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遗传性血管性水肿诊治的“院内多学科会诊协作网联动线上线下全程管理”模式的初探

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中华预防医学杂志 2024年第3期58卷 406-413页

作者：姚我吴定钱沈颖沈磊李燕葛柳雅张松照陈炯汪慧英浙江大学医学院附属第二医院变态反应科杭州310009 浙江大学医学院附属第二医院急诊科杭州310009 浙江大学医学院附属第二医院皮肤科杭州310009 浙江大学医学院附属第二医院耳鼻咽喉科杭州310009 浙江大学医学院附属第二医院消化内科杭州310009 浙江大学医学院附属第二医院门诊护理部杭州310009 浙江大学医学院附属第二医院检验科杭州310009 宁波大学农产品质量安全危害因子与风险防控国家重点实验室宁波315211

遗传性血管性水肿(hereditary angioedema,HAE)是一种常染色体显性遗传的罕见病,患病率约为50 000分之一,以反复发作、不可预测的皮肤或黏膜下水肿为临床特征,累及咽喉部可导致潜在的致命风险。其疾病的罕见性、临床表现的多样性,造成... 详细信息

遗传性血管性水肿(hereditary angioedema,HAE)是一种常染色体显性遗传的罕见病,患病率约为50 000分之一,以反复发作、不可预测的皮肤或黏膜下水肿为临床特征,累及咽喉部可导致潜在的致命风险。其疾病的罕见性、临床表现的多样性,造成医务人员认识不足,导致临床的误诊误治。因此,提高医务人员对HAE的认识非常重要。本院建立以院内多学科会诊(multi-disciplinary treatment,MDT)团队、省内协作网联动、线上线下患者管理和媒体宣教交互的管理模式(“院内MDT协作网联动线上线下全程管理”),通过这种模式的推广,显著提高了浙江省HAE患者的精准诊断,缩短了诊断时间,显著降低了患者的严重喉头水肿发作急救,同时为HAE的临床诊治提供参考。

关键词：遗传性血管性水肿管理模式临床路径 C1酯酶抑制物

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新型甲型H1N1流感孕妇的临床表现

中华结核和呼吸杂志 2010年第6期33卷 447-448页

作者：姚我吴琦冯靖天津医科大学总医院呼吸科 300052

2009年4月第1例新型甲型H1N1流感（简称甲型流感）病例确诊[1].这种起源于墨西哥的病毒已传播到美国、加拿大及中国等100多个国家.孕妇是甲型流感发生并发症的高危人群[2],孕妇患重症甲型流感病例和需住院治疗的风险是其他人群的4倍[3]... 详细信息

2009年4月第1例新型甲型H1N1流感（简称甲型流感）病例确诊[1].这种起源于墨西哥的病毒已传播到美国、加拿大及中国等100多个国家.孕妇是甲型流感发生并发症的高危人群[2],孕妇患重症甲型流感病例和需住院治疗的风险是其他人群的4倍[3].现将孕妇甲型流感病例的临床特点、诊治现状及预防等综述如下.

关键词：甲型H1N1流感孕妇临床表现甲型流感高危人群 2009年临床特点住院治疗

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Chinese Medical Journal 2010年第17期123卷 2392-2399页

作者： FENG Jing Ambrose An-Po Chiang WU Qi CHEN Bao-yuan CUI Lin-yang LIANG Dong-chun ZHANG Ze-li yao wo Department of Respiratory Disease Tianjin Medical University General Hospital Tianjin 300052 China Division of Pulmonary and Critical Care Medicine Duke University Medical Center Durham NC 27710 USA Tianjin Neurology Research Institute Tianjin 300052 China Tianjin Medical University Endocrinology Research Institute Tianjin 300052 China

Background Sleep disturbance is common in patients with emphysema. This study aimed to develop a novel model of sleep-related hypoxemia （SRH） in emphysema （SRHIE） with rats, and to explore the inflammatory status of SRHIE in lung, liver, pancreas, carotid artery and whole *** Seventy-five male Wistar rats were assigned to 5 groups with 15 per group according to the exposure conditions. The protocols varied with the degree of hypoxia exposure and severity of pre-existing emphysema caused by cigarette smoke exposure：（1） SRH control （SRHCtrl） group, sham smoke exposure （smoke exposure, exposed to smoke of 15 cigarettes twice everyday, 16 weeks） and SRH exposure （12.5% O2, 3 hours, SRH exposure, divide total hypoxia time （1.5 hours or 3 hours） into 4 periods evenly （22.5 minutes or 45 minutes） and distribute these hypoxia periods evenly into physiological sleep time of rats identified by electroencephalogram, week 9 to week 16）; （2） Emphysema control （ECtrl） group, smoke exposure and sham SRH exposure （21% O2, 3 hours）; （3） Short SRH in emphysema （SRHShort） group, smoke exposure and short SRH exposure （12.5% O2, 1.5 hours）; （4） Mild SRH in emphysema （SRHMild） group,smoke exposure and mild SRH exposure （15% O2, 3 hours）; （5） Standard SRH in emphysema （SRHStand） group, smoke exposure and SRH exposure （12.5% O2, 3 hours）. ECtrl, SRHShort, SRHMild and SRHStand groups were groups with emphysematous rats. Two days before the end of exposure, 5 rats in each group were randomly selected for arterial blood gas analysis. In the rest 10 rats in each group, we obtained blood samples and bronchoalveolar lavage fluid （BALF）for routine tests. We also obtained tissue blocks of lung, liver, pancreas, and right carotid artery for pathologic scoring and measurements of liver oxidative stress （measuring hepatic oxidative stress enzymes, superoxide dismutase （SOD） activity, catalase （CAT） activity and malondialdehyde （MDA） concentration）.Results Emphysematous groups had higher me

关键词： sleep-related hypoxemia emphysema inflammation oxidative stress bronchoalveolar lavage fluid superoxide dismutase catalase malondialdehyde

Allergen Sensitization Patterns to Aeroallergens in Allergies Involving Respiratory System,Eye,Skin and Combination:A Cross-Sectional Survey

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Allergen Sensitization Patterns to Aeroallergens in Allergie...

松辽盆地大庆长垣形成时间的厘定及其地质意义

第八次全国中西医结合变态反应学术会议暨首届深圳市中西医结合变态反应学术会议暨第十届深圳呼吸论坛

作者： Huiying Wang Lanfang Tang Ling Wu wo yao Ran Diao Xiuzhen Zhao Dai Yu Xuyan Yang Department of Allergy the Second Affiliated Hospital of Zhejiang University School of Medicine Department of Respirology the Children' s HospitalZhejiang University College of Medicine Department of Pediatrics the Chinese Traditional Medicine HospitalHangzhouChina Department of Clinic Laboratory the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Rheumatology and Clinical Immunology the Second Affiliated Hospital of Zhejiang University School of Medicine

Aim:To investigate sensitization pattern of inhalant allergens in allergies involving respiratory system,skin,eye and ***:A cross-sectional study was conducted from July 2009 to August2012 in allergic centers from three hospitals in Zhejiang *** prick test data of patients diagnosed with rhinitis,conjunctivitis,atopic cough,asthma and atopic dermatitis were collected for ***:Of total 3643 patients,2247(64.9%) had at least one positive skin *** with atopic dermatitis had the highest prevalence of sensitization rate at about 80%,followed by patients of allergic rhinitis and allergic asthma,and patients of allergic conjunctivitis or atopic cough had the lowest sensitization rate of *** have the highest prevalence of skin reaction in the total population with 56.3%for ***,55.5%for *** and 34.6%for Blomia tropicalis,followed by 8.5%for cat,8.2%for cockroach,7.0%for dog,5.9%for mould,2.5%for mugwort,2.2%for timothy grass,1.8%for ragweed,1.5%for ***-allergen sensitization is the most common phenomenon which took 68%in all groups of *** had highest skin reaction index,followed by ***,mould,and timothy *** sensitization with *** and ***,and triple sensitization with ***,*** and Blomia tropicalis are the main patterns of ***:Different allergic diseases showed different sensitization pattern of inhalant allergens with different sensitization prevalence and *** single diseases involved different systems showed different sensitization prevalence and patterns of inhalant *** diseases involving more systems has more numbers of sensitized allergens and stronger sensitized reaction presented as skin reaction *** allergen sensitization plays more important role in skin allergy than respiratory mucous allergy,and comorbid diseases had more stronger skin *** dust mites a

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吉林大学学报（地球科学版） 2017年第1期47卷 74-83页

作者：高翔刘志宏聂志阳姚勇贾卧王超宋健吉林大学地球科学学院长春130061 大庆油田勘探开发研究院黑龙江大庆163712

大庆长垣位于松辽盆地北部一级构造单元中央坳陷区内,是松辽盆地中隆升幅度最高、规模最大的背斜,由于其含有十分丰富的油气资源,长期以来备受瞩目,但其形成时间一直存在很大争议。通过对大庆长垣二维、三维地震剖面解析,应用生长地层理... 详细信息

大庆长垣位于松辽盆地北部一级构造单元中央坳陷区内,是松辽盆地中隆升幅度最高、规模最大的背斜,由于其含有十分丰富的油气资源,长期以来备受瞩目,但其形成时间一直存在很大争议。通过对大庆长垣二维、三维地震剖面解析,应用生长地层理论,厘定大庆长垣的形成时间,并探讨其地质意义。研究发现:大庆长垣呈近NNE走向,为一个与近NWW—SEE向挤压作用有关的大型背斜。大庆长垣背斜北部嫩江组—明水组(T_1-T_(02))、中部嫩江组四段—明水组(T_(05)-T_(02))、南部四方台组—明水组(T03-T02)自构造高部位向低部位厚度逐渐增大,为与大庆长垣背斜隆升相伴沉积的一套生长地层;下伏地层在大庆长垣背斜顶部、翼部及两侧向斜部位厚度基本相等,具有前生长地层特征。大庆长垣背斜自嫩江组沉积初期受到近NWW—SEE向挤压作用开始隆升,一直持续到明水组沉积末期,但大庆长垣背斜不同构造部位的隆升时间、隆升速率及隆升高度都有所不同。松辽盆地晚白垩世的挤压作用可能与太平洋板块的俯冲作用有关,对油气的运移和聚集成藏有很大的影响。

关键词：生长地层形成时间构造演化地质意义大庆长垣松辽盆地

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成人先天性小肠旋转不良长期误诊1例

中国当代医药 2015年第30期22卷 171-173页

作者：姚我潘文胜浙江大学医学院附属第二医院普内科杭州310009 浙江大学医学院附属第二医院消化内科杭州310009

目的探讨成人先天性小肠旋转不良的临床特点、诊治方法及误诊原因。方法报道本院1例成人先天性小肠旋转不良的诊治过程,并复习相关文献。结果本例患者为女性,60岁,因长期腹部不适就诊,收入我院后经小肠CT、胃肠造影及肠系膜动脉B超确诊... 详细信息

目的探讨成人先天性小肠旋转不良的临床特点、诊治方法及误诊原因。方法报道本院1例成人先天性小肠旋转不良的诊治过程,并复习相关文献。结果本例患者为女性,60岁,因长期腹部不适就诊,收入我院后经小肠CT、胃肠造影及肠系膜动脉B超确诊为成人先天性小肠旋转不良,确诊后因患者并无肠梗阻征象,暂内科保守治疗。结论当遇到成人患者长期消化道症状久治不愈时,需考虑先天性小肠旋转不良的可能。消化道造影、腹部CT及B超等影像学检查是明确诊断的重要手段,确诊本病并存在肠梗阻时,需行手术治疗。

关键词：先天性小肠旋转不良成人误诊上消化道造影

基底节区生殖细胞瘤的MRI和MRS征象分析

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中国医学计算机成像杂志 2017年第2期23卷 101-106页

作者：张大千李桥何慧瑾姚问我方慧上海市浦东医院复旦大学附属浦东医院放射科复旦大学附属华山医院放射科

目的:探讨基底节区生殖细胞瘤的MRI和MRS特征,以提高诊断准确性。方法:回顾性分析经手术病理证实或诊断性放疗临床确诊的8例基底节区生殖细胞瘤的临床及影像学资料。结果:8例基底节区生殖细胞瘤均为男性,年龄11~23岁,平均16.4岁;肿瘤实... 详细信息

目的:探讨基底节区生殖细胞瘤的MRI和MRS特征,以提高诊断准确性。方法:回顾性分析经手术病理证实或诊断性放疗临床确诊的8例基底节区生殖细胞瘤的临床及影像学资料。结果:8例基底节区生殖细胞瘤均为男性,年龄11~23岁,平均16.4岁;肿瘤实质部分T1WI呈略低于或接近脑灰质信号,T2WI和FLAIR呈高或稍高信号,DWI呈高信号;肿瘤呈实性团块状1例,肿瘤伴有囊变或呈完全囊性7例(87.5%,7/8),其中囊性伴分隔3例,囊实性4例;瘤周轻度水肿或无水肿7例(87.5%),无明显占位效应4例(50%);增强后病灶可呈环形、分隔状、斑点状、片状、团块状强化,其中1例肿瘤无明显强化;肿瘤伴有不同程度的同侧丘脑、脑干萎缩7例(87.5%,7/8),其中2例同时伴有同侧大脑半球及基底节的萎缩;3例患者同时行MRS检查,均表现为NAA峰降低,Cho峰增高,其中1例出现明显增高的Lip峰。结论:基底节区生殖细胞瘤MRI表现有一定特征性,结合MRS及临床资料,可以提高基底节区生殖细胞瘤的诊断准确率,尤其是对早期阶段的基底节区生殖细胞瘤进行早期诊断、早期治疗而改善患者预后。

关键词：基底节区生殖细胞瘤磁共振成像磁共振波谱分析

Defect engineering of W^(6+)-doped NiO for high-performance black smart windows

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Nano Research 2024年第4期17卷 3043-3052页

作者： Yingjun Xiao Xiang Zhang Dukang Yan Jianbo Deng Mingjun Chen Hulin Zhang Wenhai Sun Jiupeng Zhao yao Li School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China Center for Composite Materials and Structure Harbin Institute of TechnologyHarbin 150001China

In this report,W^(6+)doping as a defect engineering strategy has been proposed to improve the electrochromic properties of NiO *** research was conducted to explore the electrochromic properties and the modified mechanism of W-doped NiO *** to the pure NiO,W-doped NiO film exhibits improved electrochromic properties with significant optical modulation(61.56%at 550 nm),fast switching speed(4.42 s/1.40 s for coloring/bleaching),high coloration efficiency(45.41 cm^(2)·C-1)and outstanding cycling stability(no significant attenuation after 2000 cycles)in Li-based *** functional theory(DFT)calculations combined with the experimental results indicate that the improved electrochromic properties were due to enhanced the electronic conductivity and ion conductivity after the introduction of W^(6+).The charge capacity of W-doped NiO has also been improved,and it can function with wo_(3) to achieve a high performance black electrochromic smart window(ECSW)by balancing *** work could advance the fundamental understanding of defect engineering as an effective strategy to boost the electrochromic properties of NiO anodic material,manifesting a significant development as a candidate counter electrode in high-performance black smart windows.

关键词： NiO defect engineering charge balance black electrochromic windows

Efficient hydrogenolysis of fructose to 1,2-propanediol over bifunctional Ru-wo_(x)-MgO_(y) catalysts under mild reaction conditions via enhancing the chemoselective cleavage of C-C bonds

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Journal of Energy Chemistry 2024年第5期92卷 311-321页

作者： Shuang Luo Tie Shu Min Mao Haijie Yu Yuxin Zheng Daqian Ding Lingmei Liu Kexin yao Jianjian Wang School of Chemistry and Chemical Engineering State Key Laboratory of Coal Mine Disaster Dynamics and ControlInstitute of Advanced Interdisciplinary StudiesMulti-scale Porous Materials CenterChongqing UniversityChongqing 401331China Key Laboratory for Efficient Conversion and Circular Economy of Coal Chemical Engineering CollegeInner Mongolia University of TechnologyHohhot 010051Inner MongoliaChina

Selective conversion of fructose to 1,2-propanediol(1,2-PDO)is considered as a sustainable and cost-effective alternative to petroleum-based processes,however,this approach still faces challenges associated with low efficiency and harsh reaction ***,we have successfully synthesized a novel bifunctional Ru-wo_(x)-MgO_(y) catalyst through a facile'one-pot'solvothermal ***,this catalyst exhibits exceptional catalytic performances in the conversion of fructose to 1,2-PDO under mild reaction *** yield of 1,2-PDO is up to 56.2%at 140°C for 4 h under an ultra-low hydrogen pressure of only 0.2 MPa,surpassing the reported results in recent literature(below 51%).Comprehensive characterizations and density functional theory(DFT)calculations reveal that the presence of oxygen vacancies in the Ru-wo_(x)-MgO_(y) catalyst,serving as active acidic sites,facilitates the chemoselective cleavage of C-C bonds in fructose,which leads to the generation of active intermediates and ultimately resulted in the high yield of 1,2-PDO.

关键词： Biomass Fructose 1,2-Propanediol Retroaldol condensation Heterogenous catalysis