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Early surgical intervention for structural infantile spasms in two patients under 6 months old:a case report

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Acta Epileptologica 2020年第1期2卷 145-150页

作者： Haiyan Yang Zhiquan Yang Jing Peng yehong huang Zhuanyi Yang Fei Yin Liwen Wu Department of Pediatrics Xiangya HospitalCentral South UniversityChangsha 410008China. Department of Neurosurgery Xiangya HospitalCentral South UniversityChangsha 410008China. Department of Neurology Hunan Children’s HospitalChangsha 410007China.

Background:Infantile spasms(IS)are the most common childhood epileptic *** cortical dysplasia(FCD)and gray matter heterotopias(GH)are common structural causes of *** recommended first-line treatment for IS patients with structural causes is surgical intervention,according to the International League Against Epilepsy(ILAE)commission ***,there is currently no consensus on appropriate timings of *** presentations:Two structural IS cases are presented here:one was caused by FCD,and the other by *** patients exhibited recurrent seizures at the age of 2 months,had poor responses to various antiepileptic drugs(AEDs)and displayed severe mental and motor developmental *** types included focal seizures and *** magnetic resonance imaging showed abnormal gray signal or suspicious FCD lesions that coincided with the origin of the focal *** patients underwent lesion resection before the age of 6 ***-up observation showed that seizures of both patients were completely controlled several days after the *** AEDs were gradually reduced in dosage within 1 year,and the mental and motor development almost returned to ***:Early resection of lesions in structural IS patients has benefits of effectively controlling convulsions and improving developmental *** at several months of age can well tolerate craniotomy,and their cognitive development is more likely to return to normal after early surgery.

关键词： Infantile spasms Focal cortical dysplasia Gray matter heterotopias Early lesion resection

Correction to:Early surgical intervention for structural infantile spasms in two patients under 6 months old:a case report

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Acta Epileptologica 2021年第1期3卷 113-113页

作者： Haiyan Yang Zhiquan Yang Jing Peng yehong huang Zhuanyi Yang Fei Yin Liwen Wu Department of Pediatrics Xiangya HospitalCentral South UniversityChangsha 410008China Department of Neurosurgery Xiangya HospitalCentral South UniversityChangsha 410008China Department of Neurology Hunan Children’s HospitalChangsha 410007China

In this article[1],the‘Consent for publication’section need to be updated as follows:“The written consent form for publication has been obtained from the guardians of patients.”The original article has been updated.

关键词： patients infantile structural

橡胶草叶片蛋白质提取方法的选择及双向电泳体系的优化

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石河子大学学报（自然科学版） 2018年第5期36卷 609-616页

作者：李忠晴柴武慧张云川黄叶红李金环鲁培鑫闫洁石河子大学生命科学学院新疆石河子832000

目的为了建立起橡胶草叶片组织的蛋白双向电泳体系。方法采用5种不同方法提取橡胶草叶片蛋白,并通过蛋白提取率和单向SDS-PAGE电泳的比较,筛选出改良TCA-丙酮沉淀法、酚-乙酸铵沉淀法、Tris浸提法3种方法进行2-DE电泳。结果表明选择改良... 详细信息

目的为了建立起橡胶草叶片组织的蛋白双向电泳体系。方法采用5种不同方法提取橡胶草叶片蛋白,并通过蛋白提取率和单向SDS-PAGE电泳的比较,筛选出改良TCA-丙酮沉淀法、酚-乙酸铵沉淀法、Tris浸提法3种方法进行2-DE电泳。结果表明选择改良TCA-丙酮法为最合适的蛋白质提取方法。为进一步优化体系,比较了不同染色方法、上样量和固相p H梯度预制胶条(IPG)的p H范围对双向电泳结果的影响,电泳结果表明使用17 cm p H 3-10的IPG胶条、上样量为1200μg、考马斯亮蓝染色法能分离得到更多的蛋白点,是橡胶草叶片双向电泳体系的最优条件。结论本研究初步建立了橡胶草叶片蛋白质双向电泳体系,为深入研究橡胶草蛋白质组学提供依据。

关键词：橡胶草蛋白质双向电泳

质子泵抑制剂大剂量二联与铋剂四联在幽门螺杆菌根除治疗中的疗效比较

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临床荟萃 2022年第3期37卷 230-233页

作者：黄业鸿刘改芳忻晨曦赵云红吴婧华北理工大学研究生院河北唐山063000 河北省人民医院消化内科河北石家庄050051

目的比较质子泵抑制剂大剂量二联与铋剂四联对幽门螺杆菌(Helicobacter pylori,***)的根除率和不良反应的发生率。方法选择2021年1月至2021年8月就诊于河北省人民医院消化内科门诊的***阳性患者208例,随机分为试验组(质子泵抑制剂大剂... 详细信息

目的比较质子泵抑制剂大剂量二联与铋剂四联对幽门螺杆菌(Helicobacter pylori,***)的根除率和不良反应的发生率。方法选择2021年1月至2021年8月就诊于河北省人民医院消化内科门诊的***阳性患者208例,随机分为试验组(质子泵抑制剂大剂量二联)和对照组(铋剂四联),其中试验组105例,对照组103例。试验组给予“艾司奥美拉唑40 mg,2次/d、阿莫西林750 mg,4次/d”,疗程14天。对照组给予“艾司奥美拉唑20 mg,2次/d、枸橼酸铋钾220 mg,2次/d、阿莫西林1000 mg,2次/d、呋喃唑哃100 mg,2次/d”,疗程14天。疗程结束4周后复查^(13)C或^(14)C-尿素呼气试验,比较两组***根除率及不良反应的发生情况。结果试验组及对照组的ITT根除率分别为77.1%、82.5%(P=0.334),PP根除率分别为82.7%和87.6%(P=0.329);试验组的不良反应发生率低于对照组(9.0%vs 19.0%,P=0.042),其中试验组不良反应主要表现为腹胀、腹泻及皮疹等,对照组不良反应主要表现为口腔异味、便秘及腹痛等。结论质子泵抑制剂大剂量二联方案根除***的疗效与铋剂四联方案相当,但不良反应发生率更低,有望成为***治疗的一线根除方案。

关键词：幽门螺杆菌质子泵抑制剂铋剂四联根除率不良反应

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Skin rash caused by EGFR-TKI could be treated successfully by Pien Tze huang Unguentum Compositum: a case report

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The Journal of Biomedical Research 2022年第6期36卷 440-445页

作者： Mingzi Zhang Qi Li yehong Sun Department of Pharmacy Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong 518033China Department of Internal Medicine-Oncology Shenzhen Traditional Chinese Medicine HospitalShenzhen 518033China

Epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI)plays an important role in cancer ***,EGFR is highly expressed in the skin and gives rise to one of the most concerning issues for the EGFR-TKI treatment,namely skin *** and corticosteroids are usually used to treat the EGFR inhibitor-associated skin rash,with prominent side effects over long-time *** Tze huang(PZH)Unguentum Compositum is a traditional product for external application which is made of traditional Chinese medicine and oil ***,we reported the case of a 50-year-old man who presented with skin rash on the face,head,and back induced by an EGFR-TKI named *** using PZH Unguentum Compositum,we observed that the skin rash was mitigated and eventually *** case report suggests that PZH Unguentum Compositum may be an effective therapy in treating skin rash caused by EGFR-TKI with fewer side effects.

关键词： epidermal growth factor receptor tyrosine kinase inhibitor skin rash Pien Tze huang erlotinib

Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury

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Neural Regeneration Research 2023年第12期18卷 2773-2780页

作者： Zhe Liu Jingfei Xue Canying Liu Jiahui Tang Siting Wu Jicheng Lin Jiaxu Han Qi Zhang Caiqing Wu Haishun huang Ling Zhao yehong Zhuo Yiqing Li State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhouGuangdong ProvinceChina

Vision depends on accurate signal conduction from the retina to the brain through the optic nerve,an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion *** mammalian optic nerve,an important part of the central nervous system,cannot regenerate once it is injured,leading to permanent vision *** date,there is no clinical treatment that can regenerate the optic nerve and restore *** previous study found that the mobile zinc(Zn^(2+))level increased rapidly after optic nerve injury in the retina,specifically in the vesicles of the inner plexiform ***,chelating Zn^(2+)significantly promoted axonal regeneration with a long-term *** this study,we conditionally knocked out zinc transporter 3(ZnT3)in amacrine cells or retinal ganglion cells to construct two transgenic mouse lines(VGAT^(Cre)ZnT3^(fl/fl)and VGLUT2^(Cre)ZnT3^(fl/fl),respectively).We obtained direct evidence that the rapidly increased mobile Zn^(2+)in response to injury was from amacrine *** also found that selective deletion of ZnT3 in amacrine cells promoted retinal ganglion cell survival and axonal regeneration after optic nerve crush injury,improved retinal ganglion cell function,and promoted vision *** analysis of reginal ganglion cells revealed that inhibiting the release of presynaptic Zn^(2+)affected the transcription of key genes related to the survival of retinal ganglion cells in postsynaptic neurons,regulated the synaptic connection between amacrine cells and retinal ganglion cells,and affected the fate of retinal ganglion *** results suggest that amacrine cells release Zn^(2+)to trigger transcriptomic changes related to neuronal growth and survival in reginal ganglion cells,thereby influencing the synaptic plasticity of retinal *** results make the theory of zinc-dependent retinal ganglion cell death more accurate and complete and provide new insights into the com

关键词： axonal regeneration conditional knockout neurotransmitter optic nerve injury presynaptic neuron retinal network synaptic connection synaptic vesicles visual acuity zinc transporter 3

MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models

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Signal Transduction and Targeted Therapy 2019年第1期4卷 149-160页

作者： yehong Du Yexiang Du Yun Zhang Zhilin huang Min Fu Junjie Li Yayan Pang Peng Lei Yu Tian Wang Weihong Song Guiqiong He Zhifang Dong Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing400014PR China Department of Anatomy Basic Medical CollegeChongqing Medical UniversityChongqing400016PR China Townsend Family Laboratories Department of PsychiatryThe University of British ColumbiaVancouverBCV6T 1Z3Canada West China School of Basic Medical Sciences and Forensic Medicine Sichuan UniversityChengdu610041SichuanChina Brain Research Centre The University of British ColumbiaVancouverBCV6T 2B5Canada

Mitogen-activated protein kinase(MAPK)phosphatase 1(MKP-1)is an essential negative regulator of MAPKs by dephosphorylating MAPKs at both tyrosine and threonine *** of the MAPK signaling pathway has been associated with Alzheimer’s disease(AD).However,the role of MKP-1 in AD pathogenesis remains ***,we report that MKP-1 levels were decreased in the brain tissues of patients with AD and an AD mouse *** reduction in MKP-1 gene expression appeared to be a result of transcriptional inhibition via transcription factor specificity protein 1(Sp1)cis-acting binding elements in the MKP-1 gene ***-β(Aβ)-induced Sp1 activation decreased MKP-1 ***,upregulation of MKP-1 inhibited the expression of both Aβprecursor protein(APP)andβ-site APP-cleaving enzyme 1 by inactivating the extracellular signal-regulated kinase 1/2(ERK)/MAPK signaling ***,upregulation of MKP-1 reduced Aβproduction and plaque formation and improved hippocampal long-term potentiation(LTP)and cognitive deficits in APP/PS1 transgenic *** results demonstrate that MKP-1 impairment facilitates the pathogenesis of AD,whereas upregulation of MKP-1 plays a neuroprotective role to reduce Alzheimer-related ***,this study suggests that MKP-1 is a novel molecule for AD treatment.

关键词： Alzheimer Aβ impairment

Enhancement of radiosensitivity of lung adenocarcinoma using a decoction from the Fuzhengzengxiao formula

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Journal of Traditional Chinese Medicine 2015年第6期35卷 690-696页

作者： Zhang Qiaoli Wu Tong Lei Yong Li Bo Liu Weiyi Tian yehong Zhao Weipeng huang Jingchang Department of Traditional Chinese Medicine Beijing Hepingli Hospital Department of Traditional Chinese Medicine Beijing Ditan HospitalCapital Medical University Graduate School of Beijing University of Traditional Chinese Medicine Health Science Center Peking University Department of Acupuncture and Minimally Invasive Oncology Beijing University of Chinese Medicine Third Affiliated Hospital

OBJECTIVE: To study the effects of a decoction of Fuzhengzengxiao formula on lung adenocarcinoma regarding the inflammatory protein S100A9 known to enhance cancer cell ***: A nude mouse model of human lung adenocarcinoma was established. The mice were randomly divided into four groups using the random number table method: Group Ⅰ, control;Group Ⅱ, treatment with a decoction of the Fuzhengzengxiao formula alone; Group Ⅲ, treatment with radiotherapy alone; and Group Ⅳ, treatment with radiotherapy plus a decoction of Fuzhengzengxiao formula. When the tumor body was 1 cm^3 in diameter, the tumor bearing mice in GroupsⅢ and Ⅳ were irradiated at a single dose of 10 Gy and the tumor inhibition rate was *** expression of S100A9 was determined using Western blotting and q-PCR(Real-time Quantitative PCR Detecting System). The sensitivity of cells containing RNAi S100A9 to radiotherapy was evaluated using the Click multiple target model,and the cell cycle was analyzed using flow ***: Relative to the control group,the expression of S100A9 in the tumors in each treatment group was decreased,especially in Group Ⅳ. The sensitizing enhancement ratio(SER) Dq was >1 after RNAi S100A9; it decreased the surviving fraction after a 2 Gy dose exposure,and also the D_0 and Dq of the tumor cells; in addition, the radiosensitivity of G_2/M cells was significantly ***: The decoction of the Fuzhengzengxiao formula downregulated the expression of S100A9 in lung adenocarcinoma cells.

关键词： Calgranulin B RNA interference Radia-tion tolerance Adenocarcinoma of lung Fuzhengz-engxiao formula

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妊娠期外阴阴道假丝酵母菌病与垂直传播

中国实用妇科与产科杂志 2005年第11期21卷 663-665页

作者：谷晔红黄醒华首都医科大学附属北京同仁医院 100730 首都医科大学附属北京妇产医院

目的了解妊娠期外阴阴道假丝酵母菌病(vulvovaginal candidiasis,VVC)的发生率,母婴垂直传播及对孕产妇的影响。方法2002年11月至2003年5月对北京妇产医院定期产检的513例孕妇行阴道假丝酵母菌涂片、培养及菌种鉴定,并进行随诊;其间对25... 详细信息

目的了解妊娠期外阴阴道假丝酵母菌病(vulvovaginal candidiasis,VVC)的发生率,母婴垂直传播及对孕产妇的影响。方法2002年11月至2003年5月对北京妇产医院定期产检的513例孕妇行阴道假丝酵母菌涂片、培养及菌种鉴定,并进行随诊;其间对252例孕妇分娩的新生儿、胎盘行假丝酵母菌培养及菌种鉴定,31个胎盘送病理检查。结果妊娠期VVC的发病率18.71%(96/513)。孕期VVC者与携带者不增加胎膜早破发生,亦不引起产褥感染的发生。分娩的252例孕妇阴道假丝酵母菌涂片和(或)培养阳性109例,剖宫产组新生儿、胎盘该菌携带率分别为20.76%(11/53)、13.21%(7/53);阴道分娩组分别为35.71%(20/56)、23.21%(13/56),P>0.05;孕期诊断VVC者新生儿、胎盘假丝酵母菌携带率分别为16.67%(8/48)、8.33%(4/48),携带者分别为37.71%(23/61)、26.23%(16/61),P<0.05;孕期接受治疗48例新生儿、胎盘无假丝酵母菌携带;未治疗61例新生儿、胎盘假丝酵母菌携带率为50.82%(31/61)、32.79%(20/61)。胎盘假丝酵母菌携带者病理表现为急性炎症。结论孕期存在假丝酵母菌垂直传播。孕期治疗VVC与携带者可明显减少垂直传播的发生。

关键词：妊娠外阴阴道假丝酵母菌病垂直传播