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Reynosin protects neuronal cells from microglial neuroinflammation by suppressing NLRP3 inflammasome activation mediated by NADPH oxidase

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Chinese Journal of Natural Medicines 2024年第6期22卷 486-500页

作者： YANG Yanqiu CHE Yue FANG Mingxia yao xiaohu ZHOU Di WANG Feng CHEN Gang LIANG Dong LI Ning HOU Yue Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health SciencesNorth-eastern UniversityShenyang 110000China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart IndustryMinistry of EducationNortheastern UniversityShenyang 110000China School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning provinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110000China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541000China

Neuroinflammation,mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3(NLRP3)inflammasome,is a significant contributor to the pathogenesis of neurodegenerative diseases(NDDs).Reynos-in,a natural sesquiterpene lactone(SL),exhibits a broad spectrum of pharmacological effects,suggesting its potential therapeutic ***,the effects and mechanism of reynosin on neuroinflammation remain *** current study explores the effects and mechanisms of reynosin on neuroinflammation using mice and BV-2 microglial cells treated with lipopolysaccharide(LPS).Our findings reveal that reynosin effectively reduces microglial inflammation in vitro,as demonstrated by decreased CD11b expression and lowered interleukin-1 beta(IL-1β)and interleukin-18(IL-18)mRNA and protein ***,in vivo,results showed a re-duction in the number of Iba-1 positive cells and alleviation of morphological alterations,alongside decreased expressions of IL-1βand *** analysis indicates that reynosin inhibits NLRP3 inflammasome activation,evidenced by reduced transcription of NLRP3 and caspase-1,diminished NLRP3 protein expression,inhibited apoptosis-associated speck-like protein containing a CARD(ASC)oli-gomerization,and decreased caspase-1 ***,reynosin curtailed the activation of nicotinamide adenine dinuc-leotide phosphate(NADPH)oxidase,demonstrated by reduced NADP^(+)and NADPH levels,downregulation of gp91^(phox) mRNA,pro-tein expression,suppression of p47^(phox) expression and translocation to the ***,reynosin exhibited a neuroprotective effect against microglial inflammation in vivo and in *** collective findings underscore reynosin’s capacity to mitigate mi-croglial inflammation by inhibiting the NLRP3 inflammasome,thus highlighting its potential as a therapeutic agent for managing neuroinflammation.

关键词： Microglia NLRP3 inflammasome Reactive oxygen species NADPH oxidase Neuron Reynosin

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高温下多主元合金的动态变形行为与本构建模

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爆炸与冲击 2024年第7期44卷 1-11页

作者：邱吉苏步云金涛姚小虎树学峰李志强方慧青太原理工大学航空航天学院山西太原030024 华南理工大学土木交通学院广东广州510641 山西省建设投资集团有限公司山西太原030032 太原理工大学机械与运载工程学院山西太原030024

为加速多主元合金在航空工业领域的应用,将航空发动机经常面临的高温高应变率耦合环境作为实验条件,在5种温度下开展了CoCrFeNiMn多主元合金的动态压缩实验和变形后试样的塑性变形机理微观表征。结果表明:在1273 K的高温环境中,多主元... 详细信息

为加速多主元合金在航空工业领域的应用,将航空发动机经常面临的高温高应变率耦合环境作为实验条件,在5种温度下开展了CoCrFeNiMn多主元合金的动态压缩实验和变形后试样的塑性变形机理微观表征。结果表明:在1273 K的高温环境中,多主元合金的动态屈服强度可达200 MPa,表现出较好的耐高温性能;随着动态塑性应变的增加,材料内部出现了晶粒粗化的现象,并且在晶界处具有更高的亚结构孕育能力。此外,量化了不同环境温度下动态塑性变形过程中绝热温升的变化规律,指出了现有动态本构关系对CoCrFeNiMn多主元合金在宽温度域内动态应力-应变关系预测能力的不足。最后,通过解耦分析初始屈服与塑性流动阶段的温度效应,建立了一个指数形式的唯象动态本构方程。该本构方程可用于预测冲击载荷作用下宽温度域内多主元合金的屈服强度和塑性流动规律。

关键词：高温高应变率耦合塑性变形机理动态本构关系绝热温升多主元合金

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动态加载下非晶合金的塑性事件演化及非近邻相互作用

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中国科学：物理学、力学、天文学 2024年第5期54卷 2-20页

作者：唐晓畅邓杰仁莫泳晖孟令怡姚小虎华南理工大学土木与交通学院广州510640 中国科学院力学研究所非线性力学国家重点实验室北京100080

于无序中觅有序,于繁复间见真章.这是众多非晶材料研究者毕生的追求.非晶合金是基于现代冶金技术和熵调控理念,通过抑制合金熔体结晶以保持液体无序结构的一类新型金属材料.良好的综合性能使其在国防军事、航空航天、轨道交通等战略核... 详细信息

于无序中觅有序,于繁复间见真章.这是众多非晶材料研究者毕生的追求.非晶合金是基于现代冶金技术和熵调控理念,通过抑制合金熔体结晶以保持液体无序结构的一类新型金属材料.良好的综合性能使其在国防军事、航空航天、轨道交通等战略核心领域都具有广阔的应用前景.这些领域常要求结构装备能够承受连续冲击载荷,因此材料在复杂载荷作用下的动态力学响应和损伤演化过程是研究者关注的首要问题.本文尝试从动态载荷的统一视角出发,梳理非晶合金中的塑性事件演化及相互作用方面的研究发展脉络.通过明确基本单元对系统所处外界环境的响应,及其与宏观统计量之间的关联,加深对非晶体系在动载下涌现出的新现象和新机制的理解.最终希望能借助微细观机理研究明确技术发展方向,探明现象和机制背后蕴含的底层调控空间.

关键词：非晶合金损伤演化数值模拟

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体硅CMOS工艺下一种带隙基准的单粒子辐射特性分析

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国防科技大学学报 2024年第4期46卷 169-174页

作者：文溢陈建军梁斌池雅庆邢海源姚啸虎国防科技大学计算机学院湖南长沙410073

为了分析带隙基准(bandgap reference,BGR)在太空环境等极端条件下的单粒子辐射特性,分别在65 nm和28 nm体硅CMOS工艺下设计实现了一款BGR试验芯片,并采用脉冲激光单粒子模拟试验研究了其单粒子辐射特性。试验结果发现,当脉冲激光能量... 详细信息

为了分析带隙基准(bandgap reference,BGR)在太空环境等极端条件下的单粒子辐射特性,分别在65 nm和28 nm体硅CMOS工艺下设计实现了一款BGR试验芯片,并采用脉冲激光单粒子模拟试验研究了其单粒子辐射特性。试验结果发现,当脉冲激光能量足够高时,BGR的输出电压显著增加,且退火后电压不能恢复,表明BGR发生了单粒子硬损伤(single-event hard damage,SHD),进一步的试验研究证明BGR中的三极管是诱发SHD的敏感器件。该研究为在体硅CMOS工艺下对BGR进行抗SHD加固设计提供了重要理论参考。

关键词：带隙基准单粒子硬损伤脉冲激光试验体硅CMOS工艺

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Technology Dependency of TID Response for a Custom Bandgap Voltage Reference in 65 nm to 28 nm Bulk CMOS Technologies

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Chinese Journal of Electronics 2023年第6期32卷 1286-1292页

作者： LIANG Bin WEN Yi CHEN Jianjun CHI Yaqing yao xiaohu College of Computer Science National University of Defense Technology

Total ionizing dose(TID) radiation response of the custom bandgap voltage reference(BGR)fabricated with 65 nm, 40 nm and 28 nm commercial bulk CMOS technologies is investigated. TID response is assessed employing Co-60 gamma ray source. The measurements indicate that the voltage reference is reduced by5.67% in 28 nm, 0.56% in 40 nm and increased by 1.28% in65 nm devices under irradiation up to 1.2 Mrad(Si) *** 48 hours of annealing, the voltage reference changes are just-1.84% in 28 nm, 0.14% in 40 nm and 1.14% in 65nm. The obtained results demonstrate that the custom BGR has naturally superior TID response due to the circuit design margins.

关键词： Voltage measurement Annealing Photonic band gap Gamma-rays Aerospace electronics CMOS technology Circuit synthesis

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风冷干式变压器的热仿真分析及优化

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电工技术 2024年第1期 18-20,27页

作者：陈文锋李霞苏步云易吉良姚小虎顺特电气设备有限公司广东佛山528300 华南理工大学工程力学系广东广州510641

对绕组温升和热点温度的有效预测与分析,是确保干式变压器安全、稳定运行的重要前提。模拟了一台8000 kVA干式变压器在强迫风冷条件下的温度场分布情况,并通过风冷温升试验验证了仿真结果的准确性及可靠性。在此基础上,讨论了模型简化... 详细信息

对绕组温升和热点温度的有效预测与分析,是确保干式变压器安全、稳定运行的重要前提。模拟了一台8000 kVA干式变压器在强迫风冷条件下的温度场分布情况,并通过风冷温升试验验证了仿真结果的准确性及可靠性。在此基础上,讨论了模型简化方法和结构优化设计对温升模拟结果的影响规律并进行了误差分析。结果表明,所采用的数值仿真方法能够有效地预测变压器的温度分布规律,可为此类变压器的设计、优化和评估提供参考依据。

关键词：干式变压器强迫风冷温度场数值模拟结构优化

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Two-dimensional densely ordered packings of non-convex bending and assembled rods

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Particuology 2020年第3期18卷 35-42页

作者： Lingyi Meng xiaohu yao Xiaoqing Zhang Department of Mechanics Engineering School of Civil Engineering and TransportationSouth China University of TechnologyGuangzhou 510641China State Key Laboratory for Strength and Vibration of Mechanical Structure Xi'an 710049China

The investigation of the problem of particle packing has provided basic insights into the structure,symmetry,and physical properties of condensed *** packings of non-spherical particles have many applications,both in research and *** report the two-dimensional dense packing patterns of bending and assembled rods,which are non-convexly deformed from simple objects and modeled as entangled *** Carlo simulations and further analytical constructions are carried out to explore possible densely packed *** typical densely packed structures of C-bending rods are found,and their packing densities are identified as being functions of the aspect ratio and central *** shapes of assembled rods,representing the combined deformations of rods,are employed in simulations with the packing structures classified into three *** dense packing density of each packing pattern is derived as a function of different shape *** contrast with the case of disordered packings,both the shape and order are verified to affect the packing density.

关键词： Dense packings Non-convex Two-dimensional Packing density

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Numerical Simulation on Ceramic/Metal Armours Impacted by Deformable Projectile

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上海交通大学学报 2004年第Z2期38卷 142-146页

作者： Zhang Xiaoqing yao xiaohu Yang Guitong College of Traffic and Communications South China University of Technology China College of Traffic and Communications South China University of Technology China Institute of Applied Mechanics Taiyuan University of Technology China Institute of Applied Mechanics Taiyuan University of Technology China

Numerical simulation for the dynamic response of ceramic/metal armours impacted by deformable projectile is carried out with *** simulated penetration processes are shown. The mushrooming of the projectile is displayed. A distinct conoid shaped zone of fragmented ceramic is observed. A significant bending of the backing plate is revealed. Simulation results match fairly well with the experimental values and the theoretical analysis results. The accuracy of the numerical simulation is validated.

关键词： deformable projectile ceramic/metal armours numerical simulation

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Numerical Simulation for Arc Windshields of Aircrafts Subjected to Bird Impact

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上海交通大学学报 2004年第Z2期38卷 147-151页

作者： yao xiaohu Zhao Longmao Liu Xiaoming Institute of Applied Mechanics Taiyuan University of Technology China College of Traffic and Communications South China University of Technology China Institute of Applied Mechanics Taiyuan University of Technology China Chengdu Aircraft Industry Company China

A finite element model including full-scale circular arc windshield glass and the relative parts of the military plane is established in this paper. The model is analyzed by using an explicit element code LS-DYNA3D for analyzing the nonlinear dynamic response of structures. The data in aspects of displacement, strain, stress and contact force in the process of deformation are obtained. The deformation and failure mechanism of circular arc windshield glass are discussed. The possible location at which failure may take place is given. The valuable data are provided for designing,researching and producing new windshields with high crashworthiness.

关键词： bird impact arc windshield dynamic response liquid-solid coupling

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Combined torsional buckling of double-walled carbon nanotubes with axial load in the multi-field coupled condition

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Science China(Physics,Mechanics & Astronomy) 2011年第9期54卷 1659-1665页

作者： SUN YuGang yao xiaohu HAN Qiang Department of Engineering Mechanics School of Civil Engineering and Transportation South China University of Technology Guangzhou 510640 China

The present study has theoretically investigated the combined torsional buckling of double-walled carbon nanotubes (DWCNTs) with axial load in the multi-field coupled condition. The effects of torsion, axial load, thermal-electrical change, surrounding elastic medium and the Van der Waals forces are all taken into consideration. The governing equation of buckling for CNTs subjected to thermo-electro-mechanical loadings has been established based on an elastic shell model of continuum mechanics. Reasonable simplifications are made to get the explicit expression of the critical buckling shear stress of DWCNTs, and numerical experiments are conducted for further research. It is shown that under certain electric and temperature field the critical buckling shear stress of DWCNTs only depends on the wave number of buckling modes. On the other hand, all the related impact factors have enormous influence on the critical buckling shear stress under a certain buckling mode. The critical buckling shear stress changes linearly with the axial-to-shear stress ratio, as well as the thermal and electric change. Axial compression tends to make DWCNTs unstable, while axial tension benefits the buckling stability. The critical buckling shear stress is directly proportional to the applied voltage. At room or lower temperature, the critical shear stress for infinitesimal buckling increases as the temperature change increases, while it decreases at a higher temperature. The conclusions are useful for the design of nano-structures related to the buckling stability of DWCNTs.

关键词：双壁碳纳米管扭转屈曲轴向负荷耦合条件临界剪应力屈曲稳定性连续介质力学弹性介质

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