检索结果-南通市图书馆

Shengmaisan combined with Liuwei Dihuang Decoction alleviates chronic intermittent hypoxia-induced cognitive impairment by activating the EPO/EPOR/JAK2 signaling pathway

引用

Chinese Journal of Natural Medicines 2024年第5期22卷 426-440页

作者： SI Jianchao CHEN Xue QI Kerong LI Dongli LIU Bingbing ZHENG Yuying JI Ensheng yang shengchang Department of Physiology Hebei University of Chinese MedicineShijiazhuang 050000China Hebei Technology Innovation Center of TCM Combined Hydrogen Medicine Shijiazhuang 050000China Department of Geriatrics First People’s Hospital of XiaoganXiaogan 432000China

Chronic intermittent hypoxia(CIH),a principal pathophysiological aspect of obstructive sleep apnea(OSA),is associated with cognitive *** evidence suggests that a combination of Shengmaisan and Liuwei Dihuang Decoctions(SMS-LD)can enhance cognitive function by nourishing yin and strengthening the *** study aimed to assess the efficacy and underlying mechanisms of SMS-LD in addressing cognitive impairments induced by *** exposed C57BL/6N mice to CIH for five weeks(20%-5%O_(2),5 min/cycle,8 h/day)and administered SMS-LD intragastrically(15.0 or 30 g·kg^(-1)·day)30 min before each CIH ***,AG490,a JJanus kinase 2(JAK2)inhibitor,was administered via intracerebroventricular *** function was evaluated using the Morris water maze,while synaptic and mitochondrial structures were examined by transmission electron *** stress levels were determined using DHE staining,and the activation of the erythropoietin(ER)/ER receptor(EPOR)/JAK2 signaling pathway was analyzed through immunohistochemistry and Western *** further investigate molecular mechanisms,HT22 cells were treated in vitro with either SMS-LD medicated serum alone or in combination with AG490 and then exposed to CIH for 48 *** results indicate that SMS-LD significantly mitigated CIH-induced cognitive impairments in ***,SMS-LD treatment enhanced dendritic spine density,ameliorated mitochondrial dysfunction,reduced oxidative stress,and activated the EPO/EPOR/JAK2 signaling ***,AG490 negated SMS-LD’s neuroprotective and cognitive improvement effects under CIH *** findings suggest that SMS-LD’s beneficial impact on cognitive impairment and synaptic and mitochondrial integrity under CIH conditions may predominantly be attributed to the activation of the EPO/EPOR/JAK2 signaling pathway.

关键词： Chronic intermittent hypoxia Cognitive impairment Shengmaisan Liuwei Dihuang Decoction Oxidative stress EPO/EPOR/JAK2 signaling pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

多发性硬化动物模型中小胶质细胞动态变化对少突胶质细胞的影响

引用

中华神经科杂志 2024年第6期57卷 669-677页

作者：苑舒文齐珂瑢刘青青陈雪司建超杨胜昌山西中医药大学基础医学院晋中030619 河北中医药大学生理学教研室石家庄050091 河北中医药大学生理学教研室河北省中医药结合氢医学技术创新中心石家庄050091

多发性硬化(MS)是一种由自身免疫机制触发的中枢神经系统(CNS)慢性炎症性脱髓鞘疾病,是导致年轻人神经功能残疾的主要原因。在MS中,多种神经胶质细胞参与疾病的发生发展进程,其中少突胶质细胞(OL)和髓鞘被自身免疫介导的炎症破坏,少突... 详细信息

多发性硬化(MS)是一种由自身免疫机制触发的中枢神经系统(CNS)慢性炎症性脱髓鞘疾病,是导致年轻人神经功能残疾的主要原因。在MS中,多种神经胶质细胞参与疾病的发生发展进程,其中少突胶质细胞(OL)和髓鞘被自身免疫介导的炎症破坏,少突胶质前体细胞(OPC)生成OL受损导致持续性脱髓鞘、髓鞘碎片积聚和轴索损伤,临床表现为CNS残疾。而参与炎性反应和髓鞘碎片清除等过程的小胶质细胞对于OPC的分化和OL的成熟发挥核心作用,能够直接或间接影响髓鞘的再生进程,两者之间存在交互式影响机制。认识两者之间的联系能够更好地揭示MS的发病机制并制订新的治疗策略,解决MS临床治疗中的关键科学问题。本文通过总结小胶质细胞在MS及其经典动物模型中的动态变化,探讨这一过程中小胶质细胞与OL之间的内在联系,聚焦通过靶向调控小胶质细胞发挥有益作用,从而促进OPC分化和髓鞘再生,以期为MS治疗提供新的研究方向。

关键词：多发性硬化小胶质细胞少突胶质细胞髓鞘再生动物模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

福建省不同地区森林生态系统的碳汇潜力及经济价值

引用

福建林业科技 2024年第2期51卷 112-118,141页

作者：张泓宇曹文志杨盛昌厦门大学环境与生态学院福建厦门361102

以全国森林资源清查和福建省地方政府年度报告数据为资料,采用蓄积量扩展模型,研究2015—2020年福建省不同地区的森林生态系统的碳汇潜力及其分布特征。结果表明:相比过去40 a,2015—2020年间福建省森林生态系统的碳汇有所提升;在2015—... 详细信息

以全国森林资源清查和福建省地方政府年度报告数据为资料,采用蓄积量扩展模型,研究2015—2020年福建省不同地区的森林生态系统的碳汇潜力及其分布特征。结果表明:相比过去40 a,2015—2020年间福建省森林生态系统的碳汇有所提升;在2015—2020年间,福建省不同地区碳汇(CO_(2))的变化较大,介于46.9~2170万t·a^(-1),其中以南平市最高;碳汇密度(CO_(2))介于7.09~19.17 t·a^(-1)·hm^(-2),以福州市最高;各地区分布特点,碳汇和人均碳汇为“西北高、东南低”、碳汇密度为“东北高、西部低”;福建省碳汇经济价值为45.76亿元·a^(-1),不同地区变化幅度较大,介于0.20~9.30亿元·a^(-1)之间,均值为5.08亿元·a^(-1);福建省GDP水平更低的地区,碳汇经济价值相对GDP的水平更高。自然禀赋的不同,是导致福建省不同地区间碳汇潜力呈现较大差异的主要原因。

关键词：森林生态系统碳汇碳储量经济价值福建省

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway

引用

中医杂志:英文版 2023年第5期43卷 906-914页

作者： LIU Bingbing LI Jieru SI Jianchao CHEN Qi yang shengchang JI Ensheng Department of Physiology Hebei University of Chinese MedicineShijiazhuang 050200China Hebei Technology Innovation Center of TCM Combined Hydrogen Medicine Shijiazhuang 050200China

OBJECTIVE:To examine the protective effect of ginsenoside Rb1(Rb1),the main component of Renshen(Radix Ginseng),on cardiomyopathy in db/db mice exposed to chronic intermittent hypoxia(CIH)and explore the potential underlying mechanism of Rb1 in treating diabetic cardiomyopathy(DCM).METHODS:The db/db mice were randomly separated into five groups:normal control group,model group,Rb120 mg/kg group,Rb140 mg/kg group,and glucagon-like peptide-1(GLP-1)*** were exposed to aircondition or CIH for 8 weeks,and Rb1 and GLP-1 were administrated before CIH exposure every *** glucose tolerance test(OGTT),intraperitoneal insulin tolerance test(IPITT),total cholesterol(TC),triglyceride(TG),and high-density lipoprotein cholesterol(HDL-C)were detected to evaluate glycolipid *** level of insulin was detected by a mouse enzyme-linked immunosorbent assay(ELISA).Cardiac function was detected by echocardiography,and myocardial pathology was observed by hematoxylin-eosin and Masson *** expression of collagenⅠand collagenⅢwas detected by *** monophosphate-activated protein kinase(AMPK)/Nrf2/heme oxygenase-1(HO-1)signaling pathway was detected by Western blot and ***:Rb1 treatment could improve glucose tolerance and the level of cardiac function indexes,and inhibit the level of oxidative stress indexes and the expression of collagenⅠand collagenⅢ.Moreover,Rb1 treatment enhanced AMPK phosphorylation and increased Nrf2 and HO-1 ***:Rb1 treatment alleviated CIH-induced diabetic cardiomyopathy and glycolipid metabolism disorders in db/db mice by inhibiting oxidative stress and regulating the AMPK/Nrf2/HO-1 signaling pathway.

关键词： ginsenosides diabetic cardiomyopathies oxidative stress AMP-activated protein kinases heme oxygenase-1 signal transduction chronic intermittent hypoxia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Soil organic carbon storages and bacterial communities along a restored mangrove soil chronosequence in the Jiulong River Estuary:From tidal flats to mangrove afforestation

引用

Fundamental Research 2023年第6期3卷 880-889页

作者： Feifei Wang Rui Guo Ning Zhang shengchang yang Wenzhi Cao State Key Laboratory of Marine Environmental Science Key Laboratory of the Ministry of Education for Coastal and Wetland EcosystemsCollege of Environment and EcologyXiamen UniversityXiamenFujian 361102China

Among many ecological services provided by mangrove ecosystems,soil organic carbon(SOC)storages have recently received much attention owing to the increasing atmospheric partial pressure of dissolved CO_(2)(pCO_(2)).Bacteria are fundamental to ecosystem functions and strongly influence the coupling of coastal carbon,nitrogen,and sulfur cycling in *** SOC storage and bacterial communities along a restored mangrove soil chronosequence in the Jiulong River Estuary were explored using the 16S rDNA sequencing *** results showed the SOC storage in the 100 cm soil profile was 103.31±5.87 kg C m^(−2)and 93.10±11.28 kg C m^(−2)for mangroves with afforestation ages of 36 and 60 years,*** total nitrogen(TN)and total sulfur(TS)contents exhibited significant correlations with the SOC in the mangrove soils,but only TN and SOC showed significant correlation in tidal flat *** the tidal flats and mangroves occupied the contiguous intertidal zone within several kilometers,the variations in the SOC storage along the restored mangrove soil chronosequence were notably *** Functional Annotation of Prokaryotic Taxa(FAPROTAX)database was used to annotate the metabolic functions of the bacteria in the *** annotation revealed that only four metabolic functions were enriched with a higher relative abundance of the corresponding bacteria,and these enriched functions were largely associated with sulfate *** addition,the specifically critical bacterial taxa that were associated with the SOC accumulation and nutrient cycling,shaped the distinct metabolic functions,and consequently facilitated the SOC accumulation in the mangrove soils with various afforestation *** general homogenization of the microbial community and composition along the intertidal soil chronosequence was primarily driven by the reciprocating tidal flows and geographical contiguity.

关键词： Soil organic carbon storage Bacterial communities Bacterial ecological functions Mangrove afforestation Tidal flats

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sticked-Layer Strategy to a Flexible-Robust Hydrogen-Bonded Organic Framework for Efficient C_(2)H_(2)/CO_(2)Separation

引用

CCS Chemistry 2024年第3期6卷 663-671页

作者： Zhen Yuan Xianghua Jiang Liangji Chen Junjie Chen Lu Li Yisi yang Yunbin Li Fahui Xiang shengchang Xiang Banglin Chen Zhangjing Zhang Fujian Key Laboratory of Polymer Materials College of Chemistry and Materials ScienceFujian Normal UniversityFuzhou 350007

Flexible-robust hydrogen-bonded organic frameworks(HOFs)are attracting increasing interest due to their excellent separation performance for important industrial gases,but the construction remains ***,a sticked-layer strategy is first proposed to construct a flexible-robust HOF,HOFFJU-8,from a donor(D)–π–acceptor(A)molecule 4,4′,4″,4‴-(pyrrolo[3,2-b]pyrrole-1,2,4,5-tetrayl)tetrabenzonitrile(DP-4CN).HOF-FJU-8 is amicroporous three-dimensional framework composed of two kinds of DP-4CN molecules,one acting as building units for the two-dimensional layer via C≡N···H–C hydrogen bond dimers and another as the sticks to link the layers along channels through D–Aπ···π*** activated framework HOF-FJU-8a possesses flexible-robust pore characteristics,as determined by the gas adsorption and in situ gas-loaded powder X-ray ***-FJU-8a exhibits adaptive adsorption and stronger binding affinity to C_(2)H_(2)rather than CO_(2)due to the flexible-robust nature,which can effectively separate acetylene and carbon dioxide mixtures.

关键词： hydrogen-bonded organic framework flexible-robust sticked-layer D-Aπ···πinteraction in situ powder X-ray diffraction C_(2)H_(2)/CO_(2)separation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Robust In-Zr Metal-Organic Framework Nanosheets as Ultrathin Interlayer Toward High-Rate and Long-Cycle Lithium-Sulfur Batteries

引用

CCS Chemistry 2024年第4期6卷 988-998页

作者： Zhibin Cheng Jie Lian Yiyang Chen Yiyang Tang Yulian Huang Jindan Zhang shengchang Xiang Zhangjing Zhang Fujian Key Laboratory of Polymer Materials College of Materials Science and EngineeringFujian Normal UniversityFuzhou 350007 State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002

Lithium-sulfur(Li-S)batteries have great potential as the next generation of high-energy-density storage ***,the practical viability of Li-S batteries is largely hampered by undesirable shuttling behavior and sluggish conversion kinetics of ***,a multifunctional separatormodified layer(In/Zr-BTB nanosheets)with the merits of robust structures and efficient catalytic metal sites has been ***/Zr-BTB nanosheets inherit the stable structure from Zr-BTB and strengthen the catalytic performance due to the introduction of highly catalytic species indium via metal-ion *** thickness and areal mass loading of the modified layer are only 260 nm and 0.011 mg/cm2,***,the ultrathin modification layers with efficient catalytic species,compact structures,and uniform pore channels can realize fast Li+transport,effective polysulfide interception,and rapid catalytic ***,the In/Zr-BTB@PP cell with a high sulfur content of 80 wt%could maintain high capacity retention of 85.6%with a low capacity fading rate of 0.048%per cycle after 300 cycles even at a high current rate of 2 *** work opens a new door toward the design of versatile metal-organic framework(MOF)nanosheets and multifunctional separators for high-energy-density Li-S batteries.

关键词： lithium-sulfur batteries metal-organic framework shuttle effect energy storage separator modification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Linkages of flow regime and micro-topography:prediction for non-native mangrove invasion under sea-level rise

引用

Ecosystem Health and Sustainability 2020年第1期6卷 462-475,461页

作者： Luzhen Chen Hongyu Feng Xiaoxuan Gu Ying Dong Peng Cheng Xudong Guo Qiulian Lin Ting Tang Yihui Zhang Xudong Zhu shengchang yang Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystem College of the Environment and EcologyXiamen UniversityXiamenFujianChina Zhangjiang Estuary Mangrove Ecosystem Observation and Research Station of Fujian Province Zhangjiang Estuary Mangrove Ecosystem Observation and Research Station of Fujian ProvinceXiamen UniversityXiamenFujianChina State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamenFujianChina

Flow regime is a key driver of invasive aquatic organisms,and the invasiveness of mangrove species may be simultaneously attributed to plant traits and flowing hydrological conditions at the estuary *** focused on hydrological and topographic conditions for a non-native mangrove species,Sonneratia apetala,in Zhangjiang Estuary of Fujian,China.A hydrological model and a micro-topographic model were used to predict its dispersal and early establishment,and field surveys and simulated experiments were integrated to estimate its future dispersal *** mesohaline mudflat with a salinity of 8~10 PSU at the mangrove seaward edge was the most likely colonization area for *** under current *** south-western region of the estuary with native mangroves was the most likely area for its colonization according to the unstructured-grid finite-volume community ocean model(FVCOM)in September,when the largest tidal currents within a year and the maximum fruit maturity period *** 42%of the mudflats throughout the whole estuary may be available for seedling establishment under the future sea-level rise RCP 4.5 scenarios compared with 44%for current establishment;however,the RCP 8.5 scenarios would significantly decrease seedling establishment by 2100 due to serious tidal inundation according to the micro-topographical model.

关键词： Mangroves salinity elevation sea-level rise climatic change biological invasion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

锂离子电池健康状态估计及寿命预测研究进展综述

引用

高电压技术 2024年第3期50卷 1182-1195页

作者：熊庆邸振国汲胜昌西安交通大学电工材料电气绝缘全国重点实验室西安710049

随着锂离子电池的应用越来越广泛,锂电池健康状态的精确估计和剩余寿命的实时预测对于锂电池系统的安全运行和降低运维成本具有重要意义。锂电池内部复杂的物理化学反应和外部复杂工作条件,使得实现精准的健康状态估计和寿命预测具有挑... 详细信息

随着锂离子电池的应用越来越广泛,锂电池健康状态的精确估计和剩余寿命的实时预测对于锂电池系统的安全运行和降低运维成本具有重要意义。锂电池内部复杂的物理化学反应和外部复杂工作条件,使得实现精准的健康状态估计和寿命预测具有挑战性。该文综述近年来锂电池健康状态估计和剩余使用寿命预测方法的研究现状,分析基于物理/数学模型、数据驱动、模型法和数据驱动融合,以及多种数据驱动融合的锂电池健康状态估计方法的优缺点及适用条件,并对比分析不同数据驱动类型的锂电池寿命预测方法。指出锂电池健康状态估计及寿命预测尚存在的问题,并对未来研究方向进行展望,对完善锂电池健康状态估计和寿命预测算法理论体系、指导实际应用技术具有重要意义。

关键词：锂离子电池状态估计寿命预测电化学模型数据驱动技术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

河流营养物质输入及结构变化对河口富营养化潜力的影响

引用

湖泊科学 2023年第6期35卷 1990-1999页

作者：林玲许文锋刘丽华王飞飞杨盛昌曹文志厦门大学环境与生态学院厦门361102 福建省厦门环境监测中心站厦门361022

河口是连接陆地-海洋的一个关键区域,具有重要的生态系统服务价值。然而,随着经济快速发展,河口接纳了越来越多来自于流域等地的营养物质,导致河口生态系统的富营养化潜力大大增加。本研究利用沿海富营养化潜力指数(index of coastal eu... 详细信息

河口是连接陆地-海洋的一个关键区域,具有重要的生态系统服务价值。然而,随着经济快速发展,河口接纳了越来越多来自于流域等地的营养物质,导致河口生态系统的富营养化潜力大大增加。本研究利用沿海富营养化潜力指数(index of coastal eutrophication potential,ICEP)量化河流输入对九龙江河口所产生的影响,特别是对富营养化指标的年度和季节性变化动态进行了分析。结果表明,九龙江河口区溶解性无机氮(DIN)和溶解性无机磷(DIP)浓度年均值均呈波动性增长,自1980s以来九龙江河口营养负荷发生了较显著变化,1980s—2006年期间DIN通量平均值为3.967×10^(3)t/a,而2006—2020年期间增加到2.924×10^(4)t/a,增长了637.14%,其中最高值达8.279×10^(4)t/a。两个时期DIP通量平均值分别为1.131×10^(2)和2.282×10^(2)t/a,增长了101.87%,其中最高值达6.128×10^(2)t/a。河流的营养通量和营养结构均发生了明显变化。2006年以后,超过90%的年份N-ICEP处于正值区间,而P-ICEP均处于负值。在季节变化上,河口生态系统的富营养化风险冬季低,夏季高。河口叶绿素a浓度与N-ICEP、P-ICEP均呈显著正相关,河口的硅藻丰度与N-ICEP和P-ICEP呈负相关关系,但P-ICEP对叶绿素a浓度的贡献高于N-ICEP,表明河口生态系统初级生产力总体上受到磷限制,但具有季节性差异,其中夏、秋季受P、Si共同限制。在应对处理富营养化问题时需要考虑季节因素,ICEP直接反映了N、P、Si比例平衡状态和生态效应,在未来可持续管理目标下,可以考虑将该指数作为生态目标纳入河口和流域的管理决策中。

关键词：营养通量沿海富营养化潜力指数化学计量比九龙江河口

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：