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Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons

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Biomedical and Environmental Sciences 2024年第5期37卷 479-493页

作者： LI yang LIN Dan ZHANG Xiu Qin JU guang Xiu SU Ya ZHANG Qian DUAN Hai Ping yu Wei Sen WANG Bing Ling PANG Shu Tao Department of Epidemiology and Health Statistics School of Public HealthQingdao UniversityQingdao 266021ShandongChina Department of Environmental Health Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Physicochemical Laboratory Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Section of Child Health Care Huangdao Maternity and Child Health Care Hospital of QingdaoQingdao 266499ShandongChina Qingdao Blood Center Qingdao 266071ShandongChina

Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal *** Liquid chromatography-tandem mass spectrometry was used to determine ten hydroxyl metabolites of PAHs(OH-PAHs)in 36-month-old ***,37 children were categorized into low-and high-exposure groups based on the sum of the ten ***-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify non-targeted metabolites in the urine ***,fecal flora abundance was assessed by 16S rRNA gene sequencing using Illumina *** The concentrations of 21 metabolites were significantly higher in the high exposure group than in the low exposure group(variable importance for projection>1,P<0.05).Most of these metabolites were positively correlated with the hydroxyl metabolites of naphthalene,fluorine,and phenanthrene(r=0.336–0.531).The identified differential metabolites primarily belonged to pathways associated with inflammation or proinflammatory states,including amino acid,lipid,and nucleotide ***,these distinct metabolites were significantly associated with specific intestinal flora abundances(r=0.34–0.55),which were mainly involved in *** Higher PAH exposure in young children affected metabolic homeostasis,particularly that of certain gut microbiota-derived *** investigation is needed to explore the potential influence of PAHs on the gut microbiota and their possible association with neurodevelopmental outcomes.

关键词： Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile

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Comparative study on interaction between rare earth oxide refractories and rare earth treated steel

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Journal of Iron and Steel Research International 2024年第6期31卷 1493-1501页

作者： Ze Meng guang-qiang Li Cheng yuan Yi-jiang Zhao Qing Zheng Bin Zeng yu Liu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan430081HubeiChina Technical Center Lianyuan Iron and Steel Co.Ltd.Loudi417009HunanChina

Refractories have an important effect on the cleanliness of molten *** interaction between CeAlO_(3) refractories and Ce treated steel was explored and compared with that between Al_(2)O_(3) refractories and Ce treated *** results show that the Ce content in steel decreases sharply after contact with Al_(2)O_(3) refractories and the pick-up of dissolved Al *** with the test of Al_(2)O_(3) refractories,the loss of Ce content is less in the test of CeAlO_(3) refractory,and the total oxygen content and dissolved Al content in steel increase *** dense and continuous Ce_(2)O_(2)S interface layer is observed at the CeAlO_(3) refractories/steel interface,which can serve as the metallurgical isolation layer and hinder the further interaction between refractories and ***,the higher steel cleanliness and less penetration of refractories by molten steel are obtained in the test of CeAlO_(3) *** CeAlO_(3) refractories show a promising prospect in the production of clean Ce treated steel.

关键词： CeAlO_(3)refractory Steel Cleanliness Interaction Rare earth

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Comparative observation of the effectiveness and safety of remimazolam besylate versus dexmedetomidine in gastrointestinal surgery in obese patients

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1320-1327页

作者： yu-Fu Deng Xue-Run Jiang Zeng-guang Feng Department of Anesthesiology Xiangtan Central HospitalXiangtan 411100Hunan ProvinceChina

BACKGROUND Surgery for obese patients carries a higher risk of anesthesia complications compared with surgery for nonobese ***,a safe and effective anesthesia strategy is necessary to improve the medical experience of such patients and ensure their *** To compared the effectiveness and safety of remimazolam besylate versus dexmedetomidine(DEX)in gastrointestinal surgery in obese *** The study cohort included 60 obese patients undergoing gastrointestinal surgery between July 2021 and April 2023,comprising 30 patients who received DEX intervention(control group)and 30 patients who received remimazolam besylate intervention(research group).Heart rate(HR),respiratory rate(RR),mean arterial pressure(MAP),blood oxygen saturation(SpO_(2)),safety(nausea and vomiting,bradycardia,hypotension,and apnea),anesthesia and examination indices[induction time,anesthesia recovery time,and postanesthesia care unit(PACU)discharge time],sedation effect(Ramsay Sedation Scale),and postoperative pain visual analog scale were comparatively analyzed before anesthesia(T0),during anesthesia(T1),and after anesthesia(T2).RESULTS At T1,the research group showed significantly smaller changes in HR,RR,MAP,and SpO_(2) than the control group,with a significantly lower adverse reaction rate and shorter induction,anesthesia recovery,and PACU discharge ***,the intra-and postoperative Ramsay Sedation Scale scores were statistically higher in the research group than in the control *** Remimazolam besylate was significantly more effective than DEX in gastrointestinal surgery in obese patients and had a higher safety profile and value in clinical promotion.

关键词： Remimazolam besylate Dexmedetomidine Obesity Gastrointestinal surgery Effectiveness Safety

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Study on tungsten sintering temperature field based on electromagnetic simulation and computational fluid dynamics

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Tungsten 2024年第2期6卷 355-366页

作者： Lu-Yan Wang yue-guang yu Jian-Xin Dong Kai-Ping Du Shan-yu Liu Cao-Bing Li University of Science and Technology Beijing Beijing 100083China BGRIMM Technology Group Beijing 100160China China Iron&Steel Research Institute Group Beijing 100081China

In order to study the influence of various sintering variables more intuitively and clearly,electromagnetic field analysis and computational fl uid dynamics are used to analyze the infl uence of gas flow,heating power and other process parameters on the temperature range of medium-frequency sintering in this *** results indicate that the uniformity of temperature fi eld is determined by the gas flow rate and heating *** the heating power is 50 kW,the stable temperature drops about 10 K for every 1 m^(3)·h^(−1)increase of hydrogen *** peak value of the maximum temperature diff erence on the tungsten rods gradually increases with the increase of the hydrogen flow rate,and it appears slightly *** temperature distribution of tungsten rods in furnace is similar with diff erent hydrogen flow *** the same time,the closer to the furnace wall,the higher the temperature of the tungsten *** temperature diff erence between tungsten rods mainly occurred within 1 h after the beginning of *** the heating power can improve the stable temperature,but has little eff ect on the heating *** heating power can increase the peak value of the maximum temperature diff erence on the tungsten rods,but has little eff ect on the occurrence time of the peak value of the maximum temperature diff erence on the tungsten *** the heating power will increase the temperature diff erence of a single tungsten rod,but the temperature diff erence of a single tungsten rod never exceeds 65 *** study can be used to guide the process optimization *** with numerical simulation calculation,the sintering parameters with low energy consumption and high temperature uniformity can be quickly and eff ectively found,thus improving the microstructure and properties of sintered tungsten products.

关键词： Tungsten products Sintering Hydrogen flow rate Heating power

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高效的量子密钥分配协议

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北京邮电大学学报 2006年第1期29卷 128-130页

作者：杨宇光温巧燕朱甫臣北京邮电大学理学院北京100876 现代通信国家重点实验室成都610041

为提高量子密钥分配协议的密钥生成率,构造了一组两方三级系统的完备正交归一化基.利用该正交归一化基和交换粒子之间的纠缠提出了一种量子密钥分配协议.三级可以推广到多级,利用粒子之间的纠缠交换和多级密钥分配可以极大地提高检测窃... 详细信息

为提高量子密钥分配协议的密钥生成率,构造了一组两方三级系统的完备正交归一化基.利用该正交归一化基和交换粒子之间的纠缠提出了一种量子密钥分配协议.三级可以推广到多级,利用粒子之间的纠缠交换和多级密钥分配可以极大地提高检测窃听的效率、密钥生成率以及信息容量.

关键词：量子密钥分配纠缠交换正交归一化基

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Super-high bed sintering for iron ores:behaviors,causes and solutions of horizontal segregation on strand

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Journal of Iron and Steel Research International 2024年第7期31卷 1590-1596页

作者： Liang-ping Xu Hui-bo Liu Zhong-lin Dong Qiang Zhong yu-chao Zhao guang-hui Li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina

Horizontal segregation has been a constraint to the development and application of super-high bed *** eliminate the horizontal segregation of super-high bed sintering,several typical sintering machines were sampled and analyzed,and theoretical calculation was made to compare the bed depth and their differences in different areas within the mixture ***,solutions were proposed and applied to a 265 m^(2) sintering *** results showed that the horizontal seg-regation of the 265 m^(2) sintering machine was dominated by particles larger than 8 mm with horizontal segregation degree of 0.48,while 360 and 550 m^(2) sintering machines were affected by 5-8 mm and 1-3 mm particles with horizontal segregation degree of 0.27 and 0.31,*** analysis indicated the different segregation distribution results from the matching of the bed depth of each area within the mixture ***,the horizontal segregation degree not larger than 0.06 was achieved by optimizing the time parameters and the division of three zones on the 265 m^(2) sintering machine.

关键词： Super-high bed sintering Horizontal segregation Feeder Particle distribution Agglomeration

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基于W态的量子密钥分配和秘密共享

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北京邮电大学学报 2006年第3期29卷 40-43,52页

作者：杨宇光温巧燕朱甫臣北京邮电大学理学院北京100876 现代通信国家重点实验室成都610041

介绍了W态的特点,证明了量子密钥分配和秘密共享方案所基于的W态只能是一种系数全部相同的对称形式,提出了一种基于W态的量子密钥分发方案.接收方随机非对称使用消息模式和控制模式来保证该量子密钥分发协议的安全,继而分析该协议的安全... 详细信息

介绍了W态的特点,证明了量子密钥分配和秘密共享方案所基于的W态只能是一种系数全部相同的对称形式,提出了一种基于W态的量子密钥分发方案.接收方随机非对称使用消息模式和控制模式来保证该量子密钥分发协议的安全,继而分析该协议的安全性.提出了一种基于W态的量子秘密共享方案,分析了该协议的安全性.与以往采用GHZ最大纠缠态的量子密钥分配和秘密共享方案相比,基于W态的方案效率不高,研究目的是为了证明可以采用不同于GHZ态之外的其他态用于量子密钥分配和秘密共享.

关键词：量子密钥分配量子秘密共享 W态

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Dynamic Crosslinked Phosphorescent Poly(vinyl alcohol)-Terpyridine Films with Enhanced Mechanical Properties and Tunable Shape Memory

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Chinese Journal of Polymer Science 2024年第10期42卷 1595-1601,I0015页

作者： Meng Wei Wei-Hao Feng Chen yu Zhen-Yi Jiang guang-Qiang Yin Wei Lu Tao Chen Key Laboratory of Advanced Marine Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China School of Chemical Sciences University of Chinese Academy of SciencesBeijing100049China School of Materials Science and Chemical Engineering Ningbo UniversityNingbo315211China

Achieving versatile room temperature phosphorescence(RTP)materials,especially with tunable mechanical properties and shape memory is attractive and essential but rarely ***,a strategy was reported to realize multi-functional RTP films with multicolor fluorescence,ultralong afterglow,adjustable mechanical properties,and shape memory through the synergistic dynamic interaction of lanthanide(Ln~Ⅲ)-terpyridine coordination,borate ester bonds,and hydrogen bondings in a poly(vinyl alcohol)(PVA)*** varying the amount of borax,the mechanical properties of the films could be finely controlled due to the change of crosslinking degree of dynamic borate ester bonds in *** assembly and disassembly of borate ester bonds upon the trigger of borax and acid were applied as reversible linkage to achieve programmable shape memory *** addition,the films displayed both fascinating multicolor fluorescence and ultralong afterglow characteristics due to the presence of Ln III doping and confinement of terpyridine in *** study provides a new avenue to impart modulable mechanical strength and shape memory to RTP materials.

关键词： Room temperature phosphorescence materials Dynamic bonds Multicolor fluorescent Tunable mechanical properties Shape memory

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Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics

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Protein & Cell 2024年第5期15卷 364-384页

作者： Huifen Lu Ying Jing Chen Zhang Shuai Ma Weiqi Zhang Daoyuan Huang Bin Zhang yuesheng Zuo Yingying Qin guang-Hui Liu yang yu Jing Qu Si Wang Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stem cell and Regeneration CASBeijing 100101China China National Center for Bioinformation Beijing 100101China The Fifth People’s Hospital of Chongqing Chongqing 400062China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Department of Obstetrics and Gynecology Center for Reproductive MedicinePeking UniversityThird HospitalBeijing 100191China Clinical Stem Cell Research Center Peking UniversityThird HospitalBeijing 100191China Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education National Research Center for Assisted Reproductive Technology and Reproductive GeneticsShandong Key Laboratory of Reproductive MedicineShandong Provincial Clinical Research Center for Reproductive HealthJinan 250012China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Biomarker Consortium Beijing 100101China

The ovary is indispensable for female reproduction,and its age-dependent functional decline is the primary cause of ***,the molecular basis of ovarian aging in higher vertebrates remains poorly ***,we apply spatiotemporal transcriptomics to benchmark architecture organization as well as cellular and molecular determinants in young primate ovaries and compare these to aged primate *** a global view,somatic cells within the non-follicle region undergo more pronounced transcriptional fluctuation relative to those in the follicle region,likely constituting a hostile microenvironment that facilitates ovarian ***,we uncovered that inflammation,the senescent-associated secretory phenotype,senescence,and fibrosis are the likely primary contributors to ovarian aging(PCOA).Of note,we identified spatial co-localization between a PCOA-featured spot and an unappreciated MT2(Metallothionein 2)highly expressing spot(MT2^(high))characterized by high levels of inflammation,potentially serving as an aging hotspot in the primate ***,with advanced age,a subpopulation of MT2^(high)accumulates,likely disseminating and amplifying the senescent signal *** study establishes the first primate spatiotemporal transcriptomic atlas,advancing our understanding of mechanistic determinants underpinning primate ovarian aging and unraveling potential biomarkers and therapeutic targets for aging and age-associated human ovarian disorders.

关键词： spatial transcriptome primate ovary aging senescence inflammation

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Lipid-lowering effects of gefarnate in statin-treated patients with residual hypertriglyceridemia:a randomized controlled study

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Journal of Geriatric Cardiology 2024年第8期21卷 791-798页

作者： Jing SHI Ming-Lu XU Mei-Jiao HE Wan-Lan BO Hai-yu ZHANG Dang-Hui SUN Ding-yu WANG Xiao-yu WANG Qun SHAO yu-Jiao PAN yu ZHANG Chen-guang DAI Jing-Ying WANG Lin-Wei ZHANG guang-Zhong LIU yue LI for the GPROT Study Group Department of Cardiology the First Affiliated HospitalHarbin Medical UniversityHarbinChina Department of Gastroenterology the Fourth Affiliated HospitalHarbin Medical UniversityHarbinChina Department of Cardiology Harbin Medical University Cancer HospitalHarbinChina Department of Cardiology Shenzhen People’s HospitalShenzhenChina National Key Laboratory of Frigid Zone Cardiovascular Diseases Harbin Medical UniversityHarbinChina NHC Key Laboratory of Cell Transplantation Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang ProvinceHeilongjiang Province Clinical Medical Research Center for Hypertensionthe First Affiliated HospitalHarbin Medical UniversityHarbinChina Institute of Metabolic Disease Heilongjiang Academy of Medical ScienceHarbinChina 不详

BACKGROUND The prevention of coronary artery disease(CAD)faces dual challenges:the aspirin-induced gastrointestinal injury,and the residual cardiovascular risk after statin *** acetate(Gefarnate)is an anti-ulcer *** was reported that geraniol might participate in lipid metabolism through a variety of *** aim of this study was to assess the lipid-lowering effects of gefarnate in statin-treated CAD patients with residual *** In this prospective,open-label,randomized,controlled trial,69 statin-treated CAD patients with residual hypertriglyceridemia were randomly assigned to gefarnate group and control group,received gefarnate(100 mg/3 times a day)combined with statin and statin alone,*** baseline and after one-month treatment,the levels of plasma triglyceride,high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and total cholesterol were *** After one-month gefarnate treatment,triglyceride level was significantly lowered from 2.64 mmol/L to 2.12 mmol/L(P=0.0018),LDL-C level lowered from 2.7 mmol/L to 2.37 mmol/L(P=0.0004),HDL-C level increased from 0.97 mmol/L to 1.17mmol/L(P=0.0228).Based on statin therapy,gefarnate could significantly reduce the plasma triglyceride level(P=0.0148)and increase the plasma HDL-C level(P=0.0307).Although the LDL-C and total cholesterol levels tended to decrease,there was no statistically significant *** The addition of gefarnate to statin reduced triglyceride level and increased HDL-C level to a significant extent compared to statin alone in CAD patients with residual *** suggested that gefarnate might provide the dual benefits of preventing gastrointestinal injury and lipid lowering in CAD patients.

关键词： nat alone Lipid

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