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水热-辐射联用技术制备普鲁士蓝/MPC/蚕丝布复合材料及其ROS清除性能研究

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化学与生物工程 2024年第10期41卷 58-63页

作者：唐冬旭刘坤付娌丽周士忠张洋林李月生湖北科技学院医学部药学院湖北咸宁437100 湖北科技学院辐射化学与功能材料湖北省重点实验室湖北咸宁437100 湖北科技学院核技术与化学生物学院湖北咸宁437100

以蚕丝布作为基底原料,通过水热法使普鲁士蓝纳米颗粒(PBNPs)在蚕丝布的表面生长,再通过辐射接枝法将2-甲基丙烯酰氧乙基磷酰胆碱(MPC)接枝在蚕丝布上,制备了普鲁士蓝/MPC/蚕丝布复合材料(PMS),通过XRD、FTIR、TG、DTG、XPS等手段对PMS... 详细信息

以蚕丝布作为基底原料,通过水热法使普鲁士蓝纳米颗粒(PBNPs)在蚕丝布的表面生长,再通过辐射接枝法将2-甲基丙烯酰氧乙基磷酰胆碱(MPC)接枝在蚕丝布上,制备了普鲁士蓝/MPC/蚕丝布复合材料(PMS),通过XRD、FTIR、TG、DTG、XPS等手段对PMS进行了表征,并探究了PMS的活性氧自由基(ROS)清除能力。结果表明,PBNPs成功在蚕丝布上原位生长,MPC成功接枝在蚕丝布上;PMS的结构稳定,具有良好的ROS清除能力,可以有效保护细胞免受ROS攻击。PMS有望成为一种性能优异、有前景的糖尿病伤口护理敷料。

关键词：普鲁士蓝辐射接枝 ROS清除糖尿病伤口

维普期刊数据库博看期刊

Is Mg_(17)Al_(12) ductile or brittle?A theoretical insight

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Journal of Magnesium and Alloys 2023年第3期11卷 936-944页

作者： Jiajia Wang Lei Niu yanglin zhang Jianqing Chen Jinghua Jiang Dan Song Baosong Li Guobing Ying Jiangbo Cheng Aibin Ma College of Mechanics and Materials Hohai UniversityNanjing 210098P.R.of China

The Mg_(17)Al_(12)-phase,which is common and important in Mg-Al alloy,has long been regarded as a brittle phase in experiments but theoretical calculations report controversial *** unravel why theoretical calculations report controversial results and determine whether Mg_(17)Al_(12)is brittle or ductile,density functional theory calculations on atomic level are performed to investigate mechanic properties of Mg_(17)Al_(12)without containing alloying elements and without taking the size *** results showed that the parameter k-point played critical role in the DFT-based elastic *** convergent G/B ratio of Mg_(17)Al_(12)was about 0.52,suggesting that the Mg_(17)Al_(12)-phase was theoretically ductile although its ductility was *** chemical bonding in Mg_(17)Al_(12)was the mixture of metallic Mg-Mg bond and covalent Al-Al *** advantage of metallic bonding over covalent bonding provided a possible explanation for the ductility of Mg_(17)Al_(12).Possible reasons for the brittleness of Mg_(17)Al_(12)in experiments are also discussed.

关键词： Mg_(17)Al_(12) Ductile Brittle DFT Elastic properties

Ammonia Volatilization Losses from Urea Applied to Wheat on a Paddy Soil in Taihu Region, China

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Pedosphere 2005年第1期15卷 59-65页

作者： FANXiao-Hui SONGYong-Sheng LINDe-Xi yanglin-zhang ZHOUJian-Min InstituteofSoilScience ChineseAcademyofSciencesNanjing210008China

Ammonia volatilization losses from urea applied as a basal fertilizer and a top dressing at tillering stage in a wheat field of Taihu Region, China, were measured with a micrometeorological technique. Urea as fertilizer was surface broadcast at 81 (low N) and 135 (high N) kg N ha-1 as basal at the 3-leaf stage of the wheat seedling on December 2002, and 54 (low N) and 90 (high N) kg N ha-1 as top dressing on February 2003. Ammonia volatilization losses occurred mainly in the first week after applying N fert…

关键词： ammonia volatilization urea wheat

Chemical and Microbiological Parameters of Paddy Soil Quality as Affected by Different Nutrient and Water Regimes

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Pedosphere 2005年第3期15卷 369-378页

作者： YANGChang-Ming yanglin-zhang YANTing-Mei StateKeyLab.ofPollutionControlandResourceReuse CollegeofEnvironmentalScienceandEngineeringTongjiUniversityShanghai200092（China） InstituteofSoilScience ChineseAcademyofSciencesP.O.Box821Nanjing210008（China）

A field experiment was conducted from 1999 to 2002 to compare and evaluate the effects of nutrient and water regimes on paddy soil quality by investigating soil chemical and microbiological parameters. Four nutrient regimes, a control, chemical fertilizers only (CF), chemical fertilizers with swine manure (SM), and chemical fertilizers with wheat straw (WS), and two soil moisture regimes, continuous waterlogging (CWL) and alternate wetting and drying (AWD), were investigated. With SM and WS total organic carbon and total nitrogen in the paddy soil were significantly higher (P < 0.05) than those with CF. A similar effect for organic amendments was observed in the soil light fraction organic C (LFOC), water-soluble carbohydrates (WSC), and water-soluble organic C (WSOC). CWL, in particular when swine manure was incorporated into the paddy soil, markedly decreased soil redox potential (Eh) and increased total active reducing substances (ARS). Meanwhile, as compared to CF, SM and WS significantly (P < 0.05) increased soil microbial biomass C (MBC) and mineralizable carbon, with differences in AWD being higher than CWL. In addition, SM and WS treatments significantly (P < 0.05) improved rice above-ground biomass and grain yield, with AWD being greater than CWL. Thus, for ecologically sustainable agricultural management of paddy soils, long-term waterlogging should be avoided when organic manure was incorporated into paddy soil.

关键词： biological index of fertility nutrient regimes paddy soil quality water regimes

Primary Reconstruction of Completely Biologic Tissue Engineered Blood Vessel and Related Basic Research

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生物医学工程学杂志 2005年第S1期22卷 51-52页

作者： Xiu-Hua zhang Yan zhang Yu-Quan LI Xiang-Qun yanglin zhang Hui-Long HUANG(Institute of Biomedical Engineering, The Second Military Medical University, Shanghai 200433,China)

Characteristics of diffusion-tensor imaging for healthy adult rhesus monkey brains

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Neural Regeneration Research 2013年第31期8卷 2951-2961页

作者： Xinxiang Zhao Jun Pu Yaodong Fan Xiaoqun Niu Danping Yu yanglin zhang Department of Radiology Second Affiliated Hospital of Kunming Medical University Department of Neurosurgery Second Affiliated Hospital of Kunming Medical University Department of Neurosurgery Third Affiliated Hospital of Kunming Medical University Department of Pneumology Second Affiliated Hospital of Kunming Medical University Yiwu Hospital Affiliated to Zhejiang University School of Medicine

Diffusion-tensor imaging can be used to observe the microstructure of brain tissue. Fractional ani- sotropy reflects the integrity of white matter fibers. Fractional anisotropy of a young adult brain is low in gray matter, high in white matter, and highest in the splenium of the corpus callosum. Thus, we selected the anterior and posterior limbs of the internal capsule, head of the caudate nucleus, semioval center, thalamus, and corpus callosum （splenium and genu） as regions of interest when using diffusion-tensor imaging to observe fractional anisotropy of major white matter fiber tracts and the deep gray matter of healthy rhesus monkeys aged 4-8 years. Results showed no laterality dif- ferences in fractional anisotropy values. Fractional anisotropy values were low in the head of cau- date nucleus and thalamus in gray matter. Fractional anisotropy values were highest in the sple- nium of corpus callosum in the white matter, followed by genu of the corpus callosum and the pos- terior limb of the internal capsule. Fractional anisotropy values were lowest in the semioval center and posterior limb of internal capsule. These results suggest that fractional anisotropy values in major white matter fibers and the deep gray matter of 4-8-year-old rhesus monkeys are similar to those of healthy young people.

关键词： neural regeneration neuroimaging rhesus monkey fractional anisotropy brain white matter graymatter MRI diffusion-tensor imaging grants-supported paper neuroregeneration

DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation

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Cancer Biology & Medicine 2024年第3期21卷 252-266页

作者： Junya Yan Shibo Wang Jing zhang Qiangqiang Yuan Xianchun Gao Nannan zhang Yan Pan Haohao zhang Kun Liu Jun Yu Linbin Lu Hui Liu Xiaoliang Gao Sheng Zhao Wenyao zhang Abudurousuli Reyila Yu Qi Qiujin zhang Shundong Cang Yuanyuan Lu yanglin Pan Yan Kong Yongzhan Nie State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases Xijing Hospital of Air Force Military Medical UniversityXi'an 710032China Department of Oncology Henan Provincial People's HospitalZhengzhou University People's HospitalZhengzhou 450o03China Faculty of Life Science Northwest UniversityXi'an 710069China Unit 73211 of the People's Liberation Army Nanjing 211800China Key Laboratory of Resource Biology and Biotechnology in Western China(Ministry of Education) School of MedicineNorthwest UniversityXi'an 710069China Shaanxi University of Chinese Medicine Second Clinical Medicine FacultyXi'an 712046China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Renal Cancer and MelanomaPeking University Cancer Hospital and InstituteBeijing 100142China

Objective: DNA damage response(DDR) deficiency has emerged as a prominent determinant of tumor immunogenicity. This study aimed to construct a DDR-related immune activation(DRIA) signature and evaluate the predictive accuracy of the DRIA signature for response to immune checkpoint inhibitor(ICI) therapy in gastrointestinal(GI) ***: A DRIA signature was established based on two previously reported DNA damage immune response assays. Clinical and gene expression data from two published GI cancer cohorts were used to assess and validate the association between the DRIA score and response to ICI therapy. The predictive accuracy of the DRIA score was validated based on one ICI-treated melanoma and three pan-cancer published ***: The DRIA signature includes three genes(CXCL10, IDO1, and IFI44L). In the discovery cancer cohort, DRIA-high patients with gastric cancer achieved a higher response rate to ICI therapy than DRIA-low patients(81.8% vs. 8.8%;P < 0.001), and the predictive accuracy of the DRIA score [area under the receiver operating characteristic curve(AUC) = 0.845] was superior to the predictive accuracy of PD-L1 expression, tumor mutational burden, microsatellite instability, and Epstein–Barr virus status. The validation cohort demonstrated that the DRIA score identified responders with microsatellite-stable colorectal and pancreatic adenocarcinoma who received dual PD-1 and CTLA-4 blockade with radiation therapy. Furthermore, the predictive performance of the DRIA score was shown to be robust through an extended validation in melanoma, urothelial cancer, and ***: The DRIA signature has superior and robust predictive accuracy for the efficacy of ICI therapy in GI cancer and pancancer, indicating that the DRIA signature may serve as a powerful biomarker for guiding ICI therapy decisions.

关键词： DNA damage response-related immune activation immune checkpoint inhibitors biomarker gastrointestinal cancer pan-cancer

技能型社会建设中政府的角色定位及其实现路径——基于新公共管理理论的分析框架

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职业技术教育 2022年第31期43卷 35-40页

作者：张杨林雷世平乐乐郴州职业技术学院教务处郴州423000 长沙航空职业技术学院职教混改研究所长沙航空职业技术学院

新公共管理理论是现代行政管理理论的重要组成部分,其主要内容涉及政府公共行政取向、政府在公共行政中的职责以及政府实施公共行政的方法和手段。其核心要义有:立足顾客至上取向,重塑政府与公众的新型关系;强调政府有限责任,重塑政府... 详细信息

新公共管理理论是现代行政管理理论的重要组成部分,其主要内容涉及政府公共行政取向、政府在公共行政中的职责以及政府实施公共行政的方法和手段。其核心要义有:立足顾客至上取向,重塑政府与公众的新型关系;强调政府有限责任,重塑政府与社会的关系;聚焦服务质量和效率,重塑政府与市场的关系。依据新公共管理理论的要求和技能型社会建设的需要,技能型社会建设中的政府角色定位是:遵循社会需求本位,做服务型政府;正视自身权力结构,做引导型政府;发挥社会主体优势,做参与型政府。政府若要保证自身角色定位和职能的实现,必须完善技能供给的公共服务职能、强化技能供给的宏观管理职能和转化技能供给的社会管理职能。

关键词：技能型社会政府角色定位公共行政模式新公共管理理论

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机电一体化技术进展及发展趋势

机械制造 2005年第6期43卷 22-24页

作者：张杨林郴州职业技术学院湖南423000

介绍国内外机电一体化技术的进展概况,展望未来机电一体化技术的发展趋势。

关键词：发展趋势技术进展机电一体化技术国内外