检索结果-南通市图书馆

Studies on surgical methods for sporadic micromedullary thyroid carcinoma

在线全文

学校读者我要写书评

暂无评论

Oncology and Translational Medicine 2024年第4期10卷 184-189页

作者： yaqiong Ni Xiaofeng Hou Wei yao Tao Wang Qinjiang Liu Department of Head and Neck Surgery Sun Yat-sen University Cancer Center Gansu HospitalLanzhouGansuChina

Background:To observe the changes in serum calcitonin levels after application of different surgical methods for primary medullary thyroid microcarcinoma(MTMC)and explore a more reasonable surgical ***:A retrospective analysis of 36 patients with MTMC,16 in group A and 20 in group B,was *** group A,tumors were single and confined to the thyroid lobe,and thyroid lobectomy with isthmusectomy was *** group B,tumors were in the isthmus or invaded the thyroid gland,or there were multiple foci in bilateral lobes,and patients with primary foci underwent total *** median follow-up time was 3.6 *** and pathological characteristics and changes in serum calcitonin(CTn)and carcinoembryonic antigen levels after the surgery were compared between the 2 ***:The difference in the biochemical cure rate after surgery was statistically significant between patients with preoperative serum calcitonin levels0.05).One recurrence and metastasis were observed in each group after ***:After performing different surgical methods for the primary foci of MTMC,the changes in serum calcitonin and carcinoembryonic antigen levels are *** for patients with single foci confined to the thyroid lobe without lateral cervical lymph node metastasis and with serum calcitonin levels<150 pg/mL,the unilateral thyroid lobectomy with isthmectomy can achieve the same therapeutic effect and biochemical cure rate as total thyroidectomy.

关键词： Thyroid papillary carcinoma Surgery Calcitonin Carcinoembryonic antigen

miRNA-126和miRNA-155在系统性红斑狼疮中的表达及意义

在线全文

学校读者我要写书评

暂无评论

中国实用医刊 2018年第5期45卷 24-27页

作者：姚亚琼尹慧卿郑州市第一人民医院皮肤科 450004 郑州大学第一附属医院检验科 450052

目的探讨miRNA-126和miRNA-155在系统性红斑狼疮（SLE）患者血浆中的表达及其临床意义。方法选取40例SLE患者为SLE组，并根据SLE疾病活动指数分为SLE活动期患者与SLE非活动期患者；另选择同期相近年龄段20例健康体检者作为对照组。采用... 详细信息

目的探讨miRNA-126和miRNA-155在系统性红斑狼疮（SLE）患者血浆中的表达及其临床意义。方法选取40例SLE患者为SLE组，并根据SLE疾病活动指数分为SLE活动期患者与SLE非活动期患者；另选择同期相近年龄段20例健康体检者作为对照组。采用实时荧光定量聚合酶链反应（qRT-PCR）技术检测所有患者血浆miRNA-126和miRNA-155表达水平并进行统计分析。比较对照组与SLE组、SLE活动期患者与SLE非活动期患者miRNA-126和miRNA-155表达水平。结果SLE组miRNA-126表达上调倍数为3.55±2.99，miRNA-155表达下调倍数为0.49±0.24，与对照组（1.03±0.25、1.01±0.16）比较差异均有统计学意义（P均〈0.05）。SLE组中SLE非活动期者miRNA-126上调倍数[2.57（2.03-3.10）]低于SLE活动期者[4.53（2.71-6.34）]，差异有统计学意义（P〈0.05），SLE非活动期者miRNA-155下调倍数[0.47（0.22-0.63）]与SLE活动期者[0.44（0.18-0.74）]比较差异未见统计学意义（P〉0.05），表明miRNA-126与疾病活动程度成正相关，miRNA-155的表达与SLE疾病活动无关。miRNA-126和miRNA-155的ROC曲线下面积（AUC）分别为0.825（95%CI：0.697-0.953）和0.852（95%CI：0.744-0.859），在SLE患者中异常表达有较好的特异性及敏感性。结论SLE患者血浆中miRNA-126和miRNA-155均表达异常，提示其参与了SLE的发病机制并在其中发挥重要作用，且两者可成为SLE辅助诊断标志物和有效治疗靶点。

关键词：系统性红斑狼疮 miRNA-126 miRNA-155 血浆

甘肃和青海小麦条锈菌UV-B辐射敏感性测定

在线全文

学校读者我要写书评

暂无评论

植物病理学报 2024年第3期54卷 591-606页

作者：李婷婷赵雅琼金社林姚强王海光中国农业大学植物保护学院北京100193 山西农业大学植物保护学院太谷030801 甘肃省农业科学院植物保护研究所兰州730070 青海大学农林科学院青海省农业有害生物综合治理重点实验室农业农村部西宁作物有害生物科学观测实验站西宁810016

位于西北地区的甘肃和青海是我国小麦条锈病病原菌(Puccinia striiformis ***,Pst)重要的越夏区和菌源基地,也是Pst毒性变异频率较高地区,该区域海拔高,紫外线辐射强度大。为了解紫外线对Pst存活力和毒性变异的影响,本研究测定了分离自... 详细信息

位于西北地区的甘肃和青海是我国小麦条锈病病原菌(Puccinia striiformis ***,Pst)重要的越夏区和菌源基地,也是Pst毒性变异频率较高地区,该区域海拔高,紫外线辐射强度大。为了解紫外线对Pst存活力和毒性变异的影响,本研究测定了分离自甘肃和青海部分地区21个Pst菌株夏孢子的相对萌发率和UV-B辐射LT50值(UV-B致死中时间,即在一定UV-B辐射强度下夏孢子相对萌发率为50%时所需辐射时间),探索了相应菌株对UV-B辐射的敏感性。结果表明,在3个UV-B辐射强度(150、200和250μw·cm^(-2))下,分离自甘肃和青海的全部Pst供试菌株的夏孢子相对萌发率均与UV-B辐射时间呈极显著负相关(P<0.0001)。3个UV-B辐射强度下的夏孢子相对萌发率和LT50值的比较结果表明,Pst菌株对UV-B辐射的敏感性存在差异,来自于青海的Pst菌株之间对UV-B辐射的敏感性差异高于来自于甘肃的Pst菌株。研究结果为探索紫外线对Pst存活力和毒性变异的影响提供了一定理论基础,为小麦条锈病的监测和防控提供了一定依据。

关键词：小麦条锈病相对萌发率 LT50值 UV-B辐射敏感性

同方期刊数据库

Joint Optimization of Latency and Energy Consumption for Mobile Edge Computing Based Proximity Detection in Road Networks

在线全文

学校读者我要写书评

暂无评论

China Communications 2022年第4期19卷 274-290页

作者： Tongyu Zhao yaqiong Liu Guochu Shou Xinwei yao School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Beijing Laboratory of Advanced Information Networks Beijing Key Laboratory of Network System Architecture and ConvergenceBeijing 100876China School of Computer Science and Technology Zhejiang University of TechnologyChina

In recent years, artificial intelligence and automotive industry have developed rapidly, and autonomous driving has gradually become the focus of the industry. In road networks, the problem of proximity detection refers to detecting whether two moving objects are close to each other or not in real time. However, the battery life and computing capability of mobile devices are limited in the actual scene,which results in high latency and energy consumption. Therefore, it is a tough problem to determine the proximity relationship between mobile users with low latency and energy consumption. In this article, we aim at finding a tradeoff between latency and energy consumption. We formalize the computation offloading problem base on mobile edge computing(MEC)into a constrained multiobjective optimization problem(CMOP) and utilize NSGA-II to solve it. The simulation results demonstrate that NSGA-II can find the Pareto set, which reduces the latency and energy consumption effectively. In addition, a large number of solutions provided by the Pareto set give us more choices of the offloading decision according to the actual situation.

关键词： proximity detection mobile edge computing road networks constrained multiobjective optimization

Synthesis of hierarchical dendritic micro–nano structure ZnFe_2O_4 and photocatalytic activities for water splitting

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2016年第8期24卷 1112-1116页

作者： Zhongping yao Yajun Zhang yaqiong He Qixing Xia Zhaohua Jiang School of Chemical Engineering and Technology State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology

Hierarchical dendritic micro–nano structure Zn Fe_2O_4 have been prepared by electrochemical reduction and thermal oxidation method in this work. X-ray diffractometry, Raman spectra and field-emission scanning electron microscopy were used to characterize the crystal structure, size and morphology. The results show that the sample(S-2) is composed of pure ZnFe_2O_4 when the molar ratio of Zn^(2+)/Fe^(2+)in the electrolyte is 0.35. Decreasing the molar ratio of Zn^(2+)/Fe^(2+), the sample(S-1) is composed of ZnFe_2O_4 and α-Fe_2O_3, whereas increasing the molar ratio of Zn^(2+)/Fe^(2+), the sample(S-3) is composed of ZnFe_2O_4 and Zn O. The lattice parameters of ZnFe_2O_4 are influenced by the molar ratio of Zn^(2+)/Fe: Zn at excess decreases the cell volume whereas Fe at excess increases the cell volume of Zn Fe_2O_4. All the samples have the dendritic structure, of which S-2 has micron-sized lush branches with nano-sized leaves. UV–Vis diffuse reflectance spectra were acquired by a spectrophotometer. The absorption edges gradually blue shift with the increase of the molar ratio of Zn^(2+)/Fe^(2+). Photocatalytic activities for water splitting were investigated under Xe light irradiation in an aqueous olution containing 0.1 mol·L^(-1)Na_2S/0.02 mol·L^(-1)Na_2SO_3 in a glass reactor. The relatively highest photocatalytic activity with 1.41 μmol·h-1· 0.02 g^(-1)was achieved by pure ZnFe_2O_4sample(S-2). The photocatalytic activity of the mixture phase of Zn Fe_2O_4 and α-Fe_2O_3(S-1) is better than ZnF e_2O_4 and ZnO(S-3).

关键词： ZnFe2O4 Electrochemical reduction and thermal oxidation Dendritic micro–nano structure Hydrogen production

The brackish-water bivalve Waagenoperna from the Lower Jurassic Badaowan Formation of the Junggar Basin and its palaeoenvironmental and palaeogeographic significance

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2013年第1期4卷 95-103页

作者： Yanhong Pan Jingeng Sha yaqiong Wang Xiaolin Zhang Xiaogang yao Bo Peng Xin Rao State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of Sciences

The brackish-water bivalve Waagenoperna Tokuyama, 1959 is reported from the Lower Jurassic Badaowan Formation at four localities, along the southern margin and western margin of the Junggar Basin. Taphonomic features recorded in the field indicate that it occurs in autochthonous or parautochthonous assemblages. The autecology of Waagenoperna therefore yields information on the palaeoenvironment of the area. The restriction of Waagenoperna to marine and brackish-water settings suggests that the sea water once reached these areas during the Sinemurian. This paper discusses the palaeogeographic implications and suggests an ingression of the sea water from the west to the western and southern part of the Junggar Basin. Additionally, the two Waagenoperna species collected from the Haojiagou section in the Junggar Basin are taxonomically documented.

关键词： Brackish-water bivalve Waagenoperna Transgression Sinemurian Junggar Basin

经颈侧方入路甲状腺小切口手术与传统甲状腺手术治疗单侧甲状腺肿瘤的临床效果

在线全文

学校读者我要写书评

暂无评论

中外医学研究 2024年第19期22卷 143-146页

作者：王涛要巍赵晶斌魏温涛倪雅琼甘肃省肿瘤医院甘肃兰州730050

目的:分析比较经颈侧方入路甲状腺小切口手术与传统甲状腺手术治疗单侧甲状腺肿瘤的临床效果。方法:选取2022年1月—2023年12月甘肃省肿瘤医院收治的120例单侧甲状腺肿瘤患者为研究对象。根据样本纳入时间分组,其中2022年1—12月60例患... 详细信息

目的:分析比较经颈侧方入路甲状腺小切口手术与传统甲状腺手术治疗单侧甲状腺肿瘤的临床效果。方法:选取2022年1月—2023年12月甘肃省肿瘤医院收治的120例单侧甲状腺肿瘤患者为研究对象。根据样本纳入时间分组,其中2022年1—12月60例患者为参照组,实施传统甲状腺手术治疗;2023年1—12月60例患者为研究组,实施经颈侧方入路甲状腺小切口手术治疗。对比两组患者相关治疗指标、疼痛程度、并发症发生情况及术后创面美观满意度。结果:研究组患者切口长度短于参照组,术中出血量少于参照组,手术时间及住院时间短于参照组,差异有统计学意义(P<0.05);研究组患者术后1 d、3 d疼痛程度评分均低于参照组,差异有统计学意义(P<0.05);研究组并发症发生低于参照组,差异有统计学意义(P<0.05);研究组患者术后创面美观满意度总评分高于参照组,差异有统计学意义(P<0.05)。结论:与传统甲状腺手术治疗相比,对单侧甲状腺肿瘤患者实施经颈侧方入路甲状腺小切口手术治疗,可取得更为理想的疗效,有效缩短手术时间及术中出血量等,减轻患者应激反应及疼痛程度,进而可有效减少相关并发症发生,且术后创面美观度相对较高。

关键词：甲状腺肿瘤经颈侧方入路甲状腺小切口手术传统甲状腺手术疼痛程度并发症

双波长激光联合曲安奈德注射对鸡冠血管的作用

在线全文

学校读者我要写书评

暂无评论

中国中西医结合皮肤性病学杂志 2019年第2期18卷 120-122页

作者：李彦锋魏芳周自广马晓焕勾爱丽姚亚琼陈文娇郑州市第一人民医院河南郑州450004

目的研究585 nm/1 064 nm双波长激光联合曲安奈德注射对血管瘤动物模型鸡冠的作用,探讨联合应用治疗血管瘤的可行性。方法将莱亨鸡随机分为A、B、C共3组,每组10只,A组曲安奈德注射实验组,B组双波长激光实验组,C组联合应用实验组,以未处... 详细信息

目的研究585 nm/1 064 nm双波长激光联合曲安奈德注射对血管瘤动物模型鸡冠的作用,探讨联合应用治疗血管瘤的可行性。方法将莱亨鸡随机分为A、B、C共3组,每组10只,A组曲安奈德注射实验组,B组双波长激光实验组,C组联合应用实验组,以未处理侧鸡冠作为自身对照。各组观察第1、3、7、14天实验动物一般情况及鸡冠大体变化,分别在第3、7、14天切取各组鸡冠组织块,观察组织学变化。实验结束后,计算毛细血管减少率,行统计学分析。结果 3组鸡冠均出现不同程度的褪色,组织学观察均可见毛细血管减少,A、B、C组的毛细血管减少率分别为(68.03 1.80)%、(70.01 2.21)%和(89.63 1.93)%。A、B组之间比较差异无统计学意义(t=1.39,P>0.05),C组与A组、C组与B组之间比较差异均有统计学意义(t=34.31,22.09;均P <0.05)。结论双波长激光联合曲安奈德注射能有效作用于鸡冠毛细血管,且效果优于单一疗法。

关键词：血管瘤激光疗法曲安奈德

Prognostic prediction and expression validation of NSD3 in pan-cancer analyses

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2023年第5期47卷 1003-1019页

作者： SHA LI yaqiong LIU CHAOLING yao ANJI XU XIAOLING ZENG YUXIN GE XIAOWU SHENG HAILIN ZHANG XIAO ZHOU YING LONG Translational Medicine Centre Hunan Cancer HospitalThe Affiliated Cancer Hospital of XiangyaSchool of MedicineCentral South UniversityChangshaChina Hunan Provincial Clinical Research Centre for Oncoplastic Surgery Hunan Cancer HospitalThe Affiliated Cancer Hospital of XiangyaSchool of MedicineCentral South UniversityChangshaChina School of Medicine College of MedicineNursing and Health ScienceNational University of IrelandGalwayIreland Central Laboratory Hunan Cancer HospitalThe Affiliated Cancer Hospital of XiangyaSchool of MedicineChangshaChina

Background:Nuclear receptor binding SET domain protein-3(NSD3)is a histone lysine methyltransferase and a crucial regulator of carcinogenesis in several *** aimed to investigate the prognostic value and potential function of NSD3 in 33 types of human ***:The data were obtained from The Cancer Genome ***-Meier analysis,CIBERSORT,gene set enrichment analysis,and gene set variation analysis were *** expression of NSD3 was measured using quantitative real-time polymerase chain reaction and western ***:The expression of NSD3 was altered in pan-cancer *** with higher levels of NDS3 generally had shorter overall survival and disease-specific *** of NSD3 were positively correlated with DNA copy number variation(CNV)in ***3 expression was also associated with tumor mutation burden and microsatellite *** levels of immune-cell infiltration differed significantly between high and low NSD3 ***3 negatively correlated with levels of CD8+T *** enrichment analysis showed that while NSD3 expression was positively associated with several immune cell-related and histone methylation-related pathways,it was negatively correlated with cell metabolism-related,drug transport-related,and drug metabolismrelated ***3 levels in the cell lines tested were significantly *** U251 and NCI-H23 cells,silencing NSD3 inhibited cell proliferation and promoted ***:NSD3 expression was changed in pan-cancer samples that was also verified in cell ***3 was associated with CNV and immune-cell infiltration.A poor prognosis was predicted in patients with high expression of ***3 might hence be a potential marker for predicting tumor prognosis.

关键词： NSD3 Pan-cancer Prognosis Immune cell infiltration TMB MSI