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Digital signal acquisition system for complex nuclear reaction experiments

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Nuclear Science and Techniques 2024年第1期35卷 124-133页

作者： Wei-Liang pu Yan-Lin ye Jian-Ling Lou Jia-Hao Chen School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China Institute of Applied Physics and Computational Mathematics Beijing 100094China

A digital data-acquisition system based on XIA LLC products was used in a complex nuclear reaction experiment using radioactive ion beams.A flexible trigger system based on a field-programmable gate array(FPGA)parametrization was developed to adapt to different experimental sizes.A user-friendly interface was implemented,which allows converting script language expressions into FPGA internal control *** proposed digital system can be combined with a conventional analog data acquisition system to provide more *** performance of the combined system was veri-fied using experimental data.

关键词： Digital signal acquisition system Trigger Programmable logic Timestamp

High power cladding-pumped low quantum defect Raman fiber amplifier

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Photonics Research 2024年第5期12卷 995-1003页

作者： yang ZHANG JIANGMING Xu JUNRUI LIANG SICHENG LI JUN ye XIAOYA MA TIANFU YAO ZHIYONG PAN JINYONG LENG pu ZHOU College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Hunan Provincial Key Laboratory of High Energy Laser Technology National University of Defense TechnologyChangsha 410073China

Heat generated by the quantum defect(QD)in optically pumped lasers can result in detrimental effects such as mode instability,frequency noise,and even catastrophic ***,we demonstrated that boson-peakbased Raman fiber lasers have great potential in low QD laser *** their power scalability and heat load characteristics have yet to be ***,we demonstrate a boson-peak-based Raman fiber amplifier(RFA)with 815 W output power and a QD of 1.3%.The low heat generation characteristics of this low QD RFA are *** experimental and simulation results show that at this power level,the heat load of the low QD RFA is significantly lower than that of the conventional RFA with a QD of 4.8%.Thanks to its low heat generation characteristics,the proposed phosphosilicate-fiber-based low QD RFA provides an effective solution for the intractable thermal issue in optically pumped lasers,which is of significance in reducing the laser’s noise,improving the laser’s stability and safety,and solving the challenge of heat removing.

关键词： pumped fiber amplifier

A Case Series of Olfactory Dysfunction in Imported COVID-19 Patients:A 12-Month Follow-Up Study

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Biomedical and Environmental Sciences 2022年第5期35卷 402-411页

作者： WANG Ni yang Ming Bo yang pu ye CHEN Ren Bo HUANG Fei SHI Nan Nan MA Yan ZHANG Yan XU You LIU Si Hong LU Heng Yi FU Qing Qing FAN Yi Pin KAN Hong Min WANG Xiao Hong GUO Ya Ling National Center for Tuberculosis Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Hepatology Department of TCM Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Department of Integrated Chinese and Western Medicine Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Infection Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China

Objective The scientific community knows little about the long-term influence of coronavirus disease2019(COVID-19) on olfactory dysfunction(OD). With the COVID-19 pandemic ongoing worldwide, the risk of imported cases remains high. In China, it is necessary to understand OD in imported *** A prospective follow-up design was adopted. A total of 11 self-reported patients with COVID-19 and OD from Xi’an No. 8 Hospital were followed between August 19, 2021, and December 12, ***, clinical characteristics, laboratory and radiological findings, and treatment outcomes were analyzed at admission. We surveyed the patients via telephone for recurrence and sequelae at the1-, 6-, and 12-month *** Eleven patients with OD were enrolled;of these, 54.5%(6/11) had hyposmia and 45.5%(5/11)had anosmia. 63.6%(7/11) reported OD before or on the day of admission as their initial symptom;of these, 42.9%(3/7) described OD as the only symptom. All patients in the study received combined treatment with traditional Chinese medicine and Western medicine, and 72.7%(8/11) had partially or fully recovered at discharge. In terms of OD recovery at the 12-month follow-up, 45.5%(5/11) reported at least one sequela, 81.8%(9/11) had recovered completely, 18.2%(2/11) had recovered partially, and there were no recurrent *** Our data revealed that OD frequently presented as the initial or even the only symptom among imported cases. Most OD improvements occurred in the first 2 weeks after onset, and patients with COVID-19 and OD had favorable treatment outcomes during long-term follow-up. A better understanding of the pathogenesis and appropriate treatment of OD is needed to guide clinicians in the care of these patients.

关键词： COVID-19 Olfactory Imported cases Hyposmia Anosmia Follow-up

Population size estimates based on GPS telemetry

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Zoological Research 2024年第1期45卷 36-38页

作者： Yu-Xuan Fan pu-Zheng Xie Chi Ma Ting Chen Xiao ye Hua-Lin Xu Qiong yang Peng-Fei Fan School of Life Sciences Sun Yat-sen UniversityGuangzhouGuangdong 510275China College of Agriculture and Biological Sciences DaliYunnan 671003China Neilingding-Futian National Nature Reserve of Guangdong ShenzhenGuangdong 518040China

DEAR EDITOR,Accurate estimation of population size is a crucial issue in wildlife population ecology and *** Global Positioning System(GPS)collars are well recognized as an effective method for monitoring wildlife behavior,their application in direct wildlife population size estimation remains *** this study,GPS telemetry was employed to survey a rhesus macaque(Macaca mulatta)population on Neilingding Island in Guangdong,*** May 2021 to April 2022,32 macaques across nine groups were fitted with GPS collars,producing a dataset of 109739 location *** data from all tracked individuals revealed the annual home ranges of the nine groups.

关键词： China Island size

A Neural-network-based Alternative Scheme to Include Nonhydrostatic Processes in an Atmospheric Dynamical Core

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Advances in Atmospheric Sciences 2024年第6期41卷 1083-1099,I0002,I0003页

作者： yang XIA Bin WANG Lijuan LI Li LIU Jianghao LI Li DONG Shiming XU Yiyuan LI Wenwen XIA Wenyu HUANG Juanjuan LIU Yong WANG Hongbo LIU ye pu Yujun HE Kun XIA Ministry of Education Key Laboratory for Earth System Modeling and Department of Earth System ScienceTsinghua UniversityBeijing 100084China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Innovation Group 311020008 Southern Marine Science and Engineering Guangdong LaboratoryZhuhai 519000China Shanghai Ecological Forecasting and Remote Sensing Center Shanghai 200030China Key Laboratory of Earth System Modeling and Prediction China Meteorological AdministrationBeijing 100081China College of Ocean Sciences University of Chinese Academy of SciencesBeijing 100049China

Here,a nonhydrostatic alternative scheme(NAS)is proposed for the grey zone where the nonhydrostatic impact on the atmosphere is evident but not large enough to justify the necessity to include an implicit nonhydrostatic solver in an atmospheric dynamical *** NAS is designed to replace this solver,which can be incorporated into any hydrostatic models so that existing well-developed hydrostatic models can effectively serve for a longer *** advances in machine learning(ML)provide a potential tool for capturing the main complicated nonlinear-nonhydrostatic *** this study,an ML approach called a neural network(NN)was adopted to select leading input features and develop the *** NNs were trained and evaluated with 12-day simulation results of dry baroclinic-wave tests by the Weather Research and Forecasting(WRF)*** forward time difference of the nonhydrostatic tendency was used as the target variable,and the five selected features were the nonhydrostatic tendency at the last time step,and four hydrostatic variables at the current step including geopotential height,pressure in two different forms,and potential temperature,***,a practical NAS was developed with these features and trained layer by layer at a 20-km horizontal resolution,which can accurately reproduce the temporal variation and vertical distribution of the nonhydrostatic *** by the NN-based NAS,the improved hydrostatic solver at different horizontal resolutions can run stably for at least one month and effectively reduce most of the nonhydrostatic errors in terms of system bias,anomaly root-mean-square error,and the error of the wave spatial pattern,which proves the feasibility and superiority of this scheme.

关键词： neural network nonhydrostatic alternative scheme atmospheric model dynamical core

Cardiovascular toxicity with CTLA-4 inhibitors in cancer patients:A meta-analysis

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Cancer Innovation 2024年第3期3卷 49-64页

作者： Huiyi Liu Lu Fu Shuyu Jin Xingdong ye Yanlin Chen Sijia pu Yumei Xue Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhouGuangdongChina School of Medicine South China University of TechnologyGuangzhouGuangdongChina Guangdong Provincial Key Laboratory of Clinical Pharmacology Research Center of Medical SciencesGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina

Background:With the emergence of cytotoxic T lymphocyte-associated protein-4(CTLA-4)inhibitors,the outcomes of patients with malignant tumors have improved ***,the incidence of cardiovascular adverse events has also increased,which can affect tumor *** this study,we evaluated the incidence and severity of adverse cardiovascular events caused by CTLA-4 inhibitors by analyzing reported trials that involved CTLA-4 inhibitor ***:Randomized clinical trials published in English from January 1,2013,to November 30,2022,were searched using the Cochrane Library and pubMed *** included trials examined all grade and grades 3–5 cardiac and vascular adverse *** involved comparisons of CTLA-4 inhibitors to placebo,CTLA-4 inhibitors plus chemotherapy to chemotherapy alone,CTLA-4 inhibitors combined with PD-1/PD-L1 inhibitors to PD-1/PD-L1 inhibitors alone,and CTLA-4 inhibitors plus target agent to PD-1/PD-L1 inhibitors plus target *** odds ratio(OR)and corresponding 95%confidence intervals(CIs)were calculated using the Mantel-Haenszel ***:Overall,20 trials were ***-4 inhibitors significantly increased the incidence of all-grade cardiovascular toxicity(OR=1.33,95%CI:1.00–1.75,p=0.05).The incidence of all-grade cardiovascular toxicity increased in malignant tumor patients who received single-agent CTLA-4 inhibitors(OR=1.73,95%CI:1.13–2.65,p=0.01),as well as the incidence rate of grades 3–5 cardiovascular adverse events(OR=2.00,95%CI:1.08–3.70,p=0.03).Compared with the non-CTLA-4 inhibitor group,CTLA-4 inhibitors plus chemotherapy,PD-1/PD-L1 inhibitors,or target agent did not significantly affect the incidence of cardiac and vascular *** incidence of grades 3–5 cardiac failure,hypertension,pericardial effusion,myocarditis,and atrial fibrillation were much higher among patients exposed to CTLA-4 inhibitor,but the data were not statistically ***:Our findings suggest that the

关键词： cardiovascular toxicity CTLA-4 inhibitors malignancies

GRK2-YAP signaling is implicated in pulmonary arterial hypertension development

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Chinese Medical Journal 2024年第7期137卷 846-858页

作者： Peng ye Yunfei Deng Yue Gu Pengfei Liu Jie Luo Jiangqin pu Jingyu Chen Yu Huang Nanping Wang Yong Ji Shaoliang Chen Division of Cardiovascular Molecular Laboratory Third Clinical CollegeNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiovascular Laboratory Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Division of Cardiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200080China Division of pulmonary Surgery Wuxi People’s HospitalNanjing Medical UniversityWuxiJiangsu 300247China Institute of Vascular Medicine The Chinese University of Hong KongHongkong 999077China Health Science Center East China Normal UniversityShanghai 200241China School of Pharmacy Nanjing Medical UniversityNanjingJiangsu 210004China Division of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China

Background:pulmonary arterial hypertension(PAH)is characterized by excessive proliferation of small pulmonary arterial vascular smooth muscle cells(PASMCs),endothelial dysfunction,and extracellular matrix remodeling.G protein-coupled receptor kinase 2(GRK2)plays an important role in the maintenance of vascular tone and blood ***,the role of GRK2 in the pathogenesis of PAH is ***:GRK2 levels were detected in lung tissues from healthy people and PAH patients.C57BL/6 mice,vascular smooth muscle cell-specific Grk2-knockout mice(Grk2^(∆SM22)),and littermate controls(Grk2^(flox/flox))were grouped into control and hypoxia mice(n=8).pulmonary hypertension(PH)was induced by exposure to chronic hypoxia(10%)combined with injection of the SU5416(cHx/SU).The expression levels of GRK2 and yes-associated protein(YAP)in pulmonary arteries and PASMCs were detected by Western blotting and immunofluorescence *** mRNA expression levels of Grk2 and yes-associated protein(YAP)in PASMCs were quantified with real-time polymerase chain reaction(RT-PCR).Wound-healing assay,3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT)assay,and 5-Ethynyl-2′-deoxyuridine(EdU)staining were performed to evaluate the proliferation and migration of ***,the interaction among proteins was detected by immunoprecipitation ***:The expression levels of GRK2 were upregulated in the pulmonary arteries of patients with PAH and the lungs of PH ***,cHx/SU-induced PH was attenuated in Grk2^(∆SM22) mice compared with littermate *** amelioration of PH in Grk2^(∆SM22) mice was accompanied by reduced pulmonary vascular *** vitro study further confirmed that GRK2 knock-down significantly altered hypoxia-induced PASMCs proliferation and migration,whereas this effect was severely intensified by overexpression of *** also identified that GRK2 promoted YAP expression and nuclear translocation in PASMCs,resulting in excessive PA

关键词： pulmonary arterial hypertension GRK2 YAP pulmonary artery smooth muscle cell Hypoxia

A flame-retardant binder with high polysulfide affinity for safe and stable lithium–sulfur batteries

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Science China Chemistry 2024年第3期67卷 1028-1036页

作者： Guowei Yu Guofeng ye Cheng Wang Chenyang Wang Zhaoyun Wang pu Hu Yu Li Xi-Xi Feng Shuang-Jie Tan Min Yan Sen Xin Zhitian Liu Hubei Key Laboratory of Plasma Chemistry and Advanced Materials Hubei Engineering Technology Research Center of Optoelectronic and New Energy MaterialsSchool of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Lithium-sulfur(Li-S) batteries have shown promises for the next-generation, high-energy electrochemical storage, yet are hindered by rapid performance decay due to the polysulfide shuttle in the cathode and safety concerns about potential thermal runaway. To address the above challenges, herein, we show a flame-retardant cathode binder that simultaneously improves the electrochemical stability and safety of batteries. The combination of soft and hard segments in the polymer framework of binders allows high flexibility and mechanical strength for adapting to the drastic volume change during the Li(de)intercalation of the S cathode. The binder contains a large number of polar groups, which show the high affinity to polysulfides so that they help to anchor active S species at the cathode. These polar groups also help to regulate and facilitate the Li-ion transport, promoting the kinetics of polysulfide conversion reaction. The binder contains abundant phosphine oxide groups, which, in the case of battery's thermal runaway, decompose and release PO· radicals to quench the combustion reactions and stop the fire. Consequently, Li-S batteries using the new cathode binder show the improved electrochemical performance, including a low-capacity decay of 0.046% per cycle for 800 cycles at 1 C and favorable rate capabilities of up to 3 C. This work offers new insights on the practical realization of high-energy rechargeable batteries with stable storage electrochemistry and high safety.

关键词： lithium–sulfur battery polymer binder polysulfide affinity flame retardancy

应用时空滤波模型的亚洲内部国际人口迁移流影响因素分析及短期预测

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地球信息科学学报 2024年第6期26卷 1374-1389页

作者：叶绮霖蒲英霞叶翠南京大学地理与海洋科学学院南京210023 江苏省地理信息技术重点实验室南京210023 江苏省地理信息资源开发与利用协同创新中心南京210023

亚洲是国际人口迁移的活跃区域。除区域社会经济因素外,迁移流之间的时空依赖也不可忽视。本文基于1990—2020年6个时期亚洲国家双边移民流量数据,采用零膨胀负二项回归以及与之相结合的特征向量空间滤波和时空滤波模型(时空同期和时空... 详细信息

亚洲是国际人口迁移的活跃区域。除区域社会经济因素外,迁移流之间的时空依赖也不可忽视。本文基于1990—2020年6个时期亚洲国家双边移民流量数据,采用零膨胀负二项回归以及与之相结合的特征向量空间滤波和时空滤波模型(时空同期和时空滞后),分析亚洲内部国际人口迁移的影响因素,并对2020—2025年人口迁移流进行预测。结果初步表明:①亚洲国际人口迁移流存在显著的时空自相关,且同期邻近迁移流比过去邻近迁移流影响更大,加入表征时空依赖的特征向量能够有效提高模型拟合能力;②人口规模、经济水平、战乱情况以及邻近性是影响亚洲国际人口迁移流的主要因素,在1990—2020年,人口规模效应先减后增,经济差异驱动力则先强后弱,因战乱死亡人数仍具有较强的推力,地理距离的阻碍作用在减小,语言邻近和经济合作依然对人口迁移具有显著的促进作用;③综合时空同期和时空滞后2种模型的预测结果,2020—2025年巴基斯坦和印度之间、印度→沙特、巴基斯坦→阿富汗和叙利亚→约旦的迁移趋势明显;④根据2种时空滤波模型的结果,2020—2025年亚洲国际人口迁移流总量约为1.8×10^(7)人。揭示亚洲内部国际人口迁移的时空依赖特性和其他规律有助于准确预测未来人口迁移趋势,同时为国家经济社会发展的宏观政策制定等提供科学决策参考。

关键词：国际人口迁移流零膨胀负二项回归模型时空依赖特征向量时空滤波模型时空同期结构时空滞后结构人口迁移预测模型亚洲