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Multidisciplinary and Comprehensive Chinese Medicine for Advanced Non-Small Cell Lung Cancer Patients:A Retrospective Study of 855 Cases

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Chinese Journal of Integrative Medicine 2021年第7期27卷 490-495页

作者： HUANG Xian-ge ZHU Li-hua ZHOU Lei XU Wei-jie yao yi-lin ZHOU Zhi-yi LI He-gen The Third Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China

Objective To investigate the effects of multidisciplinary and comprehensive Chinese medicine(CM)treatments on progression-free survival(PFS)and median survival time(MST)in patients with advanced non-small cell lung cancer(NSCLC)and identify factors that influence progression and *** Clinical data of 855 patients with advanced NSCLC who received multidisciplinary and comprehensive CM treatments at Longhua Hospital from January 2009 to December 2018 were retrospectively *** analysis was performed by the Kaplan-Meier method and log-rank sequential *** analysis of significant variables from the univariate analysis was performed with Cox regression *** factors correlated to progression and prognosis were screened out,and a Cox proportional hazard model was established to calculate the prognostic *** The PFS and MST of 855 advanced NSCLC patients were 9.0 and 26.0 months,*** 1-,2-,3-,and 5-year survival rates were 79.2%,54%,36.2%,and 17.1%,***,pathologic type,and clinical stage were independent prognostic risk factors;surgical history,radiotherapy,treatment course of Chinese patent medicine,intravenous drip of Chinese herbal preparation,duration of oral administration of Chinese herbal decoction(CHD),and intervention measures were independent prognostic protective *** was an independent risk factor for progression,while operation history and oral CHD administration duration were independent protective factors(all P<0.05).Women with stage IIIb–IIIc lung adenocarcinoma had the best *** Female patients have lower progression risk and better prognoses than male patients,younger patients have higher progression risk but better long-term prognoses than the elderlys,and patients with lower performance status scores are at lower risk for progression and have better *** CM treatments could significantly reduce progression risk,improve pr

关键词： advanced non-small cell lung cancer prognostic factor progression factor survival analysis Chinese medicine

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PET imaging of cerebral metabolic change in tinnitususing ^(18)F-FDG

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Nuclear Science and Techniques 2000年第4期11卷 247-252页

作者： TIAN Jia-He, WANG Hong-Tian, yiN Da-yi, yao Shu-lin, SHAO Ming-Zhe, YANG Wei-Yan, JIANG Si-Chang (The PLA General Hospital, Beijing 100853) 解放军总医院北京 100853

Tinnitus is an auditory disorder hardly assessable by clinical technology. PET imaging of the brain in 13 cases with and 10 without tinnitus was undertaken at 40 min after injection of 280-440 MBq 18F-FDG. To ensure the quality of the PET study, all cases followed a normalized procedure with visual and auditory blockage. CT/MRI imaging and routine acoustic tests were carried out in all subjects. PET revealed that an increased uptake of 18F-FDG at left med-temporal lobe (primary auditory center, PAC) present exclusively in tinnitus, regardless the side of hearing hallucination. Significant asymmetry was noted between left and right PAC, but not at other cortex area. While control cases showed no asymmetric uptake between two hemispheres. The abnormal PAC uptake did not respond to external pure sound stimulus, nor did it relate to the seventy of hearing loss assessed by acoustic tests. No anatomical or morphological alteration could be proven on CT/MRI. In conclusion, PET/18F-FDG objectively revealed an increased metabolic change at left PAC in tinnitus, which is of diagnostic value; and there is evidence suggesting tinnitus is most likely induced by a functional change in the brain.

关键词： PET ^18F-FDC 氟18 放射性核素标记正电子发射X线断层摄影术放射性核素显像耳鸣诊断

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Nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： yiling Li Xiaoyao Yu yingjie Zhou yao lin ying Wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration

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CO2激光联合光动力疗法治疗口腔白斑病的临床研究

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上海交通大学学报（医学版） 2020年第10期40卷 1330-1333页

作者：姚一琳吴岚唐国瑶上海交通大学医学院附属第九人民医院·口腔医学院口腔黏膜科国家口腔疾病临床研究中心上海市口腔医学重点实验室上海市口腔医学研究所上海200011

目的·探究CO2激光联合光动力疗法(photodynamic therapy,PDT)治疗口腔白斑病的临床效果。方法·选择2018年6月—2019年6月于上海交通大学医学院附属第九人民医院就诊的21例口腔白斑病患者,随机分为试验组(11例)和对照组(10例),前者采用... 详细信息

目的·探究CO2激光联合光动力疗法(photodynamic therapy,PDT)治疗口腔白斑病的临床效果。方法·选择2018年6月—2019年6月于上海交通大学医学院附属第九人民医院就诊的21例口腔白斑病患者,随机分为试验组(11例)和对照组(10例),前者采用CO2激光联合PDT治疗,后者单一采用CO2激光治疗。记录2组患者术后第1周内出现的不良反应,第1个月的治疗效果及第3、6个月的复发情况,并对上述指标的组间差异进行统计分析。结果·术后第1个月试验组和对照组的显效率分别为100%和80%,有效率分别为100%和90%,组间差异无统计学意义。术后第1周内,2组患者均出现不同程度的烧灼样疼痛、水肿和(或)糜烂,组间差异亦无统计学意义。术后第3个月随访结果显示,试验组和对照组的复发率分别为0和10%,组间差异无统计学意义;而第6个月的结果显示,试验组的复发率显著低于对照组(P=0.038)。结论·CO2激光联合PDT和单一CO2激光治疗口腔白斑病均疗效显著,无严重不良反应,且联合疗法可明显降低疾病复发率。

关键词：光动力疗法 CO2激光口腔白斑病口腔黏膜潜在恶性疾患

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Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu linke Cai Youluan Lu Fanpeng Cheng Lijuan Shi Qun yi yao Liu yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Oxygen evolution reaction

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing yao Chubing Long Pengcheng yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue lin Gen Wei Jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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钉形搅拌桩单桩承载力及荷载传递特性的数值模拟研究

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岩土力学 2009年第6期30卷 1843-1849页

作者：易耀林刘松玉李涛王刚东南大学岩土工程研究所南京210096 武汉新区建设开发投资有限公司武汉430050

在现场试验的基础上,对钉形桩单桩承载力及荷载传递特性进行了三维数值模拟。模拟结果表明:在其他条件相同的情况下,钉形桩的单桩极限承载力在一定范围内随扩大头高度增加而增大,随扩大头直径增加而增大,但单位水泥用量的单桩极限承载力... 详细信息

在现场试验的基础上,对钉形桩单桩承载力及荷载传递特性进行了三维数值模拟。模拟结果表明:在其他条件相同的情况下,钉形桩的单桩极限承载力在一定范围内随扩大头高度增加而增大,随扩大头直径增加而增大,但单位水泥用量的单桩极限承载力随H/L和D/d均先增大后减小,存在最优值。从单桩承载力角度看,钉形桩存在有效桩长。钉形桩的桩身荷载主要集中在扩大头部分,是主要承载部位。由于扩大头的作用,钉形桩的桩身轴力在变截面附近有较大的衰减,其他条件相等,在各自的极限荷载下,钉形桩下部桩体的轴力大于常规桩,桩身侧摩阻力比常规桩发挥更加充分。

关键词：钉形搅拌桩承载力荷载传递数值模拟

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Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第1期68卷 329-336页

作者： Yuzhu Li Yumeng Gao Feng Tian Yu Wang Yuan yao Shaoliang lin Xiang Ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

关键词： self-assembly conformation ordering alternating copolymer phosphorescence emission

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基于二维图像处理方法的沥青混合料砂浆厚度谱研究

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长安大学学报（自然科学版） 2019年第1期39卷 9-16页

作者：倪富健姚琳怡蒋继望东南大学交通学院江苏南京210096

为研究沥青混合料的砂浆厚度组成规律,考虑集料间接触的最薄弱方向,提出了一种基于最短接触距离原则的沥青混合料砂浆厚度计算方法。采用高精度二维扫描仪获取混合料二维切片图像,定义沥青砂浆由沥青以及粒径小于等于1.18mm的细集料组成... 详细信息

为研究沥青混合料的砂浆厚度组成规律,考虑集料间接触的最薄弱方向,提出了一种基于最短接触距离原则的沥青混合料砂浆厚度计算方法。采用高精度二维扫描仪获取混合料二维切片图像,定义沥青砂浆由沥青以及粒径小于等于1.18mm的细集料组成,并利用MATLAB相关图像处理方法进行混合料砂浆空间结构分析。提出平均砂浆厚度、砂浆厚度谱的众数及集中度指标,并对其进行统计分析。针对6种不同类型的混合料,研究不同压实次数、沥青种类、最大公称粒径以及级配类型等因素对其砂浆厚度的影响。结果表明:提出的方法适用于分析沥青混合料的砂浆厚度组成规律;砂浆厚度谱用对数正态分布模型进行拟合的效果较好;随着压实次数的增加,平均砂浆厚度及厚度谱众数均存在最小值,而砂浆集中度则存在峰值,说明过压会破坏砂浆的稳定状态,合理选择压实次数十分重要;较小的集料最大公称粒径、悬浮密实型结构以及改性沥青混合料对应的平均砂浆厚度更小,砂浆也向更小的厚度上集中,其集中度更高;级配类型和最大公称粒径的影响最为显著,沥青种类对厚度谱的集中度也有较为显著的影响,压实次数的影响虽然不大但也呈现出明显的规律性。

关键词：道路工程砂浆厚度谱数字图像处理沥青混合料细观结构

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复合地基垫层效应研究综述

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西北地震学报 2011年第B8期33卷 15-20页

作者：易耀林刘松玉东南大学岩土工程研究所江苏南京210096

垫层技术是复合地基的关键技术之一。本文总结了当前复合地基垫层效应和作用机理的研究现状,重点介绍了刚性基础和柔性基础下垫层对复合地基荷载传递规律、破坏模式、承载力和沉降特性的影响方面的研究。并从调整基础刚度的角度出发对... 详细信息

垫层技术是复合地基的关键技术之一。本文总结了当前复合地基垫层效应和作用机理的研究现状,重点介绍了刚性基础和柔性基础下垫层对复合地基荷载传递规律、破坏模式、承载力和沉降特性的影响方面的研究。并从调整基础刚度的角度出发对垫层效应和作用机理进行了讨论。

关键词：复合地基垫层荷载传递破坏模式承载力沉降

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