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慢性乙型肝炎合并代谢相关脂肪性肝病的研究进展

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临床肝胆病杂志 2025年第12期40卷 2499-2504页

作者：殷珂宋玉芸刘峰北京大学人民医院北京大学肝病研究所丙型肝炎和肝病免疫治疗北京市重点实验室非酒精性脂肪性肝病诊断北京市国际科技合作基地北京 100044

慢性乙型肝炎（CHB）和脂肪肝是我国常见的慢性肝脏疾病，随着生活方式的改变，CHB合并代谢相关脂肪性肝病的患者逐年增加，两种疾病均存在肝硬化、肝细胞癌（HCC）等不良事件发生的风险。二者共存时肝脏的病理生理学进程与单独的疾病... 详细信息

慢性乙型肝炎（CHB）和脂肪肝是我国常见的慢性肝脏疾病，随着生活方式的改变，CHB合并代谢相关脂肪性肝病的患者逐年增加，两种疾病均存在肝硬化、肝细胞癌（HCC）等不良事件发生的风险。二者共存时肝脏的病理生理学进程与单独的疾病状态可能不同，进而存在HBV的复制，HBsAg的血清学清除及抗病毒治疗受到影响，肝纤维化、HCC等不良事件风险增加的问题，故明确这些问题会对此类患者疾病的监测、治疗及预后有重要意义，本文将对这些问题的最新研究进展进行简要综述。

关键词：乙型肝炎, 慢性乙型肝炎病毒脂肪肝

Molecule‑Level Multiscale Design of Nonflammable Gel Polymer Electrolyte to Build Stable SEI/CEI for Lithium Metal Battery

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Nano-Micro Letters 2025年第1期17卷 404-423页

作者： Qiqi Sun Zelong Gong Tao Zhang Jiafeng Li Xianli Zhu Ruixiao Zhu Lingxu Wang Leyuan Ma Xuehui Li Miaofa Yuan Zhiwei Zhang Luyuan Zhang Zhao Qian Longwei yin Rajeev Ahuja Chengxiang Wang Key Laboratory for Liquid‑Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061People’s Republic of China Condensed Matter Theory Department of Physics and AstronomyUppsala UniversityUppsala 75120Sweden

The risk of flammability is an unavoidable issue for gel polymer electrolytes(GPEs).Usually,flameretardant solvents are necessary to be used,but most of them would react with anode/cathode easily and cause serious interfacial instability,which is a big challenge for design and application of nonflammable ***,a nonflammable GPE(SGPE)is developed by in situ polymerizing trifluoroethyl methacrylate(TFMA)monomers with flame-retardant triethyl phosphate(TEP)solvents and LiTFSI–LiDFOB dual lithium *** is strongly anchored to PTFMA matrix via polarity interaction between-P=O and-CH_(2)CF_(3).It reduces free TEP molecules,which obviously mitigates interfacial reactions,and enhances flame-retardant performance of TEP *** TEP molecules are also inhibited in solvation of Li^(+),leading to anion-dominated solvation sheath,which creates inorganic-rich solid electrolyte interface/cathode electrolyte interface *** coordination structure changes Li^(+)transport from sluggish vehicular to fast structural transport,raising ionic conductivity to 1.03 mS cm^(-1) and transfer number to 0.41 at 30℃.The Li|SGPE|Li cell presents highly reversible Li stripping/plating performance for over 1000 h at 0.1 mA cm^(−2),and 4.2 V LiCoO_(2)|SGPE|Li battery delivers high average specific capacity>120 mAh g^(−1) over 200 *** study paves a new way to make nonflammable GPE that is compatible with Li metal anode.

关键词： Anchoring effect Nonflammable gel electrolyte In situ cross-linked Electrode-electrolyte interface Li metal battery

Defects‑Rich Heterostructures Trigger Strong Polarization Coupling in Sulfides/Carbon Composites with Robust Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 528-547页

作者： Jiaolong Liu Siyu Zhang Dan Qu Xuejiao Zhou Moxuan yin Chenxuan Wang Xuelin Zhang Sichen Li Peijun Zhang Yuqi Zhou Kai Tao Mengyang Li Bing Wei Hongjing Wu Mengyang Li Bing Wei Hongjing Wu School of Physics Xidian UniversityXi’an 710071People’s Republic of China School of Advanced Materials and Nanotechnology State Key Discipline Laboratory of Wide Band Gap Semiconductor TechnologyXidian UniversityXi’an 710071People’s Republic of China School of Microelectronics Xidian UniversityXi’an 710071People’s Republic of China School of Telecommunication Engineering Xidian UniversityXi’an 710071People’s Republic of China MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary School of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China The Ministry of Education Key Laboratory of Micro and Nano Systems forAerospace School of Mechanical EngineeringNorthwestern PolytechnicalUniversityXi’an 710072People’s Republic of China

Defects-rich heterointerfaces integrated with adjustable crystalline phases and atom vacancies,as well as veiled dielectric-responsive character,are instrumental in electromagnetic *** methods,however,constrain their delicate ***,an innovative alternative is proposed:carrageenan-assistant cations-regulated(CACR)strategy,which induces a series of sulfides nanoparticles rooted in situ on the surface of carbon *** unique configuration originates from strategic vacancy formation energy of sulfides and strong sulfides-carbon support interaction,benefiting the delicate construction of defects-rich heterostructures in M_(x)S_(y)/carbon composites(M-CAs).Impressively,these generated sulfur vacancies are firstly found to strengthen electron accumulation/consumption ability at heterointerfaces and,simultaneously,induct local asymmetry of electronic structure to evoke large dipole moment,ultimately leading to polarization coupling,i.e.,defect-type interfacial ***“Janus effect”(Janus effect means versatility,as in the Greek two-headed Janus)of interfacial sulfur vacancies is intuitively confirmed by both theoretical and experimental investigations for the first ***,the sulfur vacancies-rich heterostructured Co/Ni-CAs displays broad absorption bandwidth of 6.76 GHz at only 1.8 mm,compared to sulfur vacancies-free CAs without any dielectric *** defects-rich heterostructures,this one-pot CACR strategy may steer the design and development of advanced nanomaterials,boosting functionality across diverse application domains beyond electromagnetic response.

关键词： Defects-rich heterointerfaces Sulfides Polarization coupling Electromagnetic wave absorption

Community Building and Community Regeneration

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China City Planning Review 2021年第4期30卷 6-19页

作者： yin Zhi Zhou Jian Huang Ling Wang Lin Liao zhengxin Tang Yan Cao Yujun Liu Jinxin(translated) the Urban Planning Society of China Institute for China Sustainable Urbanization Tsinghua University School of Architecture Tsinghua University Urban Planning Society of China the Specialized Committee of Community Building Science and Technology CommitteeMinistry of Housing and Urban-Rural Development Shanghai Tongji Urban Planning&Design Institute School of Architecture and Urban Planning Tongji University the Housing and Community Planning Committee of the Urban Planning Society of China the School of Architecture and Urban Planning Chongqing University the Academic Committee of Urban Regeneration of the Urban Planning Society of China the School of Design Shanghai Jiao Tong University the Department of Historic and Cultural City Planning Beijing Municipal Institute of City Planning&Design the School of Architecture Tsinghua University the Bay Area Branch of Tsinghua Tongheng Urban Planning and Design Institute 不详

Introduction The 2021 Annual Conference of the Housing and Community Planning Committee of the Urban Planning Society of China(UPSC)was successfully held in Beijing on Jun.5,*** the guidance of the UPSC,the conference was hosted by the Housing and Community Planning Committee of the UPSC,and jointly supported by the Beijing Tsinghua Tongheng Urban Planning&Design Institute and the Specialized Committee of Community Building,Science and Technology Committee,Ministry of Housing and Urban-Rural Development.

关键词： jointly Development. Urban

Transcriptional dysregulation in neurodegenerative diseases:who tipped the balance of yin Yang 1 in the brain?

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Neural Regeneration Research 2019年第7期14卷 1148-1151页

作者： Zhefan Stephen Chen Ho yin Edwin Chan School of Life Sciences Faculty of ScienceThe Chinese University of Hong Kong Gerald Choa Neuroscience Centre The Chinese University of Hong Kong

yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including *** controls neuronal differentiation,as well as neuronal specification and migration during the development of the mammalian nervous ***,YY1 also mediates the transcription of genes that are required for neuronal *** impairment of the transcriptional function of YY1 causes neuronal *** review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative *** expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms,including recruitment to protein aggregates,protein degradation and aberrant nuclear/cytoplasmic *** the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis neurodegeneration protein aggregates recruitment protein degradation subcellular localization transcriptional regulation yin Yang 1

图像处理中CNN与视觉Transformer混合模型研究综述

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计算机科学与探索 2025年第1期19卷 30-44页

作者：郭佳霖智敏殷雁君葛湘巍内蒙古师范大学计算机科学技术学院

卷积神经网络（CNN）与视觉Transformer是目前图像处理领域中两大重要的深度学习模型，两者经过多年来不断的研究与进步，已在该领域取得了非凡的成就。近些年来，CNN与视觉Transformer的混合模型正在逐步兴起，广泛的研究不断克服两种... 详细信息

卷积神经网络（CNN）与视觉Transformer是目前图像处理领域中两大重要的深度学习模型，两者经过多年来不断的研究与进步，已在该领域取得了非凡的成就。近些年来，CNN与视觉Transformer的混合模型正在逐步兴起，广泛的研究不断克服两种模型存在的弱项，高效地发挥出各自的亮点，在图像处理任务中表现出优异的效果。基于CNN与视觉Transformer混合模型进行深入阐述。总体概述了CNN与Vision Transformer模型的架构和优缺点，并总结混合模型的概念及优势。围绕串行结构融合方式、并行结构融合方式、层级交叉结构融合方式以及其他融合方式等四个方面全面回顾梳理了混合模型的研究现状和实际进展，并针对各种融合方式的主要代表模型进行总结与剖析，从多方面对典型混合模型进行评价对比。多角度叙述了混合模型在图像识别、图像分类、目标检测和图像分割等实际图像处理特定领域中应用研究，展现出混合模型在具体实践中的适用性和高效性。深入分析混合模型未来研究方向，并为后续该模型在图像处理中的研究与应用提出展望。

关键词：卷积神经网络(CNN) 视觉Transformer 混合模型图像处理深度学习

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Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang Liao Mengru Cai Dongge yin Tingting Fu Jing Liu Yuji Du Jiahui Kong Rongrong Chang Jian Ni Xingbin yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(MOFs) phototherapy anti-cancer heat shock proteins inhibition

Strong Current-State Opacity Verification of Discrete-Event Systems Modeled With Time Labeled Petri Nets

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 54-68页

作者： Tao Qin Li yin Gaiyun Liu Naiqi Wu Zhiwu Li the Institute of Systems Engineering Macau University of Science and Technology IEEE the School of Electro-Mechanical Engineering Xidian University

This paper addresses the verification of strong currentstate opacity with respect to real-time observations generated from a discrete-event system that is modeled with time labeled Petri nets. The standard current-state opacity cannot completely characterize higher-level security. To ensure the higher-level security requirements of a time-dependent system, we propose a strong version of opacity known as strong current-state opacity. For any path(state-event sequence with time information)π derived from a real-time observation that ends at a secret state, the strong current-state opacity of the real-time observation signifies that there is a non-secret path with the same real-time observation as π. We propose general and non-secret state class graphs, which characterize the general and non-secret states of time-dependent systems, respectively. To capture the observable behavior of non-secret states, a non-secret observer is ***, we develop a structure called a real-time concurrent verifier to verify the strong current-state opacity of time labeled Petri nets. This approach is efficient since the real-time concurrent verifier can be constructed by solving a certain number of linear programming problems.

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Steady state response of an infinite beam on a viscoelastic foundation with moving distributed mass and load

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Science China(Physics,Mechanics & Astronomy) 2020年第8期63卷 71-85页

作者： yin Zhang State Key Laboratory of Nonlinear Mechanics(LNM) Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

Compared with the moving concentrated load model,it is more realistic and proper to use the moving distributed mass and load model to simulate the dynamics of a train moving along a railway *** the problem of a moving concentrated load,there is only one critical velocity,which divides the load moving velocity into two categories:subcritical and *** locus of a concentrated load demarcates the space into two parts:the waves in these two domains are called the front and rear waves,*** comparison,in the problem of moving distributed mass and load,there are two critical velocities,which results in three categories of the distributed mass moving *** to the presence of the distributed mass and load,the space is divided into three domains,in which three different waves *** richer and different variation patterns of wave shapes arise in the problem of the moving distributed mass and *** mechanisms responsible for these variation patterns are systematically studied.A semi-analytical solution to the steady-state is also obtained,which recovers that of the classical problem of a moving concentrated load when the length of the distributed mass and load approaches zero.

关键词： steady state beam viscoelastic foundation moving distributed mass