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BIOCELL 2024年第12期48卷 1773-1780页

作者： YAJUN CAO SHUANG YIN yidan fang JIEXIAN ZHOU YOUTAN LIU Department of Anesthesiology Shenzhen HospitalSouthern Medical UniversityShenzhen518000China The Third School of Clinical Medicine Southern Medical UniversityGuangzhou510630China Department of Anesthesia Zhuhai Center for Maternal and Child Health CareZhuhai519000China Department of Anesthesia Zhuhai Doumen Maternal and Child Health Care HospitalZhuhai519000China

Background: De novo lipogenesis (DNL) is a critical event for the development of tumors, in the present work,we revealed the role of propofol in colorectal cancer (CRC) cell proliferation. Methods: Western blotting (WB), Real-timePCR, and luciferase combined with chromatin immunoprecipitation (ChIP) were used to identify the mechanismunderlying propofol-modulated cell proliferation in CRC cells. Results: Herein, we showed that propofol suppressedcell proliferation, which was attributed to the inhibition of DNL characterized by reduced fatty acid synthase (FASN),acetyl-coA carboxylase alpha (ACCA), and stearoyl-coA desaturase-1 (SCD1) expression. Mechanically, propofolstimulation decreased sterol regulatory element-binding proteins-1c (SREBP-1c) mature and nuclear translocation,which further decreased SCD1 transactivation confirmed by luciferase and ChIP analysis, while no significantdifference in total SREBP1c was observed. What’s more, supplementation of Monounsaturated fatty acid (MuFA)could reverse the inhibitory effect of propofol on cell proliferation. Conclusion: Taken together, these resultssuggested propofol modulated cell proliferation is dependent on SREBP1c-mediated DNL.

关键词： Propofol SREBP1c De novo lipogenesis Cell proliferation Colorectal cancer cells

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基于孤立电网的综合故障诊断系统设计与实现

宁夏电力 2016年第3期 25-30页

作者：刘垚房艺丹国网宁夏电力公司吴忠供电公司宁夏吴忠751100

针对孤立电力系统的特点及其在线监测方面存在的问题,基于TCP/IP协议的光纤局域网接口技术,运用C++和汇编语言,依托100/1 000 Mbps以太网通讯技术,采用分层分布式结构,设计了孤立电网综合故障诊断系统。实现孤立电网设备的在线状态监测... 详细信息

针对孤立电力系统的特点及其在线监测方面存在的问题,基于TCP/IP协议的光纤局域网接口技术,运用C++和汇编语言,依托100/1 000 Mbps以太网通讯技术,采用分层分布式结构,设计了孤立电网综合故障诊断系统。实现孤立电网设备的在线状态监测、电气量动态记录、故障预报、故障分析等功能。结果表明:该系统通过监测系统负荷变化、谐波含量、频率变化,有效解决了孤立电网的监测和电能质量问题,在孤立电网发生故障时,可迅速采取有效措施,减小孤立电网故障对主网的冲击,避免设备损坏,确保了电力系统运行的稳定性。

关键词：孤立电力系统故障诊断数据处理软件设计

不同剂量左西孟旦治疗老年重症心力衰竭患者的疗效比较

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临床合理用药杂志 2023年第27期16卷 1-4页

作者：杨泽山方艺丹厦门大学附属第一医院心血管内科福建省厦门市361000

目的比较不同剂量左西孟旦治疗老年重症心力衰竭患者的临床疗效。方法选取2019年1月-2022年2月厦门大学附属第一医院收治的129例老年重症心力衰竭患者,按照随机数字表法分为A、B、C组,每组43例,治疗4周后失访3例,A、B、C组最终分别纳入4... 详细信息

目的比较不同剂量左西孟旦治疗老年重症心力衰竭患者的临床疗效。方法选取2019年1月-2022年2月厦门大学附属第一医院收治的129例老年重症心力衰竭患者,按照随机数字表法分为A、B、C组,每组43例,治疗4周后失访3例,A、B、C组最终分别纳入41例、42例、43例。A、B、C组患者均接受左西孟旦治疗,用药剂量分别为0.2、0.3、0.4μg·kg^(-1)·min^(-1),持续治疗4周。比较3组治疗前及治疗4周后心功能指标[心肌做功指数(MPI)、左心室射血分数(LVEF)、每搏输出量(SV)、心脏指数(CI)]、心肌细胞凋亡指标[可溶性凋亡相关因子(sFAS)、可溶性凋亡相关因子配体(sFASL)]、血流动力学指标[平均动脉压(MAP)、心率(HR)]及不良反应。结果治疗4周后,3组MPI低于治疗前,LVEF、SV、CI高于治疗前,且C组降低/升高幅度大于A、B组(P<0.05);3组血清sFAS、sFASL水平及HR低于治疗前,MAP高于治疗前,且C组降低/升高幅度大于A、B组(P<0.05)。A、B、C组不良反应总发生率比较,差异无统计学意义(19.51%vs.28.56%vs.41.87%,χ^(2)=5.052,P=0.080)。结论相较于小剂量、中等剂量用药,大剂量左西孟旦治疗老年重症心力衰竭患者可更有效地抑制心肌细胞凋亡,减轻心肌损伤,维持血流动力学稳定,进而提高心功能,且安全性较高。

关键词：重症心力衰竭左西孟旦不同剂量心肌细胞凋亡心功能

Construction of remote cyano-substituted quaternary carbon centers via nickel-catalyzed migratory hydrocyanation of unconjugated dienes

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Science China Chemistry 2024年第10期67卷 3397-3405页

作者： yidan Xing Rongrong Yu Mingdong Jiao Ting Wang Xianjie fang Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Key Laboratory of Organosilicon Material Technology of Zhejiang ProvinceCollege of MaterialChemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The transition-metal-catalyzed migratory functionalization has emerged as a robust protocol for the building of C–C bonds remote from the“initiation”***,a similar strategy for the construction of quaternary carbon centers is still underdeveloped and only a limited number of reports ***,we report a nickel-catalyzed migratory hydrocyanation of unconjugated dienes to construct remote cyano-substituted quaternary carbon *** transformation features exceptional regioselectivity,mild reaction conditions,broad substrate scope and high *** synthetic utility of this method has been highlighted by a series of product derivatizations,and the potential of this transformation has been extended to synthesize TRPV1 antagonist and the key intermediate in the total synthesis of *** functional theory(DFT)studies unveiled that the specific catalytic pocket assumed a significant role in the selective formation of cyano-substituted quaternary carbon centers.

关键词： chain-walking regioselectivity remote cyanation quaternary carbon centers unconjugated dienes

由社会主义市场经济下的瑜珈产业看太极拳产业的现状与发展

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博击(武术科学) 2007年第4期4卷 38-39页

作者：房轶丹房鹤明扬州大学体育学院泰山中学江苏扬州225009 江苏宝应225800

我国太极拳产业的市场前景广阔,只要全面导入市场经济运行机制,加强品牌意识,就会加速我国太极拳产业的发展。时下瑜珈作为一项比较成熟的产业遍布于全球各地。文章运用文献资料法、专家访谈法,通过书籍期刊及网上信息比较瑜珈和太极拳... 详细信息

我国太极拳产业的市场前景广阔,只要全面导入市场经济运行机制,加强品牌意识,就会加速我国太极拳产业的发展。时下瑜珈作为一项比较成熟的产业遍布于全球各地。文章运用文献资料法、专家访谈法,通过书籍期刊及网上信息比较瑜珈和太极拳产业发展中的一些可比因素,探究太极拳产业化的现状及其发展。

关键词：太极拳产业内涵市场发展瑜珈

基于5E理论的综合性护理对冠心病慢性心力衰竭患者的心脏康复效能及睡眠质量影响

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世界睡眠医学杂志 2024年第10期11卷 2299-2302页

作者：黄秋柳方艺丹钟丽萍刘礼芳叶青青厦门大学附属第一医院厦门361000

目的:分析基于5E理论的综合性护理对冠心病慢性心力衰竭患者的心脏康复效能及睡眠质量的影响;方法:选取2023年1月至2023年12月厦门大学附属第一医院收治的冠心病慢性心力衰竭患者180例作为研究对象,按照随机数字表法分为对照组和观察组... 详细信息

目的:分析基于5E理论的综合性护理对冠心病慢性心力衰竭患者的心脏康复效能及睡眠质量的影响;方法:选取2023年1月至2023年12月厦门大学附属第一医院收治的冠心病慢性心力衰竭患者180例作为研究对象,按照随机数字表法分为对照组和观察组,每组90例。对照组给予常规护理,观察组给予基于5E理论的综合性护理,分析2组患者阿森斯失眠量表(AIS)、6 min步行距离(6MWT)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、护理满意度数据。结果:观察组干预后LVESD、LVEF指标均高于对照组,差异有统计学意义(P<0.05);观察组干预后LVEDD、6MWT、AIS-8项评分均低于对照组,差异有统计学意义(P<0.05);观察组护理满意度97.78%,高于对照组86.67%,差异有统计学意义(P<0.05)。结论:基于5E理论的综合性护理在冠心病慢性心力衰竭患者的心脏康复和睡眠质量方面具有显著的积极影响,基于5E理论的综合性护理在提高心功能、改善运动能力、优化睡眠质量以及提升患者满意度方面具有潜在的临床应用前景。

关键词： 5E理论综合性护理冠心病慢性心力衰竭心脏康复睡眠质量满意度康复效果

Photoelectrocatalytic hydrogen evolution and synchronous degradation of organic pollutants by pg-C_(3)N_(4)/β-FeOOH S-scheme heterojunction

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Science China(Technological Sciences) 2024年第4期67卷 1238-1252页

作者： LI XiBao HAN Tao ZHOU YingTang XIE Yu LUO yidan HUANG JunTong CHEN Zhi DENG fang School of Materials Science and Engineering Nanchang Hangkong UniversityNanchang 330063China National-Local Joint Engineering Research Center of Heavy Metal Pollutants Control and Resource Utilization Nanchang Hangkong UniversityNanchang 330063China Zhejiang Key Laboratory of Petrochemical Environmental Pollution Control National Engineering Research Center for Marine AquacultureMarine Science and Technology CollegeZhejiang Ocean UniversityZhoushan 316022China

Crafting photoelectrocatalytic materials with robust oxidation-reduction properties for simultaneous hydrogen evolution and pollutant degradation poses a formidable *** this study,a pg-C_(3)N_(4)/β-FeOOH S-scheme heterostructure with a special energy band structure was developed by anchoring porous pg-C_(3)N_(4)on needle shapedβ-*** as a hole extraction layer,needle-leaf-likeβ-FeOOH can facilitate efficient hole migration and enhance charge ***,the optimized 0.2-pg-C_(3)N_(4)/β-FeOOH could degrade 78%of ofloxacin(OFLO)in 90 *** organic pollutants could absorb a large number of holes,which prompted a greater proportion of photogenerated electrons to actively participate in the hydrogen evolution reaction at the ***,the hydrogen production of 0.2-pg-C_(3)N_(4)/β-FeOOH reached 1452.88μmol cm^(-2)h^(-1),exhibiting a notable increase of 61.81-165.12μmol cm^(-2)h^(-1)compared with that in the absence of *** and theoretical calculation results underscore that this investigation is grounded in a distinctive electron and hole dual channel transfer *** findings offer novel insights for the future development of S-scheme heterojunction photoelectrocatalytic materials capable of concurrently degrading pollutants and promoting hydrogen evolution.

关键词： photoelectrocatalysis hydrogen evolution degradation synchronous S-scheme heterojunction

Real-Time 4-Mode MDM Transmission Using Commercial 400G OTN Transceivers and All-Fiber Mode Multiplexers

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ZTE Communications 2024年第1期22卷 106-110页

作者： REN fang LI yidan YE Bing LIU Jianguo CHEN Weizhang School of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083China Department of WDM System Design ZTE CorporationBeijing 100029China

Weakly-coupled mode division multiplexing(MDM)technique is considered a promising candidate to enhance the capacity of an optical transmission system,in which mode multiplexers/demultiplexers(MMUX/MDEMUX)with low insertion loss and modal crosstalk are the key *** this paper,a low-modal-crosstalk 4-mode MMUX/MDEMUX for the weakly-coupled triple-ring-core few-mode fiber(TRC-FMF)is designed and fabricated with side-polishing *** measurement results show that a pair of MMUX/MDEMUX and 25 km weakly-coupled TRC-FMF MDM link achieve low modal crosstalk of lower than−17.5 dB and insertion loss of lower than 11.56 dB for all the four *** on the TRC-FMF and all-fiber MMUX/MDEMUX,an experiment for 25 km real-time 4-mode 3-λwavelength division multiplexing(WDM)-MDM transmission is conducted using commercial 400G optical transport network(OTN)*** experimental results prove weakly-coupled MDM techniques facilitate a smooth upgrade of the optical transmission system.

关键词： optical fiber couplers mode(de)multiplexers mode division multiplexing transmission

Cathepsin K contributed to disturbed flow-induced atherosclerosis is dependent on integrin-actin cytoskeleton–NF–κB pathway

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Genes & Diseases 2023年第2期10卷 583-595页

作者： Fei fang Tang Feng Jianwei Li Huaiyi Zhang Qin Wang yidan Chen Guixue Wang Yang Shen Xiaoheng Liu Institute of Biomedical Engineering West China School of Basic Medical Sciences & Forensic MedicineSichuan UniversityChengduSichuan 610041China Department of Endocrinology and Metabolism West China HospitalSichuan UniversityChengduSichuan 610041China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsCollege of BioengineeringChongqing UniversityChongqing 400030China

Atherosclerosis is a chronic inflammatory disease, occurring preferentially in bifurcation, branching, and bending of blood vessels exposed to disturbed flow. Disturbed flow in atheroprone areas activates elevated proteases, degrading elastin lamellae and collagenous matrix, resulting in endothelial dysfunction and vascular remodeling. As a mediator for extracellular matrix protein degradation, cathepsin K (CTSK) was directly regulated by hemodynamics and contributed to atherosclerosis. The mechanism of CTSK responding to disturbed flow and contributing to disturbed flow-induced atherosclerosis is unclear. In this study, the partial carotid ligation model of mice and in vitro disturbed shear stress model were constructed to explore the contribution and potential mechanism of CTSK in atherosclerosis. Our results indicated that CTSK elevated in the disturbed flow area in vivo and in vitro along with endothelial inflammation and atherogenesis. Additionally, the expression of integrin αvβ3 was upregulated in these atheroprone areas. We found that inhibition of the integrin αvβ3-cytoskeleton pathway could significantly block the activation of NF-κB and the expression of CTSK. Collectively, our findings unraveled that disturbed flow induces increased CTSK expression, and contributes to endothelial inflammation and vascular remodeling, leading to atherogenesis eventually. This study is helpful to provide new enlightenment for the therapy of atherosclerosis.

关键词： Atherosclerosis Cathepsin K Disturbed flow Integrin NF-κB

Multiple Alleles Encoding Atypical NLRs with Unique Central Tandem Repeats in Rice Confer Resistance to Xanthomonas oryzae pv. oryzae

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Plant Communications 2020年第4期1卷 63-74页

作者： Biaoming Zhang Haitao Zhang fang Li yidan Ouyang Meng Yuan Xianghua Li Jinghua Xiao Shiping Wang National Key Laboratory of Crop Genetic Improvement National Center of Plant Gene Research(Wuhan)Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life SciencesHubei UniversityWuhan 430062China

Plants have developed various mechanisms for avoiding pathogen invasion,including resistance(R)*** R genes encode nucleotide-binding domain and leucine-rich repeat containing proteins(NLRs).Here,we report the isolation of three new bacterial blight R genes in rice,Xa1-2,Xa14,and Xa31(t),which were allelic to Xa1 and encoded atypical NLRs with unique central tandem repeats(CTRs).We also found that Xa31(t)was the same gene as *** Xa1-2 and Xa14 conferred different resistance spectra,their performance could be attenuated by iTALEs,as has previously been reported for ***1,XA1-2,XA14,and non-resistant RGAF differed mainly in the substructure of the leucine-rich repeat *** all contained unique CTRs and belonged to the CTR-NLRs,which existed only in *** also found that interactions among these genes led to differing resistance *** conclusion,our results uncover a unique locus in rice consisting of at least three multiple alleles(Xa1,Xa1-2,and Xa14)that encode CTRNLRs and confer resistance to Xanthomonas oryzae ***(Xoo).

关键词： multiple alleles NLR resistance Xanthomonas oryzae pv.oryzae iTALE CTR