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The direct targets of CBFs:In cold stress response and beyond

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Journal of Integrative Plant Biology 2021年第11期63卷 1874-1887页

作者： Yue Song Xiaoyan zhang Minze Li Hao Yang Diyi Fu Jian Lv yanglin Ding Zhizhong Gong Yiting Shi Shuhua Yang State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China

Cold acclimation in Arabidopsis thaliana triggers a significant transcriptional reprogramming altering the expression patterns of thousands of cold-responsive(COR) genes. Essential to this process is the C-repeat binding factor(CBF)-dependent pathway, involving the activity of AP2/ERF(APETALA2/ethylene-responsive factor)-type CBF transcription factors required for plant cold acclimation. In this study, we performed chromatin immunoprecipitation assays followed by deep sequencing(ChIP-seq) to determine the genomewide binding sites of the CBF transcription factors. Cold-induced CBF proteins specifically bind to the conserved C-repeat(CRT)/dehydrationresponsive elements(CRT/DRE;G/ACCGAC) of their target genes. A Gene Ontology enrichment analysis showed that 1,012 genes are targeted by all three CBFs. Combined with a transcriptional analysis of the cbf1,2,3 triple mutant, we define 146 CBF regulons as direct CBF targets. In addition, the CBF-target genes are significantly enriched in functions associated with hormone, light,and circadian rhythm signaling, suggesting that the CBFs act as key integrators of endogenous and external environmental cues. Our findings not only define the genome-wide binding patterns of the CBFs during the early cold response, but also provide insights into the role of the CBFs in regulating multiple biological processes of plants.

关键词： Arabidopsis CBF target genes ChIP-seq cold acclimation

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基于“厥阴为阖”探讨早醒型失眠的证治

中医药学报 2024年第9期52卷 6-9页

作者：崔杨霖郭玉梦孔雨晨魏雪晴张宪忠张广业山东中医药大学山东济南250355 日照市中医医院山东日照276800

早醒型失眠是以入睡尚可、凌晨易醒为主要表现的睡眠障碍,其发病主要责之阳气非时早出于阴,抑或适时而阳气不生。厥阴为阖承载阴尽阳生之转换,内涵阴气潜藏与阳气生发之功用,是中医六经阴阳气化功能的体现。本文基于厥阴为阖理论,结合... 详细信息

早醒型失眠是以入睡尚可、凌晨易醒为主要表现的睡眠障碍,其发病主要责之阳气非时早出于阴,抑或适时而阳气不生。厥阴为阖承载阴尽阳生之转换,内涵阴气潜藏与阳气生发之功用,是中医六经阴阳气化功能的体现。本文基于厥阴为阖理论,结合六经辨证及阴阳学说,深入剖析早醒型失眠的证治。认为厥阴阳郁寒胜属阖之太过,当解郁通阳,温肾散寒;厥阴阴虚热胜则属阖之不及,当清热安神,滋阴养血;厥阴寒热错杂证属阖之太过与不及并存,当清上温下,平调阴阳。

关键词：厥阴为阖早醒型失眠六经辨证伤寒论

Analysis of Steel Connections to Resist Progressive Collapse

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World Journal of Engineering and Technology 2019年第2期7卷 10-20页

作者： yanglin Gong Chen zhang Jian Deng Department of Civil Engineering Lakehead University Thunder Bay Canada

This paper presented a methodology for the analysis and design of steel connections under a double-span connection within the context of preventing progressive collapse. First, various connection models were described and their pros and cons were provided. Then, the load-displacement characteristics of a component-based spring model were described. Thirdly, an experi-mental study on the behaviors of shear tab connections under tension was presented. The main sources of the deformation capacity of the shear tab connections were identified. Finally, a design example of a shear tab connection was provided to illustrate the methodology.

关键词： Steel Steel Connections Shear Tab Connection Progressive Collapse Connection Robustness

加味连梅汤治疗不寐“热入厥阴证”的临床观察

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中医临床研究 2024年第18期16卷 36-40页

作者：郭玉梦崔杨霖隋晓琳刘红豆孔雨晨赵志鹏王安逸张宪忠山东中医药大学山东济南250355 日照市中医医院山东日照276800

目的:观察加味连梅汤治疗不寐“热入厥阴证”的临床疗效。方法:将68例辨证为热入厥阴证的不寐患者,采用随机数字表法分为对照组和观察组,每组34例。对照组每晚睡前口服艾司唑仑,每次1 mg,每日1次;观察组采用中西医结合疗法,在对照组治... 详细信息

目的:观察加味连梅汤治疗不寐“热入厥阴证”的临床疗效。方法:将68例辨证为热入厥阴证的不寐患者,采用随机数字表法分为对照组和观察组,每组34例。对照组每晚睡前口服艾司唑仑,每次1 mg,每日1次;观察组采用中西医结合疗法,在对照组治疗基础上口服加味连梅汤(黄连、生地黄、麦冬、乌梅、阿胶、酸枣仁、生龙骨、生牡蛎、肉桂),每日1剂,水煎至400 mL,早晚饭后温服。疗程均为4周。对观察组与对照组患者治疗前后的临床症状改善情况、中医证候积分、匹兹堡睡眠质量指数量表(Pittsburgh Sleep Quality Index,PSQI)评分等进行比较。结果:观察组治疗总有效率为91.2%(31/34),对照组治疗总有效率为70.6%(24/34),差异具有统计学意义(P<0.05);观察组经过治疗后,中医失眠证候积分较对照组明显降低(P<0.05),且观察组患者所涉及睡眠时间和质量、睡眠障碍情况、入睡时长、日间功能障碍、睡眠效率和促进睡眠药物使用情况的PSQI评分较对照组亦显著降低(P<0.05)。在治疗过程中未发现与加味连梅汤口服有关的不良反应。结论:加味连梅汤治疗不寐热入厥阴证具有确切疗效,可显著改善此类不寐患者的临床症状,如缩短入睡时间,并延长睡眠时间,从而提高患者生活质量。且不良反应发生率低,使用安全,适合临床推广。

关键词：连梅汤不寐热入厥阴证匹兹堡睡眠质量指数

滇西北生态脆弱区生态足迹动态变化与预测研究——以云南省丽江纳西族自治县为例

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生态学杂志 2005年第12期24卷 1418-1424页

作者：蒋依依王仰麟张源北京大学环境学院

预测研究是生态足迹研究中较为重要的一个研究方向,通过对生态足迹未来发展趋势的拟合,能够有效克服生态足迹计算结果的静态性缺陷,并对区域可持续发展状态的预测、预警和相关政策制定具有实际意义.本文以丽江纳西族自治县为研究对象,... 详细信息

预测研究是生态足迹研究中较为重要的一个研究方向,通过对生态足迹未来发展趋势的拟合,能够有效克服生态足迹计算结果的静态性缺陷,并对区域可持续发展状态的预测、预警和相关政策制定具有实际意义.本文以丽江纳西族自治县为研究对象,运用生态足迹模型,对丽江县1949～2001年共53年的生态足迹进行了计算,在此基础上分析了丽江纳西族自治县不同时期的可持续发展状态,并运用逐步回归分析方法对未来近20年的生态足迹变化进行了模拟分析.结果表明,从1949～2001年,丽江纳西族自治县的人均生态足迹呈整体上升趋势.从0.2938～1.3518 hm2·人-1,人均生态足迹增长近4.6倍,表明在人民生活水平逐渐得到改善的同时,不断增长的消费水平对当地生态环境造成的压力也日益加剧;从不同时期来看,丽江纳西族自治县均处在生态盈余状态,社会经济的发展与生态环境的保护协调程度较好;生态足迹模拟预测结果表明,如保持现有的发展速度,丽江纳西族自治县的人均生态足迹将不断增长,并在2015年超过人均生态承载力,使发展进入不可持续状态.

关键词：生态足迹动态变化预测生态脆弱区云南省丽江纳西族自治县

Analysis of risk factors associated with endoscopic retrograde cholangiopancreatography for patients with liver cirrhosis: a multicenter, retrospective, clinical study

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Chinese Medical Journal 2022年第19期135卷 2319-2325页

作者： Jielin Li Jiexuan Hu Peng Li Yongdong Wu Yongjun Wang Ming Ji Haiyang Hua Wenbin Ran yanglin Pan Shutian zhang Department of Gastroenterology Bejing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseaseBejing 100050China Department of Oncology Beijing Friendship HospitalCapital Medical UniversityBejing 100050China Department of Gastroenterology Cheng De Central HospitalChengdeHebei 06700China xjing Hospital of Digestive Diseases Air Force Medical University of People's Liberation ArmyXranShaanxi 710032China Department of Gastroenterology The Third People's Hospital of ChengduChengduSichuan 610031China.

Background:Endoscopic retrograde cholangiopancreatography(ERCP)is the endoscopic modality of choice for the treatment of biliary and pancreatic ***,patients with cirrhosis,particularly those with decompensated cirrhosis,are believed to be at increased risk for complications associated with *** is a paucity of literature describing the outcomes of ERCP for patients with *** study aimed to investigate the outcomes of ERCP for cirrhosis patients,especially adverse events,and evaluated its safety and ***:We performed a multicenter,retrospective study of all patients at Beijing Friendship Hospital affiliated to Capital Medical University,Xijing Hospital affiliated to Air Force Military Medical University,Beijing Youan Hospital affiliated to Capital Medical University,and the Fifth Medical Center of the People’s Liberation Army General Hospital from June 2003 to August *** adverse events of inpatient ERCP for patients with(n=182)and without liver cirrhosis(controls;n=385)were ***:A total of 567 patients underwent ERCP between January 2003 and December 2019 were enrolled in this *** to patients without cirrhosis,patients with cirrhosis were at higher risk for postoperative complications(odds ratio[OR],4.172;95%confidence interval[CI],1.232–7.031;P<0.001)such as postoperative pancreatitis(OR,2.026;95%CI,1.002–4.378;P=0.001)and cholangitis(OR,3.903;95%CI,1.001–10.038;P=0.036).The main indications for ERCP for patients with cirrhosis in this study included choledocholithiasis(101 cases;55.5%),benign bile duct strictures(46 cases;25.3%),and malignant bile duct strictures(28 cases;15.4%).Among them,23 patients(12.6%)underwent balloon dilation and 79 patients(43.4%)underwent *** the patients with cirrhosis,delayed bleeding occurred in ten patients(5.5%),postoperative pancreatitis occurred in 80 patients(44.0%),and postoperative cholangitis occurred in 25 patients(13.7%).An additional multivari

关键词： Risk factors Endoscopic retrograde cholangiopancreatography Liver cirrhosis

CLINIC EVALUATION OF BONE METABOLISM IN 108 PATIENTS WITH HYPERTHYROIDISM

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CLINIC EVALUATION OF BONE METABOLISM IN 108 PATIENTS WITH HY...

The Third International Congress on Osteoporosis

作者： ShuPing zhang Fengzhen Pai Xiaolan Jin yanglin Uo Zhiqing You Department of Endocrinolong Chengdu army gneral hospital

＜正＞To explore the effect of hyperthyroidism on bone metabolism.108 patients with hyperthyroidism were involved in detection of bone density and bone mass by UBIS *** results show that 78 cases （72.7%） were found bone mass lose,includin 62 cases osteopenia and 16 cases *** in osteopenia group and in osteoporosis group were significantly lower than normal bone mass group, respectively（p＜0.01）.Three index in osteoporosis group were lower than in osteopenia group（p＜0.01）. AKP in osteopenia group and in osteoporosis group were singnificantly higher than in normal bone mass

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陕北黄土高原景观动态的植被覆盖季节响应

地理学报 2005年第2期60卷 299-308页

作者：李正国王仰麟张小飞北京大学环境学院北京100871

半干旱地区生态环境状态与景观动态变化息息相关,为深入探讨景观动态的生态响应,本研究选择陕北黄土高原为研究区,分别就景观动态的3种类型(景观类型间变化、类型内组分变化及未变化)与植被覆盖状态进行分析。其中植被覆盖状态主要通过... 详细信息

半干旱地区生态环境状态与景观动态变化息息相关,为深入探讨景观动态的生态响应,本研究选择陕北黄土高原为研究区,分别就景观动态的3种类型(景观类型间变化、类型内组分变化及未变化)与植被覆盖状态进行分析。其中植被覆盖状态主要通过植被覆盖值高低及年内植被恢复期、维持期与转折点等曲线特征体现。结果发现研究区景观类型的动态变化并不显著,而各动态类型与植被覆盖的相关程度各不相同,植被覆盖不仅和景观类型有关,亦与景观动态类型有关,而在植被覆盖对景观动态的响应上,则体现出由于景观动态类型的差异,造成同一景观类型的植被覆盖季节响应模式和强度完全不同。

关键词：陕北黄土高原植被覆盖景观动态季节景观类型动态类型动态变化半干旱地区环境状态生态响应组分变化曲线特征相关程度响应模式研究区恢复期转折点维持期

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恢复力视角下的乡村空间演变与重构

生态学报 2017年第7期37卷 2147-2157页

作者：张甜刘焱序王仰麟北京大学城市与环境学院地表过程分析与模拟教育部重点实验室北京100871

乡村生产、生活、生态空间重构是中国乡村发展转型的重要途径。恢复力是指系统吸收干扰、经历变化和重组后,仍然保持原有功能、结构、特性和反馈的能力。梳理社会-生态系统恢复力、乡村社区恢复力、空间恢复力相应概念,借助宏观生态学... 详细信息

乡村生产、生活、生态空间重构是中国乡村发展转型的重要途径。恢复力是指系统吸收干扰、经历变化和重组后,仍然保持原有功能、结构、特性和反馈的能力。梳理社会-生态系统恢复力、乡村社区恢复力、空间恢复力相应概念,借助宏观生态学领域中的恢复力相关概念阐释乡村空间演变过程,可以在深化乡村空间演变与重构理论内涵的同时更有效的理解乡村空间的演变过程和重构目标。乡村空间重构并不只是国土或规划层面的景观空间优化,而需要站在强化社会-生态系统恢复力的角度,从乡村空间演化机制入手,提升乡村空间演化动力从而驱动空间重构。将乡村空间的演变阶段嵌入社会-生态系统适应性循环过程中,将作为当前国际研究热点的社会-生态系统恢复力研究引入乡村地理学研究领域,从而进一步扩展了学科研究视角,完成乡村空间演变与重构的理论抽象。

关键词：乡村空间演变乡村空间重构恢复力社会-生态系统适应性循环