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Case Report:CD19-positive acute myeloblastic leukemia with trisomy 21 as a sole acquired karyotypic abnormality

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第11期10卷 833-838页

作者： Hua-feng wang yi-zhi chenG Huan-ping wang Zhi-mei chen Ji-yu LOU jie JIN Department of Hematology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China Institute of Hematology Zhejiang University Hangzhou 310003 China key Lab of Combined Multi-Organ Transplantation Ministry of Public Health Hangzhou 310003 China

We report that a 63-year-old Chinese female had acute myeloblastic leukemia （AML） in which trisomy 21 （＋21） was found as the sole acquired karyotypic abnormality. The blasts were positive for rnyeloperoxidase, and the immunophenotype was positive for cluster of differentiation 19 （CD19）, CD33, CD34, and human leukocyte antigens （HLA）-DR. The chromosomal analysis of bone marrow showed 47,XX,＋21 [2]/46,XX[ 18]. Fluorescent in situ hybridization （FISH） showed that three copies of AML1 were situated in separate chromosomes, and that t（8;21） was negative. The patient did not have any features of Down syndrome. A diagnosis of CD 19-positive AML-M5 was established with trisomy 21 as a sole acquired karyotypic abnormality. The patient did not respond well to chemotherapy and died three months after the diagnosis. This is the first reported case of CD19-positive AML with trisomy 21 as the sole cytogenetie abnormality. The possible prognostic significance of the finding in AML with ＋21 as the sole acquired karyotypic abnormality was discussed.

关键词： Trisomy 21 Acute myeloid leukemia Cluster of differentiation 19 (CD 19)

Axonal mRNA localization and local translation in neurodegenerative diseases

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Neural Regeneration Research 2021年第10期16卷 1950-1957页

作者： Jin-Xin Lu Yang wang yi-jie Zhang mei-Fen Shen Hai-ying Li Zheng-Quan yu Gang chen Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurosurgery The First Affiliated Hospital of University of Science and Technology of ChinaHefeiAnhui ProvinceChina

The regulation of mRNA localization and local translation play vital roles in the maintenance of cellular structure and *** human neurodegenerative diseases,such as fragile X syndrome,amyotrophic lateral sclerosis,Alzheimer’s disease,and spinal muscular atrophy,have been characterized by pathological changes in neuronal axons,including abnormal mRNA translation,the loss of protein expression,or abnormal axon ***,the same protein and mRNA molecules have been associated with variable functions in different diseases due to differences in their interaction *** this review,we briefly examine fragile X syndrome,amyotrophic lateral sclerosis,Alzheimer’s disease,and spinal muscular atrophy,with a focus on disease pathogenesis with regard to local mRNA translation and axon transport,suggesting possible treatment directions.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis axonal transport fragile X syndrome local translation mRNA localization neuron spinal muscular atrophy

Artesunate inhibits proliferation and migration of RPE cells and TGF-β2 mediated epithelial mesenchymal transition by suppressing PI3K/AKT pathway

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 197-204页

作者： Zi-yi wang yu Zhang Ling-Dan Wu jie chen mei-Ling chen Ci-Min chen Qi-Hua Xu The Affiliated Eye Hospital of Nanchang University Jiangxi Clinical Research Center for Ophthalmic DiseaseNanchang 330000Jiangxi ProvinceChina

AIM:To study the braking effectiveness of artesunate on transforming growth factor(TGF)-β2 mediated epithelial-mesenchymal transition(EMT)in retinal pigment epithelium(RPE)in ***:The fostered ARPE-19 cells were processed with artesunate alone or combined with the TGF-β*** CCK-8 examination was utilized to test the cell *** migration was detected by scratch as well as the Transwell *** EMT characters and activation of PI3K/Akt signal channel were estimated by Western blotting and *** Western blotting was utilized in order to confirm the vitreous of controls as well as patients with proliferative vitreoretinopathy(PVR)were collected and the levels of PI3K,phospho-PI3K,***:Disposal of ARPE-19 cells with artesunate(50-150μmol/L)obviously suppressed their propagation and immigration,which dependent on the concentration and *** suppressed the EMT which was induced by TGF-β2 in ARPE-19 cells through sustaining the expression of vimentin andα-SMA through the suppression of PI3K,phospho-PI3K,phospho-Akt and *** of PI3K,phospho-PI3K,AKT and phospho-Akt was increased in the vitreous in PVR(P<0.05).CONCLUSION:Such findings indicate that PI3K/Akt signal channel is highly activated in vitreous of *** is an operative depressor of the propagation,immigration and TGF-β2-mediated EMT of ARPE-19 cells by reduced the expression of PI3K/Akt channel.

关键词： proliferative vitreoretinopathy artesunate epithelial-mesenchymal transition migration

Knocking down AR promotes osteoblasts to recruit prostate cancer cells by altering exosomal circ-DHPS/miR-214-3p/CCL5 pathway

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Asian Journal of Andrology 2024年第2期26卷 195-204页

作者： Zhao Yang Jia-Qi chen Tian-jie Liu yu-Le chen Zhen-Kun Ma yi-Zeng Fan Zi-Xi wang Shan Xu ke wang Xin-Yang wang Lei Li Hong-Jun Xie Department of Urology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China

Tumor-derived exosomes have been shown to play a key role in organ-specific metastasis,and the androgen receptor regulates prostate cancer(PCa)*** is unclear whether the androgen receptor regulates the recruitment of prostate cancer cells to the bone microenvironment,even bone metastases,through ***,we found that exosomes isolated from PCa cells after knocking down androgen receptor(AR)or enzalutamide treatment can facilitate the migration of prostate cancer cells to *** addition,AR silencing or treatment with the AR antagonist enzalutamide may increase the expression of circular RNA-deoxyhypusine synthase(circ-DHPS)in PCa cells,which can be transported to osteoblasts by ***-DHPS acts as a competitive endogenous RNA(ceRNA)against endogenous miR-214-3p to promote C-C chemokine ligand 5(CCL5)levels in *** the level of CCL5 in osteoblasts could recruit more PCa cells into the bone ***,blocking the circ-DHPS/miR-214-3p/CCL5 signal may decrease exosome-mediated migration of prostate cancer cells to osteoblasts.

关键词： androgen receptor circRNA exosome prostate cancer

Predictive value of CA-153,CA-125 and Apo A for ocular metastasis in menopausal female patients with breast cancer

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International Journal of Ophthalmology(English edition) 2024年第12期17卷 2265-2275页

作者： Qun-Ce Liu Qian Ling Yan-mei Zeng cheng chen Hong Wei Jin-yu Hu jie Zou Xiao-yu wang Xu chen yi Shao Department of Laboratory Medicine Guangxin District Maternal and Child Health HospitalShangrao 334000Jiangxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg ProvincieNetherlands Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China

AIM:To establish a meaningful standard for diagnosing ocular metastasis(OM)in menopausal breast cancer(BC)women,and explore the relationship between CA-153,CA-125,apolipoprotein A,and ***:A total of 1362 menopausal female BC patients with OM volunteered to take part in this study between July 2012 and July *** with BC who are menopausal were found to have an OM incidence of 1.6%.Furthermore,CA-153,CA-125,and apolipoprotein A(Apo A)all contributed to OM in women with BC who are postmenopausal according to binary logistic *** operating curve(ROC)analysis was used to assess the diagnostic value of OM in patients with ***:Both CA-153 and CA-153+CA-125 showed a higher sensitivity of 95.45%,whereas CA-153+Apo A illustrated the highest specificity of 99.02%.Moreover,CA-153 and CA-153+CA-125 had higher areas under the curve(AUC)of ***:The data indicate that the serum concentrations of CA-153 exhibited the most significant predictors of the diagnosis of OM in menopausal women with *** current study researches the utility of risk factors in predicting of OM in menopausal BC women and put forward the latest suggestions on their clinical application.

关键词： menopausal female patients breast cancer ocular metastasis CA-125 CA-153 apolipoprotein A

Predicting visual acuity with machine learning in treated ocular trauma patients

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1005-1014页

作者： Zhi-Lu Zhou yi-Fei Yan jie-Min chen Rui-Jue Liu Xiao-ying yu Meng wang Hong-Xia Hao Dong-mei Liu Qi Zhang jie wang Wen-Tao Xia Department of Forensic Medicine Guizhou Medical UniversityGuiyang 550009Guizhou ProvinceChina Shanghai key Laboratory of Forensic Medicine Shanghai Forensic Service PlatformInstitute of Forensic ScienceMinistry of JusticeShanghai 200063China The SMART(Smart Medicine and AI-based Radiology Technology)Lab Shanghai Institute for Advanced Communication and Data ScienceShanghai UniversityShanghai 200444China School of Communication and Information Engineering Shanghai UniversityShanghai 200444China Basic Medical College Jiamusi UniversityJiamusi 154007Heilongjiang ProvinceChina

AIM:To predict best-corrected visual acuity(BCVA)by machine learning in patients with ocular trauma who were treated for at least ***:The internal dataset consisted of 850 patients with 1589 eyes and an average age of *** initial visual acuity was 0.99 log *** test dataset consisted of 60 patients with 100 eyes collected while the model was *** different machine-learning algorithms(Extreme Gradient Boosting,support vector regression,Bayesian ridge,and random forest regressor)were used to predict BCVA,and four algorithms(Extreme Gradient Boosting,support vector machine,logistic regression,and random forest classifier)were used to classify BCVA in patients with ocular trauma after treatment for 6mo or *** features were obtained from outpatient records,and ocular parameters were extracted from optical coherence tomography images and fundus *** features were put into different machine-learning models,and the obtained predicted values were compared with the actual BCVA *** best-performing model and the best variable selected were further evaluated in the test ***:There was a significant correlation between the predicted and actual values[all Pearson correlation coefficient(PCC)>0.6].Considering only the data from the traumatic group(group A)into account,the lowest mean absolute error(MAE)and root mean square error(RMSE)were 0.30 and 0.40 log MAR,*** the traumatic and healthy groups(group B),the lowest MAE and RMSE were 0.20 and 0.33 log MAR,*** sensitivity was always higher than the specificity in group A,in contrast to the results in group *** classification accuracy and precision were above 0.80 in both *** MAE,RMSE,and PCC of the test dataset were 0.20,0.29,and 0.96,*** sensitivity,precision,specificity,and accuracy of the test dataset were 0.83,0.92,0.95,and 0.90,***:Predicting BCVA using machine-learning models in patients wit

关键词： ocular trauma predicting visiual acuity best-corrected visual acuity visual dysfunction machine learning

Flexible and wake-up free Hf_(0.5)Zr_(0.5)O_(2) ferroelectric thin films with ultra-low operation voltage and high polarization

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Journal of Advanced Ceramics 2024年第11期13卷 1844-1851页

作者： Jun-Hui wang Tian-Peng Duan Jia-Jia Liao Zhi-Peng wang Xin-Ran Huang Shi-jie Jia ke-yu Bao yu-Xin Fan Bing-Jian Zeng Li-mei Jiang Min Liao yi-Chun Zhou Qiong Yang jie Jiang School of Advanced Materials and Nanotechnology Xidian UniversityXi’an 710126China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China Guangzhou Institute of Technology Xidian UniversityGuangzhou 510555China

Flexible and transparent hafnium oxide-based ferroelectric films are attracting widespread attention because of the increasing demand for wearable electronic ***,the ultra-low voltage operation with robust and stable ferroelectricity,which is a prerequisite for portable device applications,has not been realized ***,we report flexible Hf_(0.5)Zr_(0.5)O_(2) ferroelectric films with a saturation voltage of only 1.3/3 V and remanent polarization(2Pr)of 38/60µC·cm^(2).Negligible wake-up effect and superior stability resistance to compressive/tensile stress and high temperature up to 150°C are also *** polarization switching dynamics under bending are investigated based on the switching current measurement,suggesting that the intrinsic switching speeds keep almost constant at different bending *** addition,there is a negative correlation between the activation field and the compressive or tensile stress,which is due to the lowered energy barrier induced by the in-plane strain applied to the[111]-oriented hexagonal *** work sheds light on the application of flexible,stable,and HfO2-based ferroelectric thin films with ultra-low consumption.

关键词： flexible ferroelectrics Hf_(0.5)Zr_(0.5)O_(2) ultra-low voltage operation reliability

Comparing the precision of the pSOFA and SIRS scores in predicting sepsis-related deaths among hospitalized children:a multi-center retrospective cohort study

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World Journal of Emergency Medicine 2022年第4期13卷 259-265页

作者： Chun Zhao mei-yun Xin Jing Li Jin-fang Zhao yu-juan wang Wei wang Qian Gao jie chen Qi-wei wang You-peng Jin Department of Pediatric Intensive Care Unit Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Department of Pediatrics Affiliated Hospital of Jining Medical UniversityJining 272129China Department of Pediatrics Qingdao Women and Children HospitalQingdao 266034China Department of Pediatric Intensive Care Unit Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan 250021China

BACKGROUND:The latest sepsis definition includes both infection and organ failure,as evidenced by the sequential organ failure assessment(SOFA)***,the applicability of the pediatric SOFA score(pSOFA)is not yet *** study evaluated the effectiveness of both pSOFA and system inflammatory reaction syndrome(SIRS)scores in predicting sepsis-related pediatric ***:This is a retrospective multi-center cohort study including hospitalized patientsyi),three sub-categories of pSOFA were screened out and a new simplified pSOFA score(spSOFA)was *** effectiveness and accuracy of prediction of pSOFA,SIRS and spSOFA was retrieved from the area under the receiver operating characteristic curve(AUROC)and Delong’s ***:A total of 1,092 participants were eligible for this study,and carried a 23.4%in-hospital mortality *** 24-h elevated pSOFA score(24 h-pSOFA),bloodstream infection,and mechanical ventilation(MV)requirement were major risk factors associated with sepsis-related *** AUROC analysis confirmed that the spSOFA provided good predictive capability in sepsis-related pediatric deaths,relative to the 24 h-pSOFA and ***:The pSOFA score performed better than SIRS in diagnosing infected children with high mortality ***,it is both costly and ***,therefore,proposed spSOFA to accurately predict patient outcome,without the ***,additional investigations,involving a large sample population,are warranted to confirm the conclusion of this study.

关键词： Simple-pSOFA pSOFA Children Mortality Infection SIRS

Acute kidney injury in acute-on-chronic liver failure is different from in decompensated cirrhosis

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World Journal of Gastroenterology 2018年第21期24卷 2300-2310页

作者： Qun-Qun Jiang mei-Fang Han ke Ma Guang chen Xiao-Yang Wan Semvua Bukheti Kilonzo Wen-yu Wu Yong-Li wang jie You Qin Ning Department and Institute of Infectious Disease Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

AIM To evaluate the differences in acute kidney injury(AKI) between acute-on-chronic liver failure(ACLF) and decompensated cirrhosis(DC) patients. METHODS During the period from December 2015 to July 2017, 280 patients with hepatitis B virus(HBV)-related ACLF(HBV-ACLF) and 132 patients with HBV-related DC(HBV-DC) who were admitted to our center were recruited consecutively into an observational study. Urine specimens were collected from all subjects and the levels of five urinary tubular injury biomarkers were detected,including neutrophil gelatinase-associated lipocalin(NGAL), interleukin-18(IL-18), liver-type fatty acid binding protein(L-FABP), cystatin C(CysC), and kidney injury molecule-1(KIM-1). Simultaneously, the patient demographics, occurrence and progression of AKI, and response to terlipressin therapy were recorded. All patients were followed up for 3 mo or until death after enrollment. RESULTS AKI occurred in 71 and 28 of HBV-ACLF and HBV-DC patients, respectively(25.4% vs 21.2%, P = 0.358). Among all patients, the levels of four urinary biomarkers(NGAL, CysC, L-FABP, IL-18) were significantly elevated in patients with HBV-ACLF and AKI(ACLF-AKI), compared with that in patients with HBV-DC and AKI(DC-AKI) or those without AKI. There was a higher proportion of patients with AKI progression in ACLF-AKI patients than in DC-AKI patients(49.3% vs 17.9%, P = 0.013). Fortythree patients with ACLF-AKI and 19 patients with DC-AKI were treated with terlipressin. The response rate of ACLFAKI patients was significantly lower than that of patients with DC-AKI(32.6% vs 57.9%, P = 0.018). Furthermore, patients with ACLF-AKI had the lowest 90 d survival rates among all groups(P kely associated with structural kidney injury, and is more progressive, with a poorer response to terlipressin treatment and a worse prognosis than that in DC patients.

关键词： Decompensated cirrhosis Acute-on-chronic liver failure Acute kidney injury Biomarker Etiology Treatment Prognosis