because of an intolerable chemotherapy adverse *** disease progressed in 2020,and the patient’s treatment was switched from nab-paclitaxel to anlotinib,while immunotherapy using toripalimab was *** patient achieved a major partial response with well-tolerated toxicities,and treatment is *** Molecular testing is advised for clinical classifications of EC owing to its high *** this case,the patient had pMMR/MSS EC and achieved a positive outcome with combination PD-1 inhibitor *** results warrant further clinical exploration.

关键词： Refractory endometrial cancer Proficient mismatch repair Miscrosatellite-stable Immunotherapy Case report

Mem Brain: An Easy-to-Use Online Webserver for Transmembrane Protein Structure Prediction

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Nano-Micro Letters 2018年第1期10卷 12-19页

作者： xi yin Jing Yang Feng xiao Yang Yang Hong-Bin Shen Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong University Key Laboratory of System Control and Information Processing Ministry of Education of China Department of Computer Science Shanghai Jiao Tong University Key Laboratory of Shanghai Education Commission for Intelligent Interaction and Cognitive Engineering

Membrane proteins are an important kind of proteins embedded in the membranes of cells and play crucial roles in living organisms, such as ion channels,transporters, receptors. Because it is difficult to determinate the membrane protein's structure by wet-lab experiments,accurate and fast amino acid sequence-based computational methods are highly desired. In this paper, we report an online prediction tool called Mem Brain, whose input is the amino acid sequence. Mem Brain consists of specialized modules for predicting transmembrane helices, residue–residue contacts and relative accessible surface area of a-helical membrane proteins. Mem Brain achieves aprediction accuracy of 97.9% of ATMH, 87.1% of AP,3.2 ± 3.0 of N-score, 3.1 ± 2.8 of C-score. Mem BrainContact obtains 62%/64.1% prediction accuracy on training and independent dataset on top L/5 contact prediction,respectively. And Mem Brain-Rasa achieves Pearson correlation coefficient of 0.733 and its mean absolute error of13.593. These prediction results provide valuable hints for revealing the structure and function of membrane *** Brain web server is free for academic use and available at ***/bioinf/Mem Brain/.

关键词： Transmembrane a-helices Structure prediction Machine learning Contact map prediction Relative accessible surface area

An Improved SDIF Algorithm for Anti-radiation Radar Using Dynamic Sequence Search 36

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An Improved SDIF Algorithm for Anti-radiation Radar Using Dy...

Single Chargino Production with R-Parity Lepton Number Violation in Photon-Photon Collisions

第36届中国控制会议

作者： yin xi yingchun Wu xiongjun Wu Kaichuang Jiang National Defense Key Laboratory of Science and Technology on Electromagnetic Scattering The 802 Institute of Shanghai Academy of Space Flight TechnologyThe Eighth Academy of China Aerospace Science and Technology Corporation

ISBN: (纸本)9781538629185

In the traditional anti-radiation radar detection,a crucial task is to separate the useful target radar signal from random overlapping pulse *** Time Difference Of Arrival（TDOA） histogram is an effective tool for pulse train de-interleaving,however,the classic Sequential Difference（SDIF for short） histogram algorithm cannot deinterleave the PRI jittered signals efficiently,since the statistics of the TDOA can be easy to be affected by PRI jitters,and thus prone to the loss of ***,in order to improve the robustness of the SDIF,an improved SDIF algorithm is proposed,where the overlapping PRI bins are adopted and can detect the PRI jittered signals,however,in some cases,it might lead to multiple PRI estimations that actually belongs to only one *** a second step of the signal sorting,in the sequence search algorithms after the estimation of PRI,the velocity of the traditional direct sequence search algorithms is not fast enough since multiplication operation is involved in this signal processing ***,it requires detail information of the first pulse in the traditional sequence search algorithms such as curve fitting,and even worse,the multiplication operation is involved,these limitations reduced the radar signal processing speed *** order to overcome these deficiencies,and to deinterleave PRI jittered signals quickly and accurately,in the paper,an improved SDIF algorithm based on dynamic sequence search is *** introducing the overlapping box and dynamic sequence search algorithm based on classic SDIF method,it no longer requires the precise information of the first pulse,and no multiplication operation is ***,the entire searching procedure turns out to be in linear form and ***,this algorithm has the characteristics of anti-interference and is able to overcome the pulse loss *** illustrative simulation is present to verify the proposed *** results showed that the algorithm can well dei

关键词： Signal Sorting SDIF Dynamic Sequence Search Anti-radiation Radar

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Communications in Theoretical Physics 2001年第11期36卷 553-562页

作者： yin xi MA Wen-Gan WAN Lang-Hui JIANG Yi HAN Liang Modern Physics Department University of Science and Technology of ChinaHefei 230027China Modern Physics DepartmentUniversity of Science and Technology of ChinaHefei 230027China Modern Physics DepartmentUniversity of Science and Technology of ChinaHefei 230027China Modern Physics DepartmentUniversity of Science and Technology of ChinaHefei 230027China Modern Physics DepartmentUniversity of Science and Technology of ChinaHefei 230027China

We examine the process γγ→ x+ - at photon-photon collider in the minimal supersymmetric standard model with R-parity violation,where all the one-loop diagrams are *** mainly discuss the effects of bilinear breaking terms,and conclude that their contributions may be important compared with trilinear *** results show that the events of this process could be detectable at photon-photon colliders,if the values of the parameters are favorable.

关键词： R-parity violation,single chargino production,lepton number violation,photon-photon collision