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气管支气管淀粉样变的诊治研究进展

中华结核和呼吸杂志 2020年第9期43卷 816-820页

作者：叶芬芬周锐中南大学湘雅二医院呼吸与危重症医学科长沙410011

气管支气管淀粉样变(Tracheobronchial amyloidosis,TBA)是一种罕见的局限性淀粉样变,以淀粉样纤维蛋白异常沉积于呼吸道黏膜下及肌层为特征,发病机制不明。由于其缺乏特异性临床表现及体征,与其他疾病不易鉴别,常被误诊和漏诊,诊断需... 详细信息

气管支气管淀粉样变(Tracheobronchial amyloidosis,TBA)是一种罕见的局限性淀粉样变,以淀粉样纤维蛋白异常沉积于呼吸道黏膜下及肌层为特征,发病机制不明。由于其缺乏特异性临床表现及体征,与其他疾病不易鉴别,常被误诊和漏诊,诊断需依靠组织病理学,临床尚无标准治疗方案,治疗存在一定困难。近年来,随着支气管镜技术的发展和普及,TBA的检出率增加,对TBA的认识有了明显提高,也为TBA患者提供了新的治疗选择。本文就TBA的诊断与治疗研究进展综述如下。

关键词：淀粉样变标准治疗方案呼吸道黏膜病理学,临床诊治研究肌层发病机制 TBA

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Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to hypothalamus and habenula

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中国药理学与毒理学杂志 2023年第7期37卷 547-548页

作者： WANG Muran LI Peijun LI Zewen Beatriz S.da SILVA ZHENG Wu XIANG Zhenghua HE Yan XU Tao Cristina CORDEIRO DENG Lu DAI Yuwei ye Mengqian LIN Zhiqing ZHOU Jianhong ZHOU Xuzhao ye fenfen Rodrigo A CUNHA CHEN Jiangfan GUO Wei Wenzhou Medical University University of Coimbra NavalMedicalUniversity

Depressive disorder ranks as a major burden of disease worldwide, yet the current antidepressant medications are limited by frequent non-responsiveness and significant side effects. The lateral septum(LS) is thought to control of depression, however, the cellular and circuit substrates are largely unknown. Here, we identified a subpopulation of LS GABAergic adenosine A2A receptors(A2AR)-positive neurons mediating depressive symptoms via direct projects to the lateral habenula(LHb) and the dorsomedial hypothalamus(DMH). Activation of A2AR in the LS augmented the spiking frequency of A2AR-positive neurons leading to a decreased activation of surrounding neurons and the bi-directional manipulation of LS-A2AR activity demonstrated that LS-A2ARs are necessary and sufficient to trigger depressive phenotypes. Thus, the optogenetic modulation(stimulation or inhibition) of LS-A2AR-positive neuronal activity or LSA2AR-positive neurons projection terminals to the LHb or DMH, phenocopied depressive behaviors. Moreover,A2AR are upregulated in the LS in two male mouse models of repeated stress-induced depression. This identification that aberrantly increased A2AR signaling in the LS is a critical upstream regulator of repeated stress-induced depressive-like behaviors provides a neurophysiological and circuit-based justification of the antidepressant potential of A2AR antagonists, prompting their clinical translation.

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菜籽油脱胶和脱臭工艺优化

中国油脂 2024年第6期49卷 18-23,29页

作者：洪坤强罗质叶展雷芬芬钟武何东平武汉轻工大学食品科学与工程学院武汉430023 国家市场监管重点实验室武汉430023 江南大学食品学院江苏无锡214122

为了对菜籽油适度精炼提供参考,以菜籽原油(磷含量693.00mg/kg)为原料,采用磷脂酶A_(1)(PLA_(1))进行预脱胶,再采用磷脂酶C(PLC)进行复脱胶,所得脱胶油采用低温短时两级捕集回流脱臭工艺进行脱臭。以磷含量为指标,通过单因素试验和响应... 详细信息

为了对菜籽油适度精炼提供参考,以菜籽原油(磷含量693.00mg/kg)为原料,采用磷脂酶A_(1)(PLA_(1))进行预脱胶,再采用磷脂酶C(PLC)进行复脱胶,所得脱胶油采用低温短时两级捕集回流脱臭工艺进行脱臭。以磷含量为指标,通过单因素试验和响应面试验对PLA_(1)预脱胶工艺条件进行优化。以生育酚损失率为指标,通过单因素试验和正交试验对脱臭工艺条件进行优化。另外,对比了不同脱胶方法(PLA_(1)-PLC复合脱胶、PLC脱胶、水化脱胶)和不同脱臭工艺(低温短时两级捕集回流脱臭工艺和常规脱臭工艺)的效果。结果表明:PLA_(1)预脱胶最优工艺条件为柠檬酸(45g/100mL)添加量3.3mL/kg、PLA_(1)(10U/mL)添加量44.0mL/kg、脱胶温度54.0℃、脱胶时间1.4h,在此条件下PLA_(1)-PLC复合脱胶菜籽油中磷含量相比菜籽原油下降了(99.01±0.05)%;与其他脱胶方法相比,PLA_(1)-PLC复合脱胶法脱胶效率高;脱臭最优工艺条件为脱臭温度220℃、脱臭时间80min,在此条件下生育酚损失率在10%以下,且各生育酚单体的相对含量基本不变;与常规脱臭工艺相比,低温短时两级捕集回流脱臭工艺具有能耗和生育酚损失率低的优点。综上,PLA_(1)-PLC复合脱胶和低温短时两级捕集回流脱臭工艺可以较好地改善菜籽油的品质,具有良好的市场应用前景。

关键词：菜籽油 PLA_(1)预脱胶 PLC复脱胶低温短时两级捕集回流脱臭

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Association between 15 known or potential breast cancer susceptibility genes and breast cancer risks in Chinese women

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Cancer Biology & Medicine 2022年第2期19卷 253-262页

作者： fenfen Fu Dongjie Zhang Li Hu Senthil Sundaram Dingge Ying Ying Zhang Shuna Fu Juan Zhang Lu Yao ye Xu Yuntao Xie Department of Breast Surgery Peking University International HospitalBeijing 102206China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Familial&Hereditary Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China Prenetics Limited Hong Kong 999077China Beijing CircleDNA Gene Technology Co. Ltd.Beijing 100020China

Objective:There are many hereditary breast cancer patients in China,and multigene panel testing has been a new paradigm of genetic testing for these patients and their ***,the magnitude of breast cancer risks related to multiple breast cancer susceptibility genes are largely unknown in Chinese ***:We screened pathogenic variants in 15 established or potential breast cancer susceptibility genes from 8,067 consecutive Chinese female breast cancer patients and 13,129 Chinese cancer-free female *** breast cancer patients were unselected for age at diagnosis or family ***:We found that pathogenic variants in TP53[odds ratio(OR):16.9,95%confidence interval(CI):5.2–55.2];BRCA2(OR:10.4,95%CI:7.6–14.2);BRCA1(OR:9.7,95%CI:6.3–14.8);and PALB2(OR:5.2,95%CI:3.0–8.8)were associated with a high risk of breast ***,BARD1,CHEK2,and RAD51D were associated with a moderate risk of breast cancer with ORs ranging from 2-fold to *** contrast,pathogenic variants of NBN,RAD50,BRIP1,and RAD51C were not associated with increased risk of breast cancer in Chinese *** pathogenic variants of PTEN,CDH1,and STK11 were very rare,so they had a limited contribution to Chinese breast *** with pathogenic variants of TP53,BRCA1,BRCA2,and PALB2 more often had earlyonset breast cancer,bilateral breast cancer,and a family history of breast cancer and/or any ***:This study provided breast cancer risk assessment data for multiple genes in Chinese women,which is useful for genetic testing and clinical management of Chinese hereditary breast cancer.

关键词： Multigene panel sequencing susceptibility genes breast cancer risk phenotype case-control study

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不同基质和激素对4种花卉扦插的影响

热带农业科学 2024年第6期44卷 55-60页

作者：张晓东闫芬芬齐聪洋袁烨张红艳马全会塔里木大学园艺与林学学院/南疆特色果树高效优质栽培与深加工技术国家地方联合工程实验室新疆阿拉尔843300 昆玉市大漠田园农业发展有限公司新疆昆玉848116

以长寿花、菊花、月季、三角梅4种花卉材料为研究对象,在设施条件下采用不同基质、不同激素研究最适宜的花卉扦插方法。结果表明:在相同基质的条件下,用NAA(500 mg/L)处理4种花卉,菊花生根率最高;用IAA(500 mg/L)处理,长寿花生长最佳;在... 详细信息

以长寿花、菊花、月季、三角梅4种花卉材料为研究对象,在设施条件下采用不同基质、不同激素研究最适宜的花卉扦插方法。结果表明:在相同基质的条件下,用NAA(500 mg/L)处理4种花卉,菊花生根率最高;用IAA(500 mg/L)处理,长寿花生长最佳;在NAA(500 mg/L)的处理下,三角梅生根率最高,但在IAA(500 mg/L)处理下,三角梅生长最佳。在相同激素的条件下,以草炭作为基质,菊花生长最佳;以粗砂作为基质,长寿花根系生长最佳;以蛭石作为基质,长寿花地上部分生长最佳;以珍珠岩作为基质,月季根系生长最佳;以蛭石作为基质,三角梅生长最佳。4种花卉的最适基质与激素组合为:菊花宜用草炭作为基质,NAA(500 mg/L)处理;长寿花宜用粗砂或蛭石作为基质,IAA(500 mg/L)处理;月季宜用以珍珠岩作为基质;三角梅宜用蛭石作为基质,IAA(500 mg/L)或NAA(500 mg/L)处理。

关键词：花卉扦插基质激素生根

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An ultra-low concentration electrolyte with fluorine-free bulky anions for stable potassium metal batteries

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Nano Research 2023年第6期16卷 8290-8296页

作者： Qinguang Liu Mei Geng Ting Yu Li Zhang Changdong Wu Jie Liu Shulin Zhao Qingxin Yang Robin Song Jingjuan ye fenfen Wang Yuping Wu Dengji Xiao Yuhui Chen State Key Laboratory of Materials-Oriented Chemical Engineering and School of Energy Science and EngineeringNanjing Tech UniversityNanjing 211816China Jiangsu Sunpower Co. Ltd.Taixing 225411China

Potassium metal battery is a promising alternative to Li-ion battery for large-scale energy storage due to the abundant potassium resources and high energy ***,it suffers from rapid capacity fading and safety issues due to the uncontrolled dendrite ***,we design a fluorine-free ultra-low concentration electrolyte(ULCE)with the super bulky[BPh_(4)]^(−) anions for stable potassium metal *** this special electrolyte,the migration rate of K+in the electrolyte is about six times faster than that of the[BPh_(4)]^(−) anions because of the super bulky structure of the[BPh_(4)]^(−) anions,thus resulting in a high K^(+)transference number of *** high transference number can effectively make up for the deficiency of K^(+)in ULCE for ensuring the normal operation of the potassium metal *** addition,the improved transference number can also promote the uniform distribution of K^(+)flux on the surface of the K metal anode,resulting in uniform K *** a result,this electrolyte achieves a high K plating/stripping Coulombic efficiency of 92.6%over 200 cycles and a stable discharging/charging for 100 cycles under the full battery configuration(K used as the anode and perylene-3,4,9,10-tetracarboxylic dianhydride used as the cathode).

关键词： potassium metal batteries ultra-low concentration electrolyte high transference number

Volatiles from <i>Acer truncatum</i>Flowers

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American Journal of Plant Sciences 2018年第2期9卷 231-238页

作者： Hongjian Ren fenfen Si Meijing ye Qian Qiao Kai An Chao Wang Zhen Feng College of Forestry Shandong Agricultural University Tai’an China College of Horticulture Science and Engineering Shandong Agricultural University Tai’an China

Plant volatile organic compounds (Biogenic Volatile Organic compounds, referred BVOCs) have a significant impact on the atmospheric environment, air quality and human health. This experiment takes Acer truncatum flowers as the research object, uses solid-phase micro-extraction combine GC-MS (SPME-GC-MS) to detect the main component of volatiles released by the flowers from 10 individual trees of Acer truncatum (Acer truncatum Bunge). The results showed that 37 kinds of volatiles were detected and they are belonged to four types organic compouds, such as terpenoids, alcohols, ketones, esters. According to the analysis of the main components of Acer truncatum flower volatiles includes Fluorene, 4,8 -Dimethyl-1,3 (E), 7-Nonene, (cis, trans)-2,6-Dimethyl-2,4,6-triene-Partenkirchen, Myrcene, Basil hexene, 3-Carene, (E)-Basil, Camphene, Caryophyllene, Linalool, α-Terpinolene, O-cymene, 3-Vinyl-1,2-dimethyl-1, Eucalyptus alcohols and Alcohol vinegar-12. However, there were no significant differences between individual trees in terms of obscure material O-cymene, Eucalyptus alcohols, Alcohol vinegar-12, as well as the significant differences in terms of remaining volatiles.

关键词： Acer truncatum Flower Volatiles SPME GC-MS

Perfluorooctane sulfonate impairs rat Leydig cell development during puberty

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Perfluorooctane sulfonate impairs rat Leydig cell developmen...

中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”

作者： Lili Li Xiaoheng Li Xianwu Chen Yong Chen Jianpeng Liu fenfen Chen Fei Ge Leping ye Qingquan Lian Ren-Shan Ge The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University

Perfluorooctane sulfonate possibly delays male sexual ***,its effects on pubertal Leydig cell development are *** objective of the present study is to investigate the effects of in vivo exposure to perfluorooctane sulfonate disrupts rat Leydig cell *** male Sprague Dawley rats orally received 5 or 10 mg/kg perfluorooctane sulfonate from

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壳聚糖涂膜板栗贮藏试验

中国果树 2010年第5期 33-36页

作者：徐芬芬叶利民上饶师范学院生命科学学院江西334001

以青扎板栗为试材,研究壳聚糖浓度、浸果时间对贮藏期间栗果呼吸强度、品质、腐烂率、失重率的影响。结果表明,青扎板栗具有呼吸跃变,壳聚糖涂膜明显降低贮藏期间栗果的腐烂率、失重率,抑制呼吸强度,推迟呼吸跃变并降低呼吸峰值;壳聚糖... 详细信息

以青扎板栗为试材,研究壳聚糖浓度、浸果时间对贮藏期间栗果呼吸强度、品质、腐烂率、失重率的影响。结果表明,青扎板栗具有呼吸跃变,壳聚糖涂膜明显降低贮藏期间栗果的腐烂率、失重率,抑制呼吸强度,推迟呼吸跃变并降低呼吸峰值;壳聚糖涂膜可延缓贮藏期间栗果维生素C和淀粉含量的下降。壳聚糖涂膜最佳处理为15 mg/mL浸果30秒,结合0℃条件板栗可贮藏101天,商业品质良好。

关键词：板栗青扎壳聚糖品质腐烂率失重率

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