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An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang liping Ding liyun Wu Songfeng E Qian He Nanyang Wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

Cycloaddition Reactions of Epoxides and CO_(2)Catalyzed by Bifunctional Rare-Earth Metal Complexes Bearing Amino-Bridged Tris(phenolato)ligands

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Chinese Journal of Chemistry 2024年第14期42卷 1571-1581页

作者： Yongjie Chen Yanwei Wang Jun nong Dan Yuan Yingming yao Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceDushu Lake CampusSoochow UniversitySuzhouJiangsu215123 China

Eight zwitterionic rare earth metal complexes stabilized by amino-bridged tris(phenolato)ligands bearing quaternary ammonium side-arms were synthesized and *** complexes were used as single-component catalysts for the cycloaddition of CO_(2)and epoxides,and their catalytic activities are obviously higher than those of their binary *** studies revealed that the halide anions(Cl^(–),Br^(–),I^(–))and the metal complexes influenced the catalytic activity,and the lanthanum complex bearing iodide anion showed the highest catalytic activity for this addition reaction.A variety of mono-substituted epoxides were converted to cyclic carbonates in good to excellent yields(55%—99%)with high selectivity(>99%)at 30℃and 1 bar CO_(2),whereas internal epoxides required higher both reaction temperatures(60—120℃)and catalyst loading(2 mol%)for high *** catalyst was recyclable for four times without noticeable loss of catalytic *** on the results of kinetic studies and in℃situ IR reactions,a plausible reaction mechanism was proposed.

关键词： Bifunctional catalyst Carbon dioxide Cyclic carbonate Rare-earth metal Tris(phenolato)ligand Insertion Cycloaddition C1 building blocks

羟乙基淀粉130/0．4对OLV犬血液稀释界值的研究

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西南国防医药 2006年第3期16卷 241-243页

作者：牛纪元姚立农孙绪德刘晓峰杨永惠柴伟臧丽萍解放军第403医院麻醉科辽宁大连116023 第四军医大学唐都医院麻醉科陕西西安710038 解放军第401医院麻醉科山东青岛266071 山东省烟台市龙口荣军医院山东烟台265700

目的:观察羟乙基淀粉130／0．4对单肺通气(OLV)犬行不同程度急性高容量血液稀释(AHHD)时全身血液动力学、肾功、血糖和血管外肺水指标的变化。方法:10只健康杂种犬,体重12～16kg,随机分为稀释A组和非稀释B组,基础麻醉后行单肺控制呼吸。... 详细信息

目的:观察羟乙基淀粉130／0．4对单肺通气(OLV)犬行不同程度急性高容量血液稀释(AHHD)时全身血液动力学、肾功、血糖和血管外肺水指标的变化。方法:10只健康杂种犬,体重12～16kg,随机分为稀释A组和非稀释B组,基础麻醉后行单肺控制呼吸。A组每只犬以80 ml·kg-1·g-1的速度行AHHD,分别将红细胞压积(Hct)降至30％(HD1)、20％ (HD2)、15％(HD3)。测定。Hct各水平时的血液动力学指标、肾功、血糖,最后重量法测定血管外肺水指标。结果:稀释A 组犬达到所要求的。Hct水平时,各时点的补液量分别为(41．3±13)、(86．6±19)、(101．2±21)ml/kg。在血液稀释过程中, MAP、HR和肾功元明显变化,血糖值与T0比较明显增强(P<0．01)。CVP、PAWP持续升高,当Hct15％时高出生理范围值 (P<0．05或0．01)。以重量法测得的血管外肺水指标在稀释A组与非稀释B组有差异,A组各肺水指标增强(P<0． 05)。结论:羟乙基淀粉130／0．4对OLV犬AHHD的生理极限应为Hct20％,对肾功能元影响。

关键词：羟乙基淀粉130/0.4 血液稀释单肺通气血管外肺水肾功血糖血液动力学

阿片δ_1受体激动剂对出血性休克大鼠心肌损伤的影响

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科学技术与工程 2009年第12期9卷 3229-3233页

作者：曾小莉赵晓玲杨永慧蒯建科赵晖于代华柴伟姚立农第四军医大学唐都医院麻醉科西安710038

为观察出血性休克后复苏开始前给予阿片δ1受体激动剂2-Methyl-4aa-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12aα-oc-tahydroquinolino[2,3,3-g]isoquinoline dihydrobromide(TAN—67)对大鼠心肌缺血缺氧性损伤的影响。将24只成年雄性SD大鼠,随机分为三组,每组8只,实验分假手术组、休克对照组、TAN-67组。休克对照组和TAN-67组大鼠放血使MAP降至40mmHg,休克持续60min,注射生理盐水或TAN-67后,回输自体血进行复苏,观察复苏2h内MAP和心功能(LVP、±dp/dtmax)的变化。实验结束时取心肌组织行病理学电镜检查。并分析各组线粒体损伤。休克对照组复苏后各时点血流动力学指标呈逐渐下降趋势。TAN-67组复苏后同一时点各项指标均显著高于对照组(P<0.05)。病理学电镜检查和线粒体损伤结果,TAN-67组心肌损伤较对照组减轻。结果表明TAN-67有利于急性出血性休克大鼠血流动力学复苏,对心肌损伤有保护作用。

关键词：出血性休克 δ阿片样受体血流动力学心肌损伤

浙江省2005-2010年土源性线虫病监测结果分析

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国际医学寄生虫病杂志 2013年第1期40卷 19-21页

作者：张轩余可根夏生荣陈华良阮卫姚立农浙江省疾病预防控制中心杭州310051

目的分析2005--2010年浙江省人群土源性线虫病感染状况和变化趋势，为制定防治策略提供科学依据。方法在浙江省设立衢江区、平湖市、景宁县、开化县、松阳县等5个监测点，以当地居民为监测对象，收集监测对象的粪便样本，采用改良加藤... 详细信息

目的分析2005--2010年浙江省人群土源性线虫病感染状况和变化趋势，为制定防治策略提供科学依据。方法在浙江省设立衢江区、平湖市、景宁县、开化县、松阳县等5个监测点，以当地居民为监测对象，收集监测对象的粪便样本，采用改良加藤厚涂片法（Kato-Katz）检查蛔虫卵、鞭虫卵、钩虫卵，3～12周岁儿童加做透明胶纸肛拭法检查蛲虫卵。根据2005—2010年土源性线虫病监测数据进行分析。结果累计粪检7442人，2005—2010年土源性线虫的感染率依次为1.30％、2.36％、6．07％、8．08％、4．80％和1．19％。2010年土源性线虫感染率低于2006--2009年（χ2=4．553，P〈0．05；χ2=58．023，P〈0．01；χ2=94．399，P〈0．01；χ2=45．855，P〈0．01）。开化县2010年土源性线虫感染率低于2007--2009年（χ2=108．957，P〈0．01；χ2=116．892，P〈0．01；χ2=43．394，P〈0．01）；景宁县2008年土源性线虫感染率高于2006年及2007年（χ2=4．376，P〈0．05；χ2=4．858，P〈0．05），两县都以钩虫感染为主。结论浙江省土源性线虫总感染率呈下降趋势，但部分地区钩虫感染率仍较高，浙江省土源性线虫病流行基本得到有效控制。

关键词：线虫感染土源性线虫病感染监测

High-temperature self-powered X-ray detection in a bilayered hybrid ferroelectric halide perovskite

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Science China Chemistry 2025年

作者： Yingying Zheng Panpan Yu Yunpeng yao Shihai You Zeng-Kui Zhu Junhua Luo School of Chemistry and Chemical Engineering Jiangxi Normal University Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal University School of Environmental and Material Engineering Yantai University Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China

X-ray detectors which convert X-ray irradiation into electrical signals play an important role in diverse applications including medical diagnosis, security examination, nondestructive inspection, personal X-ray dosimeters and fundamental research[1–5]. Recently, metal halide perovskites（MHP） have been developed as a promising family for X-ray detection contributing to their intrinsic advantages, e.g.,simple synthesis, efficient X-ray absorption and excellent semiconducting properties[5–10].

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

2006年和2007年浙江省淳安县碘缺乏病病情调查报告

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中国地方病学杂志 2008年第6期27卷 660-662页

作者：苏晓辉刘守军朱文明秦根林刘鹏张树彬纪晓红魏红联黄学敏姚立农周金水哈尔滨医科大学中国疾病预防控制中心地方病控制中心碘缺乏病防治研究所 150081 浙江省疾病预防控制中心

目的了解浙江省淳安县碘缺乏病病情，为因地制宜、科学补碘提供科学依据。方法2006、2007年在淳安县选择病情最重的3所小学（汪宅乡、屏门乡和文昌镇各1所小学）．每所小学抽取90名8～10岁学生进行甲状腺B超检查；采集学生尿样测定尿碘... 详细信息

目的了解浙江省淳安县碘缺乏病病情，为因地制宜、科学补碘提供科学依据。方法2006、2007年在淳安县选择病情最重的3所小学（汪宅乡、屏门乡和文昌镇各1所小学）．每所小学抽取90名8～10岁学生进行甲状腺B超检查；采集学生尿样测定尿碘；采集学生家庭食用盐样，定量检测盐碘。结果2006年B超检查8～10岁儿童267人，甲状腺肿大（简称甲肿）率为7．5％（20／267），尿碘中位数为247．5μg／L，盐碘均数为32．7mg／kg；2007年B超检查8～10岁儿童271人，甲肿率为3．7％（10／271），尿碘中位数为383．4μg／L，盐碘均数为33．5mg／kg。2006年汪宅乡、屏门乡和文昌镇甲肿率分别为15．2％（14／92）、6．0％（5／83）和2．2％（2／92），尿碘中位数分别为360．1、211．3、189．3μg／L；2007年汪宅乡、屏门乡和文昌镇甲肿率分别为6．6％（6／91）、3.3％（3／90）和1．1％（1／90），尿碘中位数分别为388．6、411．5、327．8μg／L。2006年调查汪宅乡、屏门乡和文昌镇的人均年收入分别为1000、2000、3000元。结论病情严重程度与经济状况、尿碘有关，营养因素在甲肿发生中的作用不容忽视，在营养水平较低的基础上，尿碘过高导致了较高的甲肿率。

关键词：甲状腺肿碘尿营养

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu linqiang Tian Sanqiao yao Feng Lai Yangfan liang Chuanchuan liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells