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International Journal of Oral Science 2023年第4期15卷 575-587页

作者： Mayank Shrivastava liang ye Adams School of Dentistry University of North CarolinaChapel HillNCUSA Department of Rehabilitation Medicine University of Minnesota Medical SchoolMinneapolisMNUSA

Chronic Painful Temporomandibular Disorders(TMD)are challenging to diagnose and manage due to their complexity and lack of understanding of brain *** the past few decades’neural mechanisms of pain regulation and perception have been clarified by neuroimaging *** in the neuroimaging have bridged the gap between brain activity and the subjective experience of *** has also made strides toward separating the neural mechanisms underlying the chronic painful ***,Artificial Intelligence(AI)is transforming various sectors by automating tasks that previously required humans’intelligence to *** has started to contribute to the recognition,assessment,and understanding of painful *** application of AI and neuroimaging in understanding the pathophysiology and diagnosis of chronic painful TMD are still in its early *** objective of the present review is to identify the contemporary neuroimaging approaches such as structural,functional,and molecular techniques that have been used to investigate the brain of chronic painful TMD ***,this review guides practitioners on relevant aspects of AI and how AI and neuroimaging methods can revolutionize our understanding on the mechanisms of painful TMD and aid in both diagnosis and management to enhance patient outcomes.

关键词： diagnosis artificial separating

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中国传统医药非物质文化遗产保护述评

南京中医药大学学报（社会科学版） 2024年第3期25卷 141-145,178页

作者：朱德明叶亮浙江中医药大学浙江中医药文化研究院浙江杭州310053 南京中医药大学学报编辑部江苏南京210023

阐述了我国非物质文化遗产的保护措施,介绍了传统医药非遗的申报条件及我国传统医药非遗保护取得的成效。指出我国现阶段传统医药非遗存在列入国家级非遗代表性项目名录数目偏少且分类不清,单位和个人对传统医药非遗保护与传承乏力,传... 详细信息

阐述了我国非物质文化遗产的保护措施,介绍了传统医药非遗的申报条件及我国传统医药非遗保护取得的成效。指出我国现阶段传统医药非遗存在列入国家级非遗代表性项目名录数目偏少且分类不清,单位和个人对传统医药非遗保护与传承乏力,传承人才缺乏,软硬传播平台和数字化建设不足等问题。提出要高度重视传统医药非遗的保护与传承工作,强化政策支持,加强对非遗项目的考核与评估,加强非遗传承人队伍建设,加快软硬传播平台、数字化建设,从而进一步促进和完善我国传统医药非遗保护与传承工作。

关键词：非物质文化遗产中医药非遗非遗传承非遗保护传承人

Adaptive SPC monitoring scheme for DOE-based APC

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Journal of Systems Engineering and Electronics 2008年第2期19卷 329-336页

作者： ye liang Pan Ershun Xi Lifeng Dept. of Industrial Engineering and Logistics School of Management Engineering Shanghai Jiaotong Univ. Shanghai 200240 P. R. China

Automatic process control (APC) based on design of experiment (DOE) is a cost-efficient approach for variation reduction. The process changes both in mean and variance owing to online parameter adjustment make it hard to apply traditional SPC charts in such DOE-based APC applied process. An adaptive SPC scheme is developed, which can better track the process transitions and achieve the possible SPC run cost reduction when the process is stable. The control law of SPC parameters is designed by fully utilizing the estimation properties of the process model instead of traditionally using the data collected from the production line. An example is provided to illustrate the proposed adaptive SPC design approach.

关键词： automatic process control statistical process control robust parameter design process transitions.

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基于特征条件扩散模型的雷达回波外推算法

科学技术与工程 2024年第22期24卷 9498-9509页

作者：吴其亮王兴苗子书叶威良王思成向磊南京信息工程大学人工智能学院南京210044 包头市气象局包头014030 南京信息工程大学计算机学院南京210044

随着外推时效的延长,回波强度愈发衰减,且对于强回波的预报性能迅速下降。这是当前雷达外推结果不准确的两个典型特征。为改善上述问题,提出了一种通过雷达回波帧驱动的扩散雷达外推算法(diffusion radar echo extrapolation,DiffREE)... 详细信息

随着外推时效的延长,回波强度愈发衰减,且对于强回波的预报性能迅速下降。这是当前雷达外推结果不准确的两个典型特征。为改善上述问题,提出了一种通过雷达回波帧驱动的扩散雷达外推算法(diffusion radar echo extrapolation,DiffREE)。该算法利用条件编码模块将过去雷达回波帧的空间信息和时效信息深度融合,通过Transformer编码器自动提取回波的时空特征,并作为条件扩散模型的条件,驱动扩散模型重建当前雷达回波帧。实验结果表明,该方法可以生成高精度、高质量的雷达预报帧,较最好的基线算法在CSI、ETS、HSS和POD上分别提升42.2%、51.1%、49.8%和39.5%。

关键词：深度学习短时预报雷达回波外推扩散模型条件编码

Numerical study on flow fields and aerodynamics of tilt rotor aircraft in conversion mode based on embedded grid and actuator model

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Chinese Journal of Aeronautics 2015年第1期28卷 93-102页

作者： Zhang Ying ye liang Yang Shuo Aviation Key Laboratory of Science and Technology on Aerodynamics of High Speed and High Reynolds Number AVIC Aerodynamics Research Institute

A method combining rotor actuator disk model and embedded grid technique is presented in this paper, aimed at predicting the flow fields and aerodynamic characteristics of tilt rotor aircraft in conversion mode more efficiently and effectively. In this method, rotor＇s influence is considered in terms of the momentum it impacts to the fluid around it; transformation matrixes among different coordinate systems are deduced to extend actuator method＇s utility to conversion mode flow fields＇ calculation. Meanwhile, an embedded grid system is designed, in which grids generated around fuselage and actuator disk are regarded as background grid and minor grid respectively, and a new method is presented for ‘donor searching＇ and ‘hole cutting＇ during grid assembling. Based on the above methods, flow fields of tilt rotor aircraft in conversion mode are simulated, with threedimensional Navier–Stokes equations discretized by a second-order upwind finite-volume scheme and an implicit lower–upper symmetric Gauss–Seidel（LU-SGS） time-stepping scheme. Numerical results demonstrate that the proposed CFD method is very effective in simulating the conversion mode flow fields of tilt rotor aircraft.

关键词： actuator aircraft rotor searching assembling symmetric coordinate donor stepping Stokes

奥马珠单抗联合CPAP治疗1例重度哮喘合并OSAHS并文献复习

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世界临床药物 2024年第4期45卷 420-423页

作者：郁飞叶亮谷伟南京医科大学附属南京医院南京市第一医院呼吸与危重症医学科江苏南京210006

阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)是哮喘常见合并症之一,常导致哮喘症状控制不佳。该文报道1例重度哮喘患者,加用奥马珠单抗治疗后,哮喘仍然难以完全控制,行多导睡眠监测后明确合并重... 详细信息

阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)是哮喘常见合并症之一,常导致哮喘症状控制不佳。该文报道1例重度哮喘患者,加用奥马珠单抗治疗后,哮喘仍然难以完全控制,行多导睡眠监测后明确合并重度OSAHS,在联合持续气道正压通气治疗后哮喘症状得到良好控制。

关键词：奥马珠单抗重度哮喘阻塞性睡眠呼吸暂停低通气综合征持续正压通气

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地塞米松罗哌卡因预防跟骨骨折切口并发症

中国矫形外科杂志 2024年第1期32卷 71-74页

作者：金文孙良业高庆郑权刘孝峰安徽医科大学附属六安市人民医院骨科安徽六安237000

[目的]探讨术中局部注射地塞米松联合罗哌卡因(dexamethasone ropivacaine,DR)预防跟骨骨折切口相关并发症的疗效。[方法]回顾性分析本院2019年1月—2022年10月开放复位内固定治疗跟骨骨折136例(137足)的临床资料。根据医患沟通结果,68... 详细信息

[目的]探讨术中局部注射地塞米松联合罗哌卡因(dexamethasone ropivacaine,DR)预防跟骨骨折切口相关并发症的疗效。[方法]回顾性分析本院2019年1月—2022年10月开放复位内固定治疗跟骨骨折136例(137足)的临床资料。根据医患沟通结果,68例(68足)术中切口周围注射DR(DR组),68例(69足)未注射DR(常规组)。比较两组围手术期资料。[结果]两组患者手术时间、切口长度、术中失血量的差异均无统计学意义(P>0.05)。DR组在术后切口肿胀时间[(4.7±1.1)d vs(6.8±2.9)d,P0.05)。[结论]术中切口周围局部注射地塞米松联合罗哌卡因能有效减轻跟骨骨折患者术后疼痛,减少切口相关并发症的发生。

关键词：地塞米松罗哌卡因跟骨骨折切口并发症

A human monoclonal antibody neutralizes SARS-CoV-2 Omicron variants bytargeting the upstream region of spike protein HR2 motif

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hLife 2024年第3期2卷 126-140页

作者： Hang Su Jun Zhang Zhenfei Yi Sajid Khan Mian Peng liang ye Alan Bao Han Zhang Guangli Suo Qian Li Housheng Zheng Dandan Wu Thomas J.Kipps Lanfeng Wang Zhenghong Lin Suping Zhang Shenzhen Key Laboratory of Precision Medicine for Hematological Malignancies Guangdong Key Laboratory for Genome Stability andHuman Disease PreventionDepartment of PharmacologySchool of Basic Medical SciencesBase for International Science and TechnologyCooperation:Carson Cancer Stem Cell Vaccines R&D CenterInternational Cancer CenterShenzhen University Medical SchoolShenzhenUniversityGuangdongChina School of Life Sciences Chongqing UniversityChongqingChina The Center for Microbes Development and HealthCAS Key Laboratory of Molecular Virology&ImmunologyShanghai Institute of Immunityand InfectionChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghaiChina College of Life Sciences University of Chinese Academy of SciencesBeijingChina Department of Critical Care Medicine Shenzhen Luohu People’s HospitalGuangdongChina University of California BerkeleyCaliforniaUSA Xenta Biomedical Science Co. LtdGuangdongChina CAS Key Laboratory of Nano-Bio Interface Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesJiangsuChina Center of Novel Therapeutics University of CaliforniaSan DiegoCaliforniaUSA

The continuous emergence of new severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants meansthere is a need to explore additional strategies to develop broad-spectrum vaccines or therapeutics for individuals remaining at risk of coronavirus disease 2019(COVID-19).Neutralizing monoclonal antibody(mAb)that binds to theconserved S2 subunit of the SARS-CoV-2 spike(S)protein alone,or in combination with mAb that binds to the receptor-binding domain(RBD)of S protein,might be effective in eliciting protection from infection by a variety of SARS-CoV2 *** high-throughput single-cell immunoglobulin sequencing of B cells from COVID-19-convalescent donors,we identified a high-affinity S2-specific mAb-39,that could inhibit original SARS-CoV-2 strain,Omicron BA.1,BA.2.86,BA.4,BA.5,and EG.5.1 S protein-mediated membrane fusion,leading to the neutralization of these ***,mAb-39 could also improve the neutralizing activity of anti-RBD antibody against the highlyneutralization-resistant Omicron *** docking and point mutation analyses revealed that mAb-39 recognized epitopes within the conserved upstream region of the heptad repeat 2(HR2)motif of the S2 ***,these findings demonstrate that targeting the conserved upstream region of the HR2 motif(e.g.,using mAbs)provides anovel strategy for preventing the infection of SARS-CoV-2 and its variants.

关键词： coronavirus disease 2019(COVID-19) severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variants monoclonal antibody upstream region of heptad repeat 2(HR2) immunoglobulin repertoiresequencing

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电动汽车电驱动系统建模及控制策略研究

机械设计与制造 2024年第1期395卷 294-298,303页

作者：冶存良杨贺绪郝杰巩云鹏宁夏理工学院机械工程学院宁夏石嘴山753000 东北大学机械工程与自动化学院辽宁沈阳110819 内蒙古一机集团宏远电器股份有限公司内蒙古包头014030

针对纯电汽车电驱动系统因受负载端转动惯量时变特性及传动部件中存在柔性的影响,导致电机端转矩波动及传动精度降低的问题,这里提出了一种通过加入陷波滤波器与前馈调整增益进行调整的控制策略。相比传统方法,此方法需要配置的参数更少... 详细信息

针对纯电汽车电驱动系统因受负载端转动惯量时变特性及传动部件中存在柔性的影响,导致电机端转矩波动及传动精度降低的问题,这里提出了一种通过加入陷波滤波器与前馈调整增益进行调整的控制策略。相比传统方法,此方法需要配置的参数更少,控制的精度更高。首先对电驱动系统建立了基于双惯量模型的动力学方程,并分析了不同负载转动惯量下系统的频率响应。依据建立的电驱动系统双惯量模型,设计了两种陷波滤波器。对比加入陷波滤波器后系统的参数变化和响应曲线,选择了一种效果更好的陷波器。最后,对加入陷波器后的控制系统,通过前馈控制和调整增益进行改进。给出了改进后控制策略的理论分析过程与参数设计方法,并进行了数值仿真。结果表明,所提出的方法可以减弱纯电汽车的电驱动系统因传动柔性与电机负载端转动惯量时变特性导致的系统扭振及传动精度降低的问题。

关键词：电动车辆电驱动系统双惯量系统负载时变陷波滤波器

A comprehensive review on biomarkers associated with painful temporomandibular disorders

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International Journal of Oral Science 2021年第3期13卷 230-242页

作者： Mayank Shrivastava Ricardo Battaglino liang ye Department of Diagnostic and Biological Sciences School of DentistryUniversity of MinnesotaMinneapolisMNUSA Department of Rehabilitation Medicine Medical SchoolUniversity of MinnesotaMinneapolisMNUSA

Pain of the orofacial region is the primary complaint for which patients seek *** all the orofacial pain conditions,one condition that possess a significant global health problem is temporomandibular disorder(TMD).Patients with TMD typically frequently complaints of pain as a *** can occur due to complex interplay between peripheral and central sensitization,endogenous modulatory pathways,and cortical *** diagnosis of TMD pain a descriptive history,clinical assessment,and imaging is ***,due to the complex nature of pain an additional step is needed to render a definitive TMD *** this review we explicate the role of different biomarkers involved in painful *** painful TMD conditions,the role of biomarkers is still *** believe that the identification of biomarkers associated with painful TMD may stimulate researchers and clinician to understand the mechanism underlying the pathogenesis of TMD and help them in developing newer methods for the diagnosis and management of ***,to understand the potential relationship of biomarkers,and painful TMD we categorize the biomarkers as molecular biomarkers,neuroimaging biomarkers and sensory *** addition,we will briefly discuss pain genetics and the role of potential microRNA(miRNA)involved in TMD pain.

关键词： diagnosis endogenous facial